Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; Ag; silver; AgNPs; silver nanoparticles; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; b.w.; body weight; BBB; blood-brain-barrier; CMT; Carousel Maze test, active place avoidance test; ENTR; number of entrance
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Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; ACP; acetophenone; AHI; Atmospheric Hazard Index; CAHI; Chemical Atmospheric Hazard Index; CEL; Chemical Exposure Limit; CHP; cumene hydroperoxide; ChV; Chronic concentration Value; CRSI; Chemical Route Safety Index; CTHI; Chemical Terrestrial Hazard Inde
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; Antioxidant enzymes; Brain; Inflammation; Nanoparticles; Oxidative stress; Renin-angiotensin system; ACTB; beta actin; APP; amyloid β (A4) precursor protein; APx; ascorbic acid peroxidase; ARO; aromatase; ANG; angiotensin; ACE; angiotensin converting e
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; C&L; Classification and Labelling; CLP; Classification and Labelling and Packaging Regulations; CMR; carcinogenicity, mutagenicity and reproductive toxicity; D/RT; developmental/reproductive toxicity; EC; European Community; ECETOC; European Centre for Ec
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti
Investigation of melamine and cyanuric acid deposition in pig tissues using LC-MS/MS methods
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; Mass spectrometry; Melamine; Cyanuric acid; Residues; Pig; ACN; acetonitrile; ACUC; Animal Care and Use Committee; APCI; atmospheric pressure chemical ionization; bw; body weight; CYA; cyanuric acid; ESI; electrospray ionization; LC-MS/MS; liquid chromato
Local country food sources of methylmercury, selenium and omega-3 fatty acids in Nunavik, Northern Quebec
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; CDC; Centre for Disease Control and Prevention; DHA; docosahexaenoic acid; DPA; docosapentaenoic acid; EPA; eicosapentaenoic acid; FFQ; food frequency questionnaire; GM; geometric mean; long-chain n â 3 PUFA; long-chain omega-3 polyunsaturated fatty a
Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; Dosimetry; Ethylene glycol phenyl ether; PBPK; Pharmacokinetics; Toxicokinetics; Uncertainty factors; GFR; glomerular filtration rate; LOAEL; lowest observable adverse effect level; NOAEL; no observable adverse effect level; PBPK; physiologically-based ph
The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; AP1; aminopentol; b.w.; body weight; CerS; ceramide Synthase; FB1 FB2 FB3; fumonisin B1 B2 B3; GGT; Gamma-glutamyl transferase; HE; hematoxylin-eosin; HFB1 HFB2 HFB3; hydrolyzed fumonisin B1 B2 B3; HPLC-FLD; high performance liquid chromatography with pos
Safety evaluation of fibermalt
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; 2-AA; 2-aminoanthracene; ABAN; absolute neutrophil bands; ABAS; absolute basophils; AEOS; absolute eosinophils; AHSN; absolute hypersegmented neutrophils; AIL; absolute immature lymphocytes; ALB; albumin; ALKP; alkaline phosphatase; ALT; alanine aminotran
Safety evaluation of Algal Oil from Schizochytrium sp.
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; ALB; albumin; ALKP; alkaline phosphatase activity; ALP; alanine aminotransferase activity; ARA; arachidonic acid; AST; aspartate aminotransferase activity; A/G; ratio albumin to globulin; bw; body weight; BUN; blood urea nitrogen; DHA; docosahexaenoic aci
Safety assessment of AGPC as a food ingredient
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; AGPC; α-glycerylphosphorylcholine; i.p.; intraperitoneal; i.v.; intravenous; s.c.; subcutaneous; p.o.; per os; NOAEL; no observable adverse effect level; MTD; maximum tolerated dose; SE; standard errors; α-Glycerylphosphorylcholine; Toxicity; Mutagenici
A sub-chronic (13 weeks) oral toxicity study in rats and an in vitro genotoxicity study with Korean pine nut oil (PinnoThin TG™)
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; Sub-chronic toxicity; Genotoxicity; Korean pine nut oil; No Observable Adverse Effect Level; NOAEL
Criteria for the safety evaluation of flavoring substances
Keywords: هیچ سطح قابل توجهی از اثرات قابل مشاهده; ABS; chromosomal aberration; ADH; alcohol dehydrogenase; ALD; aldehyde dehydrogenase; AE; anethole epoxide; CYP450; Cytochrome P450; CHO; Chinese hamster ovary; CoA; coenzyme A; CoE; Council of Europe; CCK; cholecystokinin; DDA; detailed dietary analysis;