Keywords: permeabilization غشای خارجی بیرونی میتوکندری; 5-Aza; 5-Aza-2-deoxycytidine; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; BIR; baculoviral inhibitor of apoptosis repeat; CAD; caspase-activated deoxyribonuclease; CDK; cyclin-dependent kinase; cIAP; cellular inhibitor of apoptosis; CL
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Keywords: permeabilization غشای خارجی بیرونی میتوکندری; AMPA; α-Amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid; AP; action potential; APfreq; AP frequency; ATP; Adenosine triphosphate; [Ca2+]; Calcium concentration; ECD; excitotoxic cell death; FCCP; Carbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone;
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; 3-HK; 3-hydroxykynurenine; 3-NP; 3-nitropropionic acid; 6âOHDA; 6-hydroxidopamine; AADC; aromatic amino acid decarboxylase; ACA; anterior cerebral artery; ADP; adenosine-5â²-diphosphate; ALDH; aldehyde dehydrogenases; ALS; amyotrophic lateral sclerosis
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related; AMPK; AMP-activated protein kinase; AD; Alzheimer's disease; ARE; antioxidant response element; ATF6; activating transcription factor 6; BiP; binding immunoglobulin protein; BRAC1; Breast cancer 1
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; ASH; American Society of Hematology; ATAP; amphipathic tail-anchoring peptide; BAD; BCL-2-associated death promoter protein; BAK; BCL-2 homologous antagonist killer; BAX; BCL-2-associated X protein; BCL-2; B-cell lymphoma 2; BCL-w (BCL2L2); BCL-2-like pro
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; AIPC; Androgen-independent prostate cancer; AKAP1; cAMP signaling; AML; acute myeloid leukemia; BAK; Bcl-2 homologous antagonist killer; BAX; Bcl-2-associated X protein; BCL-2; B-cell lymphoma 2; BMRP; BCL-2 interacting mitochondrial ribosomal protein; C7
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; ÎÏ; mitochondrial membrane potential; Bcl-2; B-cell CLL/lymphoma 2; BH; Bcl-2 homology; CJ; crista junction; CM; cristae membrane; Erv1; essential for respiration and viability; ETC; electron transport chain; FAD; flavin adenine dinucleotide; FADH2; fla
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; BAK; BCL-2 antagonist killer; BAX; BCL-2 associated X protein; CDK1; cyclin dependent kinase 1; CLDN-6; claudin-6; CM; cardiomyocyte; CPE; Clostridium perfringens endotoxin; GPX2; glutathione peroxidase-2; GSH; glutathione; GSR; glutathione reductase; GSS
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; COPD; chronic obstructive pulmonary disease; RS; replicative senescence; SIPS; stress induced premature senescence; OIS; oncogene induced senescence; SASP; senescence associated secretory phenotype; TNF-a; tumor necrosis factor-a; TNFR1; TNFa receptor 1;
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Apaf-1; apoptotic protease activating factor 1; CAD; caspase-activation DNase; cyt c; cytochrome c; Cy; cyclophilin; Drp-1; dynamin-related protein 1; ENDO; endonuclease; AIF; apoptosis-inducing
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; BAX; Bcl-2-associated X protein; BAK; Bcl-2-antagonist or killer; BID; Bcl-2 homology 3-interacting domain death agonist; Bcl-2; B cell lymphoma-2; Bcl-xL; B-cell lymphoma-extra large; VDAC-1; Voltage Dependent Anion Channel 1 porin; MOMP; mitochondrial o
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Glycolysis; Cancer; Cell death; GAPDH; Hexokinase; ANT; adenine nucleotide translocase; APAF-1; apoptotic protease activating factor-1; ATG5; autophagy related 5; ATP; adenosine triphosphate; Bak; Bcl-2 homologous antagonistic killer; Bax; Bcl-2-associate
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; MOMP; mitochondrial outer membrane permeabilization; ODE; ordinary differential equation; PDE; partial differential equation; Mathematical modelling; Systems biology; Caspases; Apoptosis; Ordinary differential equation (ODE); Partial differential equation
Protective effect of wax apple (Syzygium samarangense (Blume) Merr. & L.M. Perry) against streptozotocin-induced pancreatic Ã-cell damage in diabetic rats
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Bcl-2; B-cell lymphoma 2; BSA; bovine serum albumin; b.w.; body weight; CAT; catalase; DAB; 3,3â²-diaminobenzidine; DM; diabetes mellitus; ELISA; enzyme-linked immunosorbent assay; FBG; fasting blood glucose; GSH-Px; gutathione peroxidase; H&E; hematoxyl
BH3 mimetics as anti-fibrotic therapy: Unleashing the mitochondrial pathway of apoptosis in myofibroblasts
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; ECM; extracellular matrix; SSc; systemic sclerosis or scleroderma; IPF; idiopathic pulmonary fibrosis; CKD; chronic kidney disease; α-SMA; alpha-smooth muscle actin; FAK; focal adhesion kinase; ROCK; rho associated protein kinase; BH; BCL-2 homology; MOM
Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Coptisine; Apoptosis; Mitochondria; ROS; PI3K/Akt; AIF; Apoptosis inducing factor; Apaf; 1Apoptosis protease-activating factor 1; CCCP; Carbonyl cyanide 3-chlorophenylhydrazone; COP; Coptisine; CRC; Colorectal cancer; DCFH-DA-2,7; Dichlorodihydrofluoresce
Bioactive Lipid Species and Metabolic Pathways in Progression and Resolution of Nonalcoholic Steatohepatitis
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Nonalcoholic Fatty Liver Disease; Triglycerides; Fatty Acids; Therapy; AA; arachidonic acid; ACC; acetyl-coenzyme A carboxylase; ASMase; acid sphingomyelinase; CeS; ceramide synthase; CoA; coenzyme A; COX; cyclo-oxygenase; DES; dihydro-ceramide desatura
N-terminal acetylation modulates Bax targeting to mitochondria
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; MEF; mouse embryonic fibroblasts; MOMP; mitochondrial outer membrane permeabilization; OMM; outer mitochondrial membrane; cyt c; cytochrome c; tBid; truncated Bid; ART; apoptosis regulating targeting; Nt-acetylation; N-terminal acetylation; NATs; N-termin
Hypertonicity-imposed BCL-XL addiction primes colorectal cancer cells for death
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Hyperosmotic stress; BH3 mimetics; BCL-XL; BCL-2; Apoptosis; BAK; BCL-2 antagonist or killer; BAX; BCL-2-associated X protein; CRC; colorectal cancer; MOMP; mitochondrial outer membrane permeabilization; OMM; outer mitochondrial membrane;
Hepatitis B virus upregulates host microRNAs that target apoptosis-regulatory genes in an in vitro cell model
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; cFLIP; cellular FLICE-inhibitory protein; CHB; chronic hepatitis B; ER; endoplasmic reticulum; HBV; hepatitis B virus; HBx; HBV X protein; HCC; hepatocellular carcinoma; MOMP; mitochondrial outer membrane permeabilization; SODD; silencer of death domains;
The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; DIC; dicarboxylate carrier; GSHEE; GSH ethyl ester; HCC; hepatocellular carcinoma; OGC; 2-oxoglutarate carrier; MOMP; mitochondrial outer membrane permeabilization; mGSH; mitochondrial GSH; mt-cholesterol; mitochondrial cholesterol; TICs; tumor-initiating
Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; ÎÏm; mitochondrial membrane potential; FCCP; carbonylcyanide-4-(trifluoromethoxy)-phenylhydrazone; FITC; fluorescein isothiocyanate; BSA; bovine serum albumin; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolylcarbocyanine iodide; MO
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; 1α,25(OH)2D3; 1,25-dihydroxyvitamin D3; ADAM10; a disintegrin and metalloproteinase 10; AIF; apoptosis-inducing factor; AP-1; activator protein 1; ATRA; all-trans retinoic acid; BMP-2; bone morphogenic protein 2; CLNX; calnexin; CRT; calreticulin; ECM; e
Cytotoxic effect of Kalanchoe flammea and induction of intrinsic mitochondrial apoptotic signaling in prostate cancer cells
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; 2AA; 2-aminoanthracene; 4NQO; 4-nitroquinoline; BCA; bicinchoninic acid; Bcl-2; B-cell lymphoma 2; CA; coumaric acid; CAD; caspase-activated dnase; DAPI; 4',6-diamidino-2-phenylIndole; DCF; oxidize 2'-7'-dichlorodihydrofluorescein; DCFH; reduced 2â
Inhibition of Drp1 protects against senecionine-induced mitochondria-mediated apoptosis in primary hepatocytes and in mice
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; ALT; Alanine aminotransferase; ActD; Actinomycin D; CYP; Cytochrome P450; CQ; Chloroquine; Drp1; Dynamin-related protein 1; DHPAs; Dehydropyrrolizidine alkaloids; DHR; dehydroretronecine; EM; Electron microscopy; GSH; Glutathione; GAPDH; Glyceradehyde-3-p
6-shogaol induces autophagic cell death then triggered apoptosis in colorectal adenocarcinoma HT-29 cells
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; CRC; Colorectal cancer; PAHs; polycyclic aromatic hydrocarbons; PCD; program cell death; ER; endoplasmic reticulum; MOMP; mitochondrial outer membrane permeabilization; APAF1; apoptotic protease activating factor 1; DMSO; dimethyl sulfoxide; PI; propidium
Bax and Bak Pores: Are We Closing the Circle?
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; apoptosis; Bax; Bcl-2 proteins; cell death; mitochondrial outer membrane permeabilization; pore-forming proteins;
BH3-only protein BIM: An emerging target in chemotherapy
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; A1; Bcl-2-related protein A1; Apaf-1; Apoptotic protease-activating factor 1; ASK1; Apoptosis Signal Regulated Kinase 1; Bad; Bcl-2 associated agonist of cell death; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell l
NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; NF-κB; nuclear factor-κB; Bcl-2; B cell lymphoma protein 2; Bcl-xl; Bcl-2-related protein long form of Bcl-x; Mcl-1; myeloid cell leukemia 1; Bax; bcl-2-associated X protein; NAPs; nucleosome assembly proteins; NAP1L; NAP1 like protein; ÎÎÎζ; diacyl
DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Apaf1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma 2; DKO; Bax Bak double knockout; Drp1; Dynamin Related Protein 1; ER; endoplasmic reticulum; IMM; inner mitochondrial membrane; MEFs; mouse embryonic fibroblasts; MFN; mitofusin; MOMP;
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2Â + signaling
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; a.a.; amino acid; ATP; adenosine triphosphate; BH domain; Bcl-2-homology domain; BI-1; Bax inhibitor-1; BIRD-2; Bcl-2/IP3R disruptor-2; BRCA1; breast and ovarian cancer susceptibility gene 1; [Ca2Â +]cyt; cytosolic Ca2Â + concentration; CLL; chronic lymph
Differential regulation of caspase-2 in MPP+-induced apoptosis in primary cortical neurons
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; PD; Parkinson׳s disease; MPTP; 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium; MOMP; mitochondrial outer membrane permeabilization; PCD; programmed cell death pathway; Bax; Bcl-2 associated protein X; JNK; stress-activ
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; 3-Methyladenine (Pubmed CID 1673); Camptothecin (Pubmed CID 24360); Etoposide (Pubmed CID 36462); 7-Bromoindirubin-3-oxime (Pubmed CID 11846148); Necrostatin-1 (Pubmed CID 282833); Q-VD-OPh (Pubmed CID 11237609); 2-Phenylethynesulfonamide (Pubmed CID 3276
Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; AMPK; AMP-activated protein kinase; BSA; bovine serum albumin; DCFH-DA; dichlorofluorescin diacetate; DR4; death receptor 4; ETC; electron transport chain; FBS; fetal bovine serum; HEGU; hexane/ethanol extract of Glycyrrhiza uralensis Fisch; IAA; isoangus
BH3 profiling in whole cells by fluorimeter or FACS
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; MOMP; mitochondrial outer membrane permeabilization; ÎΨm; mitochondrial transmembrane potential; MFI; median fluorescence intensity; Mitochondria; Apoptosis; BCL-2; Flow Cytometry; Cancer; Chemotherapy;
Crosstalk between apoptosis, necrosis and autophagy
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; AIF; Apoptosis Inducing Factor; AMPK; Adenosine Monophosphate activated Kinase; APAF1; Apoptotic Protease Activating Factor 1; BCL-2; B-cell lymphoma 2; BCL-Xl; B-cell lymphoma extra large; BEC1; Beclin-1; BH; Bcl-2 homology; cIAP1; cellular inhibitor of
Noxa couples lysosomal membrane permeabilization and apoptosis during oxidative stress
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; MEFs; mouse embryonic fibroblasts; H2O2; hydrogen peroxide; DFO; desferrioxamine; MOMP; mitochondrial outer membrane permeabilization; LMP; lysosomal membrane permeabilization; AO; acridine orange; Oxidative stress; Apoptosis; Bcl-2 proteins; Lysosomes; I
The oxidized phospholipid PazePC modulates interactions between Bax and mitochondrial membranes
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; CD; circular dichroism; DSC; differential scanning calorimetry; IMM; inner mitochondrial membrane; MAS; magic angle spinning; MLVs; multilamellar vesicles; MOM; mitochondrial outer membrane; MOMP; mitochondrial outer membrane permeabilization; NMR; nuclea
The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; TRAIL; tumor necrosis factor-related apoptosis inducing ligand; DR; death receptor; HNSCC; head and neck squamous cell carcinoma; MOMP; mitochondrial outer membrane permeabilization; mAb; monoclonal antibody; CI; combination index.; TRAIL receptors; Prote
Mitochondrial outer membrane permeabilization during apoptosis: The role of mitochondrial fission
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; MOMP; mitochondrial outer membrane permeabilization; MIM; mitochondrial inner membrane; MOM; mitochondrial outer membrane; IMS; intermembrane space; BH3; Bcl-2 homology domain 3; MEFs; mouse embryonic fibroblasts; Mitochondria; Apoptosis; Fission; Fusion;
Is mPTP the gatekeeper for necrosis, apoptosis, or both?
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; CsA; cyclosporine A; ROS; reactive oxygen species; MPT; mitochondrial permeability transition; MOMP; mitochondrial outer membrane permeabilization; iMACs; inhibitors of MAC; mPTP, mitochondrial permeability transition pore; MAC, mitochondrial apoptosis-in
Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Hexokinase; VDAC1; Mitochondrial outer membrane permeabilization; Protein modeling; Docking simulations; Apoptosis; Cancer;
Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; CFU; colony-forming units; DAPI; 4â²,6-diamidino-2-phenylindole; GFP; green fluorescent protein; mtDNA; mitochondrial DNA; MOMP; mitochondrial outer membrane permeabilization; ÎÏm; mitochondrial transmembrane potential; OD; optical density; PFT; pifith
Mitochondria-dependent apoptosis in yeast
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; Yeast apoptosis; Apoptotic regulators; Mitochondrial outer membrane permeabilization; Permeability transition pore; Bcl-2 family; Mitochondrial fragmentation
Therapeutic role of coenzyme Q10 in Parkinson's disease
Keywords: permeabilization غشای خارجی بیرونی میتوکندری; AIF; apoptosis-inducing factor; ATP; adenosine 5â² triphosphate; C. elegans; Caenorhabditis elegans; CoA; coenzyme A; ETC; electron transport chain; FADH2; flavin adenine dinucleotide; IAP; inhibitors of apoptosis proteins; MOMP; mitochondrial outer memb