Novel inhibitors of Staphylococcus aureus RnpA that synergize with mupirocin
Keywords: Antibiotic; Mupirocin; RnpA; RNase P; Synergy;
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A three-dimensional model of RNase P in the hyperthermophilic archaeon Pyrococcus horikoshii OT3
Keywords: Archaea; Protein-RNA interaction; Pyrococcus horikoshii; Ribonuclease P; Three-dimensional model; 3-D; three-dimensional; C-domain; catalytic domain; CR; conserved region; K-turn; kink-turn; PDB; protein data bank; PhopRNA; Pyrococcus horikoshii ribonucle
ReviewTargeted inhibition of WRN helicase, replication stress and cancer
Keywords: WRN helicase; RNase P; EGS; Selective cancer therapy; Replication stress; DNA repair;
Functional characterization of archaeal homologs of human nuclear RNase P proteins Rpp21 and Rpp29 provides insights into the molecular basis of their cooperativity in catalysis
Keywords: Archaeal homologs of human proteins Rpp21 and Rpp29; Pull-down assay; Pyrococcus horikoshii; Ribonuclease P proteins; RNA-Binding protein; CD; circular dichroism; CR; conserved region; PhopRNA; ribonuclease P RNA from Pyrococcus horikoshii; pre-tRNA; prec
Structural basis for recognition of a kink-turn motif by an archaeal homologue of human RNase P protein Rpp38
Keywords: Crystal structure; Kink-turn; Pyrococcus horikoshii; Ribonuclease P; Ribosomal protein L7Ae; ITC; isothermal temperature calorimetry; K-turn; kink-turn; PfupRNA; ribonuclease P RNA from Pyrococcus furiosus; PhopRNA; ribonuclease P RNA from P. horikoshii;
Analysis of the Cleavage Mechanism by Protein-Only RNase P Using Precursor tRNA Substrates with Modifications at the Cleavage Site
Keywords: pre-tRNA; precursor tRNAs; RNase P; ribonuclease P; PRORPs; protein-only RNase P; AtPRORP1; PRORP1 isoenzyme from Arabidopsis thaliana; SEM; standard errors of the mean; tRNA processing by protein-only RNase P PRORP3 from Arabidopsis thaliana; catalytic m
Mutation of the gene encoding the ribonuclease P RNA in the hyperthermophilic archaeon Thermococcus kodakarensis causes decreased growth rate and impaired processing of tRNA precursors
Keywords: Hyperthermophilic archaea; Pre-tRNA processing; Ribonuclease P; Thermococcus kodakarensis; ASW; artificial sea water; CBP; calmodulin-binding peptide; 5-FOA; 5-fluoroorotic acid; PhopRNA; RNase P RNA in Pyrococcus horikoshii; qRT-PCR; quantitative RT-PCR;
Mitochondrial energy failure in HSD10 disease is due to defective mtDNA transcript processing
Keywords: MHBD disease; HSD10 disease; RNase P; MRPP2; RNA processing
Pentatricopeptide repeat motifs in the processing enzyme PRORP1 in Arabidopsis thaliana play a crucial role in recognition of nucleotide bases at TÏC loop in precursor tRNAs
Keywords: NSRs; nucleotide-specifying residues; PPR; pentatricopeptide repeat; PRORP; proteinaceous ribonuclease P; RNase P; ribonuclease P; pre-tRNA; precursor tRNA; Arabidopsis thaliana; Pentatricopeptide repeat; PRORP1; tRNA precursor;
Extra-structural elements in the RNA recognition motif in archaeal Pop5 play a crucial role in the activation of RNase P RNA from Pyrococcus horikoshii OT3
Keywords: AN; RNA annealing; CD; circular dichroism; FRET; fluorescence resonance energy transfer; PhopRNA; ribonuclease P RNA from P. horikoshii; RNase P; ribonuclease P; pre-tRNA; precursor tRNA; SD; strand displacement; Archaea; Pyrococcus horikoshii; Protein-
A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model
Keywords: Staphylococcus aureus; RNase P; Skin wounds; PMOs
A subset of human gliomas shows over-expression of KIT without its amplification
Keywords: AA; Anaplastic astrocytoma; ACTB; Beta-actin; AO; Anaplastic oligodendroglioma; AOA; Anaplastic oligoastrocytoma; BAC; Bacterial artificial chromosome; BSA; Bovine serum albumin; cDNA; complementary DNA; CISH; Chromogenic in situ hybridization; CNS; Centr
Of P and Z: Mitochondrial tRNA processing enzymes
Keywords: RNase P; RNase Z; transfer RNA; RNA processing; Mitochondria;
3′–5′ tRNAHis guanylyltransferase in bacteria
Keywords: tRNAHis guanylyltransferase; Thg1; tRNA processing; Histidyl-tRNA synthetase; RNase P
Unexpected diversity of RNase P, an ancient tRNA processing enzyme: Challenges and prospects
Keywords: RNase P; Precursor tRNA; Diversity; Evolution; Organellar
Aminoglycoside modifying enzymes
Keywords: Antibiotic resistance; Aminoglycoside; Aminoglycoside modifying enzyme; Acetyltransferase; Nucleotidyltransferase; Phosphotransferase; Kinase; Antisense; RNase P; RNase H; Bacterial infection
Novel function of C5 protein as a metabolic stabilizer of M1 RNA
Keywords: M1 RNA; C5 protein; RNase P; RNA stability
Identification of catalytic metal ion ligands in ribozymes
Keywords: RNA; Ribozymes; Catalysis; Metal ion–ligand interactions; X-ray crystallography; EPR; NMR; Isotope effects; Tetrahymena group I ribozyme; RNase P; Metal ion rescue
A 40.7 kDa Rpp30/Rpp1 homologue is a protein subunit of Dictyostelium discoideum RNase P holoenzyme
Keywords: RNase P; DRpp30; tRNA; Ribonucleoprotein; Molecular dynamics simulations; RNase P; ribonuclease P; DRpp30; Dictyostelium RNase P Protein 30; Pre-tRNA; precursor transfer RNA; RNP; ribonucleoprotein; EST; expressed sequence tags; DTT; dithiothreitol; PMSF;
Inhibition of gene expression in human cells using RNase P-derived ribozymes and external guide sequences
Keywords: RNase P; External guide sequence; Ribozyme; Gene targeting; Antisense; Gene therapy
RNase P of the Cyanophora paradoxa cyanelle: A plastid ribozyme
Keywords: Cyanelle of Cyanophora paradoxa; RNase P; Ribozyme; Organellar RNase P; tRNA processing
RNase P RNA mediated cleavage: Substrate recognition and catalysis
Keywords: RNase P; Ribozyme; Divalent metal ions; tRNA precursors; tRNA processing
Evidence for Induced Fit in Bacterial RNase P RNA-mediated Cleavage
Keywords: RNase P; ribozyme; divalent metal ions; tRNA precursors; tRNA processing
Ribozyme: A clinical tool
Keywords: Ribozyme; Clinical applications; Hammerhead; RNAse P
The Exocyclic Amine at the RNase P Cleavage Site Contributes to Substrate Binding and Catalysis
Keywords: RNase P; ribozyme; divalent metal ions; tRNA precursors; RNA processingRS, RNase P RNA–substrate
RNA-dependent Folding and Stabilization of C5 Protein During Assembly of the E. coli RNase P Holoenzyme
Keywords: ribonucleoprotein; RNase P; C5 protein; circular dichroism
Secondary structure probing of the human RNase MRP RNA reveals the potential for MRP RNA subsets
Keywords: Ribonucleoprotein; RNase MRP; RNase P; RNA; Structure probing; Secondary structure;
Porphyrins and porphines bind strongly and specifically to tRNA, precursor tRNA and to M1 RNA and inhibit the ribonuclease P ribozyme reaction
Keywords: DMSO; dimethyl sulfoxide; PPIX; Protoporphyrin IX; RNase P; ribonuclease P; TCPP; meso-tetrakis(4-carboxyphenyl)porphine; T4MPyP; meso-tetrakis(N-methyl-pyridyl)porphine; TMAP; meso-tetrakis[4-(trimethylammonio)phenyl]porphine; Transfer RNA; Ribozyme inhi