Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Ginkgolic acid; Type 2 diabetes; Glucose-uptake; PTPN9; DUSP9; Dual-targeting inhibitor;
مقالات ISI پروتئین تیروزین فسفاتاز (ترجمه نشده)
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Keywords: پروتئین تیروزین فسفاتاز; CCA; Cholangiocarcinoma; iCCA; Intrahepatic CCA; pCCA; Perihilar CCA; dCCA; Distal CCA; CDK; Cyclin dependent kinase; CDKN2A/B; Cyclin-dependent kinase inhibitor 2A/B; PLK2; Polo-like kinase 2; FGF; Fibroblast growth factor; HGF; Hepatocyte growth factor;
Keywords: پروتئین تیروزین فسفاتاز; AGEs; advanced glycation end products; CEL; Nε-(carboxyethyl) lysine; CMA; NÏ-(carboxymethyl) arginine; CML; Nε-(carboxymethyl) lysine; H2O2; hydrogen peroxide; HCC; hepato-cellular carcinoma-; HMGB1; high mobility group box-1; NAFLD; nonalcoholic fatt
Keywords: پروتئین تیروزین فسفاتاز; DCA; dichloroacetate; FAO; fatty acid oxidation; GO; glucose oxidation; HIF-1; hypoxia-inducible factor 1; CaL channels; L-type calcium channels; NFATs; nuclear factor of activated T cells; NO; nitric oxide; MCT-PAH; monocrotaline-induced PAH; PAH; pulmon
Keywords: پروتئین تیروزین فسفاتاز; Missense mutations; Protein tyrosine phosphatases; SHP-1; FAP-1;
Keywords: پروتئین تیروزین فسفاتاز; BSA; bovine serum albumin; CK; creatine kinase; DMSO; dimethylsulfoxide; DTNB; 5,5â²-dithio-(2-nitrobenzoic acid); DTT; dithiothreitol; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HBSS; Hank's buffered salt solution without calcium and magnesium; HM
Keywords: پروتئین تیروزین فسفاتاز; Beta cells; Diabetes; Eicosanoids; Fatty aldehyde dehydrogenase; Glutathione peroxidase; Glutathione-S-transferase4-hydroxyalkenals; 4-Hydroxynonenal; Lipid peroxidation; Phospholipase A; 12-HETE (PubChem CID: 5283155); 15-HETE (PubChem CID: 280724); 4-HN
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Phosphorylation; Substrates; Signal transduction; Proteomics; Genomics
Keywords: پروتئین تیروزین فسفاتاز; protein tyrosine phosphatases; metabolism; type 1 diabetes; type 2 diabetes
Keywords: پروتئین تیروزین فسفاتاز; Biarsenicals; FlAsH; Protein tyrosine phosphatases; Allostery; Protein engineering; Inhibitor sensitization;
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; PTP; Inhibitor; Thrombosis; Antithrombotic; Platelets; Antiplatelet; Therapy; Drug; GPVI; CLEC-2; DUSP3; VHR; CD148; PTP1B; SHP1; SHP2;
Keywords: پروتئین تیروزین فسفاتاز; protein tyrosine phosphatases; obesity; type 2 diabetes; hypothalamus; leptin; insulin
Keywords: پروتئین تیروزین فسفاتاز; BSA; bovine serum albumin; BSA-Cl; N-chloramines formed on bovine serum albumin; eNOS; endothelial nitric oxide synthase; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GlyCl; glycine N-chloramine; GPx; glutathione peroxidase; GSH; glutathione; H2O2;
Keywords: پروتئین تیروزین فسفاتاز; AP1; activator protein 1; APE1; apurinic/apyrimidinase endonuclease 1; BIAM; biotinylated iodoacetamide; GSH; reduced glutathione; GSSG; oxidized glutathione; ho-1; heme oxygenase-1; IAM; iodoacetamide; Keap1; Kelch-like ECH-associated protein 1; MBrB; mo
Keywords: پروتئین تیروزین فسفاتاز; AD; Alzheimer's disease; ALD; X-linked adrenoleukodystrophy; ALDRP; adrenoleukodystrophy-related protein; ALDP; adrenoleukodystrophy protein; ALS; amyotrophic lateral sclerosis; ATF-2; activating transcription factor 2; BBB; blood-brain barrier; AP-1; a
Mechanism of insulin-like effect of chromium(III) ions on glucose uptake in C2C12 mouse myotubes involves ROS formation
Keywords: پروتئین تیروزین فسفاتاز; DCFH DA; dichorodihydrofluorescein diacetate; DCFH 2â²,7â²; dichorodihydrofluorescein; DCF 2â²,7â²; dichorofluorescein; DMEM; dulbecco modified eagle's medium; DOG; deoxyglucose; DPI; diphenyleneiodonium; GTF; glucose tolerance factor; GLUT4; glucos
Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules
Keywords: پروتئین تیروزین فسفاتاز; AsCy3; FlAsH; Enzyme inhibition; Protein engineering; Protein tyrosine phosphatases;
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: پروتئین تیروزین فسفاتاز; Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
New insights into the Vav1 activation cycle in lymphocytes
Keywords: پروتئین تیروزین فسفاتاز; Exchange factors; Rac1; JNK; NFAT; Lck; Src family; Zap70; Lat; Phospholipase Cγ; Slp76; Protein tyrosine phosphatases; T cell receptor; B cell receptor; Phosphosites; Conformational states; Signaling diversification; Lymphocytes;
Chronic exposure of the RAW246.7 macrophage cell line to H2O2 leads to increased catalase expression
Keywords: پروتئین تیروزین فسفاتاز; ROS; reactive oxygen species; GSH; glutathione; SOD; superoxide dismutase; PTPs; protein tyrosine phosphatases; NEM; N-ethylmaleimide; DTNB; 5,5-dithio-bis-(2-nitrobenzoic acid); PMA; phorbol 12-myristate 13-acetate; ASK1; apoptosis signal-regulating kina
Disruption of SHP1/NMDA receptor signaling in spinal cord dorsal horn alleviated inflammatory pain
Keywords: پروتئین تیروزین فسفاتاز; N-methyl-d-aspartate subtype of glutamate receptors; Protein tyrosine phosphatases; Src-family protein tyrosine kinases; Src-homology 2 domain-containing protein tyrosine phosphatase-1; Pain; SHP1; Src-homology 2 domain-containing protein tyrosine phospha
An epigenetic modifier induces production of (10â²S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla
Keywords: پروتئین تیروزین فسفاتاز; Epigenetic; Phoma sp. nov. LG0217; Histone deacetylase inhibitor; (10â²S)-verruculide B; Protein tyrosine phosphatases;
Identification of sennoside A as a novel inhibitor of the slingshot (SSH) family proteins related to cancer metastasis
Keywords: پروتئین تیروزین فسفاتاز; PTPs; protein tyrosine phosphatases; PTKs; protein tyrosine kinases; DUSP; dual specificity phosphatase; ADF; actin-depolymerizing factor; IPTG; isopropyl-β-d-thiogalactoside; DiFMUP; 6,8-difluoro-4-methylumbelliferyl phosphate; MBP; maltose binding prot
OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity
Keywords: پروتئین تیروزین فسفاتاز; crystallography; Orf virus; tyrosine phosphatase; phosphatidylinositol; ORFV; Orf virus; DUSP; dual-specificity phosphatase; PTPs; protein tyrosine phosphatases; P-loop; phosphate-binding loop; PtdIns; phosphoinositides; SEC; size exclusion chromatography
Discovery of 4-[(5-arylidene-4-oxothiazolidin-3-yl)methyl]benzoic acid derivatives active as novel potent allosteric inhibitors of protein tyrosine phosphatase 1B: In silico studies and in vitro evaluation as insulinomimetic and anti-inflammatory agents
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Enzyme inhibitors; Insulinomimetic effects; Anti-inflammatory activity; Molecular docking; 5-Arylidene-4-thiazolidinone derivatives; COX; cyclooxygenase; DM; diabetes mellitus; EI; enzyme-inhibitor complex; ESI; enzyme-subst
Redox regulation of the actin cytoskeleton and its role in the vascular system
Keywords: پروتئین تیروزین فسفاتاز; α; alpha; β; beta; γ; gamma; G-actin; globular actin; F-actin; filamentous actin; ROS; reactive oxygen species; O2â¢â; superoxide; H2O2; hydrogen peroxide; HOâ¢; hydroxyl radical; RNS; reactive nitrogen species; NO; nitric oxide; â¢NO2; nitrogen d
Prediction and verification of novel peptide targets of protein tyrosine phosphatase 1B
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Computational prediction; Peptide substrates; PTP1B;
Inhibition of Setaria cervi protein tyrosine phosphatases by Phenylarsine oxide: A proteomic and biochemical study
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Phenylarsine oxide; Necrosis; Oxidative stress; Lymphatic filariasis;
Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans
Keywords: پروتئین تیروزین فسفاتاز; Phosphoproteomics; Protein tyrosine phosphatases; Tyrosine phosphorylation;
PTP1B confers liver fibrosis by regulating the activation of hepatic stellate cells
Keywords: پروتئین تیروزین فسفاتاز; HSCs; Hepatic stellate cells; PTP1B; Protein tyrosine phosphatase 1B; TGF-β1; Transforming growth factor-β1; MDI; Adipogenic differentiation mixture; ECM; Extracellular matrix; qHSCs; Quiescent HSCs; α-SMA; α-smooth muscle actin; col1α1; Type I colla
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: پروتئین تیروزین فسفاتاز; AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Azide-alkyne cycloaddition-mediated cyclization of phosphonopeptides and their evaluation as PTP1B binders and enrichment tools
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Azide-alkyne click chemistry; Pull-down baits; Cyclic peptides; PTP1B and TCPTP;
Research ReportSepsis-induced brain mitochondrial dysfunction is associated with altered mitochondrial Src and PTP1B levels
Keywords: پروتئین تیروزین فسفاتاز; LPS; lipopolysaccharide; MMP; mitochondrial membrane potential; NO; nitric oxide; OXPHOS; oxidative phosphorylation; PTPs; protein tyrosine phosphatases; ROS; reactive oxygen species; SFKs; Src family kinases; SIBD; sepsis-induced brain dysfunction; Sepsi
Light-switched inhibitors of protein tyrosine phosphatase PTP1B based on phosphonocarbonyl phenylalanine as photoactive phosphotyrosine mimetic
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Enzyme inhibitors; Phosphotyrosine mimetics; Protein phosphorylation; PTP1B; Photo-switchable inhibitors;
Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination
Keywords: پروتئین تیروزین فسفاتاز; ISH; in situ hybridization; OPCs; oligodendrocyte progenitor cells; PFA; paraformaldehyde; PTKs; protein tyrosine kinases; PTPRD; protein tyrosine phosphatase, receptor type D; PTPRS; protein tyrosine phosphatase, receptor type S; PTPs; protein tyrosine p
Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases
Keywords: پروتئین تیروزین فسفاتاز; PTKs; protein tyrosine kinases; PTPs; protein tyrosine phosphatases; PTP1B; protein tyrosine phosphatase 1B; NAFLD; non-alcoholic fatty liver disease; HCC; hepatocellular carcinoma; DSPs; dual specificity phosphatases; LMW; low molecular weight; RPTPs; tr
Is RK-682 a promiscuous enzyme inhibitor? Synthesis and in vitro evaluation of protein tyrosine phosphatase inhibition of racemic RK-682 and analogues
Keywords: پروتئین تیروزین فسفاتاز; Tyrosine phosphatases inhibitors; Natural 3-acyl-5-hydroxymethyltetronic acid; RK-682; Meldrum's acid derivatives; Enzyme inhibition; Promiscuous enzyme inhibition; PTP-1B; protein tyrosine phosphatase 1B; LMW-PTP; low molecular weight protein tyrosine ph
Analysis of PTP1B sumoylation
Keywords: پروتئین تیروزین فسفاتاز; Signal transduction; Protein tyrosine phosphatases; Phosphorylation; Posttranslational modification; Sumoylation;
Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells
Keywords: پروتئین تیروزین فسفاتاز; GSK-3; glycogen synthase kinase-3; IHCs; inner hair cells; LEF; lymphoid enhancer-binding factor; OCs; organs of Corti; OHCs; outer hair cells; PTpase; protein tyrosine phosphatases; ROS; reactive oxygen species; TCF; T-cell-specific transcription factor;
Research ArticleNintedanib (BIBF-1120) inhibits hepatocellular carcinoma growth independent of angiokinase activity
Keywords: پروتئین تیروزین فسفاتاز; HCC; hepatocellular carcinoma; Ab; antibody; IP; immunoprecipitation; p-STAT3; phosphorylated STAT3; PTPs; protein tyrosine phosphatases; SH2; Src homology region 2; SHP-1; SH2 domain-containing phosphatase 1; STAT3; signal transducer and activator of tra
Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling
Keywords: پروتئین تیروزین فسفاتاز; LPA; lysophosphatidic acid; LPAR; LPA receptor; ERK; extracellular signal-related kinase, p44/42 MAP kinase; GPCR; G-protein coupled receptor; ROS; reactive oxygen species; Nox; NADPH oxidase; EGF; epidermal growth factor; EGFR; EGF receptor; PDGF; platel
Synthesis, biological activity and structure–activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Enzyme inhibitors; Insulinomimetic effects; Molecular docking; 5-Arylidene-4-thiazolidinone derivatives; 4-[(5-Arylidene-4-oxo-2-phenylimino/oxothiazolidin-3-yl)methyl]benzoic acids2-DOG, 2-deoxyglucose; IR, insulin receptor
Crosstalk between kinases, phosphatases and miRNAs in cancer
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine kinases; Protein tyrosine phosphatases; miRNA; Cell signaling; Cancer aggressiveness; Chemotherapy resistance;
PRL-3 activates NF-κB signaling pathway by interacting with RAP1
Keywords: پروتئین تیروزین فسفاتاز; PRL-3; phosphatase of regenerating liver-3; RAP1; repressor/activator protein 1; PTP; protein tyrosine phosphatases; PRL-3; RAP1; NF-κB; Cancer;
Inhibition of protein tyrosine phosphatases in spinal dorsal horn attenuated inflammatory pain by repressing Src signaling
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Protein tyrosine kinases; Inflammatory pain; Orthovanadate; NMDA receptors;
Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
Keywords: پروتئین تیروزین فسفاتاز; AD; Alzheimer's disease; NFT; neurofibrillary tangles; PHF; paired helical filaments; SP; senile plaques; APP; apolipoprotein; PP1; protein phosphatase-1; PP2A; protein phosphatase-2A; PP2B; protein phosphatase-2B; PP5; protein phosphatase-5; PTEN; phosph
Low electric fields induce ligand-independent activation of EGF receptor and ERK via electrochemical elevation of H+ and ROS concentrations
Keywords: پروتئین تیروزین فسفاتاز; EF(s); Electric field(s); LEF; Low electric fields; ROS; Reactive oxygen species; H2DCF-DA; Dichlorodihydrofluorescein diacetate; DHA; Dehydroascorbic acid; RTK; Receptor tyrosine kinase; PTPs; Protein tyrosine phosphatases; DC; Direct current; FITC; Fluo
Synthesis and evaluation of copper complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatases
Keywords: پروتئین تیروزین فسفاتاز; Copper complexes; Protein tyrosine phosphatases; Selective inhibitor; Schiff base; CSD; Cambridge Structural Database; ESI-MS; electrospray ionization mass spectra; Hcpmp; 4-chloro-2-((phenylimino)methyl)phenol; Hnpmp; 4-bromo-2-((phenylimino)methyl)pheno
Absence of pyruvate anti-oxidant effect on granulocytes stimulated toll-like receptors
Keywords: پروتئین تیروزین فسفاتاز; Type 2 diabetes; Pyruvate; ROS; TLR4; Granulocytes; AGEs; advanced glycation end products; Con A; concanavalin A; DAG; diacylglycerol; DMEM; Dulbecco's modified Eagle's medium; GSH; glutathione; GSH-Et; glutathione ethyl ester; HMGB-1; high-mobility g
A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells
Keywords: پروتئین تیروزین فسفاتاز; Protein tyrosine phosphatases; Yeast; Cell-based assay; TCPTP; Shp2; PEST; PTPα