Keywords: Sclerostin; SOST; Bone; Standardization; Intact; Parathyroid hormone; Estrogen;
مقالات ISI (ترجمه نشده)
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Keywords: Galectin-3; Bone remodeling; Bone strength; Osteoblasts; Osteoclasts; Macrophages; VSMCs; vascular smooth muscle cells; Lgal-3â/â; galectin-3 knockout; Runx2; Runt-related transcription factor 2; WT; wild type; μCT; micro-computed tomography; BV/TV;
Keywords: SOST; Wnt signaling; Sarcoma; Osteosarcoma; Enchondroma; Chondrosarcoma
Keywords: Osteocyte; Mechanical stress; Apoptosis; Rankl; Sost
Keywords: Bone; Rotational culture; Bone progenitor cells; SOST; BMP;
The association of novel polymorphisms with stress fracture injury in Elite Athletes: Further insights from the SFEA cohort
Keywords: Bone; Genetics; Bone remodelling; SOST; Wnt signalling;
Computational and functional characterization of four SNPs in the SOST locus associated with osteoporosis
Keywords: Osteoporosis; SOST; SNPs; Transcription factors; MicroRNA;
Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models
Keywords: Sclerosteosis; van Buchem disease; Sost; Sclerostin; High bone mass;
Histone deacetylases and their roles in mineralized tissue regeneration
Keywords: HAT; histone acetyltransferase; HDAC; histone deacetylase; MSCs; mesenchymal stem cells; hPDLCs; human periodontal ligament cells; DPSCs; dental-derived stem cells; ADSCs; adipose tissue-derived stem cells; WNT/β-catenin; Wingless-int; TGF-β/BMP; transf
Ex vivo construction of human primary 3D-networked osteocytes
Keywords: Human bone tissue model; Human primary osteocytes; Human primary osteoblasts; 3D culture; Microfluidic; Sclerostin; SOST; FGF23;
The systemic effects of sclerostin overexpression using ΦC31 integrase in mice
Keywords: Sost; Serum sclerostin; ΦC31 integrase; Bone;
Expression of SOST/sclerostin in compressed periodontal ligament cells
Keywords: compressive force; orthodontic tooth movement; periodontal ligament; sclerostin; SOST
Rictor is required for optimal bone accrual in response to anti-sclerostin therapy in the mouse
Keywords: Rictor; mTORC2; Wnt; Sost; Bone; Osteoblast; Osteoclast
Successful induction of sclerostin in human-derived fibroblasts by 4 transcription factors and its regulation by parathyroid hormone, hypoxia, and prostaglandin E2
Keywords: Sclerostin; SOST; Human fibroblasts; Hypoxia; Parathyroid hormone; Prostaglandin E2
Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation
Keywords: Sost; Sclerostin; Mechanotransduction; ECR5; Enhancer; Skeleton; Disuse;
Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23
Keywords: DMP1; Hypophosphatemic rickets; PDL; SOST; Sclerostin antibody; Osteocytes
Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells
Keywords: Sostdc1; Wise; Ectodin; Sost-like; Usag-1; Sost; Wnt signaling; Periosteum; Bone regeneration; Fracture repair;
Circulating TGF-β1 levels are negatively correlated with sclerostin levels in early postmenopausal women
Keywords: TGF-β1; transforming growth factor β 1; SOST; sclerostin; L1-4; BMD of lumbar spine 1-4; FN; BMD of femur neck; Total hip; BMD of total hip; P1NP; N-terminal propeptide of type I collagen; PTH; parathyroid hormone; VitD; serum 25(OH)D; CTX; cross-link
Variations of SOST mRNA expression in human bone are associated with DNA polymorphism and DNA methylation in the SOST gene
Keywords: SOST; Polymorphism; DNA methylation; Osteogenesis imperfecta; Bone; Gene expression;
Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells
Keywords: Zfp467; Sost; Wnt signaling; ADSCs
Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength
Keywords: WT; wild type; microCT; micro-computed tomography; TV; total volume; BV; bone volume; TMD; tissue mineral density; Tb.Th; trabecular thickness; Tb.Sp; trabecular separation; Tb.N; trabecular number; MMI(polar); polar moment of inertia; IHC; immunohistoche
1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion
Keywords: Vitamin D; Vitamin D response element; SOST; Sclerostin; Osteocyte; Gene regulation; Promoter
Expression of genes related to energy metabolism (osteocalcin, FOXO1, insulin receptor, and SOST) in bone cells of Goto-Kakizaki rats and response to bariatric surgery
Keywords: Type 2 diabetes; Osteocalcin; SOST; FOXO1;
High-concentration of BMP2 reduces cell proliferation and increases apoptosis via DKK1 and SOST in human primary periosteal cells
Keywords: High-concentration BMP2; Wnt; SOST; DKK1; Periosteum; Proliferation;
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
Keywords: WNT signaling; Sost; Sclerostin; Sostdc1; Shh; Limb formation; Polydactyly; syndactyly;
Regulation of Wnt/β-catenin signaling within and from osteocytes
Keywords: Wnt; Lrp5; Sclerostin; SOST; B-catenin; Osteocyte
Role of BMPs in the regulation of sclerostin as revealed by an epigenetic modifier of human bone cells
Keywords: SOST; Gene transcription; BMPs; DNA methylation
Appearance of Osteolysis with Melorheostosis: Redefining the Disease or a New Disorder? A Novel Case Report with Multimodality Imaging
Keywords: 4melorheostosis; osteolysis; sclerosing bone dysplasia; sclerotomes; SOST
Frizzled7 as an emerging target for cancer therapy
Keywords: ALL; Acute lymphoblastic leukemia; APC; Adenomatous polyposis coli; CamKII; Calmodulin kinase II; Cthrc1; Collagen triple helix repeat containing protein; CK1; Caseine kinase 1; CTNNB1; β-catenin gene; CRD; Cysteine rich domain; CSC; Cancer stem cells; D
TGF-β regulates sclerostin expression via the ECR5 enhancer
Keywords: TGF-β, transforming growth factor-beta; Lrp5, low-density lipoprotein-related receptor 5; Wnt, wingless int; ECR5, evolutionarily conserved region 5; PTH, parathyroid hormoneTransforming growth factor-beta; Sost; ECR5; Osteoblast; Bone; Wnt
Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton
Keywords: Sclerostin; Sost; Skeleton; Cartilage; Brain
The effect of TNFα secreted from macrophages activated by titanium particles on osteogenic activity regulated by WNT/BMP signaling in osteoprogenitor cells
Keywords: Particle; TNFα; Osteolysis; WNT; BMP; SOST;
Loss-of-function of ACVR1 in osteoblasts increases bone mass and activates canonical Wnt signaling through suppression of Wnt inhibitors SOST and DKK1
Keywords: ACVR1; activin A receptor type I; ALK; activin receptor-like kinase; BMP; bone morphogenetic protein; BMPR; BMP receptor; DEXA; dual-emission X-ray absorptiometry; E; embryonic day; FOP; fibrodysplasia ossificans progressiva; HBM; high bone mass; P; postn
Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK
Keywords: ALP; alkaline phosphatase; BMP; bone morphogenetic protein; Col1α1; collagen type I α1; CFU-M; colony forming cells by M-CSF; CTx-1; C-terminal telopeptide of type I collagen; Dkk1; Dickkopf 1; Dlx5; distal-less 5; GSH; glutathione; GSK3β; glycogen syn
High-bone-mass-producing mutations in the Wnt signaling pathway result in distinct skeletal phenotypes
Keywords: Wnt; High bone mass; Lrp5; Sclerostin; Sost
Sclerostin is a direct target of osteoblast-specific transcription factor osterix
Keywords: Osx; Sost; Osteoblast; Wnt signaling; Bone formationOsx, Osterix; Sost, Sclerostin; ChIP, chromatin immunoprecipitation; Ihh, Indian hedgehog; LRP, low-density lipoprotein receptor-related proteins; Dkk, Dickkopf; Tet, tetracycline
Genetic evidence that SOST inhibits WNT signaling in the limb
Keywords: WNT signaling; SOST; Sclerostin; Shh; Limb formation
NMR structure of the Wnt modulator protein Sclerostin
Keywords: SOST; NMR structure; LRP5; Wnt antagonist; Cystin-knot; Bone metabolism