Keywords: AGEs; advanced glycation end products; ATM; Adipose tissue macrophage; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor 1; CXCL; CXC chemokine l
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Keywords: ACP5; Acid phosphatase 5; ADAR1; Adenosine deaminase RNA-specific 1; AGS; Aicardi-Goutières syndrome; ALRs; AIM2-like receptors; AIM2; Absent in melanoma 2; ASC; Apoptosis-associated speck-like protein containing a CARD; CANDLE; Chronic atypical neutroph
Keywords: pattern recognition receptors; inflammasome; NLRP3; caspase; IL-1β; viroporin
Keywords: PCD; programmed cell death; FADD; fas-associated protein with death domain; FLIP; FLICE-inhibitory protein; NLRP3; (NACHT, LRR and PYD domain-containing protein3); cIAP; cellular inhibitor of apotosis protein; Z-YVAD-FMK; benzyloxycarbonyl-Tyr-Val-Ala-Asp
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; BW; body weight; CAT; catalase; CMS; unpredictable chronic mild stress; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorbent assay; FST; forced swim test; HPA; h
Keywords: 11β-HSD1; 11β-hydroxysteroid dehydrogenase type 1; BDNF; brain-derived neurotrophic factor; CCI; controlled cortical impact; CD11b; complement receptor 3; CORT; corticosterone; ERK; extracellular signal-regulated protein kinase; GC; glucocorticoid; GLT1
Keywords: ER; endoplasmic reticulum; FA; fatty acid; Gpr120; G-protein-coupled receptor 120; HGO; hepatic glucose output; LA; linoleic acid (18: 2 n 6); HPA; high-palmitic-acid diet; HOA; high-oleic-acid and low-palmitic-acid diet; IL; interleukin; JNK; c-Jun N-ter
Keywords: BoHV-1; Inflammasome; DNA sensor IFI16; NLRP3; Caspase 1
Keywords: Intermittent fasting; Inflammasomes; Ischemic stroke; NLRP1; NLRP3
Keywords: Asthma; inflammatory phenotypes; gene expression; induced sputum; neutrophils; eosinophils; ACQ; Asthma Control Questionnaire; ALPL; Alkaline phosphatase, tissue-nonspecific isozyme; AUC; Area under the curve; BIRC3; Baculoviral IAP repeat containing 3; B
Keywords: AIM2; absent in melanoma 2; AP-1; activating protein-1; APOBEC; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like; AZT; azidothymidine; CCCR5; C-C chemokine receptor type 5; CDK1; cyclin-dependent kinase 1; CXCR4; C-X-C chemokine receptor t
Keywords: Decorin; Lumican; Fibromodulin; Toll-like receptor; Matrix metalloproteinases; 5/6-Nx; 5/6-nephrectomized Sprague-Dawley rats; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; ALK; activin like kinase; ATS; hymocyte serum; BGN (Bgn)
Keywords: ABCA; ATP-binding cassette transporter; AIM; Apoptosis inhibitor of macrophage; APC; antigen-presenting cell; ASC; apoptotic speck protein containing a caspase recruitment domain; AT; adipose tissue; ATM; AT macrophage; BLT; leukotriene B4 receptor; BM; b
Keywords: ABR; auditory brainstem responses; AD; Alzheimers disease; ADP; adenosinediphosphate; AGEs; advanced glycation end products; ATP; adenosinetriphosphate; CAPD; chronic ambulatory peritoneal dialysis; CDP-DAG; cytidinediphosphate-diacylglycerol; CFS; chroni
Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
Keywords: Inflammasome; PULMONARY TB; polymorphisms; NLRP3; CTSB; P2X7; CARD8
PPARÃ/δ agonist alleviates NLRP3 inflammasome-mediated neuroinflammation in the MPTP mouse model of Parkinson's disease
Keywords: PPARβ/δ; NLRP3; Neuroinflammation; Astrocytes; Parkinson's disease;
Activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation contribute to the protective effect of chlorogenic acid on acute liver injury
Keywords: ALT; alanine transaminase; ASC; apoptosis-associated speck-like protein; AST; aspartate transaminase; AREs; antioxidant response elements; CAT; catalase; CGA; chlorogenic acid; CCl4; carbon tetrachloride; CYP2E1; cytochrome P450 2E1; GCLC; glutamate-cyste
Emerging role of the P2X7-NLRP3-IL1β pathway in mood disorders
Keywords: P2X7; NLRP3; Microglia; Mood disorders; Depression; Neuroinflammation; Neuropsychiatry; Neuroimmunology;
NLRP3 inflammasomes and NLRP3 inflammasome-derived proinflammatory cytokines in peripheral blood mononuclear cells of patients with ankylosing spondylitis
Keywords: Ankylosing spondylitis; NLRP3; Inflammasome; Interleukin-1β; Interleukin-17;
Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD
Keywords: COPD; Melatonin; Inflammation; NLRP3; SIRT1;
Nebulized lidocaine ameliorates allergic airway inflammation via downregulation of TLR2
Keywords: TLR2; toll-like receptor 2; P-NF-κBp65; phosphorylated nuclear factor -κBp65; NLRP3; NOD-like receptor pyridine containing 3; OVA; ovalbumin; Lidocaine; Allergic airway inflammation; TLR2; Pam3CSK4; NLRP3;
Association of NLRP3 single nucleotide polymorphisms with ulcerative colitis: A case-control study
Keywords: Ulcerative colitis; Single nucleotide polymorphisms; NLRP3;
Actinidia arguta extract attenuates inflammasome activation: Potential involvement in NLRP3 ubiquitination
Keywords: Actinidia arguta; Inflammasome; NLRP3; Ubiquitination; ASC; Peritonitis;
Mitophagy and the release of inflammatory cytokines
Keywords: Autophagy; Inflammasome; Il-1; Il-18; MIF; NLRP3; Pyroptosis;
Decreased NLRP3 inflammasome expression in aged lung may contribute to increased susceptibility to secondary Streptococcus pneumoniae infection
Keywords: S. pne; Streptococcus pneumoniae; NLRP3; NACHT, LRR, and PYD domains-containing protein 3; ASC; apoptosis-associated speck-like protein containing a CARD; NOD; nucleotide-binding oligomerization domain-containing protein; RIP2; receptor-interacting serine
ALK is required for NLRP3 inflammasome activation in macrophages
Keywords: ALK; Macrophage; Inflammasome; NF-κB; Lipid peroxidation; PAMP; pathogen-associated molecular pattern molecule; DAMP; damage-associated molecular pattern molecule; NLRP3; NLR family pyrin domain containing; PYCARD; PYD and CARD doma0069n containing; ATP;
Leucine rich α-2 glycoprotein is a potential urinary biomarker for renal tubular injury
Keywords: LRG; Biomarker; Albumin overload; NLRP3; IL-1β; Renal tubular injury;
Interleukin-enhanced binding factor 2 interacts with NLRP3 to inhibit the NLRP3 inflammasome activation
Keywords: Apoptosis-associated speck-like protein containing a CARD; ASC; Caspase-1; Casp-1; Interleukin-1β; IL-1β; Interleukin-enhanced binding factor 2; ILF2; NACHT; LRR and PYD domains-containing protein 3; NLRP3; The NLRP3 inflammasome;
Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression
Keywords: MDD; major depressive disorder; HPA; Hypothalamus-Pituitary-Adrenal; CNS; central nervous system; NSCs; neural stem cells; DG; dentate gyrus; CUMS; chronic unpredictable mild stress; BA; Baicalin; SPT; sucrose preference test; FST; forced swimming test; O
Leucodin attenuates inflammatory response in macrophages and lipid accumulation in steatotic hepatocytes via P2x7 receptor pathway: A potential role in alcoholic liver disease
Keywords: Leucodin; Alcoholic liver steatosis; Inflammation; P2x7R; NLRP3;
MicroRNA-30c-5p inhibits NLRP3 inflammasome-mediated endothelial cell pyroptosis through FOXO3 down-regulation in atherosclerosis
Keywords: Atherosclerosis; miR-30c-5p; NLRP3; Pyroptosis; FOXO3;
NLRP3 as a potentially novel biomarker for the management of osteoarthritis
Keywords: Osteoarthritis; NLRP3; Inflammasome; Biomarker; Inflammation;
Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib
Keywords: Bortezomib; NLRP3; Painful neuropathy; STAT3; Histone acetylation;
Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury
Keywords: Nuclear factor erythroid 2-related factor 2; Nod-like receptor protein 3 inflammasome; Thioredoxin1; Thioredoxin interacting protein; Inflammation; NLRP3; nod-like receptor protein 3; TXNIP; thioredoxin interacting protein; Trx1; thioredoxin1; Nrf2; nucle
The role of the NLRP3 inflammasome and the activation of IL-1β in the pathogenesis of chronic viral hepatic inflammation
Keywords: CHB; chronic hepatitis B; CHC; chronic hepatitis C; NLRP3; NACHT, LRR, and PYD domains-containing protein 3/cryopyrin; LRR; leucine-rich repeat; NACHT; nucleotide-binding and oligomerization domain; NAD; NACHT-associated domain; NBD; nucleotide-binding do
Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome
Keywords: Oxidative stress; Cathepsin B; NLRP3; Inflammasome; IL-1β;
Inflammatory mediators ATP and S100A12 activate the NLRP3 inflammasome to induce MUC5AC production in airway epithelial cells
Keywords: Airway epithelial cells; ATP; MUC5AC; NLRP3; NF-κB; S100A12;
LncRNA FIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells
Keywords: FIRRE; NF-kB; NLRP3; Stroke;
BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis
Keywords: AIH; autoimmune hepatitis; EAH; experimental autoimmune hepatitis; BMSCs; bone marrow derived mesenchymal stem cells; miR 223; microRNA 223; LPS; lipopolysaccharide; ATP; adenosine triphosphate; ALT; alanine transaminase; AST; aspartate transaminase; NLRP
NLRP3: A promising therapeutic target for autoimmune diseases
Keywords: NOD; nucleotide-binding domain; ASC; apoptosis-associated speck-like protein; PRRs; sensor- pattern-recognition receptors; NLRP3; nucleotide-binding oligomerization domain and leucine rich repeat pyrin 3 domain; PAMPs; pathogen-associated molecular patter
Clinical significance of serum NLRP3 levels in patients with chronic gouty arthritis
Keywords: Gout; NLRP3; Interleukin-1beta; Uric acid; Inflammasome;
Atractylodin attenuates lipopolysaccharide-induced acute lung injury by inhibiting NLRP3 inflammasome and TLR4 pathways
Keywords: Atractylodin; Inflammation; Acute lung injury; NLRP3; TLR4;
Reduced inflammatory factor expression facilitates recovery after sciatic nerve injury in TLR4 mutant mice
Keywords: TLR4 mutant; Recovery of sciatic nerve injury; Inflammation; Nlrp3; Nlrp6;
Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, improves cognitive impairment in lipopolysaccharide-induced mouse model of Alzheimer's disease
Keywords: Nootkatone; Alpiniae Oxyphyllae Fructus; Alzheimer's disease; Neuroinflammation; Lipopolysaccharide; NF-κB p65; NLRP3;
A critical appraisal of the role of intracellular Ca2+-signaling pathways in Kawasaki disease
Keywords: [Ca2+]cyt; free cytosolic Ca2+ concentration; CRAC; Ca2+-release activated Ca2+ entry; EBV; Epstein-Barr virus; ER; endoplasmic reticulum; IP3; inositol 1,4,5-trisphosphate; IP4; inositol 1,3,4,5-tetrakisphosphate; IP3R; IP3 receptor; KD; Kawasaki disease
Endogenous n-3 polyunsaturated fatty acids prevent azoxymethane-induced colon tumorigenesis in mice fed a high-fat diet
Keywords: n-3 polyunsaturated fatty acids; Fat-1; Colon tumour; High fat diet; Inflammatory pathways; PUFAs; polyunsaturated fatty acids; AOM; azoxymethane; HFD; high-fat diet; NFD; normal food diet; WT; wild-type; TNF-α; tumour necrosis factor-alpha; IL-6; interl
Resveratrol: An overview of its anti-cancer mechanisms
Keywords: Resveratrol; Cancer metabolism; Nrf2; NLRP3; MAPK; NFkB; MKP-1; Autophagy;
Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release
Keywords: NAFLD; Non-alcoholic fatty liver disease; NLRP3; NACHT, LRR, and PYD domains-containing protein 3; NAFL; Non-alcoholic fatty liver; NASH; non-alcoholic steatohepatitis; FFA; free fatty acid; PA; palmitic acid; KCs; Kupffer cells; MCD; methionine choline d
Synthesis of 1,5-Anhydro-d-fructose derivatives and evaluation of their inflammasome inhibitors
Keywords: Carbohydrates; 1,5-Anhydro-d-fructose derivatives; Enones; Inflammasome; NLRP3;