Keywords: Tobacco vapor product; Cigarette smoke; Hoffmann analytes; Mutagenicity; In vitro genotoxicity; Cytotoxicity; CMF-PBS; Calcium- and magnesium-free phosphate buffer saline; CI; Confidence interval; CO; Carbon monoxide; DMSO; Dimethyl sulfoxide; GVP; Gas va
مقالات ISI (ترجمه نشده)
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Keywords: Carcinogenesis; Chemoprevention; Chemotherapy; Oxidative stress; Nrf2; Phytochemicals; AKT; protein kinase B; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ATF-2; activating transcriptional factor; BBN; N-butyl-N-(4-hydroxybutyl)n
Keywords: β-HCH; β-hexachlorocyclohexane; µg/l; microgram per liter; µM/l; micromolar per liter; Ʃ; total; 1-HP; 1-hydroxypyrene; 2; 3-DHBA, 2,3-dihydroxybenzoic Acid; 2cx-MMHP; mono-(2-carboxymethylhexyl) phthalate; 3PBA; 3-phenoxybenzoic acid; 4F3PBA; 4-fluo
Keywords: DIW; deionized water; Gua; guanine; LC-MS/MS; liquid chromatography-tandem-mass spectrometry; LODs; limits of detection; MRM; multiple reaction monitoring; MS; mainstream smoke; N3-EtAde; N3-ethyladenine; N3-MeAde; N3-methyladenine; N7-EtGua; N7-ethylgu
Keywords: Oxysterols; Cancer; Polymorphism; Risk; Genetics; Cholesterol; 25(OH)D; 25-hydroxyvitamin D; ABC; ATP-binding cassette; AEBS; antiestrogen-binding site; BC; breast cancer; BCR; biochemical recurrence; CETP; cholesteryl ester transfer protein; CH25H; chole
Keywords: CENTRAL; Cochrane Central Register of Controlled Trials; CINAHL; Cumulative Index to Nursing and Allied Health Literature; 3-EP; 3-ethenylpyridine; e-cig; e-cigarrettes; FeNO; exhaled nitric oxide; h; hours; ICTRP; International Clinical Trials Registry P
Keywords: Alternative sampling strategies; Adduct; DNA; Proteins; Biomarker; Dried blood spots; 4-ABP; 4-aminobiphenyl; AFB1; aflatoxin B1; B[a]P; benzo[a]pyrene; BChE; butyrylcholinesterase; DBS; dried blood spot; dG-C8; N-(deoxyguanosin-8-yl); DPS; dried plasma s
Keywords: Tobacco heating system; Heat-not-burn; THS2.2; Modified risk tobacco product; Harmful and potentially harmful constituents; HPHC; Aerosol chemistry; Blend comparison; NNK; 4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone; HPHC; harmful and potentially ha
Keywords: 5(6)-CFDA; 5-(and-6)-carboxyfluorescein diacetate; AIG; anchorage-independent growth; ALDH; aldehyde dehydrogenase; ATCC; American Type Culture Collection; B[α]P; benzo[α]pyrene; BrdU; 5-bromo-2â²-deoxyuridine; CF; carboxyfluorescein; CM medium; comple
Keywords: BL group; red, mature betel nut wrapped in Piper betle leaf; BN group; red, mature betel nut only; BQ group; betel quid consisting of young, green betel nut wrapped in Piper betle leaf with lime and tobacco; IS; internal standard; NAT; N-nitrosoanatabine;
Keywords: BoE; biomarker of exposure; BoBE; biomarker of biological effect; BoED; biomarker of effective dose; FDA; Food and Drug Administration; IOM; Institute of Medicine; ISO; International Organisation for Standardisation; ISRCTN; International Standard Randomi
Keywords: A/C; air conditioning; BEF; building envelope factor; D; non-oil sector diversification factor; E; energy; EE; energy efficiency; f; fertility factor; FGDP; GDP factor; GDP; gross domestic product; GW; giga watt; KPC; Kuwait Petroleum Corporation; L; loss
Keywords: ADC; arginine decarboxylase; BBL; berberine bridge enzyme-like; bHLH; basic helix-loop-helix; DMN; dihydrometanicotine; ERF; ethylene response factor; JA; jasmonic acid; JAZ; jasmonate ZIM-domain; MAPKK; mitogen-activated protein kinase kinase; MATE;
A simple and highly sensitive UPLC-ESI-MS/MS method for the simultaneous quantification of nicotine, cotinine, and the tobacco-specific carcinogens N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in serum samples
Keywords: Tobacco; Nicotine; Cotinine; NNN; NNK; UPLC-ESI-MS/MS;
An evaluation of electronic cigarette formulations and aerosols for harmful and potentially harmful constituents (HPHCs) typically derived from combustion
Keywords: E-cigarette; E-liquid; ENDS; Combustion; Harmful and potentially harmful constituents; HPHC; 1-NA; 1-aminonaphthalene; 2-NA; 2-aminonaphthalene; 4-ABP; 4-aminobiphenyl; B[a]P; benzo[a]pyrene; CFP; Cambridge Filter Pad; CORESTA; Cooperation Centre for Scie
A high efficient nanostructured filter based on functionalized carbon nanotube to reduce the tobacco-specific nitrosamines, NNK
Keywords: Nanostructured filter; NNK; Tobacco smoke; Functionalized carbon nanotubes;
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model
Keywords: DSB; double-strand breaks; ELISA; enzyme-linked immunosorbent assay; WB; western blot; FC; flow cytometry; HCS; high content screening; PAHs; polyaromatic hydrocarbons; WHO FCTC; World Health Organization Framework Convention on Tobacco Control; CCK8; cel
Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1
Keywords: PHF5A; ERK; Pancreatic Carcinogenesis; Nicotine Receptor Signaling; AF; autofluorescence; ALDH; aldehyde dehydrogenase; AP-1; Activator Protein-1; C-CSE; commercial CSE; ChIP; chromatin immunoprecipitation; CHRNA7; cholinergic receptor nicotinic alpha 7
Identification of 5-hydroxymethylfurfural in cigarette smoke extract as a new substrate metabolically activated by human cytochrome P450 2A13
Keywords: CYP; cytochrome P450; CYP2A13; cytochrome P450 2A13; CYP2A5; cytochrome P450 2A5; 8-MOP; 8-methoxypsoralen; BEAS-2B; immortalized human bronchial epithelial cells; B-2A13; BEAS-2B cells stably expressing CYP2A13; CSE; cigarette smoke extract; TSNA; tobacc
Exposure to fine particulate matter causes oxidative and methylated DNA damage in young adults: A longitudinal study
Keywords: 1-OHP; 1-hydroxypyrene; 8-oxodG; 8-oxo-7,8-dihydro-2-deoxyguanosine; GPX; glutathione peroxidase; GEE; generalized estimating equation; MNU; N-methyl-N-nitrosourea; N7-MeG; N7-methylguanine; NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NOCs; N-nit
Acetylsalicylic acid application decreased tobacco-specific nitrosamines and its precursors but maintained quality of air-cured burley tobacco (Nicotiana tabacum L.)
Keywords: ASA; acetylsalicylic acid; NAB; N-nitrosoanabasine; NAT; N-nitrosoanatabine; NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NNN; N-nitrosonornicotine; TSNA; tobacco-specific nitrosamines; Nicotiana tabacum L.; Tobacco-specific nitrosamines (TSNA); N
The tobacco carcinogen NNK disturbs mitotic chromosome alignment by interrupting p53 targeting to the centrosome
Keywords: NNK; Chromosome alignment; p53; Lung cancer; Centrosome;
Urinary NNAL in hookah smokers and non-smokers after attending a hookah social event in a hookah lounge or a private home
Keywords: Hookah; Waterpipe; NNAL; NNK; Secondhand smoke;
Do Animal Models of Acute Pancreatitis Reproduce Human Disease?
Keywords: Acute Pancreatitis; Animal Models; Caerulein; Alcohol; CRISPR; clustered regularly interspaced short palindromic repeats; ERCP; endoscopic retrograde cholangiopancreatography; LPS; lipopolysaccharide; NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; P
Potential of α7 nicotinic acetylcholine receptor PET imaging in atherosclerosis
Keywords: 5-HT3; type of 5-hydroxytryptamine (serotonin) receptor; (125I-)αBTX; (125I-labeled) α-bungarotoxin; α-CT; α-contotoxin, α7 nAChR antagonist; AAA; abdominal aorta aneurysm; ACh; acetylcholine; AChE; acetylcholinesterase; AngII; angiotensin II therapy
Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014
Keywords: TSNA; NNN; NNK; Tobacco; Cigarette smoke; Smoke transfer;
Tumorigenesis of smoking carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is related to its ability to stimulate thromboxane synthase and enhance stemness of non-small cell lung cancer stem cells
Keywords: Lung cancer; Stem cells; Smoking; NNK; Thromboxane;
Five-year yield variation in N-nitrosonornicotine and (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone from the smoke of commercial cigarette brands on the Japanese market
Keywords: Cigarette smoke; Japan; NNN; NNK; Variation; CO; carbon monoxide; HCI; Health Canada Intense; ISO; International Organization for Standardization; JT; Japan Tobacco Inc.; NNK; (4-methylnitrosoamino)-1-(3-pyridyl)-1-butanone; NNN; N-nitrosonornicotine; RSD
Roles of translesion synthesis DNA polymerases in the potent mutagenicity of tobacco-specific nitrosamine-derived O2-alkylthymidines in human cells
Keywords: NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NNN; N'-nitrosonornicotine; O2-Me-dT; O2-methylthymidine; O2-POB-dT; O2-[4-(3-pyridyl)-4-oxobut-1-yl]thymidine; HEK293T; human embryonic kidney 293T; TLS; translesion synthesis; MF; mutation frequency;
Tobacco smoke induces production of chemokine CCL20 to promote lung cancer
Keywords: Tobacco smoke; NNK; Lung cancer; CCL20;
Dose-dependent induction of preneoplastic lesions by the tobacco-specific nitrosamine carcinogen NNK in the in ovo carcinogenicity assessment (IOCA) assay
Keywords: Cancer; Liver; Tobacco; Preneoplasia; Foci; Avian; Ovo; NNK;
Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?
Keywords: NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; 2NF; 2-nitrofluorene; MTT test; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide test; TPA; 12-O-tetradecanoylphorbol-13-acetate; AFB1; Aflatoxin B1; BaP; benzo(a)pyrene; CA; chromosome aber
TSNA exposure from cigarette smoking: 18Â Years of urinary NNAL excretion data
Keywords: NNAL; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NNN; N-nitrosonornicotine; CPD; cigarettes per day; TSNA; tobacco specific nitrosamine; Cigarettes; NNAL; NNN; NNK; Tobacco products; Tobacco specifi
Napsin A is possibly useful marker to predict the tumorigenic potential of lung bronchiolo-alveolar hyperplasia in F344 rats
Keywords: Napsin A; DHPN; NNK; Rat; Lung; Carcinogenesis;
Nicotine, cotinine, and β-nicotyrine inhibit NNK-induced DNA-strand break in the hepatic cell line HepaRG
Keywords: 8-MOP; 8-methoxypsoralen; dH2O; deionosed water; HBECS; human bronchial epithelial cells; HPB; 4-oxo-4-(3-pyridyl) 1-butanol; HPLC; high pressure liquid chromatography; IARC; International Agency for the Research on Cancer; NNK; 4-(methylnitrosamino)-1-(3
In vitro exposure of tobacco specific nitrosamines decreases the rat lung phospholipids by enhanced phospholipase A2 activity
Keywords: BSA; bovine serum albumin; DMSO; dimethyl sulphoxide; DPPC; dipalmitoylphosphatidylcholine; DPPG; dipalmitoylphosphatidylglycerol; EDTA; ethylene diamine tetra acetic acid; EGTA; ethylene glycol tetraacetic acid; FFA; free fatty acid; LPLA2; lysosomal PLA
Isolation and cultivation of metabolically competent alveolar epithelial cells from A/J mice
Keywords: AECs; alveolar epithelial cells; AP; alkaline phosphatase; B[a]P; benzo[a]pyrene; CYP; cytochrome P; DMEM; Dulbecco's modified Eagle Medium; EROD; ethoxyresorufin-O-deethylase; FCS; Fetal Calf Serum; FITC; fluorescein isothiocyanate; FMO; flavine monoox
Insights from analysis for harmful and potentially harmful constituents (HPHCs) in tobacco products
Keywords: 1,2,3,4,6,7,8-HpCDD; 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin; 1,2,3,4,6,7,8-HpCDF; 1,2,3,4,6,7,8-heptachlorodibenzo-p-furan; 1,2,3,4,7,8,9-HpCDF; 1,2,3,4,7,8,9-heptachlorodibenzo-p-furan; 1,2,3,4,7,8-HxCDD; 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin; 1,2,3,
Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms
Keywords: BaP; Benzo(a)pyrene; BCRP; Breast Cancer Resistance Protein; CSC; Cancer Stem cells; ECS; Environmental Cigarette Smoke; GPX; Glutathione peroxidase; GSH; Glutathione; GST; Glutathione S-transferase; HBEC; Human Bronchial Epithelial Cells; HBP; 4-hydroxy-
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) regulates CTL activation and memory programming
Keywords: Carcinogen; CTLs; NNK; CD62L; Cytokines; Memory; Activation;
Characterization of a gap-junctional intercellular communication (GJIC) assay using cigarette smoke
Keywords: 2R4F; Kentucky reference cigarette code; CSC; cigarette smoke condensate; CV%; coefficient of variation; EC50; effective concentration 50% effect; GJIC; gap junctional intercellular communication; NNAL; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol; NNK;
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism-related enzymes gene polymorphisms, NNK metabolites levels and urothelial carcinoma
Keywords: NNK; CYP2A13; UGT2B7; Polymorphism; NNAL; Urothelial carcinoma;
β-Adrenergic system, a backstage manipulator regulating tumour progression and drug target in cancer therapy
Keywords: FAK; focal adhesion kinase; PKA; protein kinase A; BAD; BCL2-associated death protein; VEGF; vascular endothelial growth factor; PlGF; placenta-derived growth factor; PDGF; platelet-derived growth factor; TGF-β; transforming growth factor β; HIF-1α; hy
TSNA levels in machine-generated mainstream cigarette smoke: 35Â years of data
Keywords: MS; mainstream; NNK; 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; NNN; N-nitrosonornicotine; PM USA; Philip Morris USA Inc.; TSNA; tobacco specific nitrosamine; Cigarettes; Mainstream cigarette smoke; NNN; NNK; Tobacco products; Tobacco specific nitros
Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone suppresses a newly identified anti-tumor IGFBP-3/IGFBP-3R system in lung cancer cells
Keywords: IGFBP-3; Tobacco; NNK; Lung cancer; DNA methylation; ApoptosisNNK, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone; IGF, insulin-like growth factor; IGFBP, IGF binding protein; NSCLC, non-small cell lung cancer; 5′-aza-dC, 5′-aza-2′-deoxycytidine; Ad, aden
Proteomic analysis of differentially expressed proteins in lung cancer in Wistar rats using NNK as an inducer
Keywords: Lung cancer; NNK; Mass spectrometry; 2-DE
The burning question: Why is smoking a risk factor for pancreatic cancer?
Keywords: Smoking; Pancreatic cancer; Fibrosis; Inflammation; cAMP; cyclic AMP; EGFR; epidermal growth factor receptor; ECM; extracellular matrix protein; IL-1β; interleukin 1 beta; MIP-1α; macrophage inflammatory protein 1 alpha; MMPs; matrix metalloproteinases;
Intercepting neoplastic progression in lung malignancies via the beta adrenergic (β-AR) pathway: Implications for anti-cancer drug targets
Keywords: β-AR; beta-adrenergic receptors; cAMP; cyclic adenosine 3â²,5â²-monophosphate; CREB; cAMP response element binding protein; EGFR; epidermal growth factor receptor; GABA; gamma-aminobutyric acid; GPCR; G protein-coupled receptor; ICI; a selective beta2
Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells
Keywords: BSA; bovine serum albumin; CI; cell index; DAPI; 4â²,6-diamidino-2-phenyindole; DMEM; Dulbecco's Modified Eagle Medium; DTSP; 3,3â²-dithiodipropionic acid di(N-hydroxysuccinimide ester); FITC; fluorescein isothiocyanate; GSH; glutathione; GST; glutath
Systematics and health effects of chemically distinct tannins in medicinal plants
Keywords: ACTH; adrenocorticotropic hormone; ADP; adenine 5â²-diphosphate; AIBN; 2,2â²-azobisisobutyronitrile; B[a]p diol epoxide; ±7β 8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; DHHDP; dehydrohexahydroxydiphenoyl; DMBA; 7,12-dimethylbenz[a]