Keywords: cGMP; cyclic guanosine monophosphate; DAPI; (4â²,6-Diamidino-2-Phenylindole, Dihydrochloride); EC; endothelial cell; ECs; endothelial cells; eNOS; endothelial nitric oxide synthase; FBS; fetal bovine serum; FITC; Fluorescein isothiocyanate; HAPE; high-al
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Keywords: AAC; abdominal aortic constriction; ADAMS; a disintegrin and metalloproteases; ADAMTS; a distingetrin and metalloproteinase with a thrombospondin domain; Ang II; angiotensin II; BM; basement membrane; BMP-1; bone morphogenic protein-1; CITP; carboxy-termi
Myocardin-related transcription factor A (MRTF-A) mediates doxorubicin-induced PERP transcription in colon cancer cells
Keywords: Transcriptional regulation; MRTF-A; AP-1; Apoptosis; Colon cancer cell; Epigenetics;
PHACTR1 regulates oxidative stress and inflammation to coronary artery endothelial cells via interaction with NF-κB/p65
Keywords: Atherosclerosis; Endothelial dysfunction; PHACTR1; NF-κB signaling; MRTF-A;
MRTF-A mediates the activation of COL1A1 expression stimulated by multiple signaling pathways in human breast cancer cells
Keywords: COL1A1; MRTF-A; Rho-ROCK; TGF-β; Wnt; Breast cancer;
AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis
Keywords: AMPK; chronic kidney disease; cofilin; fibroblast; fibrosis; MRTF-A;
ARF GTPases control phenotypic switching of vascular smooth muscle cells through the regulation of actin function and actin dependent gene expression
Keywords: ARF; ADP-ribosylation factor; αSMA; α-Smooth muscle actin; Mkl1; Megakaryoblastic leukemia 1; MRTF-A; Myocardin-related transcription factor; sm22α; Smooth muscle 22α; VSMC; vascular smooth muscle cells; SecinH3; ADP-ribosylation factor (ARF); G-actin
Paving the Rho in cancer metastasis: Rho GTPases and beyond
Keywords: ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMT; amoeboid-mesenchymal transition; APC; adenomatosis polyposis coli; Arp2/3; actin related protein 2/3; Cdc42; cell division control protein 42 homolog; CK1; casein kinase 1; COX-2; cyclooxygena
Transcription of HOTAIR is regulated by RhoC-MRTF-A-SRF signaling pathway in human breast cancer cells
Keywords: Breast cancer; Rho-signaling; MRTF-A; HOTAIR; Transcription;
FHOD1 formin is upregulated in melanomas and modifies proliferation and tumor growth
Keywords: Formin; FHOD1; Cytoskeleton; Actin; Melanoma; Tumorigenesis; SRE; MKL-1; MRTF-A; MAL;
MRTF-A signaling regulates the acquisition of the contractile phenotype in dedifferentiated chondrocytes
Keywords: Chondrocyte; Dedifferentiation; Cartilage; Actin; MRTF; Contraction; G-actin; globular actin; F-actin; filamentous actin; MRTF-A; myocardin related transcription factor-A; SRF; serum response factor; αSMA; alpha-smooth muscle actin; TAGLN; transgelin; VC
Regulation of microRNA expression in vascular smooth muscle by MRTF-A and actin polymerization
Keywords: miRNA/miR; microRNA; MRTF; myocardin related transcription factor; SMC; smooth muscle cell; HCASMC; human coronary artery smooth muscle cell; mAoSMC; mouse aortic smooth muscle cell; G-actin; globular actin; F-actin; filamentous actin; SRF; serum response
Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics
Keywords: MICAL; Flavoprotein; FAD-containing monooxygenase/oxidase; F-actin depolymerization; Semaphorin signaling; Cytoskeleton; ABS; actin binding site; CasL; Crk (p38)-associated substrate-related protein; CC; coiled-coils; CH; calponin homology; CRMP; collapsi
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Research reportThe role of myocardin-related transcription factor-A in Aβ25-35 induced neuron apoptosis and synapse injury
Keywords: MRTF-A; Myocardin-related transcription factor-A; SRF; serum response factor; Mcl-1; Myeloid cell leukemia-1; Arc; activity-regulated cytoskeletal-associated protein; IEGs; immediate early genes; F-actin; filamentous actin; Alzheimer; MRTF-A; Mcl-1; Arc;
Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs
Keywords: Sphingosine-1-phosphate; GPCR; Cardiac progenitor cells; MRTF-A; RhoA;
Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling
Keywords: Liver fibrosis; MRTF-A; Hepatic stellate cell; TGF-β; Epigenetics; Histone methylation
Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells
Keywords: p300; MRTF-A; Transcription; Cell migration; Breast cancer;
Research ArticleMyocardin related transcription factor A programs epigenetic activation of hepatic stellate cells
Keywords: HSC; hepatic stellate cell; MRTF-A; myocardin related transcription factor A; ASH2; absent, small, or homeotic discs 2; WDR5; WD domain repeat 5; SMA; smooth muscle actin; shRNA; short hairpin RNA; Hepatic stellate cell; Liver fibrosis; Transcriptional re
Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity
Keywords: Baicalin; MRTF-A; Neuronal apoptosis; MCL-1; BCL-2; PI3K; ERK1/2
A crosstalk between chromatin remodeling and histone H3K4 methyltransferase complexes in endothelial cells regulates angiotensin II-induced cardiac hypertrophy
Keywords: Ang II; angiotensin II; Ash2; absent, small, or homeotic discs 2; Brg1; Brahma-related gene 1; COMPASS; complex proteins associated with SET1; ET-1; endothelin; HMT; histone methyltransferase; MRTF-A; myocardin-related transcription factor A; Wdr5; WD dom
Histone methyltransferase SMYD3 promotes MRTF-A-mediated transactivation of MYL9 and migration of MCF-7 breast cancer cells
Keywords: Breast cancer; MRTF-A; SMYD3; Cell migration; Transactivation; Histone methylation; MYL9
Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection
Keywords: CCN1; RhoA; MRTF-A; GPCRs; Cardioprotection;
MRTF-A and STAT3 synergistically promote breast cancer cell migration
Keywords: MRTF-A; myocardin-related transcription factor A; STATs; the signal transducers and activators of transcription; p-STAT3; the phosphorylated form of STAT3; DMEM; Dulbecco's modified Eagle's medium; RT-PCR; reverse-transcription polymerase chain reaction;
Myocardin-related transcription factor-A is a key regulator in retinoic acid-induced neural-like differentiation of adult bone marrow-derived mesenchymal stem cells
Keywords: MSCs; mesenchymal stem cells; RA; retinoic acid; MRTF-A; myocardin-related transcription factor-A; SRF; serum response factor; DN-MRTF-A; dominant-negative form of MRTF-A; db-cAMP; dibutyryl-cAMP; BDNF; brain-derived neurotrophic factors; IBMX; 3-isobutyl
The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis
Keywords: Oxygen toxicity; Lung; Fibroblasts; Collagen; Reactive oxygen species; MRTF-A; Free radicals;
Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal muscles
Keywords: Serum response factor (SRF); MRTF-A; MyoD; Aging; Skeletal muscle