Keywords: BB; bevacizumab-bevacizumab; BP; bevacizumab followed by panitumumab; CA9; carbonic anhydrase 9; CRC; colorectal cancer; DEGs; differentially expressed genes; EGFR; epidermal growth factor receptor; EPHA2; ephrin type-A receptor 2; FASN; fatty acid syntha
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Keywords: 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Tyrosine kinase activity of EphA2 promotes its S897 phosphorylation and glioblastoma cell proliferation
Keywords: EphA2; ERK; Cell proliferation; Glioblastoma; BrdU; bromodeoxyuridine; EGF; epidermal growth factor; ICD; intracellular domain; PI3K; phosphatidylinositol 3-kinase; PKA; protein kinase A; RSK; p90 ribosomal S6 kinase; RTK; receptor tyrosine kinase; S897;
Sargaquinoic acid ameliorates hyperpigmentation through cAMP and ERK-mediated downregulation of MITF in α-MSH-stimulated B16F10 cells
Keywords: α-MSH; α-melanocyte stimulating hormone; BISA; bisabolangelone; cAMP; cyclic adenosine monophosphate; CREB; cAMP-responsive element-binding protein; DOPA; 3, 4-dihydroxyphenylalanine; ESS; ethanolic extract of Sargassum serratifolium; ERK; extracellular
Infraciliature of Opisthotrichum janus, Epidinium ecaudatum, and Ophryoscolex purkynjei (Ciliophora, Entodiniomorphida)
Keywords: AC; adoral ciliary zone; AP; adoral polybrachykinety; CP; cytoproct; CV; contractile vacuole; DC; dorsal ciliary zone; DP; dorsal polybrachykinety; DPR; dorsal primordium; LPR; left primordium; LSK; left skeletal plate; MA; macronucleus; MI; micronucleus;
Natural and synthetic polymers/bioceramics/bioactive compounds-mediated cell signalling in bone tissue engineering
Keywords: ALP; alkaline phosphatase; ANG; angiogenin; AuNPs; gold nanoparticles; BMP; bone morphogenetic protein; BSP; bone sialoprotein; BTE; bone tissue engineering; COL1; collagen type 1; CSL; CBF1/Su(H)/Lag-1 protein; ERK; extracellular signal-regulated kinase;
AGC kinases, mechanisms of regulation âand innovative drug development
Keywords: AGC kinase; group of kinases related to PKA PKG and PKC; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PRK; protein kinase C related kinase (also termed PKN protein kinase N); PDK1; 3-phosphoinositide-dependent protein kinase 1; PKB
ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway
Keywords: Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf
Hypoxia-induced ADAM 17 expression is mediated by RSK1-dependent C/EBPβ activation in human lung fibroblasts
Keywords: ADAM 17; a disintegrin and metalloproteinase 17; C/EBPβ; CCAAT/enhancer-binding protein β; ChIP; chromatin immunoprecipitation; COA; chronic obstructive asthma; CTGF; connective tissue growth factor; ECL; enhanced chemiluminescence; ECM; extracellular m
The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice
Keywords: Th17 cell; RORgt; RSK;
Loss of striatal 90-kDa ribosomal S6 kinase (Rsk) is a key factor for motor, synaptic and transcription dysfunction in Huntington's disease
Keywords: HD; Huntington's disease; Rsk; 90-kDa ribosomal S6 kinase; AAV5; adeno-associated-virus 5; htt; huntingtin; BDNF; brain-derived neurotrophic factor; SRF; serum response factor; iEGs; immediate early-genes; GFP; green fluorescent protein; rpm; rotations pe
Performance of a phosphoflow assay to determine phosphorylation of S6 ribosomal protein as a pharmacodynamic read out for mTOR inhibition
Keywords: Akt; protein kinase B; BSA; bovine serum albumin; CRP; C-reactive protein; CsA; cyclosporine A; CV; coefficient of variation; EDTA; ethylenediaminetetraacetic acid; ELISA; enzyme-linked, immunosorbent assay; ERK; extracellular signal-regulated kinase; Evr
Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1
Keywords: A2AR; adenosine A2A receptor; AP-1; activator protein 1; BLC; B-lymphocyte chemoattractant; BMDM; bone marrow derived macrophage; CREB; cAMP response element-binding protein; DUSP1; dual specific phosphatase; Epac; exchange protein activated by cAMP; ERK;
EphA2 is a key effector of the MEK/ERK/RSK pathway regulating glioblastoma cell proliferation
Keywords: EphA2; RSK; EGF; Cell proliferation; Glioblastoma;
Current activities of the Yersinia effector protein YopM
Keywords: CPE; cell-penetrating effector protein; CPP; cell-penetrating peptide/protein; Egr1; early growth response transcription factor 1; iDC; inflammatory dendritic cell; IFN; interferon; IL; interleukin; LRR; leucine-rich repeat; MAPK; mitogen-activated protei
Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamus
Keywords: α-MSH; α-melanocyte-stimulating hormone; AC; adenylate cyclase; BDNF; brain-derived neurotrophic factor; CREB; cAMP responsive element binding protein; DAPI; 4â²,6-diamido-2-phenylindole dihydrochloride; ERK; extracellular signal-regulated kinase; GFAP
RhoA Kinase (Rock) and p90 Ribosomal S6 Kinase (p90Rsk) phosphorylation of the sodium hydrogen exchanger (NHE1) is required for lysophosphatidic acid-induced transport, cytoskeletal organization and migration
Keywords: LPA; lysophosphatidic acid; NHE1; sodium hydrogen exchanger isoform 1; Rock; RhoA kinase; RSK; ribosomal S6 kinase RSK; ctNHE; C-Terminus Recombinant human NHE1.; Sodium hydrogen exchanger; NHE1; Rock kinase; Rsk; Cytoskeleton; Lysophosphatidic acid;
Interlacing networks: Birational RSK, the octahedron recurrence, and Schur function identities
Keywords: Lindström–Gessel–Viennot; Plücker relations; RSK; Octahedron recurrence; Schur functions; Schur positivity
2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors
Keywords: RSK; Kinase; Heterocycle; Benzoxazole; HTS;
Parameters characterization and optimization of activated carbon (AC) cathodes for microbial fuel cell application
Keywords: AC; activated carbon; MFC; microbial fuel cell; ORR; oxygen reduction reaction; PTFE; polytetrafluoroethylene; SEM; scanning electron microscope; XPS; X-ray photoelectron spectroscopy; PCA; principal components analysis; LSV; linear sweep voltammetry; Rex
Phosphoprotein enriched in astrocytes (PEA)-15: A potential therapeutic target in multiple disease states
Keywords: PEA-15; ERK1/2; Proliferation; Apoptosis; Cancer; Type 2 diabetes; CaMKII; calcium/calmodulin-dependent protein kinase II; DED; death effector domain; DISC; death initiation signalling complex; ERK1/2; extracellular signal-regulated kinases 1/2; FADD; Fas
AKT activation drives the nuclear localization of CSE1L and a pro-oncogenic transcriptional activation in ovarian cancer cells
Keywords: CSE1L; chromosome segregation 1-like; AKT1/AKT2; v-akt murine thymoma viral oncogene homolog 1 and 2; Ran; Ras-related nuclear protein; RanBP3; Ran-binding protein-3; RSK; ribosomal S6 kinase; Ovarian cancer; Chromosome segregation 1-like protein CSE1L; E
Defective synaptic transmission and structure in the dentate gyrus and selective fear memory impairment in the Rsk2 mutant mouse model of Coffin-Lowry syndrome
Keywords: AMPAr; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CLS; Coffin-Lowry syndrome; CREB; cAMP-response element binding protein; CS; Conditioned stimulus; EM; Electron microscopy; EPSC; Excitatory postsynaptic currents; ERK; Extracellular
ERK and RSK regulate distinct steps of a cellular program that induces transition from multicellular epithelium to single cell phenotype
Keywords: ALLM; N-Acetyl-l-leucyl-l-leucyl-l-methional; ALLN; N-Acetyl-l-leucine-l-leucine-l-norleucinal; 4HT; 4-hydroxytamoxifen; EMT; epithelial-mesenchymal transition; ER; ligand binding domain of estrogen receptor; MDCK; Madin-Darby Canine Kidney; MAPK/ERK;
Synthetic Lethality Screen Identifies RPS6KA2 as Modifier of Epidermal Growth Factor Receptor Activity in Pancreatic Cancer
Keywords: EGFR; epidermal growth factor receptor; RNAi; RNA interference; RSK; ribosomal S6 kinase; PARP; poly(ADP-ribose) polymerase;
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues
Keywords: TPCK; N-alpha-tosyl-l-phenylalanyl chloromethyl ketone; PDK1; 3-phosphoinositide dependent protein kinase-1; AGC; related to protein kinase A, protein kinase G and protein kinase C; RSK; ribosomal S6 kinase; S6K; S6 kinase; PKA; protein kinase A; ERK; ext
p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: A pathogenic mechanism for ischemia-reperfusion injury
Keywords: Renin-angiotensin system; RSK; Renin; Aliskiren; Ischemia-reperfusion;
HCV-induced PKR activation is stimulated by the mitogen- and stress-activated protein kinase MSK2
Keywords: PKR; HCV; IFN; dsRNA signaling; RSK
ERK-associated changes of AP-1 proteins during fear extinction
Keywords: ERK; extracellular signal-regulated kinase; AP-1; activator protein-1; CRE; cAMP-dependent element; DSE; dyad symmetry element; HDAC1; histone deacetylase 1; JDP2; Jun dimerization protein 2; RSK; 90Â kDa ribosomal S6 kinase; MEK; mitogen activated protei
Genetic variation in RPS6KA1, RPS6KA2, RPS6KB1, RPS6KB2, and PDK1 and risk of colon or rectal cancer
Keywords: Colon cancer; Rectal cancer; S6K; RSK; PDK1; Akt; CIMP+; KRAS2
Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations
Keywords: Sunitinib; Human stem cell derived cardiomyocytes; Induced pluripotent stem cells; AMPK; RSK; Cardiotoxicity
The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
Keywords: AR; androgen receptor; c.s.FBS; charcoal/dextran-stripped fetal bovine serum; ERK; extracellular signal-regulated kinase; MEK; mitogen activated protein kinase kinase; NEP; neutral endopeptidase; NSE; neuron specific enolase; PCa; prostate cancer; PSA; pr
C/EBPβ enhances NF-κB-associated signalling by reducing the level of IκB-α
Keywords: NF-κB; nuclear factor-κB; C/EBP; CCAAT/enhancer-binding protein; IκB; inhibitor of NF-κB; TNF; tumor necrosis factor; LPS; bacterial lipopolysaccharide; IKK; IκB kinase; C/EBPβwt; C/EBPβ wild type cells; C/EBPβko; C/EBPβ knock out cells; FCS;
Influence of tool wear on surface roughness in hard turning using differently shaped ceramic tools
Keywords: ap; depth of cut; f; feed rate; rÉ; radius of the tool corner; rÉ1 and rÉ2; radii of wiper curvature; rbo; radius of smoothing part of wiper insert; vc; cutting speed; Ra; the centre line average; Rku; kurtosis; Rmax; maximum roughness height; Rmr(c);
The ERK-RSK1 activation by growth factors at G2 phase delays cell cycle progression and reduces mitotic aberrations
Keywords: G2 delay; Genomic integrity; HGF; RSK
Anti-apoptotic actions of vasopressin in H32 neurons involve map kinase transactivation and bad phosphorylation
Keywords: Vasopressin; V1a receptor; Apoptosis; MAPK/ERK; Bad; RSK;
Effects of acute cocaine on ERK and DARPP-32 phosphorylation pathways in the caudate-putamen of Fischer rats
Keywords: Cocaine; ERK; Elk-1; DARPP-32; RSK; STEP;
Structural basis for the activity of the RSK-specific inhibitor, SL0101
Keywords: Kaempferol 3-O-(3″,4″-di-O-acetyl-α-l-rhamnopyranoside); SL0101; RSK; Kinase inhibitor; Structure–activity relationship
Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK
Keywords: Kaempferol 3-O-(3″,4″-di-O-butyryl-α-l-rhamnopyranoside), Bu-SL0101; Kaempferol 3-O-(2″,3″,4″-tri-O-acetyl-α-l-rhamnopyranoside), 3Ac-SL0101; RSK; Kinase inhibitor
Calcineurin dephosphorylates the C-terminal region of filamin in an important regulatory site: A possible mechanism for filamin mobilization and cell signaling
Keywords: Androgen receptor; Calpain; Calcineurin; Cyclosporin; Filamin; Insulin receptor; NFAT; Pak; Rsk; Tau
Bcl-2 Reduced and Fas Activated by the Inhibition of Stem Cell Factor/KIT Signaling in Murine Melanocyte Precursors
Keywords: Bcl-2; ERK; fas; fas ligand; neural crest cells; RSK;
Two G protein-coupled receptors activate Na+/H+ exchanger isoform 1 in Chinese hamster lung fibroblasts through an ERK-dependent pathway
Keywords: BCECF; 2â²,7â²-bis-(carboxyethyl)-5-(and-6)-carboxyfluorescein; ERK; extracellular signal-regulated kinase; GPCR; G protein-coupled receptors; KI-MEK1; kinase inactive MAP kinase/ERK kinase 1; LPA; lysophosphatidic acid; NHE1; sodium hydrogen exchanger