Keywords: AHE; Acute Hepatic Encephalopathy; ALF; Acute Liver Failure; CHE; Chronic Hepatic Encephalopathy; CNS; Central Nervous System; CSF; Cerebrospinal Fluid; ECs; Endothelial Cells; HE; Hepatic Encephalopathy; IL; Interleukin; LPS; Lipopolysaccharide; MAPKs; M
مقالات ISI (ترجمه نشده)
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Keywords: Amyotrophic lateral sclerosis; Frontotemporal dementia; Magnetic resonance imaging; Pathology; Perfusion; TDP-43;
Keywords: Aβ1-42; 42-amino acid-long Aβ peptide; AD; Alzheimer's disease; ADAPT; Alzheimer's Disease Anti-Inflammatory Prevention Trial; ADAS-Cog; Alzheimer's Disease Assessment Scale-Cognitive Subscale; ADCS-ADL; Alzheimer's Disease Cooperative Study Activ
Keywords: Frontotemporal dementia; Amyotrophic lateral sclerosis; Motor neuron disease; C9ORF72; TDP-43;
Keywords: Alzheimer's disease (AD); Cerebrovascular disease; Lewy body disease; Frontotemporal degeneration; β-amyloid; Tau; α-Synuclein; TDP-43;
Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; DLB; dementia with Lewy bodies; MSA; multiple system atrophy; ALS; amyotrophic lateral sclerosis; αSyn; α-synuclein; TDP-43; TAR DNA binding protein of 43 kDa; FTLD; frontotemporal lobar degeneration; P
Keywords: AD; Alzheimer disease; TEM; transmission electron microscopy; ThS; thioflavin S; PI; propidium iodide; DAPI; 4â²,6â²-diamino-2-phenylindole dihydrochloride; IAPP; islet amyloid polypeptide; TDP-43; TAR DNA-binding protein of 43Â kDa; MTT; 3-(4,5-dimethy
Keywords: ABIN; A20 binding and inhibitor of NF-κB; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; Atg; autophagy-related gene; C9ORF72; chromosome 9 open reading frame 72; CC; coiled-coil; cIAP; cellular inhibitor of apoptosis protein; CYLD; cylin
Keywords: Traumatic brain injury; Chronic traumatic encephalopathy; Tauopathy; Concussion; Repetitive head injury; 2-AG; 2-arachidonoylglycerol; 3-NT; 3-nitrotyrosine; 4-HNE; 4-hydroxynonenal; Ach; acetylcholine; AChEI; acetylcholine esterase inhibitor; AD; Alzheim
Keywords: Alzheimer disease; Early-onset dementia; Tau; TDP-43; LRRK2; Exome sequencing;
Keywords: Neurodegenerative disease; Parkinson's disease; α-synuclein; Amyotrophic lateral sclerosis; TDP-43; Niemann-Pick disease;
Keywords: Biomarkers; Cerebrospinal fluid; Proteomics; Frontotemporal dementia; Pathology; TDP-43; Tau; Differential diagnosis
Keywords: KATP; TDP-43; Stroke; VCID; Arteriosclerosis; Lipohyalinosis; Synucleinopathy; NFT; Neuropathology; SUR2; Oldest-old; PART;
Keywords: CD39; M1/M2 microglia; Motoneuron; Oligodendrocyte; P2X7; P2Y12; ALS; amyotrophic lateral sclerosis; BBG; Brilliant Blue G; BDNF; brain-derived neurotrophic factor; BzATP; 2â²-3â²-O-(benzoyl-benzoyl) ATP; fALS; familial ALS; FUS; fused in sarcoma; HuR
Keywords: HIBM; hereditary inclusion-body myopathy; s-IBM; sporadic inclusion-body myositis; GNE; UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; GNE/MNK; UDP-GlcNAc 2-epimerase/ManNAc kinase; DMRV; distal myopathy with rimmed vacuoles; CK; creatine
Keywords: TDP-43; 43 kDa TAR DNA-binding protein; AD; Alzheimer's disease; APOE ε4; apolipoprotein ε4; Aβ; beta-amyloid; CSF; cerebrospinal fluid; CTE; chronic traumatic encephalopathy; p-tau; hyperphosphorylated tau; mTBI; mild traumatic brain injury; NFTs; ne
Keywords: Demencia frontotemporal variante conductual; Degeneración lobar frontotemporal; Biomarcador; TDP-43; Tau; GenéticaBehavioural variant frontotemporal dementia; Frontotemporal lobar degeneration; Biomarker; TDP-43; Tau; Genetics
Keywords: Behavioural variant frontotemporal dementia; Frontotemporal lobar degeneration; Biomarker; TDP-43; Tau; GeneticsDemencia frontotemporal variante conductual; Degeneración lobar frontotemporal; Biomarcador; TDP-43; Tau; Genética
Keywords: Frontotemporal dementia; Frontotemporal lobar degeneration; Cognitive impairment; Neural network; Theory of mind; TDP-43; Tau;
Keywords: Amyotrophic lateral sclerosis; Neuropathology; TDP-43; Motor neuron degeneration; C9orf72;
Keywords: ataxin-2; amyotrophic lateral sclerosis; neurodegeneration; TDP-43; FUS; antisense oligonucleotide therapy
Keywords: TDP-43; Neuropathology; Cerebrovascular; Hippocampal sclerosis; HS-Aging;
Keywords: Aβ; amyloid-β; AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoER2; apolipoprotein E receptor 2; APP; Aβ precursor protein; BDNF; brain-derived neurotrophic factor; CSF; cere
Keywords: API; Alzheimer's prevention initiative; DIAN; dominantly inherited Alzheimer's network; NMDA; N-methyl-d-aspartate; TDP-43; RNA binding protein; Alzheimer's disease; Therapeutic developments; Drugs; Dementia;
Keywords: ACC; nucleus accumbens; AD; Alzheimer's disease; BG; basal ganglia; BL; blepharospasm; BS; brainstem; CAUD; caudate; CD; cervical dystonia; COD; complication of the disorder; CNF; cuneiform nucleus; CN III; cranial nerve III; CN IV; cranial nerve IV; CRB;
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; EDTA; ethylenediaminetetraacetic acid; FTLD; frontotemporal lobar degeneration; GFAP; glial fibrillary acidic protein; HE; hematoxylin and eosin; HPRT; hypoxanthine phosphoribosyltransferase;
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ANOVA; Analysis of variance; Aβ; amyloid β; bHLH; basic Helix-Loop-Helix; C4; complement C4; CLEAR; coordinated lysosomal expression and regulation; Cyba; cytochrome b-245 light chain; DW; d
Keywords: Frontotemporal degeneration; Treatment; Tau; Progranulin; TDP-43;
TDP-43 NTD can be induced while CTD is significantly enhanced by ssDNA to undergo liquid-liquid phase separation
Keywords: Amyotrophic lateral sclerosis (ALS); TDP-43; Liquid-liquid phase separation (LLPS); Ubiquitin-like fold; Prion-like domain; Single-stranded DNA (ssDNA);
Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells
Keywords: TDP-43; 35kD fragment; Caspase; Apoptosis; Breast cancer;
Aim for the core: suitability of the ubiquitin-independent 20S proteasome as a drug target in neurodegeneration
Keywords: 20S; core 20S proteasome; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; BBB; blood-brain barrier; DUB; deubiquitinating enzyme; HbYX; hydrophobic-tyrosine-unspecified residue 'X'; IDP; intrinsically disorder
Latent classes of mild cognitive impairment are associated with clinical outcomes and neuropathology: Analysis of data from the National Alzheimer's Coordinating Center
Keywords: Aβ; amyloid-beta; AD; Alzheimer's disease; ADC; Alzheimer's Disease Center; AMN; amnestic; CSF; cerebrospinal fluid; DLB; dementia with Lewy bodies; FTLD; frontotemporal lobar degeneration; FX; functional impairments; GEE; generalized estimating equation
Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS
Keywords: CNS; central nervous system; NPAS3; neuronal per-arnt-sim domain protein 3; NMD; nonsense-mediated mRNA decay; PTBP; polypyrimidine tract binding proteins; PSD-95; postsynaptic density-95; TDP-43; TAR DNA-binding protein-43; qPCR; quantitative real-time P
Research PaperReversible induction of TDP-43 granules in cortical neurons after traumatic injury
Keywords: TDP-43; Cortical injury; ALS;
Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions
Keywords: Sporadic inclusion body myositis; TAR DNA-binding protein of 43â¯kDa; Creatine kinase 8 promoter; Endoplasmic reticulum stress; Calcium homeostasis; AST; aspartate aminotransferase; Aβ; amyloid β; ALS; amyotrophic lateral sclerosis; BiP; immunoglobulin
La infusión intracerebroventricular prolongada de lÃquido cefalorraquÃdeo procedente de pacientes con esclerosis lateral amiotrófica provoca cambios histológicos en el cerebro y la médula espinal de la rata similares a los hallados en la enfermedad
Keywords: Esclerosis lateral amiotrófica; Modelo experimental ELA; Periferina; TDP-43; Enfermedades neurodegenerativas; Citotoxicidad; Amyotrophic lateral sclerosis; ALS experimental model; Peripherin; TDP-43; Neurodegenerative diseases; Cytotoxicity;
TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics
Keywords: APP; amyloid precursor protein; VDAC1; voltage dependent anion channel 1; TDP-43; TAR DNA binding protein of 43â¯kDa; PSEN1/PS1; presenilin 1; AD; Alzheimer disease; hnRNP; heterogeneous nuclear ribonucleoprotein; ALS; amyotrophic lateral sclerosis; MND;
Dynamic duo - FMRP and TDP-43: Regulating common targets, causing different diseases
Keywords: RNA binding proteins; FMRP; TDP-43; mRNA targets; Fragile X syndrome; Amyotrophic lateral sclerosis; Frontotemporal dementia;
Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome
Keywords: Perry syndrome; Distal hereditary motor neuropathy 7B; Mouse model; Dynactin; Dynein; TDP-43;
Raloxifene, a promising estrogen replacement, limits TDP-25 cell death by enhancing autophagy and suppressing apoptosis
Keywords: ALS; amyotrophic lateral sclerosis; CCK-8; Cell Counting Kit-8; CTF25; C-terminal fragment-25; TDP-43; TAR DNA-binding protein 43; Ral; raloxifene; E2; 17β-estradiol; SERMs; selective estrogen receptors; ER; estrogen receptor; GPR30; G-protein coupled re
The physical forces mediating self-association and phase-separation in the C-terminal domain of TDP-43
Keywords: TDP-43; transactivation response element DNA-binding protein of 43Â kDa; IDP; intrinsically disordered protein; LLPS; liquid-liquid phase separation; ALS; amyotrophic lateral sclerosis; HSQC; heteronuclear single-quantum coherence; TDP-43; Self-associatio
Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses
Keywords: ALS; amyotrophic lateral sclerosis; BMDM; bone marrow-derived macrophages; C9orf72; chromosome 9 open-reading frame 72; CNS; central nervous system; CXCL; CXC chemokine ligand; DAMPs; damage-associated molecular patterns; DMEM; Dulbecco's Modified Eagle
The multi-dimensional roles of astrocytes in ALS
Keywords: Astrocyte; Neuroinflammation; ALS; TDP-43; SOD1;
FTLD/ALS-linked TDP-43 mutations do not alter TDP-43's ability to self-regulate its expression in Drosophila
Keywords: TDP-43; FTLD; ALS; Drosophila; Autoregulation; Mutation;
Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS
Keywords: ALS; amyotrophic lateral sclerosis; Caz; Cabeza; CNS; central nervous system; DAPI; 4,6-diamino-2-phenylidole dihydrochloride; FALS; familial amyotrophic lateral sclerosis; FUS; Fused in Sarcoma; hpo; Hippo; HRP; horseradish peroxidase; MST; Mammalian ste
The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration
Keywords: ADMA FUS; asymmetrically di-methylated arginine FUS; CHOP; C/EBP homologous protein gene; DDX4; DEAD box helicase 4; EWS; Ewing sarcoma protein; fALS; familial amyotrophic lateral sclerosis; FTLD; frontotemporal lobar degeneration; FUS; fused in sarcoma p
The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology
Keywords: Alzheimer's disease; Tau; TDP-43; MRI; Semantic variant of progressive primary aphasia; Frontotemporal dementia; Memory; Hippocampus;
The amyloidogenicity of a C-terminal region of TDP-43 implicated in Amyotrophic Lateral Sclerosis can be affected by anions, acetylation and homodimerization
Keywords: TDP-43; ALS; Amyloid; Hofmeister effect; Acetylation; Homodimerization;
Astrocyte elevated gene-1 is a novel regulator of astrogliosis and excitatory amino acid transporter-2 via interplaying with nuclear factor-κB signaling in astrocytes from amyotrophic lateral sclerosis mouse model with hSOD1G93A mutation
Keywords: ALS; Amyotrophic lateral sclerosis; AEG-1; Astrocyte elevated gene-1; ACM; astrocyte-conditioned medium; CBP; CREB-binding protein; COX-2; Cyclooxygenase-2; DMSO; dimethyl sulfoxide; DL-NBP; DL-3-n-butylphthalide; DMEM; Dulbecco modified Eagle medium; EAA
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy
Keywords: MPS; α-methyl-α-phenylsuccinimide; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; BSA; Bovine serum albumin; CNS; Central nervous system; DRS; Dent's Ringer solution; FTLD; Frontotemporal lobar degeneration; MOO; Multi-objective optimisati