Keywords: هیچ عوارض جانبی مشاهده نشده; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; MRL; minimal risk level; JECFA; joint expert committee on food additives; ATSDR; agency for toxic substances and disease registry; PTWI; provisional tolerable weekly int
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Keywords: هیچ عوارض جانبی مشاهده نشده; ADI; acceptable daily intake; BMI; body mass index; BW; body weight; BP; bisphenol; BP-3; oxybenzone/benzophenone-3; BuP; butyl paraben; DEMOCOPHES; Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale; EDCs; endocrin
Keywords: هیچ عوارض جانبی مشاهده نشده; Biotherapeutics; Gene and cell therapy; Pharmacokinetics; Non-clinical safety; Immunogenicity; Cross-reactive species; ATMP; advanced therapy medicinal products; CAR; chimeric antigen receptor; CD; cluster of differentiation; CMC; chemistry manufacturing
Keywords: هیچ عوارض جانبی مشاهده نشده; salt; solubility; stability; biopharmaceutical; poorly water soluble; solution phase; solid phase; equilibrium; pKa; pH; AB; acetate buffer; ACN; acetonitrile; API; active pharmaceutical ingredient; BS; benzoate salt; CB; citrate buffer; DSC; differential
Keywords: هیچ عوارض جانبی مشاهده نشده; β-HCH; β-hexachlorocyclohexane; µg/l; microgram per liter; µM/l; micromolar per liter; Æ©; total; 1-HP; 1-hydroxypyrene; 2; 3-DHBA, 2,3-dihydroxybenzoic Acid; 2cx-MMHP; mono-(2-carboxymethylhexyl) phthalate; 3PBA; 3-phenoxybenzoic acid; 4F3PBA; 4-fluo
Keywords: هیچ عوارض جانبی مشاهده نشده; Safety; Evaluation; Genotoxicity; Toxicity; Functional; Food; SFG; steady-fiber granule; NOAEL; no observed adverse effect level; β-NADP; β-nicotinamide adenine dinucleotide phosphate; FDA; Food and Drug Administration; OECD; Organization for Economic C
Keywords: هیچ عوارض جانبی مشاهده نشده; 2D-sw; 2D-sandwich; AMI; amiodarone; APAP; acetaminophen; BA; bile acid; BC; bile canaliculi; BOS; bosentan; BSEP; bile salt export pump; CPZ; chlorpromazine; CSA; cyclosporine A; CYP450; cytochrome P450; DIC; drug-induced cholestasis; DICI; drug-induced
Keywords: هیچ عوارض جانبی مشاهده نشده; Pyrrolizidine alkaloids; Acute toxicants; Genotoxic carcinogens; Hepatotoxic agents; Food; Food supplements; ANZFA; Australia New Zealand Food Authority; acute reference dose; ARfD; DHP; 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5[[H]]-pyrrolizine; BfR; Feder
Keywords: هیچ عوارض جانبی مشاهده نشده; Steaming; Seafood; Toxic elements; PFCs; PAHs; Musk fragrances and UV-Filters; 4-MBC; 3-(4-Methylbenzylidene)camphor; AHTN; 7-acetyl-1,1,3,4,4,6-hexamethyl-1,2,3,4-tetrahydronaphthalene; ANOVA; analysis of variance; AsV; arsenic V; BaP; benzo(a)pyrene; BM
Keywords: هیچ عوارض جانبی مشاهده نشده; Health risk assessment; Air freshener consumer products; Inhalation and dermal hazard; Fragrance ingredients; Tiered 1 and 2 risk assessment; IAQ; indoor air quality; KME; Korean Ministry of Environment; KNLIC; Korean National Law Information Center; SCCN
Keywords: هیچ عوارض جانبی مشاهده نشده; ADME; Absorption, Distribution, Metabolism, Excretion; AOPs; adverse outcome pathways; AUC; Area under the Curve; AEs; assessment elements; AOs; assessment options; BMDL; benchmark dose lower bound; CAAT; Center for Alternatives to Animal Testing; Cefic-L
Keywords: هیچ عوارض جانبی مشاهده نشده; Cumulative acute exposure; Probabilistic method; Organophosphorus pesticides; Effect of LOQ and zero residues; EFSA; European Food Safety Authority; LOQ; limit of quantification; LOR; limit of reporting; OP; organophosphates; RPF; relative potency factor;
Keywords: هیچ عوارض جانبی مشاهده نشده; Pyrrolizidine; Echimidine; Lasiocarpine; bw; bodyweight; d; day; NOAEL; No Observed Adverse Effect Level; NTP; National Toxicology Program; PA; pyrrolizidine alkaloid; TBHQ; tert-butylhydroquinone;
Keywords: هیچ عوارض جانبی مشاهده نشده; DEHP; Di(2-ethylhexyl) phthalate; CNS; central nervous system; E; embryonic day; P; postnatal day; PLP; periodate lysin paraformaldehyde; PBS; phosphate-buffered saline; Tuj1; neural class III β-tubulin; BrdU; bromo-deoxyuridine; CldU; chloro-deoxyuridin
Keywords: هیچ عوارض جانبی مشاهده نشده; 2D; two dimensional; 3D; three dimensional; ATP; adenosine triphosphate; BALF; bronoalveolar lavage fluid; CA; chromosome aberration; CB; conduction band; CHO; Chinese hamster ovary; CNT; carbon nanotubed; DEPMPO; 5-diethoxyphosphoryl-5-methyl-1-pyrroline
Keywords: هیچ عوارض جانبی مشاهده نشده; Windows of sensitivity; Motor development; Chemical exposures; Laboratory animals; GD; gestation day; LOAEL; lowest observed adverse effect level; NOAEL; no observed adverse effect level; PND; post-natal day; PNM; post-natal month; PNW; post-natal week;
Keywords: هیچ عوارض جانبی مشاهده نشده; Allergy; Dose distribution; Modelling; Sesame; Threshold; DBPCFC; Double Blind Placebo Controlled Food Challenge test; ED; Eliciting Dose; EU; European Union; LOAEL; Lowest Observed Adverse Effect Level; NOAEL; No Observed Adverse Effect Level;
Keywords: هیچ عوارض جانبی مشاهده نشده; Triclosan; Exposure; Reproductive endocrine-disruption; Steroidogenesis; Hormone receptor; TCS; triclosan; EDCs; endocrine-disrupting chemicals; PCPs; personal care products; NOAEL; no observed adverse effect level; NHANES; national health and nutrition e
Keywords: هیچ عوارض جانبی مشاهده نشده; MoA; mode of action; HPT; hypothalamic pituitary thyroid; UGT; uridine diphosphate glucuronosyltransferase; NOAEL; no observed adverse effect level; CAR; Constitutive Androstane Receptor; PCBs; polychlorinated biphenyls; USEPA; United States Environmental
Keywords: هیچ عوارض جانبی مشاهده نشده; Benzophenone; Ethylhexyl Methoxycinnamate; Butyl Methoxydibenzoylmethane; Dermal permeation; Systemic Exposure Dosage; Margin of Safety; AD; applied dose (sunscreen); BMDBM; Butyl Methoxydibenzoylmethane; BP3; Benzophenone-3; CID; compound identifier; EC;
Keywords: هیچ عوارض جانبی مشاهده نشده; SHetA2; N-(2,3-dihydro-2,2,4,4-tetramethyl-6-benzothiopyranyl), Nâ²-(4-nitrophenyl)thiourea; ATRA; all trans retinoic acid; NOAEL; no observed adverse effect level; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; MTS; MTT coupled with
Keywords: هیچ عوارض جانبی مشاهده نشده; EDCs; endocrine disrupting chemicals; PCBs; polychlorinated biphenyls; PAHs; polyaromatic hydrocarbons; BFRs; brominated flame retardants; Aps; alkylphenols; PFCs; perfluorinated chemicals; POPs; persistent organic pollutants; ER; estrogen receptor; NOAEL
Keywords: هیچ عوارض جانبی مشاهده نشده; ADA; Anti-drug antibody(ies); ADCC; Antibody-dependent cellular cytotoxicity; AE; Adverse event; CBA; Cell-based assay; CDC; Complement dependent cytotoxicity; CLB; Competitive ligand binding; EIP; European Immunogenicity Platform; EIP-AWG; European Immun
Keywords: هیچ عوارض جانبی مشاهده نشده; BMD; benchmark dose; BMDL; lower confidence bound of the benchmark dose; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; EFSA; European Food Safety Authority; OECD; Organisation for Economic Co-operation and Developme
Keywords: هیچ عوارض جانبی مشاهده نشده; DNEL; derived no effect level; ECHA; European Chemicals Agency; LD; lethal dose; LOAEL; lowest observed adverse effect level; MoS; margin of safety; NOAEL; no observed adverse effect level; REACH; registration, evaluation, authorization and restriction of
Keywords: هیچ عوارض جانبی مشاهده نشده; ADME; absorption, distribution, metabolism, elimination; ATUS; American Time Use Survey; BE; biomonitoring equivalent; BEPOD; biomonitoring equivalent corresponding to the point of departure; BW; body weight; CDC; Centers for Disease Control and Preventio
Keywords: هیچ عوارض جانبی مشاهده نشده; ARA; arachidonic acid; DHA; docosahexaenoic acid; GLP; good laboratory practices; GRAS; generally recognized as safe; LC-PUFA; long-chain polyunsaturated fatty acids; NOAEL; no observed adverse effect level; RBC; red blood cells; wt%; weight percent; Doco
Keywords: هیچ عوارض جانبی مشاهده نشده; AGD; anogenital distance; BBP; butyl benzyl phthalate; CE; creatinine excretion; DBP; di-n-butyl phthalate; DEHP; di(2-ethylhexyl) phthalate; DEP; diethyl phthalate; DI; daily intake; DNEL; Derived No Effect Level; DiBP; diisobutyl phthalate; DiNP; diison
Keywords: هیچ عوارض جانبی مشاهده نشده; DBPCFC; double-blind placebo-controlled food challenge; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; ED; eliciting dose; Threshold dose distribution; Simulation study; Allergenic foods;
Keywords: هیچ عوارض جانبی مشاهده نشده; ADD; average daily dose; COPC; contaminant of potential concern; CR; concentration ratio; EA; environmental assessment; EFW; energy-from-waste; EHQ; environmental hazard quotient; EPC; exposure point concentration; ERA; environmental risk assessment; HHRA
Keywords: هیچ عوارض جانبی مشاهده نشده; 2,4-D; 2,4-dichlorophenoxyacetic acid; ACD; allergic contact dermatitis; ACSA; agricultural chemical safety assessment; AFC; antibody forming cell; CP; cyclophosphamide; CT; carbon tetrachloride; DART; developmental and reproductive toxicology; DIT; devel
Keywords: هیچ عوارض جانبی مشاهده نشده; NOAEL; no observed adverse effect level; LOAEL; lowest observed adverse effect level; fcan; daily feed consumption per animal; fcbw; daily feed consumption per bodyweight; Dose decrement; NOAEL; LOAEL; Study design; Pesticide toxicity;
Keywords: هیچ عوارض جانبی مشاهده نشده; Allergenic foods; threshold dose distributions; children; eliciting dose; DBPCFC; Double-blind, placebo-controlled food challenge; ED; Eliciting dose; LOAEL; Lowest observed adverse effect level; NOAEL; No observed adverse effect level;
Keywords: هیچ عوارض جانبی مشاهده نشده; DBPCFC; Double-blind, placebo-controlled oral food challenge; FAAN; Food Allergy & Anaphylaxis Network; FALCPA; Food Allergen Labeling and Consumer Protection Act; FDA; U.S. Food and Drug Administration; LOAEL; Lowest Observed Adverse Effect Level; NHANES
Keywords: هیچ عوارض جانبی مشاهده نشده; ACP; Acid Phosphatase; ALP; Alkaline Phosphatase; DMSO; Dimethylsulfoxide; EDTA; Ethylenediaminetetraacetic acid; GGT; γ-Glutamyltransferase; H&E; Hematoxylin and eosin; HGB; Hemoglobin; LDH; Lactate Dehydrogenase; NOAEL; No observed adverse effect level
Keywords: هیچ عوارض جانبی مشاهده نشده; ANSES; French Agency for Food, Environmental and Occupational Health & Safety; BfR; Bundesinstitut für Risikobewertung, German Federal Institute for Risk Assessment; BPA; bisphenol A; EAC; endocrine active compound; EDC; endocrine disrupting chemical; EF
Keywords: هیچ عوارض جانبی مشاهده نشده; ADH; aldehyde dehydrogenase; BMD; benchmark dose; BMDL10; benchmark dose lower bound 10%; bw; body weight; CYP; cytochrome P450; DCA; 1,3-dichloroacetone; 1,3-DCP; 1,3-dichloro-2-propanol; 2,3-DCP; 2,3-dichloro-1-propanol; EC; the European Commission; EFS
Keywords: هیچ عوارض جانبی مشاهده نشده; Methyl methacrylate; Olfactory effects; Human relevance; Occupational levels; Physiologically based pharmacokinetic (PBPK) model; Dosimetric adjustment factors; 2-EH; 2-ethyl Hexanol; AA; acrylic acid; ACGIH; American Conference of Governmental Industrial
Keywords: هیچ عوارض جانبی مشاهده نشده; ABC; ATP-binding cassette; ATR; atrazine, 2-chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine; AUC; area under the curve; BW; body weight; 14C-ATR; 14C-atrazine; DACT; didealkylatrazine, 2-chloro-4,6-diamino-1,3,5-triazine; DE; desethylatrazine, 2-chlor
28-day inhalation toxicity of 3-methoxybutyl chloroformate in rats
Keywords: هیچ عوارض جانبی مشاهده نشده; ANOVA; analysis of variance; CT; computed tomography; EDTA; ethylenediamine tetraacetic acid; GHS; Globally Harmonized System of Classification and Labelling of Chemicals; GLP; Good Laboratory Practice; HCT; hematocrit; HGB; hemoglobin concentration; MCH;
Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p
Keywords: هیچ عوارض جانبی مشاهده نشده; 3-MCPD; 3-chloro-1,2-propanediol; 3â²UTR; 3â² un-translated region; AKI; acute kidney injury; BMD10; Benchmark doses; BMDL10; BMD Lower Confidence Limit; BW; body weight; CXCl; chemokine (C-X-C motif) ligand; DE; differentially expressed; DR6; death rec
Single ingestion of di-(2-propylheptyl) phthalate (DPHP) by male volunteers: DPHP in blood and its metabolites in blood and urine
Keywords: هیچ عوارض جانبی مشاهده نشده; AUC; area under the concentration-time curve in blood; bw; body weight; cx-MPHP(-d4); non- or ring-deuterated mono-(2-propyl-6-carboxyhexyl) phthalate; cx-MPHP; mono-(2-propyl-6-carboxyhexyl) phthalate; cx-MPHP-d4; ring-deuterated mono-(2-propyl-6-carboxy
A 14-day repeated-dose oral toxicological evaluation of an isothiocyanate-enriched hydro-alcoholic extract from Moringa oleifera Lam. seeds in rats
Keywords: هیچ عوارض جانبی مشاهده نشده; ANOVA; analysis of variance; GLP; good laboratory practice; ITC; isothiocyanate; MIC-1; moringa isothiocyanate-1; MICs; moringa isothiocyanates; MSE; moringa seed extract; NF-κB; nuclear factor kappa B; NO; nitric oxide; NOAEL; no observed adverse effect
Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits
Keywords: هیچ عوارض جانبی مشاهده نشده; BW; body weight; CpG; unmethylated 2â² deoxyribo (cytidine-phosphate-guanosine); EFD; embryo-fetal development; EMA; European Medicines Agency; FDA; Food and Drug Administration; G0; day 0 of gestation; GSK; GlaxoSmithKline; HLS; Huntington Life Sciences
Safety assessment of methanolic extract of Terminalia chebula fruit, Terminalia arjuna bark and its bioactive constituent 7-methyl gallic acid: In vitro and in vivo studies
Keywords: هیچ عوارض جانبی مشاهده نشده; Terminalia chebula; Terminalia arjuna; 7-Methyl gallic acid; Salmonella reversion assay; Comet assay; Hemolytic activity; Cytotoxicity; Acute toxicity; Sub acute toxicity; TCF; Methanolic fruit extract of Terminalia chebula; TAB; Methanolic fruit extract
Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat
Keywords: هیچ عوارض جانبی مشاهده نشده; Physiologically based kinetic (PBK) model; Lasiocarpine; Riddelliine; Liver toxicity; In vitro-in vivo extrapolation; Reverse dosimetry; BMDL5-BMDU5; lower/upper limit of the 90% confidence interval of the benchmark dose that gives a 5% response; BMDL10;
Effects of daily exposure to saccharin sodium and rebaudioside A on the ovarian cycle and steroidogenesis in rats
Keywords: هیچ عوارض جانبی مشاهده نشده; T1R3; taste receptor type 1 subunit 3; Gα; G protein α-gustducin; T2R38; taste receptor type 2 subunit 38; GPCR; G-protein coupled receptors; PLC-β2; phospholipase C-β2; cAMP; cyclic adenosine monophosphate; FSH; follicle-stimulating hormone; LH; lute
Initial hazard assessment of 4-benzylphenol, a structural analog of bisphenol F: Genotoxicity tests in vitro and a 28-day repeated-dose toxicity study in rats
Keywords: هیچ عوارض جانبی مشاهده نشده; CAS no. 101-53-1; 4-Benzylphenol; Genotoxicity; Repeated-dose toxicity; Rat; Gavage; NOAEL; D-value; Hazard class; Screening risk assessment; CHL; Chinese hamster lung fibroblastic cell; CSCL; The Japanese Chemical Substances Control Law; JECDB; Japan Exi
Urine bisphenol A and pubertal development in boys
Keywords: هیچ عوارض جانبی مشاهده نشده; BMI; body mass index; BPA; bisphenol A; CI; confidence interval; EDC; endocrine-disrupting compound; HPLC; high-performance liquid chromatography; LOD; limit of detection; NOAEL; no observed adverse effect level; PR; prevalence ratio; TV; testicular volum
A 28-day oral toxicology study of an aqueous extract of Polypodium leucotomos (Fernblock®)
Keywords: هیچ عوارض جانبی مشاهده نشده; A/G ratio; albumin to globulin ratio; ANOVA; analysis of variance; BALT; bronchus associated lymphoid tissue; FOB; functional observation battery; MTD; maximum tolerated dose; NOAEL; no observed adverse effect level; OECD; Organisation for Economic Cooper