Centella asiatica water extract inhibits iPLA2 and cPLA2 activities in rat cerebellum
Keywords: Centella asiatica; Umbelliferae; PLA2; Rat; Cerebellum; Neuropsychiatric disorders
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Neutralization of the pharmacological effects of Cobra and Krait venoms by chicken egg yolk antibodies
Keywords: Venom; Chicken antibodies (IgY); PLA2
Generation of multifunctional murine monoclonal antibodies specifically directed to the VP1unique region protein of human parvovirus B19
Keywords: Human parvovirus B19; Monoclonal antibody; VP1unique region protein; VP1u; Phospholipase A2-like activity; AA; arachidonic acid; aa; amino acid; aPL; antiphospholipid antibodies; APS; antiphospholipid syndrome; B19; human parvovirus B19; ELISA; enzyme-lin
Studies on pharmacological effects of Russell's viper and Saw-scaled viper venom and its neutralization by chicken egg yolk antibodies
Keywords: Venom; Chicken antibodies (IgY); PLA2
Prospection, structural analysis and phylogenetic relationships of endogenous γ-phospholipase A2 inhibitors in Brazilian Bothrops snakes (Viperidae, Crotalinae)
Keywords: Phospholipase A2 inhibitor; PLI; Phospholipase A2; PLA2; Viperidae; Bothrops; Snake
FRET between non-substrate probes detects lateral lipid domain formation during phospholipase A2 interfacial catalysis
Keywords: FRET; Lipid domains; PLA2; Interfacial activity;
Exploration of associations between phospholipase A2 gene family polymorphisms and AIDS progression using the SNPlex™ method
Keywords: PLA2; AIDS; Genomic; Disease; Progression; Pathogenesis; HIV; Genetic association
A presynaptically toxic secreted phospholipase A2 is internalized into motoneuron-like cells where it is rapidly translocated into the cytosol
Keywords: ACh; acetylcholine; Atn; ammodytin; AtxA; B and C, ammodytoxins A, B and C; CaM; calmodulin; NMJ; neuromuscular junction; PLA2; phospholipase A2; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; sPLA2; secreted PLA2; sulpho-SBED; sulphosuccinimidyl
Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii
Keywords: Bothrops; Trichoderma; Koninginin; PLA2; Myotoxicity; Phospholipase A2
Synthesis and evaluation of nitrostyrene derivative compounds, new snake venom phospholipase A2 inhibitors
Keywords: Nitrostyrene; Bothrops jararacussu; DFT; Chemometrics; PLA2
Isolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA2 activity
Keywords: Ellagic acid; PLA2; Bothrops jararacussu; Casearia sylvestris; Enzymatic activity
Oscillatory signaling and network responses during the development of Dictyostelium discoideum
Keywords: cAMP; Adaptation; Chemotaxis; Protein kinases; PI3K; PTEN; PLA2; cGMP
Purification, characterization and bactericidal activities of basic phospholipase A2 from the venom of Agkistrodon halys (Chinese pallas)
Keywords: Bactericidal; Myotoxin; Phospholipase A2; Amino acid sequence; Agkistrodon halys; Cytotoxicity; AgkTx-II; Agkistrodon halys toxin; LPS; lipopolysaccharide; TFA; trifluoroacetic acid; PLA2; phospholipases A2; MALDI-TOF; matrix-assisted laser desorption ion
A colorimetric assay for measuring phospholipase A2 degradation of phosphatidylcholine at physiological pH
Keywords: Lipase; PLA2; Phospholipase; Bromothymol blue; High-throughput; Microplate
A bactericidal homodimeric phospholipases A2 from Bungarus fasciatus venom
Keywords: PLA2; Bungarus fasciatus; Antibacterial; Snake venom
Pain signalling pathways: From cytokines to ion channels
Keywords: NGF; nerve growth factor; TNFα; tumor necrosis factor α; IL-Iβ; interleukin 1β; PLCβ; phospholipase Cβ; PLA2; phospholipase A2; PKC; protein kinase C; TTX-R; tetrodotoxin-resistant; AA; arachidonic acid; PGE2; prostaglandin E2; COX; cyclooxygenase;
Liposomes for phospholipase A2 triggered siRNA release: Preparation and in vitro test
Keywords: siRNA; RNAi; Delivery; Liposome; PLA2
A micelle nucleation model for the interaction of dodecyl sulphate with Lys49-phospholipases A2
Keywords: PLA2; phospholipase A2; Lys49-PLA2; a family of PLA2 homologues with Lys at position 49; BthTx-I; Lys49-PLA2 homologue isolated from the venom of Bothrops jararacussu; SDS; sodium dodecyl sulphate; DPPC; dipalmitoylphosphatidylcholine; CD; circular di
In vivo activation of N-methyl-d-aspartate receptors generates free radicals and reduces antioxidant ability in the rat hippocampus: Experimental protocol of in vivo ESR spectroscopy and microdialysis for redox status evaluation
Keywords: ESR; electron spin resonance; POBN; α-(4-pyridyl-1-oxide)-N-tert-butylnitrone; hfc; hyperfine coupling constant; PCAM; 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl; EAATs; excitatory amino acids transporters; PLA2; phospholipase A2; NOS; nitri
The co-purification of a lectin (BJcuL) with phospholipases A2 from Bothrops jararacussu snake venom by immunoaffinity chromatography with antibodies to crotoxin
Keywords: Bothrops jararacussu; Crotoxin; Immunoaffinity; Bothropstoxin; BthTX-I; BJcuL; PLA2
Purification and partial characterization of two phospholipases A2 from Bothrops leucurus (white-tailed-jararaca) snake venom
Keywords: Bothrops leucurus; PLA2; Platelet aggregation; Blood coagulation; Angiogenesis; Snake venomAA, arachidonic acid; ADP, adenosine 5′-diphosphate; ELISA, enzyme-linked immunosorbent assay; FPLC, fast protein liquid chromatography; FUNED, Fundacao Ezequiel Di
In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease
Keywords: PD; Parkinson disease; DA; dopamine; DAT; dopamine transporter; AA; arachidonic acid; PLA2; phospholipase A2; cPLA2; cytosolic PLA2; 6-OHDA; 6-hydroxydopamine; rCMRglc; regional cerebral metabolic rate for glucose; Arachidonic acid; PLA2; D2 receptors; d-
Mapping of the structural determinants of artificial and biological membrane damaging activities of a Lys49 phospholipase A2 by scanning alanine mutagenesis
Keywords: Bothropstoxin-I; Myotoxin; Bactericide; Myoblast; Liposome; PLA2
Comparative study on the cell toxicity and enzymatic activity of two northern scyphozoan species Cyanea capillata (L.) and Cyanea lamarckii (Péron & Léslieur)
Keywords: Cyanea; Jellyfish; Cnidaria; Venom; Cytotoxicity; PLA2
Hydrolysis of minor glycerophospholipids of plasma lipoproteins by human group IIA, V and X secretory phospholipases A2
Keywords: BSA; bovine serum albumin; CapEx; capillary exit voltage; CID; collision induced dissociation; CL; cardiolipin; GLC; gas-liquid chromatography; GroPCho; glycerophosphocholine; GroPEtn; glycerophosphoethanolamine; GroPGro; glycerophosphoglycerol; GroPSer
Effect of tricyclodecan-9-yl potassium xanthate (D609) on phospholipid metabolism and cell death during oxygen-glucose deprivation in PC12 cells
Keywords: phosphatidylcholine; sphingomyelin; phospholipases; D609; ceramide; sphingomyelinase; A-SMase; acidic sphingomyelinase; [Ca2+]i; intracellular Ca2+; CCT; cytidine triphosphate:phosphocholine cytidylyltransferase; cPLA2; cytosolic phospholipase A2; CPT; CD
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
Phospholipase A2 diversity and polymorphism in European viper venoms: Paradoxical molecular evolution in Viperinae
Keywords: PLA2; Snake venom; Viperinae; Evolution
Glycosylated inositol phospholipid from Entamoeba histolytica: Identification and structural characterization
Keywords: ESMS; electro spray mass spectrometry; GIPL; glycoinositolphospholipid; GPI; glycosylated phosphatidyl inositol; HPTLC; high performance thin layer chromatography; HPAEC; high pH anion exchange chromatography; LPG; lipophosphoglycan; MeOH; methanol; PBS;
Phospholipase A2 is involved in muscarinic receptor-mediated sAPPα release independently of cyclooxygenase or lypoxygenase activity in SH-SY5Y cells
Keywords: Muscarinic receptors; sAPPα release; PLA2; COX; LOX; Arachidonic acid
Oxidative stress and arachidonic acid mobilization
Keywords: AA; arachidonic acid; PLA2; phospholipase A2; iPLA2; calcium-independent phospholipase A2 activity (undefined molecular identity); iPLA2-VIA; Group VIA phospholipase A2; cPLA2α; cytosolic Group IVA phospholipase A2; cPLA2γ; Group IVC phospholipase A2; s
Molecular cloning of the major lethal toxins from two kraits (Bungarus flaviceps and Bungarus candidus)
Keywords: Bungarus flaviceps; Bungarus candidus; β-Bungarotoxin; cDNA cloning; β-Bgt; β-bungarotoxin; PLA2; phospholipase A2; PVDF; polyvinylidene difluoride; UTR; untranslated region; nt; nucleotide number;
Binding to the high-affinity M-type receptor for secreted phospholipases A2 is not obligatory for the presynaptic neurotoxicity of ammodytoxin A
Keywords: Phospholipase A2; Snake venom; Vipera ammodytes ammodytes; Neurotoxicity; M-type phospholipase A2 receptor; Abs; antibodies; Atx; ammodytoxin; 12-AtxA; ARIRARGSIEGR-AtxA; CaM; calmodulin; CTLD; C-type lectin-like domain; DAB; 3,3â²-diaminobenzidine; FABP
Mechanism of cytosol phospholipase C and sphingomyelinase-induced lysosome destabilization
Keywords: Lysosome; Phospholipase C; Sphingomyelinase; Calcium ion; Potassium ion; Proton; Ara-AMP; adenine 9-beta-d-arabinofuranoside 5â²-monophosphate; [Ca2+]; Ca2+ concentration; CCCP; carbonyl cyanide mchlorophenylhydrazone; D609; O-tricyclo[5.2.1.02,6]dec-9-y
Implications of oxidative stress in the cytotoxicity of Pseudomonas aeruginosa ExoU
Keywords: Pseudomonas aeruginosa; ExoU; Pla2; Arachidonic acid; Oxidative stress; Lipid peroxidation
Cardiolipin metabolism and Barth Syndrome
Keywords: BTHS; Barth Syndrome; CL; cardiolipin; TAZ; tafazzin; PA; phosphatidic acid; CDP-DG; cytidine-5â²-diphosphate-1,2-diacyl-sn-glycerol; CDS; CDP-DG synthetase; PG; phosphatidylglycerol; PGP; PG phosphate; PLA2; phospholipase A2; MLCL; Monolysocardiolipin;
Blockade of arachidonic acid pathway induces sprouting in the adult but not in the neonatal uncrossed retinotectal projection
Keywords: visual system; retrograde messenger; arachidonic acid pathway; lesion-induced plasticity; topographical map; critical period; AA; arachidonic acid; HRP; horseradish peroxidase; NDGA; nordihydroguaiaretic acid; PLA2; phospholipase A2; PND; postnatal day; S
Stepwise control of osteogenic differentiation by 5-HT2B receptor signaling: Nitric oxide production and phospholipase A2 activation
Keywords: 5-HT2B receptor; Osteogenic differentiation; PLA2; NO; COX/PGE2; Bone mineralization
Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels
Keywords: AS; analytical sensitivity; BSA; bovine serum albumin; DTPA; diethylenetriaminepentaacetic acid; cps; counts per second; cv; coefficient of variation; G; group; IgG; Immunoglobulin G; LPS; lipopolysaccaride; PBS; phosphate buffered saline; PLA2; phospholi
From endothelium-derived hyperpolarizing factor (EDHF) to angiogenesis: Epoxyeicosatrienoic acids (EETs) and cell signaling
Keywords: Angiogenesis; Ca2+-dependent K+ channels; Cytochrome P450; Eicosanoids; Endothelium; Hyperpolarization; Membrane potential; Signal transduction; bFGF; basic fibroblast growth factor; BKCa channels; large conductance KCa+ channels; COX; cyclooxygenase; cyc
Reduced mitochondrial formation of H2O2 is responsible for resistance of dimethyl sulfoxide differentiated U937 cells to peroxynitrite
Keywords: AA; arachidonic acid; AACOCF3; arachidonyl trifluoromethyl ketone; ATZ; 3-amino-1,2,4-triazole; cPLA2; cytosolic phospholipase A2; DMSO; dimethyl sulfoxide; D-U937; dimethyl sulfoxide-differentiated U937 cells; iPLA2; calcium-independent phospholipase A2;
Impact of inhibiting activity of indole inhibitors on phospholipid hydrolysis by phospholipase A2
Keywords: Indole; PLA2; Catalyzed;
The protein composition of honeybee venom reconsidered by a proteomic approach
Keywords: 2-DE; two-dimensional gel electrophoresis; ESI; electrospray ionization; EST; expressed sequence tag; IEF; isoelectric focusing; IPG; immobilized pH gradient; IUIS; International Union of Immunology Societies; LC; liquid chromatography; MALDI; matrix-assi
Phosphorylation of AMPA receptor subunits is differentially regulated by phospholipase A2 inhibitors
Keywords: AACOCF3; arachidonyl trifluoromethyl ketone; AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionate; BEL; bromoenol lactone; NMDA; N-methyl-d-aspartate; PKC; protein kinase C; PLA2; phospholipase A2; cPLA2; calcium-dependent phospholipase A2; iPLA2; calc
Characterization of the insulinotropic action of a phospholipase A2 isolated from Crotalus durissus collilineatus rattlesnake venom on rat pancreatic islets
Keywords: Arachidonic acid; Insulin secretion; Pancreatic islets; PLA2; Snake venom;
Role of Ca2+-independent phospholipase A2 and cytochrome P-450 in store-operated calcium entry in 3T6 fibroblasts
Keywords: AA; arachidonic acid; AACOCF3; arachidonyl trifluoromethylketone; ARC; arachidonate-regulated Ca2+; BEL; bromoenol lactone; CCE; capacitative calcium entry; CRAC; calcium release-activated Ca2+ channels; CIF; calcium influx factor; EET; epoxyeicosatrienoi
Antiophidian properties of the aqueous extract of Mikania glomerata
Keywords: AEDS; aqueous extract of the dried stem from Mikania glomerata; AEDL; aqueous extract of the dried leaves from Mikania glomerata; AEDR; aqueous extract of the dried root from Mikania glomerata; AEFR; aqueous extract of the fresh root from Mikania glomerat
μ-opioid-mediated inhibition of glutamate synaptic transmission in rat central amygdala neurons
Keywords: phospholipase A2; 4AP-sensitive potassium channel; reward; analgesia; AP5; 2-amino-5-phosphonovaleric acid; BLA; basolateral nucleus of the amygdala; CeA; central nucleus of the amygdala; CNQX; 6-cyano-7-nitroquinoxaline-2,3-dione; DAMGO; [d-Ala2,N-MePhe4
Two groups of entomopathogenic bacteria, Photorhabdus and Xenorhabdus, share an inhibitory action against phospholipase A2 to induce host immunodepression
Keywords: PLA2; Immunodepression; Heterorhabditis; Steinernema; Photorhabdus; Xenorhabdus; Spodoptera exigua;
Detection of polychlorinated biphenyls using an antibody column in tandem with a fluorescent liposome column
Keywords: PCBs detection; Fluorescent; Liposome column; PLA2; Albumin; Anionic liposomes; Immunoassay;