Keywords: Kushenin; HCV replication; Cell apoptosis; NS5A; PI3K-Akt-mTOR
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Cellular Hsp27 interacts with classical swine fever virus NS5A protein and negatively regulates viral replication by the NF-κB signaling pathway
Keywords: CSFV; NS5A; Hsp27; Interaction; NF-κB signaling pathway;
The eukaryotic translation initiation factor 3 subunit E binds to classical swine fever virus NS5A and facilitates viral replication
Keywords: CSFV; NS5A; eIF3E; Interaction; Replication;
Efficacy of Sofosbuvir and Velpatasvir, With and Without Ribavirin, in Patients With Hepatitis C Virus Genotype 3 Infection and Cirrhosis
Keywords: Direct-Acting Antiviral Agent; Outcome; Drug Resistance; AE; adverse event; HCV; hepatitis C virus; HIV; human immunodeficiency virus; NS5A; nonstructural protein 5A; NS5B; nonstructural protein 5B; RAS; resistance-associated substitution; SAE; serious ad
Rab1A is required for assembly of classical swine fever virus particle
Keywords: Rab1A; Classical swine fever virus (CSFV); Viral particle assembly; NS5A;
Natural NS5A inhibitor resistance associated substitutions in hepatitis C virus genotype 1 infected patients from Italy
Keywords: Direct-acting antivirals; Drug resistance; Hepatitis C virus; NS5A; Pegylated interferon-α and ribavirin;
Antiviral activity of K22 against members of the order Nidovirales
Keywords: CAVV; Cavally virus; CM; convoluted membrane; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DMV; double membrane vesicles; DNA; deoxyribonucleic acid; dsRNA; double-stranded RNA; EAV; equine arteritis virus; EToV; equine toroviru
Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1
Keywords: Hepatitis C virus (HCV); Hypericin; Epigenetic; Deacetylation; HCV; Hepatitis C virus; NS5A; non-structure protein 5A; NS3; non-structure protein 3; HO-1; heme oxygenase 1; 5-Aza-dC; 5-aza-2â²-deoxycytidine; DAAs; direct acting antivirals; PCR; polymeras
Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity
Keywords: ABH; 2-azabicyclo[2.2.1]heptanyl; Bpin; (pinacolato)boryl; BZD; benzimidazolyl; CL; clearance; Cp; cyclopentadienyl; Fc; ferrocene or ferrocenyl; FcI2; 1,1â²-diiodoferrocene; FQ; ferroquine; GT; genotype; Im; imidazolyl; Moc; methoxycarbonyl; MRT; mean r
Live cell imaging and analysis of lipid droplets biogenesis in hepatatis C virus infected cells
Keywords: LDs; lipid droplets; ER; endoplasmic reticulum; HCV; hepatitis C virus; GFP; green fluorescent protein; NS5A; non-structural protein 5A; OA; oleic acid; Lipid droplets; Confocal microscopy; Lipophilic dye; BODIPY®; Nile red; Oil red O; Hepatitis C virus;
A genotype independent, full-genome reverse-transcription protocol for HCV genotyping and resistance testing
Keywords: Hepatitis C virus; Genotyping; Antiviral treatment; NS5A; Reverse transcription; Resistance testing;
The effect of classical swine fever virus NS5A and NS5A mutants on oxidative stress and inflammatory response in swine testicular cells
Keywords: Classical swine fever virus; NS5A; Mutants; Oxidative stress; Inflammatory response;
Post-treatment resistance analysis of hepatitis C virus from phase II and III clinical trials of ledipasvir/sofosbuvir
Keywords: Hepatitis C virus; Drug resistance; NS5A; NS5B; DAA; Ledipasvir; Sofosbuvir; Ribavirin;
Sensitive luminescent reporter viruses reveal appreciable release of hepatitis C virus NS5A protein into the extracellular environment
Keywords: Hepatitis C virus; NS5A; Virus replication; Virus assembly; Exosome; Luciferase;
Discovery of silyl proline containing HCV NS5A inhibitors with pan-genotype activity: SAR development
Keywords: HCV; NS5a; Pan-genotype
Matched and mixed cap derivatives in the tetracyclic indole class of HCV NS5A inhibitors
Keywords: Hepatitis C; NS5A; Infectious diseases; Indole; Capping
A telomerase-derived peptide regulates reactive oxygen species and hepatitis C virus RNA replication in HCV-infected cells via heat shock protein 90
Keywords: Antioxidant; GV1001; Heat shock protein 90; Hepatitis C virus; Low-density lipoprotein receptor-related protein 1; eHSP90; extracellular heat-shock protein 90; NOX; NADPH oxidase; LRP1; low-density lipoprotein receptor-related protein 1; NS5A; hepatitis C
Golgi protein 73 facilitates the interaction of hepatitis C virus NS5A with apolipoprotein E to promote viral particle secretion
Keywords: Hepatitis C virus; HCV; Golgi protein 73; GP73; Apolipoprotein E; ApoE; Hepatocellular carcinoma; HCC; Nonstructural protein 5A; NS5A; HCV particle assembly and secretion;
PI3K-Akt signaling pathway upregulates hepatitis C virus RNA translation through the activation of SREBPs
Keywords: Hepatitis C virus (HCV); HCV RNA translation modulation; PI3K; Akt isoforms; SREBPs; NS5A;
NS5A resistance leading to failure of 24-week therapy with sofosbuvir/ledipasvir and ribavirin for the treatment of hepatitis C genotype 1a infection in a HIV-1 co-infected patient
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; cART; combination antiretroviral therapy; DAA; direct-acting antiviral; DDI; drug-drug interaction; EOTR; end-of-treatment response; GT; genotype; HCV; hepatitis C virus; HIV-1; human immun
HCV RNA traffic and association with NS5A in living cells
Keywords: Hepatitis C Virus; RNA; Live cell Imaging; NS5A; Lipid droplets; Traffic; Replication;
Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation
Keywords: Hepatitis C virus; NS5A; Phosphorylation; Replication; Replication complex; Replication factory; Phosphatidylinositol-4 kinase III alpha
ReviewThe importance of resistance to direct antiviral drugs in HCV infection in clinical practice
Keywords: HCV; hepatitis C virus; DAA; direct-acting antiviral agent; NS3; non-structural protein 3; NS5A; non-structural protein 5A; NS5B; non-structural protein 5B; RAVs; resistance associated variants; IP-10; interferon-gamma-inducible protein 10; IFNL4; interfe
Analysis of hepatitis C NS5A resistance associated polymorphisms using ultra deep single molecule real time (SMRT) sequencing
Keywords: Hepatitis C virus; NS5A; Resistance; RAV; Deep sequencing; Pacific biosciences;
Design and synthesis of imidazole N-H substituted amide prodrugs as inhibitors of hepatitis C virus replication
Keywords: Hepatitis C virus; NS5A; Prodrug; Daclatasvir; Pharmacokinetics;
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b
Keywords: NS5A; HCV; Hepatitis C; Thienoimidazole;
Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers
Keywords: NS5a; HCV; Hepatitis C; Thienoimidazole;
Structure ReportStructure of the c-Src-SH3 domain in complex with a proline-rich motif of NS5A protein from the hepatitis C virus
Keywords: c-Src-SH3; Src-homology 3 domain of c-Src tyrosine kinase; Abl-SH3; Src-homology 3 domain of the Abl tyrosine kinase; DLS; dynamic light scattering; PRM; proline rich motif; HCV; hepatitis C virus; SH3 domain; c-Src tyrosine kinase; X-ray structure; NS5A;
Dynamics of HCV genotype 4 resistance-associated variants during virologic escape with pIFN/RBVÂ +Â daclatasvir: A case study using ultra deep pyrosequencing
Keywords: Hepatitis C virus; Genotype 4; NS5A; UDPS; Daclatasvir;
Identification of a duplicated V3 domain in NS5A associated with cirrhosis and hepatocellular carcinoma in HCV-1b patients
Keywords: Cirrhosis; Hepatitis C virus; Hepatocellular carcinoma; NS5A; V3 domain;
Research ArticleAssociation between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A
Keywords: DAA; direct acting antiviral; SVR; sustained virological response; HCV; Hepatitis C virus; NS5A; non-structural protein 5A; ISG; interferon stimulated gene; IFNL4; interferon lambda 4; IFNL3; interferon lambda 3 (formerly IL28B); RT-PCR; real-time polymer
Heat shock protein 70 is associated with CSFV NS5A protein and enhances viral RNA replication
Keywords: Classical swine fever virus (CSFV); NS5A; HSP70;
Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency
Keywords: NS5A; HCV; Hepatitis C virus;
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores
Keywords: NS5A; HCV; Hepatitis C;
Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors
Keywords: HCV; NS5A inhibitor; Benzidine; Diaminofluorene; Structure-activity relationship; HCV; hepatitis C virus; Peg-IFNα; pegylated interferon α; SVR; sustained virological response; GT1a; hepatitis C virus genotype 1a, a subtype of hepatitis C virus genoty
Proliferating cell unclear antigen-associated factor (PAF15): A novel oncogene
Keywords: APC/C; anaphase-promoting complex/cyclosome; ATF3; transcription factor 3; Bax; B cell lymphoma-associated X; Cdh1; Fizzy/Cell Division Cycle 20 Related 1; CDK; cyclin-dependent kinase; CDT2; chromatin licensing and DNA replication factor 2; CRL4; cytokin
Characterization of the C-terminal sequence of NS5A necessary for the assembly and production of classical swine fever virus infectious particles
Keywords: Classical swine fever virus; NS5A; Core; NS5A–Core interaction
Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner
Keywords: HCV, hepatitis C virus; PI4P, phosphatidylinositol 4-phosphate; ACBD3, acyl-coenzyme A binding domain containing protein 3; Co-IP, co-immunoprecipitation; GST, glutathione-S-transferaseACBD3; HCV; NS5A; PI4P; PI4KB
Research ArticleA randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4
Keywords: HCV; hepatitis C virus; NS5A; nonstructural protein 5A; DAA; direct-acting antiviral agent; EC50; 50% effective concentration; CYP; cytochrome P450; HBV; hepatitis B virus; HIV; human immunodeficiency virus; QD; once daily; BID; twice daily; AE; adverse e
Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a
Keywords: Hepatitis C virus; Genotype 3; Replicon; NS5A; NS5B; chimera;
The lysine methyltransferase SMYD3 interacts with hepatitis C virus NS5A and is a negative regulator of viral particle production
Keywords: SMYD3; NS5A; HCV; TAP-MS; Virus particle assembly;
Immunoreactivity assessment of hepatitis C virus NS3 protease and NS5A proteins expressed in TOPO cloning system
Keywords: Hepatitis C virus; Indirect enzyme-linked immunosorbent assay; NS3 protease; NS5A; TOPO cloning
Inhibition of hepatitis C virus infection by NS5A-specific aptamer
Keywords: HCV; NS5A; Aptamer; Antivirals; Replication; Mutation;
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors
Keywords: NS5A; Antiviral agent; HCV;
Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors
Keywords: Daclatasvir (DCV); NS5A; Hepatitis C virus; GS-5885;
HCV versus HIV drug discovery: Déjà vu all over again?
Keywords: HIV; HCV; Antivirals; Clinical development; Combination therapy; Single tablet regimen; Protease; Integrase; Polymerase; NS3; NS5A; Nucleoside; Non-nucleoside; NNI; CCR5;
Research ArticleTIP47 plays a crucial role in the life cycle of hepatitis C virus
Keywords: HCV; hepatitis C virus; LD; lipid droplet; TIP47; tail interacting protein of 47Â kD; NS5A; non-structural protein 5A; RC; replicon complex; ER; endoplasmic reticulum; MPR; mannose-6-phosphate receptor; PEI; polyethyleneimine; HPLC; high performance liqui
HCV NS5A replication complex inhibitors. Part 5: Discovery of potent and pan-genotypic glycinamide cap derivatives
Keywords: Daclatasvir; HCV; NS5A; Mandelamide X-ray; Pan-genotype HCV replicon inhibition; Phenylglycine;
Research ArticleDual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options
Keywords: HCV; hepatitis C virus; DAA; direct-acting antiviral; PegIFN-α/RBV; peginterferon alfa and ribavirin; SVR; sustained virologic response; HIV; human immunodeficiency virus; NS5A; non-structural protein 5A; NS3; non-structural protein 3; ALT; alanine amino