Keywords: فارماکوکینتیک پیشکلامی; clinical pharmacokinetics; distribution; hepatic clearance; in vitro-in vivo correlations (IVIVC); metabolic clearance; oral absorption; physiological model; preclinical pharmacokinetics; protein binding; simulations;
مقالات ISI فارماکوکینتیک پیشکلامی (ترجمه نشده)
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Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; physiological model; simulations; clearance; absorption; distribution; ADAM; advanced dissolution absorption and metabolism; B:P; blood-to-plasma ratio; CLint; intrinsic clearance; CLiv; intravenous clearance; CLu,intH; unbou
Keywords: فارماکوکینتیک پیشکلامی; clearance; clinical pharmacokinetics; preclinical pharmacokinetics; proteins; simulations; AC; antigen concentration; ADCC; antibody-dependent cellular cytotoxicity; BrW; brain weight; CL; clearance; mAb; monoclonal antibody; MLP; maximum life span potent
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; drug interactions; serial sampling method;
Keywords: فارماکوکینتیک پیشکلامی; ADME; bioavailability; biopharmaceutics classification system (BCS); clinical pharmacokinetics; clearance; formulation; oral absorption; physiological model; preclinical pharmacokinetics; solubility
Keywords: فارماکوکینتیک پیشکلامی; preclinical species; animal models in drug delivery; preclinical pharmacokinetics; in vitro/in vivo correlations; pharmacokinetic/pharmacodynamic models; absorption; oral drug delivery; bioavailability
Keywords: فارماکوکینتیک پیشکلامی; prodrugs; drug delivery systems; blood flow; controlled release; preclinical pharmacokinetics; RBC; red blood cell;
Keywords: فارماکوکینتیک پیشکلامی; blood-brain barrier; CNS; diphenhydramine; drug disposition; drug transport; preclinical pharmacokinetics;
Keywords: فارماکوکینتیک پیشکلامی; bioavailability; polymeric drug delivery systems; preclinical pharmacokinetics; antioxidants; toxicology; in vitro/in vivo correlations; green tea polyphenols; GTPs green tea polyphenols; poly E polyphenone E; PCL poly (ε-caprolactone);
Keywords: فارماکوکینتیک پیشکلامی; robotics; mass spectrometry; HPLC; protein binding; preclinical pharmacokinetics; equilibrium dialysis;
Keywords: فارماکوکینتیک پیشکلامی; collagen binding; osteoporosis; peptides; peptide delivery; pharmacokinetic/pharmacodynamic models; population pharmacokinetics; preclinical pharmacokinetics; PTH(1-34); teriparatide; AIC, akaike information criterion; CBD, collagen-binding domain; PTH,
Elucidation of pharmacokinetics of novel DNA ligase I inhibitor, S012-1332 in rats: Integration of in vitro and in vivo findings
Keywords: فارماکوکینتیک پیشکلامی; S012-1332; LC-ESI-MS/MS; Preclinical pharmacokinetics; Plasma protein binding; In vitro metabolism;
Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma
Keywords: فارماکوکینتیک پیشکلامی; Bexarotene; HPLC-UV; Preclinical pharmacokinetics; Rat plasma; Human plasma; Mouse plasma;
R- and S-Warfarin Were Transported by Breast Cancer Resistance Protein: From In Vitro to Pharmacokinetic-Pharmacodynamic Studies
Keywords: فارماکوکینتیک پیشکلامی; ABC transporters; drug transport; mass spectrometry; preclinical pharmacokinetics; pharmacokinetics/pharmacodynamics; INR; international normalized ratio; BCRP; breast cancer resistance protein; ABCG2; ATP-binding cassette transporter G2; CYP450; cytochro
Hepatobiliary Clearance Prediction: Species Scaling From Monkey, Dog, and Rat, and In Vitro-In Vivo Extrapolation of Sandwich-Cultured Human Hepatocytes Using 17 Drugs
Keywords: فارماکوکینتیک پیشکلامی; hepatobiliary disposition; hepatic transport; efflux pumps; hepatic clearance; preclinical pharmacokinetics;
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling
Keywords: فارماکوکینتیک پیشکلامی; clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm
Utility of PBPK Absorption Modeling to Guide Modified Release Formulation Development of Gaboxadol, a Highly Soluble Compound With Region-Dependent Absorption
Keywords: فارماکوکینتیک پیشکلامی; in vitro/in vivo correlations (IVIVC); controlled release; preclinical pharmacokinetics; physiologically based pharmacokinetic modeling; site-specific absorption; bioavailability; intestinal absorption;
A robust LC-MS/MS method for the determination of pidotimod in different biological matrixes and its application to in vivo and in vitro pharmacokinetic studies
Keywords: فارماکوکینتیک پیشکلامی; Pidotimod; LC-MS/MS; Preclinical pharmacokinetics; Caco-2 cell;
A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients
Keywords: فارماکوکینتیک پیشکلامی; clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti
Assessing Supersaturation and Its Impact on In Vivo Bioavailability of a Low-Solubility Compound ABT-072 With a Dual pH, Two-Phase Dissolution Method
Keywords: فارماکوکینتیک پیشکلامی; in vitro models; in vitro/in vivo correlations (IVIVC); absorption; preclinical pharmacokinetics; clinical pharmacokinetics; precipitation; dissolution;
Anatomical, Physiological, and Experimental Factors Affecting the Bioavailability of sc-Administered Large Biotherapeutics
Keywords: فارماکوکینتیک پیشکلامی; bioavailability; proteins; preclinical pharmacokinetics; absorption; biotechnology;
Intravenous Administration of Stable-Labeled N-Acetylcysteine Demonstrates an Indirect Mechanism for Boosting Glutathione and Improving Redox Status
Keywords: فارماکوکینتیک پیشکلامی; N-acetylcysteine (NAC); glutathione (GSH); redox ratio; stable-label; prodrugs; metabolism; metabolite kinetics; preclinical pharmacokinetics; pharmacodynamics;
Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer
Keywords: فارماکوکینتیک پیشکلامی; ADME; absorption enhancer; bioavailability; Caco-2 cells; cytochrome P450; drug interactions; efflux pumps; preclinical pharmacokinetics;
Suitability of a Minipig Model in Assessing Clinical Bioperformance of Matrix and Multiparticulate Extended-Release Formulations for a BCS Class III Drug Development Candidate
Keywords: فارماکوکینتیک پیشکلامی; controlled release; preclinical pharmacokinetics; pharmacokinetics; food effects; controlled delivery; formulation; in vitro/in vivo correlations (IVIVC);
Preclinical Pharmacokinetics and In Vitro Metabolism of BMS-605339: A Novel HCV NS3 Protease Inhibitor
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; oral absorption; metabolism; hepatic clearance; in vitro/in vivo correlations (IVIVC); ADME; protease;
Nebulization of mycophenolate mofetil inhalation suspension in rats: Comparison with oral and pulmonary administration of Cellcept®
Keywords: فارماکوکینتیک پیشکلامی; Mycophenolate mofetil; Immunosuppressant; Pulmonary delivery; Preclinical pharmacokinetics; Lung; Lymphatic system;
A Toxicity Risk Index, An Index for Warning Idiosyncratic Drug Toxicity
Keywords: فارماکوکینتیک پیشکلامی; metabolism; pharmacokinetics; preclinical pharmacokinetics; protein binding; toxicokinetics; black box warning; drug toxicity; covalent binding; idiosyncratic drug toxicity
Mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers
Keywords: فارماکوکینتیک پیشکلامی; Prodrugs; Controlled release; Synthesis; Preclinical pharmacokinetics; Stability; Mutual prodrugs; Drug releasable disulfide linkers; Self-immolative bio-cleavable linkers; Sulfhydryl-assisted cleavage; Thiol-assisted cleavage
Disposition of ON 01210.Na (Ex-RAD(R)), a Novel Radioprotectant, in the Isolated Perfused Rat Liver: Probing Metabolic Inhibition to Increase Systemic Exposure
Keywords: فارماکوکینتیک پیشکلامی; metabolic clearance; disposition; drug interactions; hepatic metabolism; glutathione-S-transferases; preclinical pharmacokinetics;
Biodistribution and Excretion of Radiolabeled 40Â kDa Polyethylene Glycol Following Intravenous Administration in Mice
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; distribution; disposition; excretion; pegylation;
Moving from Basic Toward Systems Pharmacodynamic Models
Keywords: فارماکوکینتیک پیشکلامی; pharmacokinetics; pharmacodynamics; pharmacometrics; systems pharmacology; indirect response models; dose response; mathematical model; preclinical pharmacokinetics
An Alternative Approach for Quantitative Bioanalysis using Diluted Blood to Profile Oral Exposure of Small Molecule Anticancer Drugs in Mice
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; bioanalysis; cancer; oral drug delivery; LC-MS; chromatography; cassette dosing; serial blood sampling;
Development and Evaluation of a Novel Microemulsion Formulation of Elacridar to Improve its Bioavailability
Keywords: فارماکوکینتیک پیشکلامی; ABC Transporters; preclinical pharmacokinetics; Target drug delivery; elacridar; GF120918; bioavailability; microemulsion;
Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset
Keywords: فارماکوکینتیک پیشکلامی; blood–brain barrier; membrane transporter; proteomics; multidrug resistance transporters; P-glycoprotein; receptors; tight junction; permeability; ADME; preclinical pharmacokinetics
Influence of the Compound Selection Process on the Performance of Human Clearance Prediction Methods
Keywords: فارماکوکینتیک پیشکلامی; allometry; interspecies scaling; in vitro/in vivo correlations (IVIVC); pharmacokinetics; human liver microsomes; clearance; hepatic clearance; preclinical pharmacokinetics;
Analytical Approach to Characterize the Intratumoral Pharmacokinetics and Pharmacodynamics of Gefitinib in a Glioblastoma Model
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; pharmacodynamics; cancer; blood brain barrier; liquid chromatography; mass spectrometry; LC/MS/MS; MSD assay; gefitinib; mouse orthotopic glioblastoma model; intratumoral pharmacokinetics and pharmacodynamics;
Dose Dependence of Intratumoral Perivascular Distribution of Monoclonal Antibodies
Keywords: فارماکوکینتیک پیشکلامی; carcinoembryonic antigen; tumor penetration; microdistribution; transport barriers; mathematical models; protein delivery; cancer; drug transport; macromolecular drug delivery; preclinical pharmacokinetics;
Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and In Vivo bioavailability
Keywords: فارماکوکینتیک پیشکلامی; freeze drying/lyophilization; formulation; protein delivery; stabilization; protein aggregation; preclinical pharmacokinetics;
Interspecies Scaling in Pharmacokinetics: A Novel Whole-Body Physiologically Based Modeling Framework to Discover Drug Biodistribution Mechanisms in vivo
Keywords: فارماکوکینتیک پیشکلامی; nonlinear pharmacokinetics; whole-body physiologically based pharmacokinetic model; cyclosporin; scaling; biodistribution; animal model; metabolic clearance; drug transport; preclinical pharmacokinetics; individualized drug therapy;
Comparative Assessment of Empirical and Physiological Approaches on Predicting Human Clearances
Keywords: فارماکوکینتیک پیشکلامی; clearance; metabolism; Log P; preclinical pharmacokinetics; clinical pharmacokinetics;
A feasibility study of differential delivery of levodopa ester and benserazide using site-specific intestinal loops in rats
Keywords: فارماکوکینتیک پیشکلامی; bioavailability; colonic drug delivery; gastrointestinal transit; intestinal absorption; prodrugs; site-specific absorption; metabolism; jejunum; absorption enhancer; preclinical pharmacokinetics;
Terminology Challenges: Defining Modified Release Dosage Forms in Veterinary Medicine
Keywords: فارماکوکینتیک پیشکلامی; bioavailability; controlled release; formulation; pharamcokinetics; preclinical pharmacokinetics;
Impact of Chlorpromazine Self-Association on Its Apparent Binding Constants With Cyclodextrins: Effect of SBE7-β-CD on the Disposition of Chlorpromazine in the Rat
Keywords: فارماکوکینتیک پیشکلامی; physicochemical properties; cyclodextrins; physical; characterisation; micelle; formulation vehicle; inclusion compounds; preclinical pharmacokinetics; renal excretion;
Utilization of in vitro Cacoâ2 permeability and liver microsomal halfâlife screens in discovering BMSâ488043, a novel HIVâ1 attachment inhibitor with improved pharmacokinetic properties
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; HIVâ1 attachment inhibitor; Cacoâ2 permeability; liver microsomal halfâlife;
Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology*
Keywords: فارماکوکینتیک پیشکلامی; distribution; proteins; elimination; preclinical pharmacokinetics; biotechnology;
Physiologically based pharmacokinetic model for T84.66: A monoclonal anti-CEA antibody
Keywords: فارماکوکینتیک پیشکلامی; pharmacokinetics; physiological model; PBPK; T84.66 anti-CEA antibody; tumor associated antigen; carcinoembryonic antigen (CEA); target mediated disposition; mathematical model; preclinical pharmacokinetics;
Development and validation of a LC-MS/MS method for the determination of the novel oral 1,14 substituted taxane derivatives, IDN 5738 and IDN 5839, in mouse plasma and its application to the pharmacokinetic study
Keywords: فارماکوکینتیک پیشکلامی; LC-ESI-MS and CID-MS/MS method development; SRM analysis; Oral taxanes; Preclinical pharmacokinetics;
Fed and fasted gastric pH and gastric residence time in conscious beagle dogs
Keywords: فارماکوکینتیک پیشکلامی; gastrointestinal; intestinal absorption; food effect; physiological model; preclinical pharmacokinetics;
Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals
Keywords: فارماکوکینتیک پیشکلامی; protein binding; albumin; distribution; PET; preclinical pharmacokinetics;
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials
Keywords: فارماکوکینتیک پیشکلامی; preclinical pharmacokinetics; drug design; pro-drugs; ADME; cytochrome P450; MDCK cells; protein binding; blood partitioning; anti-malarials; bioactivation;