Keywords: Abl; Abelson leukemia proto-oncogene; ADAP; adhesion and degranulation promoting adapter protein (Fyb, SLAP-130); Asc; apoptosis-associated speck-like protein containing a CARD; BCR; B-cell receptor; C3G; Crk SH3 domain-binding guanine nucleotide exchange
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Immunoreceptors on neutrophils
Keywords: ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing Zeta Associated Protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells
Keywords: Zeta Associated Protein-70 kD (ZAP-70); Syk family kinase; T-cell receptor; Signal transduction; Fluorescence resonance energy transfer (FRET); Biosensor; ZAP-70; Zeta Associated Protein 70 kD; SH2; Src homology 2; LAT; Linker for Activation of T cells; P
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads
Keywords: DAG; diacylglycerolDSB, double strand break; Gads; Grb2-related adaptor downstream of Shc; Indel; insertion and deletion mutation; GFP; green fluorescent protein; Grap; Grb2-related adaptor protein; Grb2; growth factor receptor-bound 2; IRES; internal rib
A critical role for the regulation of Syk from agglutination to aggregation in human platelets
Keywords: Agglucetin; Convulxin; Glycoprotein Ibα; Integrin αIIbβ3; Syk; ADAP; adhesion and degranulation promoting adapter protein; FcRγ; Fc receptor γ-chain; FITC; fluorescein isothiocyanate; GP; glycoprotein; LAT; linker for activation of T-cells; mAb; mono
P21-activated kinase in inflammatory and cardiovascular disease
Keywords: AID; Auto-inhibitory domain; ATP; Adenosine-triphosphate; B-cell; B lymphocytes; BLNK; B cell linker protein; CaM; Calmodulin; Cdc; Cell division control protein; cyt b558; Flavocytochrome b558; DUOX1/2; Dual oxidase 1/2; EF hand motif; Helix-loop-helix s
Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets
Keywords: FcRγ-chain; Fc receptor γ-chain; SLP-76; SH2 domain-containing leukocyte protein of 76 KDa; PLCγ2; phospholipase C γ 2; LAT; linker for activation of T cells; TxA2; thromboxane A2; Syk; spleen tyrosine kinase; RGDS; Arg-Gly-Asp-Ser; ITAM; immunorecep
The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts
Keywords: ADAP; adhesion- and degranulation-promoting adapter protein; Carma1; caspase-recruitment domain [CARD]-membrane-associated guanylate kinase [MAGUK] protein 1; CDR3; complementary determining region 3; GM1; ganglioside M1; GC; gas chromatography; HER2; hum
The Bcr–Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway
Keywords: Bcr–Abl; Actin cytoskeleton; Adaptor proteins; GADS; Slp-76; Nck
Understanding signal integration through targeted mutations of an adapter protein
Keywords: Signal transduction; Immunoreceptor; Adapter protein; SLP-76
Novel synthetic collagen fibers, poly(PHG), stimulate platelet aggregation through glycoprotein VI
Keywords: GP; glycoprotein; LAT; linker for activation of T cells; SLP-76; SH2 domain-containing leukocyte protein of 76; PATI; platelet aggregation threshold index; PLCγ2; phospholipase Cγ2; TXA2; thromboxane A2; Collagen; Synthetic collagen; Collagen-related pe
Mutation of tyrosine 145 of lymphocyte cytosolic protein 2 protects mice from anaphylaxis and arthritis
Keywords: Mast cells; neutrophils; Fc receptors; integrins; signal transduction; SLP-76; passive systemic anaphylaxis; localized Shwartzman reaction; arthritisBMMC, Bone marrow–derived mast cell; Btk, Bruton tyrosine kinase; DB, Double-mutant; DNP, Dinitrophenol; F
A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally
Keywords: Allergy and inflammation; anaphylactic shock; degranulation; druglike compound; mast cells/basophils; tyrosine kinase; Syk; BMMC; Bone marrow-derived mast cell; C-13; Compound 13; ITAM; Immunoreceptor tyrosine-based activation motif; LAT; Linker for act
Structure, organization and expression of common carp (Cyprinus carpio L.) SLP-76 gene
Keywords: SLP-76; RACE; Molecular cloning; Common carpSLP-76, SRC homology 2 (SH2) domain-containing leukocyte-specific phosphoprotein of 76 kDa; TCR, T cell antigen receptor; Gads, Grb2-related adapter downstream of shc; GH, growth hormone; PTKs, protein tyrosine
Involvement of Src kinases and PLCγ2 in clot retraction
Keywords: ACD; acid/citrate/dextrose; mAb; monoclonal antibody; SLP-76; SH2-containing leucocyte phosphoprotein of 76 kDa; PLCγ2; phospholipase Cγ2; PP2; 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo-d-3,4-pyrimidine; PRP; platelet-rich plasma; TBS-T; Tris-buff
Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3–SH3 interaction
Keywords: SH3, Src homology 3; SH2, Src homology 2; LAT, linker for activation of T cell; r.m.s.d., root-mean-square difference; PRS, prolin-rich sequencesGADS; SLP-76; SH3; SH3–SH3 interaction; Signaling transduction; X-ray crystallography
Retinoic acid induces expression of SLP-76: Expression with c-FMS enhances ERK activation and retinoic acid-induced differentiation/G0 arrest of HL-60 cells
Keywords: Cell differentiation; SLP-76; Retinoic acid; BLR1; Burkitt's lymphoma receptor-1; CXCR5; CSF-1; colony stimulating factor-1; EGFP; enhanced green fluorescent protein; FMS; CSF-1 receptor; IRES; internal ribosome entry site; NBT; nitroblue tetrazolium; PDG
A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions
Keywords: A; adenosine; AMV; avian myeloma virus; ATP; adenosine triphosphate; bp; base pair(s); C; cytidine; c-Cbl; cellular homolog of CAS-BR-M murine ecotropic retroviral transforming sequence; cdc2; cell division cycle 2; cDNA; DNA complementary to RNA; DMEM; D
Spi-1 and Spi-B control the expression of the Grap2 gene in B cells
Keywords: BCR; B cell antigen receptor; BLNK; B cell linker protein; bp; base pair; Btk; Bruton's tyrosine kinase; cbl; Casitas b-lineage lymphoma; cDNA; complementary DNA; EDTA; ehylenediamine tetra-acetic acid; EMSA; electrophoretic mobility shift assay; FITC; fl