Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives
Keywords: Antidiabetic; PPARγ; Thiazolidinedione; Molecular docking;
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Keywords: 2-DG; 2-deoxy glucose; Akt; protein kinase B; ARDS; acute respiratory distress syndrome; Arg; arginase; BALF; broncho-alveolar lavage fluid; BCG; Bacillus Calmette-Guérin; CD; cluster of differentiation; cGAS; cyclic GMP-AMP synthase; COX-2; cyclooxyge
Keywords: Diabetes mellitus; Antioxidants; Oxygen free radicals; Nitrative stress; Animal; Human; eNOS; endothelial nitric oxide synthase; NOS3; nitric oxide synthase 3; cNOS; constitutive nitric oxide synthase; nNOS; neuronal nitric oxide synthase; iNOS; induced n
Keywords: Multi-target drug design; Steered molecular dynamics; Alzheimer's disease; Amyloid beta peptide; β-secretase; PPARγ; LXRα;
Keywords: ADIG; adipogenin; PPARγ; peroxisome proliferator activated receptor γ; Hh; hedgehog; siRNA; small interfering RNA; TNFα; Tumor Necrosis Factor α; Mw; molecular weight; pI; theoretical isoelectric point; CDS; coding sequence; qPCR; quantitative real ti
Keywords: APP; amyloid precursor protein; Aβ; amyloid-β; BACE; beta-site APP cleaving enzyme; BBB; blood-brain barrier; CMC-Na; sodium carboxymethyl cellulose; CNS; central nervous system; ELISA; enzyme-linked immunosorbent assay; FBG; fasting blood glucose; HD
Keywords: PANSS; Positive and Negative Syndrome Scale; FEP; first-episode psychosis; IL; interleukin; TNF; tumor necrosis factor; NF; nuclear factor; PPARγ; peroxisome proliferator-activated receptor gamma; ROS; reactive oxygen species; TBARS; thiobarbituric acid
Keywords: Fibroblast; Cell-Cell interactions; Neutral lipid trafficking; PTHrP; ADRP; PPARγ;
Keywords: AH; alfalfa hay; FO; fish oil; LPL; lipoprotein lipase; PPARγ; peroxisome proliferator activated receptorγ; SCD; stearoyl-COA desaturase; UFAs; unsaturated fatty acids; SFAs; saturated fatty acids; DHA; docosahexaenoic acids; EPA; eicosapentaenoic acids
Keywords: BMI; Body mass index; T2DM; Type 2 diabetes mellitus; MHO; Metabolically healthy but obese; MUHNW; Metabolically unhealthy normal weight; MUHO; Metabolically unhealthy obese; MAO; Metabolically abnormal obese; LDL; Low density lipoprotein; HDL; High densi
Keywords: 3β-HSD I; 3β-hydroxysteroid dehydrogenase type I; CL; corpus luteum; DBT; dibutyltin; DMSO; dimethyl sulfoxide; FCS; fetal calf serum; hCG; human chorionic gonadotropin; GR; glucocorticoid receptor; LG; LG100268; LUC; luciferase; MEM; minimal essential
Keywords: BMD; bone mineral density; BMSC; Bone marrow stromal cell; Col1a1; collagen type 1 alpha-1; CTSK; cathepsin K; CTx; cross-linked type I collagen; HDL; high density lipoprotein; HFD; high-fat diet; LDL; low density lipoprotein; LDLRâ/â; Low-density lip
Keywords: ABCA1; ATP-binding cassette transporter 1; ABCG1; ATP Binding Cassette G1; AMPK; 5â²AMP-activated protein kinase; AP-1; activator protein 1; apo A-I; apolipoproteins A-I; AT; adipose tissue; CCK-1; cholecystokinin; CD; Crohn's disease; CVD; cardiovascula
Keywords: CRP; C-reactive protein; HDL; high density lipoprotein; LDL; low density lipoprotein; PPARγ; peroxisome proliferator activated receptor-γ; DPP-4; dipeptidyl peptidase-4; GLP-1; glucagon like peptide-1; TRIB3; tribbles homolog 3; ATF-4; activating transc
Keywords: ABCA1; ATP-binding cassette, sub-family A (ABC1) member 1; ALP; alkaline phosphatase; ANGPTL4; angiopoietin-like 4; BSA; bovine serum albumin; CA9; carbonic anhydrase IX; C/EBP; CCAAT/enhancer binding protein; CMFDA; 5-chloromethylfluorescein diacetate; D
Keywords: Cardioprotection; Gamma-oryzanol rich fractions-palm oil blend nanoemulsion; Lipid parameter; F2-isoprostane; Heart weight; Hepatic cholesterol metabolism; ABCA; ATP-binding cassette; BF3; boron trifluoride; CVD; cardiovascular disease; EORY; gamma-oryz
Keywords: ACToR; EPA's Aggregated Computational Toxicology Resource; AHHS; American Healthy Homes Survey; AhR; aryl hydrocarbon receptor; AR; androgen receptor; CASRN; Chemical Abstract Services Registry Number; DI; deionized; DSSTox; EPA's Distributed Structure-Se
Keywords: Runx2; Runt-related transcription factor 2; SPARC; secreted protein acidic and rich in cysteine; dAza; 5-aza-2â²-deoxycytidine; PPARγ; Peroxisome proliferator activated receptor γ; ROI; regions of interest; PTEN; phosphatase and tensin homolog; ME; mic
Keywords: AD; Alzheimer's disease; TLRs; toll-like receptors; AβPP; amyloid-β protein precursor; NSAIDs; non-steroidal anti-inflammatory drugs; CNS; central nervous system; TNF-α; tumor necrosis factor-α; IL-1β; interleukin 1-β; IL-6; interleukin-6; NO; nit
Keywords: AP-1; activator protein 1; APEX1; , DNA-(apurinic or apyrimidinic site) lyase; AP-MS; , affinity purification followed by mass spectrometry; ARID3A; , AT-rich interactive domain-containing protein 3A; Asc/Men; , ascorbate/menadione; ATRA; , all-trans-Reti
Keywords: Ang1/2; angiopoietin 1 or 2; BMPR2; Bone morphogenetic protein receptor type 2; CAV-1/2; caveolin-1/2; CHD; congenital heart disease; EC; endothelial cell; ECFC; endothelial colony forming cells; EGR-1; early growth response protein 1; EndoMT; endothelial
Keywords: ALS; amyotrophic lateral sclerosis; ALT; alternative telomere lengthening mechanisms; ARIC; Atherosclerosis risk in communities; BP; blood pressure; CAD; coronary artery disease; CML; chronic myelogenous leukemia; CVD; cardiovascular disease; EC; endothel
Keywords: Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis (NASH); Thiazolinediones; Pioglitazone; Dipeptidyl peptidase 4 (DPP-4) inhibitors; Glucagon-like peptide-1 receptor agonists (GLP-1RA); BCAAs; branched-chain amino acids; ARB; angioten
Keywords: AMPK; AMP-activated protein kinase; BM; bone marrow; CAT; catalase; Complex I; NADH-coenzyme Q oxidoreductase; Complex II; succinate-coenzyme Q oxidoreductase; Complex III; ubiquinol-cytochrome c oxidoreductase; COX; cytochrome c oxidase; Complex V; FoF1A
Keywords: Adipogenesis; Pre-adipocytes; MSCs; Cdo1; Pparγ;
Keywords: Bmp4; bone morphogenetic protein 4; EGCG; (-)-epigallocatechin-3-gallate; Ex; voluntary exercise; GTE; decaffeinated green tea extract; HF; high fat diet; Lipe; hormone sensitive lipase; LF; low fat; mt-Co3; cytochrome C oxidase subunit III; mt-Cytb; cyto
Keywords: Resveratrol; Pigs; Lipid metabolism; Obesity; Visceral adipose tissue; TC; total cholesterol; HDL-C; high density lipoprotein cholesterol; LDL-C; low density lipoprotein cholesterol; GOT; aspartate aminotransferase; GPT; alanine aminotransferase; PPARγ;
Keywords: ACh; acetylcholine; AChE; acetylcholinesterase; AChR; acetylcholine receptors; agg; aggrecan; B2M; β2-microglobulin; BMP; bone morphogenetic protein; cAMP; cyclic adenosine monophosphate; cDNA; complementary desoxyribonucleic acid; CO2; carbon dioxide; D
Keywords: Selenium; Selenate; High fat diet; Obesity; Insulin resistance; BAT; brown adipose tissue; C/EBP; CCAAT/enhancer binding protein; DGAT2; diacylglycerol acyltransferase 2; FAS; fatty acid synthase; H&E; haematoxylin and eosin; HF; high fat; HOMA-IR; homeos
Keywords: 24OHC; 24S-Hydroxycholesterol; 27OHC; 27-Hydroxycholesterol; ABC; ATP-binding cassette transporter; ACAT; Acyl-Coa:cholesterol acyltransferase; AD; Alzheimer disease; ApoE; Apolipoprotein E; BACHD; Bacterial artificial chromosome HD; BDNF; Brain-derived n
Keywords: BM; bone marrow; MSCs; mesenchymal stromal cells; RSV; resveratrol; Dex; dexamethasone; SM; standard medium; OM; osteogenic medium; AM; adipogenic medium; Runx-2; Runt-related transcription factor-2; PPARγ; peroxisome proliferator-activated receptor gamm
Keywords: GluOC; uncarboxylated osteocalcin; GlaOC; γ-carboxylated osteocalcin; PKA; protein kinase A; ERK; extracellular signal-regulated kinase; PPAR; peroxisome proliferator-activated receptor; GLP-1; glucagon-like peptide-1; gWAT; gonadal white adipose tissue;
Keywords: AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ATRA; all-trans retinoic acid; BHA; butylated hydroxyanisole; C/EBP; CCAAT/enhancer binding proteins; CREB; cyclic AMP response element-binding proteins; CSF; cerebrospinal fluid; DUOX; dual
Keywords: Cox; cyclooxygenase; CREB; cAMP response element binding protein; CACS; cancer-related anorexia and cachexia syndrome; CRP; C-reactive protein; COPD; chronic obstructive pulmonary disease; DAG; des-acyl ghrelin; ERK; extracellular signal-regulated kinase;
Keywords: ADSCs; adipose derived stem cells; α-SMA; alpha smooth muscle actin; bFGF; basic fibroblast growth factor; BMSCs; bone marrow stem cells; BMP; bone morphogenic protein; COMP; cartilage oligomeric matrix protein; CD; cluster of differentiation; CTGF; conn
Keywords: Vanadium; Diabetes; Aminophenol; PPARα; PPARγ;
Keywords: Abl; Abelson murine leukemia viral oncogene homolog 1; Akt/PKB; protein kinase B; bZIP; basic leucine zipper; C/EBP-β; CCAAT-enhancer-binding protein β; Egr; early growth response; ER; estrogen receptor; Fox; Forkhead box protein; hGH; human growth horm
Keywords: hAT-MSCs; human adipose tissue-derived mesenchymal stem cells; PPARγ; peroxisome proliferator-activated receptor gamma; Cinnamic acid; Kojyl cinnamate ester; Adipogenesis; Human mesenchymal stem cells;
Keywords: Combinational therapy; PPARγ; LXR; Lung cancer; Tyrosine kinase inhibitors;
Keywords: AbFW; abdominal fat weight; ADD-1; adipocyte determination and differentiation-dependent factor 1; ANOVA; analysis of variance; BJY; Beijing-You; C/EBPα; CCAAT/enhancer-binding protein factors α; C/EBPβ; CCAAT/enhancer-binding protein factors β; GLM;
Keywords: NAFLD; Non-alcoholic fatty liver disease; dG-TAM; (E)-α-(deoxyguanosin-N2-yl)-tamoxifen; dG-DesMeTAM; (E)-α-(deoxyguanosin-N2-yl)-N-desmethyltamoxifen; ALT; alanine transaminase; AST; aspartate transaminase; LDH; lactate dehydrogenase; α-SMA; α-smooth
Keywords: T2DM; type 2 diabetes mellitus; CM; conditioned medium; ATM; adipose tissue macrophage; TNFα; tumor necrosis factor alpha; LPS; lipopolysaccharide; IFNγ; interferon gamma; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; MCP-1; monocyte c
Keywords: Asthma; diet; obesity; fatty acids; n-6; n-3; inflammation; resolution; AA; Arachidonic acid; AHR; Airway hyperresponsiveness; AIA; Aspirin-intolerant asthma; cLA; Conjugated linoleic acid; CRTH2/DP2; Chemoattractant receptor-homologous molecule express
Keywords: IL-6; Interleukin-6; DXA; dual energy x-ray absorptiometry; BMI; body mass index; HDL; high-density lipoprotein; PPARγ; the nuclear hormone receptor peroxisome proliferator-activated receptor γ; CEBP; CCAAT/enhancer binding protein; PLIN; perilipin; GLU
Keywords: DMC; dimethylcrocetin; CHD; coronary heart disease; LDL; low density lipoprotein; ROS; reactive oxygen species; PCa; prostate cancer; COX-2; cycloxygenase-2; NF-κB; nuclear factor-κB; RAR; retinoid-like receptors; PPARγ; Peroxisome proliferator-activat
Keywords: GLI1/2/3; glioma-associated oncogene homologue 1/2/3; PTCH; patched; SMO; smoothened; SUFU; suppressor of fused; CDO; CAM-related/downregulated by oncogenes; BOC; brother of CDO; GAS1; growth arrest-specific 1; PKA; protein kinase A; GSK3β; glycogen synt
Keywords: ADP; adenosine 5â²-diphosphate; AA; arachidonic acid; CLA; conjugated linoleic acid; COX-1; cyclooxygenase-1; CVD; cardiovascular disease; DHA; docosahexaenoic acid; EFSA; European Food Safety Authority; EPA; eicosapentaenoic acid; GP; glycoprotein; ICAM
Keywords: ACP; antegrade cerebral perfusion; AMES; assisted movement with enhanced sensation; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; BAIPC; bilateral arm ischemic preconditioning; BBB; blood-brain barrier; BCI; Brain-Computer Interface; B
Keywords: AJ; adherens junction; APC; adenomatous polyposis coli; ARD; armadillo repeat domain; ARVC; arrhythmogenic right ventricular cardiomyopathy; Bsk; Basket; CaM; calmodulin; Cav-1; caveolin-1; CCM; cerebral cavernous malformations; Ccm3; cerebral cavernous m
Keywords: AF-2; activation function 2; AP; alternative pocket; AR; androgen receptor; BF-3; binding function 3; DBD; DNA-binding domain; ER; estrogen receptor; GP; genomic pocket; GR; glucocorticoid receptor; H12; helix 12; HDX; hydrogen/deuterium exchange; LBD; li