Keywords: گیرنده Fc نوزادان; Biotherapeutics; Gene and cell therapy; Pharmacokinetics; Non-clinical safety; Immunogenicity; Cross-reactive species; ATMP; advanced therapy medicinal products; CAR; chimeric antigen receptor; CD; cluster of differentiation; CMC; chemistry manufacturing
مقالات ISI گیرنده Fc نوزادان (ترجمه نشده)
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Keywords: گیرنده Fc نوزادان; ALB; serum albumin (protein); ALB; albumin gene; FcRn; neonatal Fc receptor; Human serum albumin; Analbuminemia; Heteroduplex analysis; Hypercholesterolemia; Single-strand conformation polymorphism; DNA sequence;
Keywords: گیرنده Fc نوزادان; FcRn; neonatal Fc receptor; TfR; transferrin receptor; TGN; trans-Golgi network; M6P-R; mannose-6-phosphatemannose-6-phosphate receptor; GFP; green fluorescent protein; Endosomal sorting; Receptor recycling; Recycling endosomes; Neonatal Fc receptor; Late
Comparability study of Rituximab originator and follow-on biopharmaceutical
Keywords: گیرنده Fc نوزادان; AA; amino acid; ABC; ammonium bicarbonate; ACN; acetonitrile; ADCC; antibody-dependent cellular cytotoxicity; CD; circular dichroism; CDC; complement-dependent cytotoxicity; CDRs; complementarity determining regions; CH; constant region of heavy chain; CH
Keywords: گیرنده Fc نوزادان; APC; antigen-presenting cells; BcR; B cell receptor; EMA; European Medicines Agency; Fc; crystallizable fragment; FcγR; receptor for IgG Fc portion; FcRn; neonatal Fc receptor; FVIIa; activated factor VII; FVIII; factor VIII; GLP-1; glucagon-like peptide
Keywords: گیرنده Fc نوزادان; BBB; bloodâbrain barrier; Col-IV; collagen IV; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; EB; evans blue; FcRn; neonatal Fc receptor; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; H/I; hypoxic/ischemic; LRP1; low-density lipoprotein recep
Keywords: گیرنده Fc نوزادان; APD-FM; avalanche photodiode fluorescence microscopy; AFM; atomic force microscopy; CDR; complementarity determining regions; Chol; cholesterol; D; diffusion constant; di-8-ANEPPS; 4-[2-[6-(dioctylamino)-2-naphthalenyl]ethenyl]-1-(3-sulfopropyl)-pyridiniu
Keywords: گیرنده Fc نوزادان; ADP; adenosine diphosphate; AE2; anion exchanger 2; Ala; alanine; AMP; adenosine monophosphate; AP; alkaline phosphatase; Arg; arginine; ATP; adenosine triphosphate; ASGP-R; asialoglycoprotein receptor; Asn; asparagine; ASOR; asialoorosomucoid; BDL; bile
Development of a label-free FcRn-mediated transcytosis assay for in vitro characterization of FcRn interactions with therapeutic antibodies and Fc-fusion proteins
Keywords: گیرنده Fc نوزادان; mAb; monoclonal antibody; IgG; immunoglobulin G; FcRn; neonatal Fc receptor; MHC; major histocompatibility complex; B2M; β2 microglobulin; TEER; trans-epithelial electrical resistance; MDCK; Madin-Darby Canine Kidney; FACS; florescence-activated cell sor
Cellular recycling-driven in vivo half-life extension using recombinant albumin fusions tuned for neonatal Fc receptor (FcRn) engagement
Keywords: گیرنده Fc نوزادان; Albumin; Albumin fusion; Intracellular recycling; Neonatal Fc receptor; Half-life extension; Pharmacokinetics;
Boosting half-life and effector functions of therapeutic antibodies by Fc-engineering: An interaction-function review
Keywords: گیرنده Fc نوزادان; Antibody Fc region; Fc-engineering; Fc gamma receptor; Monoclonal antibody; Neonatal Fc receptor; Serum half-life;
Certolizumab pegol for the treatment of chronic plaque psoriasis: Results through 48Â weeks from 2 phase 3, multicenter, randomized, double-blinded, placebo-controlled studies (CIMPASI-1 and CIMPASI-2)
Keywords: گیرنده Fc نوزادان; anti-TNF; anti-tumor necrosis factor; certolizumab pegol; chronic plaque psoriasis; CIMPASI-1; CIMPASI-2; phase 3 trial; CZP; certolizumab pegol; DLQI; Dermatology Life Quality Index; FcRn; neonatal Fc receptor; PASI; Psoriasis Area and Severity Index;
Certolizumab pegol for the treatment of chronic plaque psoriasis: Results through 48Â weeks of a phase 3, multicenter, randomized, double-blind, etanercept- and placebo-controlled study (CIMPACT)
Keywords: گیرنده Fc نوزادان; anti-TNF; anti-tumor necrosis factor; certolizumab pegol; chronic plaque psoriasis; CIMPACT; etanercept; phase 3 trial; CZP; certolizumab pegol; FcRn; neonatal Fc receptor; PASI; Psoriasis Area and Severity Index; PASI 50; â¥50% reduction in PASI from
The expression and function of the neonatal Fc receptor in thyrocytes of Hashimoto's thyroiditis
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; Hashimoto's thyroiditis; Th1/Th2 cytokines; TgAb; IgG;
Neonatal Fc receptor FcRn is involved in intracellular transport of the Fc fusion protein aflibercept and its transition through retinal endothelial cells
Keywords: گیرنده Fc نوزادان; Retinal endothelial cells; Aflibercept; Fc fusion protein; IgG; Neonatal Fc receptor; Internalization; Transport; Transcytosis; DMSO; dimethyl sulfoxide; EEA1; early endosome antigen 1; Fc; fragment crystalisable; FcRn; neonatal Fc receptor; FBS; fetal bo
Medical BiotechnologyAlbumin-binding domain from Streptococcus zooepidemicus protein Zag as a novel strategy to improve the half-life of therapeutic proteins
Keywords: گیرنده Fc نوزادان; ABD; albumin binding domain; AUC; area under the curve; FcRn; neonatal Fc receptor; HSA; human serum albumin; IgG; immunoglobulin G; PEG; polyethylene glycol; MSA; mouse serum albumin; RSA; rat serum albumin; TNFα; necrosis factor; sdAb; single-domain an
Half-life of IgE in serum and skin: Consequences for anti-IgE therapy in patients with allergic disease
Keywords: گیرنده Fc نوزادان; Immunoglobulin; IgE; half-life; metabolism; omalizumab; FcRn; Neonatal Fc receptor; Gal; Galectin; PK; Prausnitz-Küstner;
Phase I Trial of Anti-Vascular Endothelial Growth Factor/Anti-angiopoietin 2 Bispecific Antibody RG7716 for Neovascular Age-Related Macular Degeneration
Keywords: گیرنده Fc نوزادان; AE; adverse event; AMD; age-related macular degeneration; BCVA; best-corrected visual acuity; CNV; choroidal neovascularization; CST; central subfield thickness; FcRn; neonatal Fc receptor; IgG; immunoglobulin G; IOP; intraocular pressure; MD; multiple do
Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum
Keywords: گیرنده Fc نوزادان; Lactobacillus plantarum; Influenza virus; M2e; Neonatal Fc receptor;
Bisalbuminaemia due to novel mutation at a critical residue involved in recycling; Albumin Lyon (510His â Arg)
Keywords: گیرنده Fc نوزادان; TOF MS; Time-of-fight mass spectrometry; t-PA; Tissue plasminogen activator; Albumin mutation; Protein mass spectrometry; Albumin recycling; Neonatal Fc receptor;
Human IgGs induce synthesis and secretion of IgGs and neonatal Fc receptor in human umbilical vein endothelial cells
Keywords: گیرنده Fc نوزادان; HUVECs; human umbilical vein endothelial cells; HSP; heat shock protein; MMP; matrix metalloprotease; FcRn; neonatal Fc receptor; Ab; antibody; EBM; endothelial basal medium; GADPH; glyceraldehyde-3-phosphate dehydrogenase; AP; alcaline phosphatase; MTT;
Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection
Keywords: گیرنده Fc نوزادان; ADCC; Antibody-dependent cell-mediated cytotoxicity; ARV; Anti-retroviral; AZT; Zidovudine; bnAb; Broadly neutralizing antibody; CD4bs; CD4 binding site; dIgA; Dimeric IgA; FcRn; Neonatal Fc receptor; GalCer; Galactosyl ceramide; GI; Gastrointestinal; GU;
Generation of a double transgenic humanized neonatal Fc receptor (FcRn)/albumin mouse to study the pharmacokinetics of albumin-linked drugs
Keywords: گیرنده Fc نوزادان; Albumin; Drug delivery; Neonatal Fc receptor; Protein engineering; Animal model; Drug development;
Manufacturing process used to produce long-acting recombinant factor VIII Fc fusion protein
Keywords: گیرنده Fc نوزادان; rFVIIIFc; Human cell line; HEK 293H; Hemophilia A; Manufacturing; Recombinant; aPTT; activated partial thromboplastin time; α-Gal; galactose-α-1,3-galactose; BDD; B domain-deleted; FcRn; neonatal Fc receptor; FVIII; factor VIII; HC; heavy chain; HCP; ho
Effect of protein aggregates on characterization of FcRn binding of Fc-fusion therapeutics
Keywords: گیرنده Fc نوزادان; BLI; biolayer interferometry; CH2-CH3; constant regions of heavy chains IgG; ELISA; enzyme-linked immunosorbent assay; FcRn; neonatal Fc receptor; FRET; fluorescence resonance energy transfer; HMW; high molecular weight aggregates; HPLC; high-pressure l
Effect of Individual Fc Methionine Oxidation on FcRn Binding: Met252 Oxidation Impairs FcRn Binding More Profoundly than Met428 Oxidation
Keywords: گیرنده Fc نوزادان; monoclonal antibody; serum half-life; oxidation; critical quality attributes; neonatal Fc receptor; protein binding; surface plasmon resonance; HPLC; stability; calorimetry;
A novel bispecific antibody targeting tumor necrosis factor α and ED-B fibronectin effectively inhibits the progression of established collagen-induce arthritis
Keywords: گیرنده Fc نوزادان; RA; rheumatoid arthritis; CIA; collagen-induced arthritis; HSA; human serum albumin; HRP; horseradish peroxidase; TNF; tumor necrosis factor; TNF-scFv; anti-TNF-α scFv; CD3-scFv; anti-CD3 scFv; IMAC; immobilized-metal affinity chromatography; MTT; 3-(4,5
Analysis of heavy and light chain sequences of conventional camelid antibodies from Camelus dromedarius and Camelus bactrianus species
Keywords: گیرنده Fc نوزادان; C1q; multivalent complex and immunoglobulin binding component of the complement activation cascade; CDR; complementarity determining region; CH1 CH2 & CH3; first, second and third heavy chain constant region domains; FcRn; neonatal Fc receptor; Cκ; kappa
Discovery and structure-activity relationships of small molecules that block the human immunoglobulin G-human neonatal Fc receptor (hIgG-hFcRn) protein-protein interaction
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; Protein-protein interactions; FcRn; Small molecule; Inhibitor;
Research ReportEfflux of monoclonal antibodies from rat brain by neonatal Fc receptor, FcRn
Keywords: گیرنده Fc نوزادان; FcRn; neonatal Fc receptor; IgG; immunoglobulin G; WT; wild type; Blood-brain-barrier; IgG; FcRn; Efflux; Intracranial; Intranasal;
ReviewAre endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?
Keywords: گیرنده Fc نوزادان; IgG; immunoglobulin G; FcRn; neonatal Fc receptor; Fc; fragment crystallisable (antibody constant region); Fab; fragment with antigen binding (antibody variable region); F(ab')2; covalently bound Fab portions of an antibody; PBPK; physiologically based
Receptor fusion proteins for the inhibition of cytokines
Keywords: گیرنده Fc نوزادان; Akt; a serine-threonine protein kinase; Bcr-Abl; fusion of the breakpoint cluster region (bcr) gene and a cellular Abelson murine leukemia viral oncogene homolog; CAPS; cryopyrin-associated periodic syndromes; CBM; cytokine binding module; CLC; cardiotr
Directed evolution of stabilized IgG1-Fc scaffolds by application of strong heat shock to libraries displayed on yeast
Keywords: گیرنده Fc نوزادان; IgG1; immunoglobulin G class 1; Fcab; antigen binding Fc protein; Fc-wt; recombinant wild-type Fc protein; scTCR; single-chain T-cell receptor; MHC; major histocompatibility complex; CDC; complement dependent cytotoxicity; ADCC; antibody dependent cell-me
Neonatal Fc receptor stimulation induces ubiquitin c-terminal hydrolase-1 overexpression in podocytes through activation of p38 mitogen-activated protein kinase
Keywords: گیرنده Fc نوزادان; Glomerulonephritides; Neonatal Fc receptor; p38; Podocyte; Ubiquitin c-terminal hydrolase-1 (UCH-L1)
Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; β2-microglobulin; In vivo biotinylation; pH dependence; Surface plasmon resonance; Multicistronic episomal vector;
PEGylation enhances the therapeutic potential of peptide antagonists of the neonatal Fc receptor, FcRn
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; FcRn inhibitor; PEGylation; Autoimmune disease
Expression of soluble and functional human neonatal Fc receptor in Pichia pastoris
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; Two-promoter vector system; Pichia pastoris; Functional expression; Fc engineering;
Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG
Expression and immunohistochemical localization of the neonatal Fc receptor (FcRn) in the mammary glands of the Egyptian water buffalo
Keywords: گیرنده Fc نوزادان; Mammary glands; Neonatal Fc receptor; Egyptian water buffalo; Immunohistochemistry
Cytomegalovirus-specific, high-avidity IgG with neutralizing activity in maternal circulation enriched in the fetal bloodstream
Keywords: گیرنده Fc نوزادان; CMV, cytomegalovirus; DMEM, Dulbecco's modified Eagle's medium; ELISA, enzyme-linked immunosorbent assay; gB, glycoprotein B; IE, immediate early; PCR, polymerase chain reactionCongenital CMV infection; Passive immunity; Neonatal Fc receptor; High-avidity
Structural characterization of a human Fc fragment engineered for extended serum half-life
Keywords: گیرنده Fc نوزادان; Immunoglobulin G; Fc; X-ray crystal structure; Serum half-life; Neonatal Fc receptor
The neonatal Fc receptor plays a crucial role in the metabolism of IgG in livestock animals
Keywords: گیرنده Fc نوزادان; FcRn; neonatal Fc receptor; β2m; beta 2-microglobulin; Ig; immunoglobulin; IgG; immunoglobulin G; IgG metabolism; Neonatal Fc receptor; Maternal immune transport;
Structure–activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction
Keywords: گیرنده Fc نوزادان; Neonatal Fc receptor; FcRn; Autoimmune disease; Peptide antagonist; Peptidomimetic; Inhibition
Association Between IgG2 and IgG3 Subclass Responses to Toxin A and Recurrent Clostridium difficile-Associated Disease
Keywords: گیرنده Fc نوزادان; CDAD; Clostridium difficile-associated disease; ELISA; enzyme-linked immunosorbent assay; Fc; fragment crystallizable; FcR; neonatal Fc receptor;
Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathway
Keywords: گیرنده Fc نوزادان; FcRn; Transepithelial transport; Erythropoietin; Interferon alpha; Interferon beta; Follicle stimulating hormone; Aerosol; Fc-fusion protein; Neonatal Fc receptor; Lung
Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
Keywords: گیرنده Fc نوزادان; FcγR; Fcγ receptor; FcRn; Neonatal Fc receptor; TCR; T-cell receptor; Ig; Immunoglobulin; T-Ag; T-antigen; SV40 ori; SV40 origin of replication; EBV; Epstein Barr virus; EBNA1; Epstein Barr virus nuclear antigen 1; oriP; EBV origin of replication; CMV;
The generation of immunotoxins using chimeric anti-CD22 antibodies containing mutations which alter their serum half-life
Keywords: گیرنده Fc نوزادان; AUC; area under the curve; cRFB4; wild-type chimeric cRFB4; cRFB4-H435A; chimeric H435A mutant antibody; cRFB4-TM; T307A/E380A/N434A mutant; FCR; fractional catabolic rate; FcRn; neonatal Fc receptor; GAHuIg; goat anti-human immunoglobulin; hIgG; human im