Keywords: S1P، اسپینگوزین-1-فسفات; HQ, 2-hydrazinoquinoline; S1P, sphingosine-1-phosphate; LC/MS, liquid chromatography/mass spectrometry; C17-S1P, sphingosine-1-phosphate; MRM, multiple reaction monitoring; CE, collision energy; CV, cone votage; DNPH, 2,4-dinitrophenylhydrazine; DAIH, 2-d
مقالات ISI S1P، اسپینگوزین-1-فسفات (ترجمه نشده)
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Keywords: S1P، اسپینگوزین-1-فسفات; dLNs, draining lymph nodes; LVs, lymphatic vessels; LNs, lymph nodes; DCs, dendritic cells; LEVs, lymphatic endothelial vessels; FRCs, fibroblastic reticular cells; S1P, sphingosine-1-phosphate; S1PRs, S1P receptors; LECs, lymphatic endothelial cells; Sem
The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice
Keywords: S1P، اسپینگوزین-1-فسفات; DE, diesel exhaust; DEP, diesel exhaust particles; PBS, phosphate-buffered saline; PM, particulate matter; ROS, reactive oxygen species; S1P, sphingosine-1-phosphate; SP, surfactant protein; SphK1, sphingosine kinase 1Diesel exhaust; Ceramide; Fumonisin B
Fingolimod suppresses bone resorption in female patients with multiple sclerosis
Keywords: S1P، اسپینگوزین-1-فسفات; MS, multiple sclerosis; IFN, interferon; S1P, sphingosine-1-phosphate; S1PR, sphingosine-1-phosphate receptor; UT, untreated; HC, healthy controls; uNTX, urinary type I collagen cross-linked N-telopeptide; EIA, enzyme immunoassay; TRACP, tartrate-resistan
Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury
Keywords: S1P، اسپینگوزین-1-فسفات; MSCs; NK cells; S1PR5; Liver injuryMSCs, mesenchymal stem cells; BM, bone marrow; NK, natural killer; PolyI:C, polyinosinic: polycytidylic acid; S1P, sphingosine-1-phosphate; S1PR5, S1P receptor type 5; ALT, alanine transaminase
MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells
Keywords: S1P، اسپینگوزین-1-فسفات; ERK, extracellular regulated kinase; HIF-1α, hypoxia inducible transcription factor 1α; LOX, lysyl oxidase; MMP, matrix metalloproteinase; PKC, protein kinase C; PI3K, phosphoinositide 3-kinase; S1P, sphingosine-1-phosphate; S1P1,3, S1P receptors 1 and 3;
Induction of chemokine (C-C motif) ligand 2 by sphingosine-1-phosphate signaling in neuroblastoma
Keywords: S1P، اسپینگوزین-1-فسفات; NB, neuroblastoma; S1P, sphingosine-1-phosphate; CCL2, chemokine (C-C motif) ligand 2; TAMs, tumor-associated macrophages; VEGF, vascular endothelial growth factor; S1PR, S1P receptorSphingosine 1-phosphate; Sphingosine 1-phosphate receptor 2; Chemokine (
Visualizing S1P-directed cellular egress by intravital imaging
Keywords: S1P، اسپینگوزین-1-فسفات; S1P, sphingosine-1-phosphate; S1P1–5, S1P G protein-coupled receptors 1–5; LYVE-1, lymphatic vascular endothelial gene-1; MZ, marginal zoneSphingosine-1-phosphate; Sphingolipid; Signaling; Gradient; Receptor; Two-photon microscopy
Sphingolipids in Lung Growth and Repair
Keywords: S1P، اسپینگوزین-1-فسفات; ASMase, acid sphingomyelinase; BPD, bronchopulmonary dysplasia; CF, cystic fibrosis; LPS, lipopolysaccharide; nSMase, neutral sphingomyelinase; S1P, sphingosine-1-phosphate; SP-B, surfactant protein B; VEGF, vascular endothelial growth factor
Sphingolipids in colon cancer
Keywords: S1P، اسپینگوزین-1-فسفات; CRC, colorectal cancer; FAP, Familial Adenomatous Polyposis; AFAP, Attenuated Familial Adenomatous Polyposis; APC, Adenomatous Polyposis Coli; K-Ras, Kirsten rat sarcoma viral oncogene homolog; ACF, aberrant crypt foci; S1P, Sphingosine-1-Phosphate; CerS,
Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics
Keywords: S1P، اسپینگوزین-1-فسفات; UV, Ultraviolet light; S1P, sphingosine-1-phosphate; SPT, Serine Palmitoyl Transferase; CerS, Ceramide synthase; SK, Sphingosine Kinase; PKH, Phosphoinositide-dependent protein kinase (PDK) Kinase Homolog; SNARE, Soluble NSF attachment protein receptor; S
RhoA/rho kinase signaling reduces connexin43 expression in high glucose-treated glomerular mesangial cells with zonula occludens-1 involvement
Keywords: S1P، اسپینگوزین-1-فسفات; Cx43, connexin43; Cx43-CT, Cx43-c-terminal; DN, diabetic nephropathy; FN, fibronectin; GJIC, gap junctional intercellular communication; GMCs, glomerular mesangial cells; NF-κB, nuclear factor kappa-B; ROCK, Rho kinase; S1P, sphingosine-1-phosphate; ZO-1,
Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways
Keywords: S1P، اسپینگوزین-1-فسفات; ESC, Embryonic stem cell; S1P, Sphingosine-1-phosphate; Flk-1, Fetal Liver Kinase 1; VEGF, Vascular endothelial growth factor; ERK, Extracellular signal-regulated kinases; JNK, c-Jun N-terminal kinases; RTK, Receptor tyrosine kinase; CDK, Cyclin dependent
Fingolimod protects cultured cortical neurons against excitotoxic death
Keywords: S1P، اسپینگوزین-1-فسفات; FTY720f, ingolimod; S1PR, sphingosine-1-phosphate receptor; S1P, sphingosine-1-phosphate; NMDA, N-methyl-d-aspartate; FDA, Food and Drug Administration; EMA, European Medicines Agency; GCM, glial conditioned medium; MEM, minimum essential medium; DMEM, Du
Shaping the landscape: Metabolic regulation of S1P gradients
Keywords: S1P، اسپینگوزین-1-فسفات; S1P, sphingosine-1-phosphate; ER, endoplasmic reticulum; SphK, sphingosine kinase; ABC, ATP-binding cassette; LPP, lipid phosphate phosphataseSphingosine-1-phosphate; Sphingolipid; Signaling; Gradient; Receptor; Metabolism
Specific sphingolipid content decrease in Cerkl knockdown mouse retinas
Keywords: S1P، اسپینگوزین-1-فسفات; knockout models; retinal dystrophy; sphingolipidSPL, Sphingolipid; DhSPL, Dihydrosphingolipid; CER, Ceramide; C1P, Ceramide-1-Phosphate; SPH, Sphingosine; S1P, Sphingosine-1-Phosphate; DhCER, Dihydroceramide; MHCer, Monohexosyl Ceramide; GlcCer, Glucosyl
A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1
Keywords: S1P، اسپینگوزین-1-فسفات; Cer, ceramide; DMS, N,N-dimethylsphingosine; S1P, sphingosine-1-phosphate; nSMase2, neutral sphingomyelinase-2; SK1, sphingosine kinase-1; H2O2, hydrogen peroxide; SM, sphingomyelinHydrogen peroxide; Mitogenic signaling; Neutral sphingomyelinase-2; Sphing
Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation
Keywords: S1P، اسپینگوزین-1-فسفات; BL, baseline; COX-1/2, cyclooxygenase-1/2; LC–MS/MS, liquid chromatography–tandem mass spectrometry; PG, prostaglandin; PWL, paw withdrawal latency; S1P, sphingosine-1-phosphate; SPHK, sphingosine kinase; Tx, thromboxaneInflammation; Cyclooxygenase-2; Pro
Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells
Keywords: S1P، اسپینگوزین-1-فسفات; S1P, sphingosine-1-phosphate; ACTH, adrenocorticotropin; PLC, phospholipase C, StAR, steroidogenic acute regulatory protein; TSPO, translocator protein; CamKII, Ca2+/calmodulin-dependent kinase II; IP3, inositol 1,4,5-triphosphate; PKA, protein kinase A;
Ceramide biosynthesis and metabolism in trophoblast syncytialization
Keywords: S1P، اسپینگوزین-1-فسفات; aSMase, acid sphingomyelinase; hCG, human chorionic gonadotropin; SM, sphingomyelin; CERK, ceramide kinase; SPL, sphingolipid; Sph, sphingosine; SPHK, sphingosine kinase; S1P, sphingosine-1-phosphate; C1P, ceramide-1-phosphate; PK, protein kinase; BCRP, b
A ceramide analog inhibits cPLA2 activity and consequent PGE2 formation in LPS-stimulated macrophages
Keywords: S1P، اسپینگوزین-1-فسفات; CERA-1, ceramide analogue-1; PCERA-1, phospho-ceramide analogue-1; AA, arachidonic acid; cPLA2, cytosolic phospholipase A2; PG, prostaglandin; COX, cyclooxygenase; NO, nitric oxide; C1P, ceramide-1-phosphate; S1P, sphingosine-1-phosphate; PC, phosphatidyl
Biochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal Antibody
Keywords: S1P، اسپینگوزین-1-فسفات; CDR, complementarity-determining region; cLPA, cyclic LPA; IgG, immunoglobulin G; LPA, lysophosphatidic acid; PEG, polyethylene glycol; PGE, triethylene glycol; S1P, sphingosine-1-phosphate; PBS, phosphate-buffered salineantibodies; cancer therapies; lipi
Regulation of ryanodine receptors by sphingosylphosphorylcholine: Involvement of both calmodulin-dependent and -independent mechanisms
Keywords: S1P، اسپینگوزین-1-فسفات; CaM, calmodulin; CMC, critical micelle concentration; LPA, lysophosphatidic acid; LPC, lysophosphatidylcholine; RyR, ryanodine receptor; S1P, sphingosine-1-phosphate; SPC, sphingosylphosphorylcholine; SR, sarcoplasmic reticulumRyanodine receptor; Sphingos
Distinct receptor-mediated activities in macrophages for natural ceramide-1-phosphate (C1P) and for phospho-ceramide analogue-1 (PCERA-1)
Keywords: S1P، اسپینگوزین-1-فسفات; PCERA-1, phospho-ceramide analogue-1; CERA-1, ceramide analog-1; TLR, toll like receptor; LPS, lipopolysaccharide; TNFα, tumor necrosis factor alpha; IL-10, interleukin-10; S1P, sphingosine-1-phosphate; LPA, lysophosphatidic acid; C1P, ceramide-1-phosphat
Sphingomyelinase dependent apoptosis of dendritic cells following treatment with amyloid peptides
Keywords: S1P، اسپینگوزین-1-فسفات; DC, dendritic cells; IAPP, islet amyloid polypeptide; Asm, acid sphingomyelinase; asm−/−, acid sphingomyelinase deficient mice; S1P, sphingosine-1-phosphate; IL, interleukin; Aβ1–42, amyloid β-peptide; TNF, tumor necrosis factorCeramide; Phosphatidylserin
Export and functions of sphingosine-1-phosphate
Keywords: S1P، اسپینگوزین-1-فسفات; S1P, sphingosine-1-phosphate; SphK, sphingosine kinase; SPL, S1P lyase; SPP, S1P phosphohydrolase; GPCR, G protein-coupled receptor; ABC transporters, ATP-binding cassette transporters; MDR, multi-drug resistance; Pgp, P-glycoproteinABC transporter; Sphin
Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro
Keywords: S1P، اسپینگوزین-1-فسفات; Cer, ceramide; CerK, ceramide kinase; C1P, ceramide-1-phosphate; DMB-Cer, N-(5-(5,7-dimethyl BODIPY)-l-pentanoyl)-d-erythro-sphingosine; DMECs, dermal microvascular endothelial cells; FCS, fetal calf serum; S1P, sphingosine-1-phosphate; S1PR, S1P receptor
Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet β-cells
Keywords: S1P، اسپینگوزین-1-فسفات; SPHK, sphingosine kinase; NC, neutral ceramidase; AC, acid ceramidase; S1P, sphingosine-1-phosphate; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α; IFN-γ, interferon-γ; FCS, fetal calf serum; NOE, N-oleoylethanolamine; MTT, thiazolyl blue tetrazol
Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes
Keywords: S1P، اسپینگوزین-1-فسفات; APN, adiponectin; SKI, sphingosine kinase inhibitor; APN-KO, APN-deficient; WT, wild-type; SphK-1, sphingosine kinase-1; S1P, sphingosine-1-phosphate; COX-2, cyclooxygenase-2; AMPK, AMP-activated protein kinase; TNF-α, tumor necrosis factor-α; PG, prostag
Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis
Keywords: S1P، اسپینگوزین-1-فسفات; S1P, sphingosine-1-phosphate; MM, multiple myeloma; S1PR, S1P receptor; PTX, pertussis toxin; MAPK, mitogen-activated protein kinase; PI3K, Phosphoinositide-3 kinase; SPK, sphingosine kinaseMultiple myeloma; Sphingosine1-phosphate; Mcl-1; Apoptosis
Effects of fumonisin B1 on the expression of cytokines and chemokines in human dendritic cells
Keywords: S1P، اسپینگوزین-1-فسفات; DC, dendritic cells; FB1, fumonisin B1; IFNγ, interferon-γ; IL, interleukin; LPS, lipopolysaccharide; PBMC, peripheral blood mononuclear cells; S1P, sphingosine-1-phosphate; TNFα, tumour necrosis factor-αFumonisin B1; Dendritic cells; Cytokine; Chemokine
Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver
Keywords: S1P، اسپینگوزین-1-فسفات; PPARα, peroxisome proliferator-activated receptor alpha; PH, partial hepatectomy; TNFα, tumor necrosis factor α; S1P, sphingosine-1-phosphate; SPH, sphingosine; SPA, sphinganine; CER, ceramide; SM, sphingomyelin; Mg2+ nSMase, Mg2+-dependent neutral sphing
FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3
Keywords: S1P، اسپینگوزین-1-فسفات; Cer, ceramide; DHS1P, dihydro-sphingosine-1-phosphate; LPA, lyso-phosphatidic acid; LPP, lipid phosphate phosphohydrolase; S1P, sphingosine-1-phosphate; SM, sphingomyelin; SPHK, sphingosine kinase; Sph, sphingosine; SPP, sphingosine-1-phosphate phosphatas
Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice
Keywords: S1P، اسپینگوزین-1-فسفات; [Ca2+]i, intracellular free calcium concentration; DHS, dl-threo-dihydrosphingosine; DMS, N,N-dimethylsphingosine; HBSS, Hank's buffered salt solution; PAF, platelet-activating factor; S1P, sphingosine-1-phosphate; SPHK, sphingosine kinaseSphingosine kina
Antiproliferative effect of sphingosylphosphorylcholine in thyroid FRO cancer cells mediated by cell cycle arrest in the G2/M phase
Keywords: S1P، اسپینگوزین-1-فسفات; SPC, sphingosylphosphorylcholine; S1P, sphingosine-1-phosphate; Ptx, pertussis toxin; PLC, phospholipase C; PKC, protein kinase C; PKB, protein kinase B; MAPK, mitogen-activated protein kinase; FBS, foetal bovine serum; MTT, 3-(4,5 dimethylthiazol-2yl) 2-
FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions
Keywords: S1P، اسپینگوزین-1-فسفات; BW, body weight; GPCRs, G-protein-coupled receptors; LN, lymph node; LP, lamina propria; LPMCs, lamina propria mononuclear cells; MPO, myeloperoxidase; S1P, sphingosine-1-phosphate; S1PRs, sphingosine-1-phosphate receptors; SphK2, sphingosine kinase 2; Th
Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses
Keywords: S1P، اسپینگوزین-1-فسفات; DC, dendritic cells; RPMI, Roswell-Park Memorial Institute; S1P, sphingosine-1-phosphate; siRNA, small-interfering RNA; SPHK, sphingosine kinase; SPP, sphingosine-1-phosphate phosphataseSphingolipids; Sphingosine kinase; Sphingosine 1-phosphate phosphatas
Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C
Keywords: S1P، اسپینگوزین-1-فسفات; SPC, sphingosylphosphorylcholine; S1P, sphingosine-1-phosphate; PTX, pertussis toxin; PKC, protein kinase C; PMA, phorbol 12-myristate-13-acetate; DAG, diacylglycerol; OAG, 1-oleoyl-2-acetyl-sn-glycerol; [Ca2+]i, intracellular free calcium concentration;
Sphingosine kinase regulates voltage operated calcium channels in GH4C1 rat pituitary cells
Keywords: S1P، اسپینگوزین-1-فسفات; S1P, sphingosine-1-phosphate; SOCE, store-operated calcium entry; VOCC, voltage-operated calcium channels; cSPP, caged sphingosine-1-phosphate; DMS, dimethylsphingosine; [Ca2+]i, free intracellular calcium concentration; TRH, thyroliberin; PKC, protein ki
De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells
Keywords: S1P، اسپینگوزین-1-فسفات; SK1, sphingosine kinase 1; SK2, sphingosine kinase 2; Sph, sphingosine; DHSph, dihydrosphingosine; S1P, sphingosine-1-phosphate; DHS1P, dihydrosphingosine-1-phosphate; Cer, ceramides; SPT, serine palmitoyltransferase; LC-MS/MS, liquid chromatography tande