Keywords: Connexin-43; Heart; IFM; Methods; Mitochondria isolation; Mitofusin; Nagarse; SSM; Subtilisin BPN'; ADP; adenosine diphosphate; ATP5A; ATP synthase subunit alpha; BNIP3; bcl-2/adenovirus E1B 19Â kDa protein-interacting protein 3; COX4; cytochrome c oxidas
مقالات ISI (ترجمه نشده)
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Keywords: WT; wild-type; KO; knockout; tau-/-; homozygous tau KO; mPTP; Mitochondrial permeability transition pore; AD; Alzheimer's disease; GR; Glucocorticoid Receptor; HO; heme oxygenase; GCS; γ-glutamine cysteine synthase; ROS; reactive oxygen species; Mfn1; Mi
Keywords: AIF; apoptosis-inducing factor; ASL; argininosuccinate lyase; ASS; argininosuccinate synthetase; AST; aspartate aminotransferase; BER; base excision repair; cGC; cyclic guanylyl cyclase; CNS; central nervous system; DRP-1; dynamin-related protein 1; EAE;
Keywords: Atherosclerosis; Cardiovascular diseases; Cell cycle; Proliferation; Pulmonary hypertension; Restenosis; Signaling pathway; Vascular smooth muscle cells; ACE; angiotensin converting enzyme; aFGF; acidic FGF; Ang II; angiotensin II; AP-1; activating protei
Keywords: MFN2; CMT2; Compound heterozygosity; Inheritance; Genetic counseling;
Keywords: AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; BNIP3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; CHOP; C/EBP homologous protein; DRP1; dynamin-related protein 1; FIS1; fission protein 1; GRP78; 78Â kDa glucose-regulat
Keywords: ALCAR; Acetyl-l-carnitine; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; CS; citrate synthase; PGC-1α; peroxisome proliferator-activated receptor γ [PPARγ] coactivator-1α; PGC-1β; peroxisome proliferator-activated receptor γ [PPARγ] coactivator-1 β
Keywords: Mitochondrial dynamics; Cytosolic calcium; Hepatocellular carcinoma; Autophagy; Drp1; dynamin 1-like; ER; endoplasmic reticulum; FIS1; fission, mitochondrial 1; IHC; immunohistochemistry; LMNB1; lamin B1; MFN1; mitofusin 1; MFN2; mitofusin 1; NFATC2; nucl
Keywords: ATP; adenosine triphosphate; Ca2+; Â calcium; CamK; calmodulin-dependent kinase; ChREBP; carbohydrate response element binding protein; CypD; cylophilin D; DGAT2; diacylglycerol acyltransferase 2; ER; endoplasmic reticulum; FOXO1; Forkhead box O1; G6P; gl
Keywords: Glycosaminoglycans; Weight loss; Fat loss; White adipose tissue; Oxidative metabolism; B2m; beta-2 microglobulin; BAT; brown adipose tissue; CCK; cholecystokinin; Cox5a; cytochrome c oxidase subunit Va; Cpt1a; carnitine palmitoyltransferase 1a (liver isof
Keywords: Mitochondria; Mitochondrial fission; Mitochondrial fusion; DRP1; OPA1; MFN1; MFN2; GDAP1; Neurodegeneration; Charcot-Marie-Tooth disease; Dominant Optic Atrophy; Neuronal maturation; Neuronal plasticity; Synapse; Dendrite; Axon;
Keywords: Mitochondrial dynamics; Mfn2; Drp1; Mdivi-1; ROS; Vascular smooth muscle cells;
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; CL; cardiolipin; EM; electron microscopy; EMC; ER membrane protein complex; ER; endoplasmic reticulum; ERMES; ER-mitochondria encounter structure; FFAT; two phenylalanines in an acid tract; HOPS;
Keywords: Mitochondria; Drp-1; Mfn2; Heart; Cytochrome c; Calcium; Serca-2a;
Keywords: Mir; microRNA; DNMT; DNA methyltransferase; CBS; cystathionine β-synthase; HHcy; hyperhomocysteinemia; Hcy; homocysteine; mtTFA; mitochondrial transcription factor A; Mfn2; mitofusion 2; H3K18; histone H3 lysine 18; LDH; lactate dehydrogenase; CS; citrat
Keywords: Mitochondrial fusion; Mitochondrial fission; MFN1; MFN2; Drp1; OPA1; Chemical compounds studied in this article; mdivi-1 (PubChem CID:3825829); Calcineurin (PubChem CID:16219117); Dynasore (PubChem CID:5717066); Phenylephrine (PubChem CID:6041);
Keywords: Pelvic organ prolapse; Laser capture microdissection; Fibroblast; Procollagen; Mfn2
Keywords: AICAR; 5â²aminoimidazole-4-carboxyamide-ribonucleoside; AD; Alzheimer's disease; ATF-2; activating transcription factor-2; AMPK; AMP-activated protein kinase; Bnip3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; BnipL/Nix; BCL2/adenovirus E1B 19Â
Keywords: Mitochondrial fission; Mitochondrial fusion; Mild cognitive impairment; Oxidative stress; ERK; Mfn2; Cybrid cells; Free radicals;
Keywords: B2MG; beta-2 microglobulin; CNS; central nervous system; COX-6A1; cytochrome oxidase-6a1; ERR; estrogen-related receptor; G/M; glutamate + malate; GABPA/NRF-2A; GA-binding protein alpha (mouse)/nuclear respiratory factor-2a (human); MFN2; mitofusin-2; P
Keywords: AKAP1; A kinase anchoring protein 1; Endo B1; endophilin B1; ER; endoplasmic reticulum; GDAP1; ganglioside-induced differentiation-associated protein 1; GED; GTPase effector domain; GFP; green fluorescent protein; KO; knockout; LRRK2; leucine-rich repeat
The thiol switch C684 in Mitofusin-2 mediates redox-induced alterations of mitochondrial shape and respiration
Keywords: Oxidative stress; MFN2; Hyperfusion; Mitochondria; Fusion/fission;
Different mitochondrial fragmentation after irradiation with X-rays and carbon ions in HeLa cells and its influence on cellular apoptosis
Keywords: Mitochondrial dynamics; Different quality radiations; Release of cytochrome c; Apoptosis; Radiosensitivity; LET; linear energy transfer; RBE; relative biological effectiveness; Mfn1; mitofusin1; Mfn2; mitofusin 2; OPA1; optic atrophy 1; Drp1; Dynamin-rela
Deficiency of parkin suppresses melanoma tumor development and metastasis through inhibition of MFN2 ubiquitination
Keywords: Parkin; MFN2; Melanoma; Metastasis; Ubiquitination;
Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure
Keywords: AAV; adenovirus-associated virus; ANP; atrial natriuretic protein; ANG II; angiotensin II; BNP; brain natriuretic protein; Drp1; dynamin-related protein 1; ERK; extracellular signal-regulated kinase; IGF-II; insulin-like growth factor II; IGF-IIR; insulin
A novel homozygous MFN2 mutation associated with severe and atypical CMT2 phenotype
Keywords: Charcot-Marie-Tooth; CMT2; Mitofusin 2; MFN2; Neuropathy; Homozygous mutation; CMT; Charcot-Marie-Tooth disease; CMT2A; Charcot-Marie-Tooth type 2A; MFN2; mitofusin 2; NCV; nerve conduction velocity; EMG; electromyography; CMAP; compound motor action pote
TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
Keywords: APP; amyloid precursor protein; VDAC1; voltage dependent anion channel 1; TDP-43; TAR DNA binding protein of 43â¯kDa; PSEN1/PS1; presenilin 1; AD; Alzheimer disease; hnRNP; heterogeneous nuclear ribonucleoprotein; ALS; amyotrophic lateral sclerosis; MND;
Protective effect of mitochondrial-targeted antioxidant MitoQ against iron ion 56Fe radiation induced brain injury in mice
Keywords: IR; iron ion 56Fe radiation; ROS; reactive oxygen species; cyto c; cytochrome c; Mfn2; mitofusin2; Drp1; dynamic-like protein; OPA1; andoptic atrophy gene1; ATP; adenosine triphosphate; mtDNA; mitochondrial DNA; nDNA; nuclear DNA; ADP; adenosine 5â²-diph
MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α
Keywords: MitoQ; Parkinson's disease; Mitochondrial fusion; Mfn2; PGC-1α;
Heme oxygenase-1 protects liver against ischemia/reperfusion injury via phosphoglycerate mutase family member 5-mediated mitochondrial quality control
Keywords: ALT; Alanine aminotransferase; Drp1; dynamin-related protein 1; EDTA; ethylenediaminetetraacetic acid; GDH; glutamate dehydrogenase; H&E; hematoxylin&eosin; HO-1; heme oxygenase-1; H/R; hypoxia/reoxygenation; IL; interleukin; I/R; ischemia/reperfusion; LP
FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission
Keywords: AGEs; advanced glycation end products; Drp1; dynamin-relatedprotein-1; ECs; endothelial cells; FOXO1; forkhead box O1; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HUVECs; human umbilical vein endothelial cells; HG; high glucose concentration; mtROS;
Progesterone treatment modulates mRNA OF neurosteroidogenic enzymes in a murine model of multiple sclerosis
Keywords: CC1; anti-adenomatours polyposis coli clone CC1; CD11b; cluster of differentiation molecule 11B; CFA; complete Freund adjuvant; DHP; dihydroprogesterone; EAE; experimental autoimmune encephalomyelitis; Fis1; mitochondrial fission 1; GABA; gamma-aminobutyr
Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice
Keywords: ALT; Alanine aminotransferase; ActD; Actinomycin D; CYP; Cytochrome P450; CQ; Chloroquine; Drp1; Dynamin-related protein 1; DHPAs; Dehydropyrrolizidine alkaloids; DHR; dehydroretronecine; EM; Electron microscopy; GSH; Glutathione; GAPDH; Glyceradehyde-3-p
Research PaperAge-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression
Keywords: CMT; Charcot-Marie-Tooth; DBA; DBA/2J; DOA; dominant optic atrophy; D2G; DBA/2JGpnmb +;  IOP; intraocular pressure; Mfn1; mitofusin 1; Mfn2; mitofusin 2; NICIF; nanoimmuno capillary isoelectric focusing; NP; NanoPro; ON; optic nerve; Opa1; optic atrophy
CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus
Keywords: SE; status epilepticus; MFN1; mitofusin 1; MFN2; mitofusin 2; OPA1; optic atrophy 1; DRP1; dynamin-related protein 1; Fis-1; fission related protein-1; MFF; mitochondrial fission factor; CDK5; cyclin-dependent kinase 5; PKA; protein kinase A; AIF; apoptot
MiR-485-5p modulates mitochondrial fission through targeting mitochondrial anchored protein ligase in cardiac hypertrophy
Keywords: MAPL; Mfn2; MiR-485-5p; Cardiac hypertrophy; Mitochondrial fission;
Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice
Keywords: PGC-1α; peroxisome proliferator-activated receptor gamma co-activator 1α; TFAM; mitochondrial transcription factor A; BDNF; brain-derived neurotrophic factor; ETC; electron transport chain; OC; old control group; OT; old trained group; YC; young control
An mtDNA mutation accelerates liver aging by interfering with the ROS response and mitochondrial life cycle
Keywords: CAT; catalase; COX; cytochrome c oxidase; DJ7; Parkinson 7; DNM1L; dynamin-1-like protein; FIS1; mitochondrial fission protein 1; MFF; mitochondrial fission factor; MFN1; mitofusin-1; MFN2; mitofusin-2; mtDNA; mitochondrial DNA; mtNOD; C57BL/6NTac-mtNODLt
Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway
Keywords: ADP; adenosine diphosphate; AFC; amino-4-trifluoromethyl coumarin; Akt; protein kinase B; ATP; adenosine triphosphate; Drp1; dynamin-related protein 1; ERK; extracellular signal regulated kinases; Fis1; mitochondrial fission-1 protein; Gp91phox; glycoprot
Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK
Keywords: I/R; ischemia/reperfusion; OGD/REP; oxygen-glucose deprivation/reperfusion; ROS; reactive oxygen species; Drp-1; dynamin- related protein 1; MFN2; mitofusin-2; HG; high glucose; MCAO; middle cerebral artery occlusion; TTC; triphenyltetrazolium chloride; S
Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability
Keywords: OMM; outer mitochondrial membrane; DRP1; dynamin-related protein-1; MFN1; mitofusin 1; MFN2; mitofusin 2; mtDNA; mitochondrial DNA; PINK1; PTEN-induced putative kinase 1; PARK2; parkin; DOA; dominant optic atrophy; CMT2A; Charcot-Marie-Tooth neuropathy ty
Regulation of autophagy by mitochondrial phospholipids in health and diseases
Keywords: ALCAT1; lysocardiolipin acyltransferase 1; ALE1; lysophospholipid acyltransferase (yeast); AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATGL; adipose triglyceride lipase; AVT1; amino acid vacuolar transport; BNIP3; BCL2/adenovirus E1B
Drp1 guarding of the mitochondrial network is important for glucose-stimulated insulin secretion in pancreatic beta cells
Keywords: Pancreatic beta cells; Dynamin-related protein 1 (Drp1); Mitochondrial fission; Mitochondrial dynamics; Glucose-stimulated insulin secretion; Drp1; dynamin-related protein 1; ER; endoplasmic reticulum; Fis1; fission protein 1; Mff; mitochondrial fission f
Genetic variants of the MAVS, MITA and MFN2 genes are not associated with leprosy in Han Chinese from Southwest China
Keywords: Leprosy; MAVS; MITA; MFN2; SNP; Susceptibility
Influence of the APOE genotype on hepatic stress response: Studies in APOE targeted replacement mice and human liver cells
Keywords: AD; Alzheimer's disease; APOE; apolipoprotein E; ATP; adenosine triphosphate; ATP5A1; ATP synthase subunit alpha, mitochondrial; B2M; beta-2 microglobulin; BAX; BCL2-associated X protein; BCL2; B-cell leukemia/lymphoma 2; BiP; binding immunoglobulin prote
Analysis of mitochondrial structure and function in the Drosophila larval musculature
Keywords: ATP; adenosine triphosphate; AEL; after egg laying; CMT2A; Charcot-Marie-Tooth Type 2A; ConA; concanavalin A; Drp1; dynamin-related protein; DOA; dominant optic atrophy; GFP; green fluorescent protein; IFM; indirect flight muscle; IMF; intermyofibrill
Candesartan cilexetil attenuated cardiac remodeling by improving expression and function of mitofusin 2 in SHR
Keywords: LVH; left ventricular hypertrophy; VSMC; vascular smooth muscle cell; EH; essential hypertension; Mfn2; mitofusin 2; SHR; spontaneously hypertensive rat; WKY; Wistar-Kyoto rat; ÎÏm; mitochondrial membrane potential; ROS; reactive oxygen species; BW; bod
Rg1 prevents myocardial hypoxia/reoxygenation injury by regulating mitochondrial dynamics imbalance via modulation of glutamate dehydrogenase and mitofusin 2
Keywords: H/R; hypoxia/reoxygenation; I/R; ischemia/reperfusion; CK; creatine kinase; LDH; lactate dehydrogenase; ROS; reactive oxygen species; OCR; oxygen consumption rate; ECAR; extracellular acidification rate; α-KG; α-ketoglutaric acid; GDH; glutamate dehydro
A combination of an iron chelator with an antioxidant effectively diminishes the dendritic loss, tau-hyperphosphorylation, amyloids-β accumulation and brain mitochondrial dynamic disruption in rats with chronic iron-overload
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β; BBB; blood-brain barrier; DFO; deferoxamine; DFP; deferiprone; DFX; deferasirox; Drp1; dynamin-related protein 1; HFe; high-iron diet; Mfn2; mitofusin2; NAC; n-acetyl cysteine;
Melatonin prevents adverse myocardial infarction remodeling via Notch1/Mfn2 pathway
Keywords: Myocardial infarction; Mitochondria; Melatonin; Notch1; Mfn2; ROS;