Keywords: پیرووات دهیدروژناز کیناز; AMPK; AMP-activated protein kinase; DCA; Dichloroacetate; FACD; Fatty acyl CoA dehydrogenase; G-6-Pase; Glucose-6-phosphatase; HFD; High-fat diet; HGP; Hepatic glucose production; KCT; β-ketoacyl CoA thiolase; LDH; Lactate dehydrogenase; MPC; Mitochondri
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Keywords: پیرووات دهیدروژناز کیناز; ACC; acetyl-CoA carboxylase; ACE; angiotensin-converting enzyme; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; ALDH2; aldehyde dehydrogenase 2; AMPK; 5' AMP-activated protein kinase; ATP; adenosine triphosphate; Bax; Bcl-2-like protein 4; BNIP3; B
Keywords: پیرووات دهیدروژناز کیناز; ACC; acetyl-CoA carboxylase; ALDOA; aldolase A; AIs; aromatase inhibitors; AMPK; AMP-activated protein kinase; BC; breast cancer; CML; chronic myelogenous leukemia; CT; computed tomography; CPT1; carnitine palmitoyltransferase 1; CRC; colorectal cancer; 2
Keywords: پیرووات دهیدروژناز کیناز; Docosahexaenoic acid; Eicosapentaenoic acid; Lipid droplets; Phaeodactylum tricornutum; Polyunsaturated fatty acid; Triacylglycerol; ACCase; acetyl-CoA carboxylase; ACP; acyl carrier protein; ALA; α-linolenic acid; ATS1; plastidic glycerol-3-phosphate ac
Keywords: پیرووات دهیدروژناز کیناز; Proliferation; Target; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase complex;
Keywords: پیرووات دهیدروژناز کیناز; Dichloroacetate; Pyruvate dehydrogenase kinase; GSTZ1; Pharmacogenetics; Pharmacokinetics; Inhibition of metabolism;
Keywords: پیرووات دهیدروژناز کیناز; ATP; adenosine triphosphate; BrP; bromopyruvate; CO2; carbon dioxide; CoA; acetyl-coenzyme A; 2-DG; 2-deoxyglucose; ETC; electron transport chain; FAO; fatty acid oxidation; FAD; flavin adenine dinucleotide; FDG; fluorinated deoxyglucose; FFA; free fatty
Keywords: پیرووات دهیدروژناز کیناز; 2-DG; 2-deoxyglucose; 2-HG; 2-hydroxyglutarate; 5mC; 5-methlycystosine; ACACA; acetyl-CoA carboxylase; AML; acute myeloid leukemia; AMPK; adenosine monophosphate-activated protein kinase; ATP; adenosine triphosphate; ALDH; aldehyde dehydrogenase; ADCs; an
Keywords: پیرووات دهیدروژناز کیناز; AAT; aspartate aminotransferase; Ala; alanine; AlaT; alanine aminotransferase; ALD; aldolase; AOA; aminooxyacetate; Asp; aspartate; CS; citrate synthase; 2-DOG; 2-deoxyglucose; DCA; dichloroacetate; DHAP; dihydroxyacetone phosphate; ENO; enolase; Ery4P; e
Keywords: پیرووات دهیدروژناز کیناز; 2,2DCPA; 2,2-dichloropropionate; 2MCPA; 2-monochloropropionic acid; 3-BrPA; 3-bromopyruvic acid; 5-FU; 5-fluorouracil; Bcc; Burkholderia cepacia complex; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; DBA; dibromoacetic acid; DCA; dichloroacetic acid; F
Keywords: پیرووات دهیدروژناز کیناز; Metabolic modulation; Pyruvate dehydrogenase kinase; Warburg effect; Dichloroacetate;
Keywords: پیرووات دهیدروژناز کیناز; M-CSF; macrophage colony-stimulating factor; IFN-γ; interferon-gamma; M-MÏ; macrophage differentiated from CD14 positive monocytes in the presence of M-CSF; Mγ-MÏ; macrophage differentiated from CD14 positive monocytes in the presence of M-CSF and IFN
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Lactic acid; Neuron; Glia; Neuropathophysiology; Biobehavioral response; Lactate transporter; Lactate receptor; Neuroinflammation; Neurodegeneration; Pain; Metabolism; Mitochondria;
Keywords: پیرووات دهیدروژناز کیناز; Radiation; Skin injury; Pyruvate dehydrogenase kinase;
Keywords: پیرووات دهیدروژناز کیناز; CRC; colorectal cancer; DCA; dichloroacetate; PDH; pyruvate dehydrogenase; PDK; pyruvate dehydrogenase kinase; MA; mitochondrial activity.; Dichloroacetate; Pyruvate dehydrogenase kinase; Anoxia; Mitochondrial function; Colorectal cancer;
Keywords: پیرووات دهیدروژناز کیناز; ACC; Acetyl CoA carboxylase; AMP; Adenosine monophosphate; AMPK; 5׳AMP activated protein kinase; AUC; Area under the curve; CPT; Carnitine palmitoyl transferase; FFA; Free fatty acids; HFD; High fat diet; PDK; Pyruvate dehydrogenase kinase; SSAT; Spermid
Keywords: پیرووات دهیدروژناز کیناز; Gastric neoplasm; 5-Flurouracil; Hypoxia; Chemoresistance; Pyruvate dehydrogenase kinase; Dichloroacetate
Keywords: پیرووات دهیدروژناز کیناز; ACAA2; 3-oxoacyl-CoA thiolase; ADIPOR; adiponectin receptor; AF1,2; activation function 1,2; AMPK; AMP-activated protein kinase; ATF4; activating transcription factor 4; ATGL; adipose triglyceride lipase; CaMK; calcium/calmodulin-dependent kinase; CD36; f
Keywords: پیرووات دهیدروژناز کیناز; AMPK; AMP activated protein kinase; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase; FLIP; FLICE inhibitory protein; FAK; focal adhesion kinase; GSK-3;
Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase complex; Antiproliferative activity; Dichloroacetophenone; Kinase inhibition;
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors
Keywords: پیرووات دهیدروژناز کیناز; MAPK; mitogen-activated protein kinase; BRAF; v-raf murine sarcoma viral oncogene homolog B1; MEK; mitogen-activated protein/extracellular signal- regulated kinase kinase; ERK; extracellular signal-regulated kinase; HIF-1α; hypoxia inducible factor 1 alp
Novel approaches in the treatment of diabetic cardiomyopathy
Keywords: پیرووات دهیدروژناز کیناز; ACE; angiotensin convertase enzyme; ACEi; angiotensin convertase enzyme inhibitor; ADP; adenosine di phosphate; AGE; advanced glycation end products; AM; adrenomedullin; AMP; adenosine mono phosphate; ARB; angiotensin receptor blocker; ATP; adenosine tri
Anticancer effects of some novel dichloroacetophenones through the inhibition of pyruvate dehydrogenase kinase 1
Keywords: پیرووات دهیدروژناز کیناز; PDK; pyruvate dehydrogenase kinase; PDC; pyruvate dehydrogenase complex; MMP; mitochondrial membrane potential; ROS; reactive oxygen species; OXPHOS; oxidative phosphorylation; TCA; tricarboxylic acid; PDPs; pyruvate dehydrogenase phosphatases; DCA; dichl
Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors
Keywords: پیرووات دهیدروژناز کیناز; Cancer; Shikonin; Twin drug; Pyruvate dehydrogenase kinase; Tubulin; CADD; computer assistant drug design; NOS; nitric oxide synthase; PKM2; pyruvate kinase isozymes M2; GLUT1; Glucose transporter 1; LA; alpha-lipoic acid; PDH; pyruvate dehydrogenase; PDC
The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions
Keywords: پیرووات دهیدروژناز کیناز; 15-LOX-1; 15-lipoxygenase; AIF; apoptosis inducing factor; APC; adenomatous polyposis coli; AKT or PKB; protein kinase B; ATG16L2; autophagy related 16 like 2; AUC; area under the curve; Bad; Bcl-2 associated death promoter; Bcl-2; B-cell lymphoma 2; Bcl-
Transcriptomic analysis of Momordica charantia polysaccharide on streptozotocin-induced diabetic rats
Keywords: پیرووات دهیدروژناز کیناز; M. charantia; Momordica charantia; RNA-seq; RNA sequencing; T2DM; Type 2 diabetes mellitus; IR; insulin resistance; PPAR; peroxisome proliferator-activated receptor; FBG; fasting blood glucose; G6Pase; glucose-6-phosphatase; PEPCK; phosphoenol pyruvate ca
Anemone rivularis inhibits pyruvate dehydrogenase kinase activity and tumor growth
Keywords: پیرووات دهیدروژناز کیناز; Warburg's effect; Pyruvate dehydrogenase kinase; Anemone rivularis; Mitochondria; Apoptosis;
Mitochondrial hyperpolarization in iPSC-derived neurons from patients of FTDP-17 with 10+16 MAPT mutation leads to oxidative stress and neurodegeneration
Keywords: پیرووات دهیدروژناز کیناز; 2-NBDG; 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose; AD; Alzheimer's disease; CBD; Corticobasal Degeneration; CSF; Cerebrospinal Fluid; DHE; Dihydroethidium; ETC; Electron Transport Chain; FCCP; Carbonyl cyanide-4-(trifluoromethoxy)pheny
Synthesis and biological evaluation of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides as pyruvate dehydrogenase kinase 1 (PDK1) inhibitors to reduce the growth of cancer cells
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase complex; Anti-proliferation; Binding affinity;
Indazole-based ligands for estrogen-related receptor α as potential anti-diabetic agents
Keywords: پیرووات دهیدروژناز کیناز; Estrogen-related receptor α; ERRα; Nuclear receptor; Anti-diabetic; Metabolic syndrome; Indazole; Thiazolidenedione; TZD; Insulin resistance; ERR; estrogen-related receptor; ER; estrogen receptor; ERE; estrogen response element; ERRE; estrogen-related r
Anti-cancer synergy of dichloroacetate and EGFR tyrosine kinase inhibitors in NSCLC cell lines
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Dichloroacetate; Epidermal growth factor Receptor; Erlotinib; Gefitinib; Drug combination
GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate
Keywords: پیرووات دهیدروژناز کیناز; [Clâ]; chloride concentration; DCA; dichloroacetate; ERK; extracellular signal-regulated kinase; GSTZ1; glutathione transferase Z1; HER2; human epidermal growth factor receptor 2; PDC; pyruvate dehydrogenase complex; PDK; pyruvate dehydrogenase kinase;
Profiling metabolic remodeling in PP2Acα deficiency and chronic pressure overload mouse hearts
Keywords: پیرووات دهیدروژناز کیناز; ACADM; acylâcoenzyme A dehydrogenase, middle chain (C4-C12); ACADS; acylâcoenzyme A dehydrogenase, short chain (C4-C8); ACADVL; acylâcoenzyme A dehydrogenase, very long chain; ACSL1; acylâCoA synthetase longâchain family member 1; ANP; atria
Hypoxia-induced IL-32β increases glycolysis in breast cancer cells
Keywords: پیرووات دهیدروژناز کیناز; ECAR; extracellular acidification rate; HIF-1; hypoxia inducible factor-1; IL-32; interleukin-32; LDH-A; lactate dehydrogenase A; OCR; oxygen consumption rate; OXPHOS; oxidative phosphorylation; PDK1; pyruvate dehydrogenase kinase; PFKFB4; fructose-2,6-bi
A novel effect of DMOG on cell metabolism: direct inhibition of mitochondrial function precedes HIF target gene expression
Keywords: پیرووات دهیدروژناز کیناز; α-KG; α-ketoglutarate; AMPK; AMP-activated protein kinase; DMSO; dimethyl sulfoxide; EGFP; enhanced green fluorescence protein; EPAS1; endothelial PAS domain-containing protein 1 (known as HIF-2α); EPO; erythropoietin; esiRNA; endoribonuclease-prepared
The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy
Keywords: پیرووات دهیدروژناز کیناز; GBM; glioblastoma multiforme; let-7a; lethal-7a; miRNA; microRNA; TCGA; The Cancer Genome Atlas; GLUT; glucose transporter; PKM2; pyruvate kinase M2; PDK; pyruvate dehydrogenase kinase; MGMT; O6-methylguanine-DNA methyltransferase; GSK3β; glycogen syntha
Des-acyl-ghrelin (DAG) normalizes hyperlactacidemia and improves survival in a lethal rat model of burn trauma
Keywords: پیرووات دهیدروژناز کیناز; DAG; des-acyl-ghrelin; EDL; extensor digitorum longus; PDC; pyruvate dehydrogenase complex; PDK; pyruvate dehydrogenase kinase; PDP; pyruvate dehydrogenase phosphatase; TBSA; total body surface area; Burn injury; Des-acyl-ghrelin (DAG); Hyperlactacidemia;
Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells
Keywords: پیرووات دهیدروژناز کیناز; Component co-expression; Pyruvate dehydrogenase; Pyruvate dehydrogenase kinase
An insight into pyruvate dehydrogenase kinase (PDHK) inhibition through pharmacophore modeling and QSAR studies
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Principal Component Analysis; Clustering; Genetic Function Algorithm; Pharmacophore; 3D-QSAR
Enzymes involved in l-lactate metabolism in humans
Keywords: پیرووات دهیدروژناز کیناز; ALT; alanine aminotransferase; ATP; adenine triphosphate; CoA; coenzyme A; FAD; flavin adenine dinucleotide; GPT; glutamate pyruvate transaminase; GSD; glycogen storage disease; LDH; lactate dehydrogenase; NAD+; oxidized nicotinamide adenine dinucleotide;
Pyruvate dehydrogenase E1α phosphorylation is induced by glucose but does not control metabolism-secretion coupling in INS-1E clonal β-cells
Keywords: پیرووات دهیدروژناز کیناز; Beta-cell; Insulin; Pyruvate dehydrogenase; Pyruvate dehydrogenase kinase;
Comparative expression analysis of multiple PDK genes in Xenopus laevis during oogenesis, maturation, fertilization, and early embryogenesis
Keywords: پیرووات دهیدروژناز کیناز; Xenopus; Oocytes; Eggs; Embryos; Pyruvate dehydrogenase kinase; Expression; Real-time PCR
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
Keywords: پیرووات دهیدروژناز کیناز; FXR; farnesoid X receptor; SHP; small heterodimer partner; BSEP; bile salt export pump; MCD; methionine- and choline-deficient; NASH; nonalcholic steatohepatitis; NAFLD; non-alcoholic fatty liver disease; CYP7A1; cholesterol 7α-hydroxylase; CYP8B1; stero
PPARs and the orchestration of metabolic fuel selection
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Metabolic inflexibility; Lipid buffering; Skeletal muscle; Adipose tissue
Hypoxia and the metabolic phenotype of prostate cancer cells
Keywords: پیرووات دهیدروژناز کیناز; ALDO; aldolase; CS; citrate synthase; COX; cytochrome c oxidase; DCA; dichloroacetate; G3PDH; glyceraldehyde-3-phosphate dehydrogenase; G6PDH; glucose-6-phosphate dehydrogenase; HK; hexokinase; HIF; hypoxia-inducible factor; LDH; lactate dehydrogenase; NR
Regulation of PDK mRNA by high fatty acid and glucose in pancreatic islets
Keywords: پیرووات دهیدروژناز کیناز; Islets of Langerhans; Pyruvate dehydrogenase; Pyruvate dehydrogenase kinase; Pyruvate carboxylase; Type 2 diabetes mellitus
Assay of the pyruvate dehydrogenase complex by coupling with recombinant chicken liver arylamine N-acetyltransferase
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase complex; Pyruvate dehydrogenase kinase; Pyruvate dehydrogenase phosphatase; Arylamine N-acetyltransferase; 4-Aminoazobenzene-4′-sulfonic acid; Acetyl-CoA
Molecular cloning and expression analysis of PDK family genes in Xenopus laevis reveal oocyte-specific PDK isoform
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; Isoforms; mRNA expression; Real-time PCR; Xenopus laevis; Tissue-specific distribution;
Mammalian histidine kinases
Keywords: پیرووات دهیدروژناز کیناز; NDPK; nucleoside diphosphate kinase; NTP; nucleoside triphosphate; HHK; histone H4 histidine kinase; KI; inhibitory constant; BCKDHK; branched chain α-ketoacid dehydrogenase kinase; PDHK; pyruvate dehydrogenase kinase; eEF-2; eukaryotic elongation factor
Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase
Keywords: پیرووات دهیدروژناز کیناز; Pyruvate dehydrogenase kinase; GHKL superfamily; Protein kinase; Reaction mechanism.;