Keywords: ATCC; American Type Culture Collection; BBB; blood-brain barrier; CDR; cumulative drug release; DH; hydrodynamic diameter (nm); DLS; dynamic light scattering; EDTA; ethylenediaminetetraacetic acid; FCS; fetal calf serum; Foscan®; original foscan® formul
مقالات ISI (ترجمه نشده)
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Keywords: W256; Walker-256; HPLC-UV; high pressure liquid chromatography-ultraviolet; PK/PD; pharmacokinetic/pharmacodynamic; popPK; population pharmacokinetic; TGI; Tumor Growth Inhibition; NAD; Naïve Average Data; SAEM; stochastic approximation expectation maxim
Keywords: MRCLS; myxoid/round cell liposarcoma; UPS; undifferentiated pleomorphic sarcoma; CSC; cancer stem cell; hBMSC; human bone marrow-derived mesenchymal stromal/stem cell; CPT; campthotecin; STS; soft tissue sarcomas; NER; nucleotide excision repair; DSB; dou
Keywords: Oxindole; Knoevenagel reaction; Antiproliferative activity; NADPH oxidase 4; Tubulin assembly; DTP; Developmental Therapeutics Program; NCI; National Cancer Institute; CSA4; combretastatin A-4; Nox; NAD(P)H oxidase enzyme; ROS; reactive oxygen species; EC
Targeting c-Myc: JQ1 as a promising option for c-Myc-amplified esophageal squamous cell carcinoma
Keywords: Esophageal squamous cell carcinoma; Targeting c-Myc; JQ1; c-Myc amplification; Patient derived xenograft; ESCC; esophageal squamous cell carcinoma; BET; bromodomain and extra-terminal; IC 50; the half maximal inhibitory concentration; NGS; Next-Generation
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFRα kinase inhibitor for PDGFRα driving chronic eosinophilic leukemia
Keywords: PDGFR kinase; Type II inhibitor; Kinase inhibitor; CEL; PDGFR; platelet-derived growth factor receptor; RTK; Receptor Tyrosine Kinases; ABL kinase; Abelson kinase; KIT kinase; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; RTK; receptor ty
The respiratory effect of tracheal gas insufflation (TGI) on tracheostomized spontaneously breathing ICU patients
Keywords: Tracheal Gas Insufflation; TGI; Tracheostomy; ICU;
Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors
Keywords: Selective survivin inhibitors; Structure-activity relationships; Antiproliferative activities; P-glycoprotein overexpression; ABC; ATP-binding cassette; IAP; inhibitor of apoptosis proteins; P-gp; P-glycoprotein; RI; resistance index; SAR; structure-activ
Rhodospirillum rubruml-asparaginase targets tumor growth by a dual mechanism involving telomerase inhibition
Keywords: Rhodospirillum rubrum l-asparaginase; hTERT; Telomerase; Telomere length; Antitumor activity; IU/ml; International Units per 1Â ml; MTT; 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; RrA; Rhodospirillum rubrum asparaginase mutant E149R, V
Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines
Keywords: Quinazoline; Quinone; α1-Adrenoreceptor antagonist; DNA fragmentation; Antiproliferative activity; α1-AR; α1-adrenoreceptor; BPH; benign prostatic hyperplasia; CHO; Chinese hamster ovary; Dox; doxazosin; GSH; glutathione; LUTS; lower urinary tract symp
Novel phosphonate analogs of sulforaphane: Synthesis, in vitro and in vivo anticancer activity
Keywords: AITC; allyl isothiocyanate; ALT; alanine transaminase; An V; annexin V; ANOVA; analysis of variances; APC; allophycocyanin; AST; aspartate transaminase; b.w.; body weight; BITC; benzyl isothiocyanate; BTMS; bromotrimethylsilane; BuITC; butyl isothiocyanat
Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents
Keywords: Multiple receptor tyrosine kinase inhibitors; Antiangiogenic agents; Pyrimido[4,5-b]indole synthesis; Thymidylate synthase inhibitors; Combination chemotherapeutic potential in single agents; RTK; receptor tyrosine kinases; VEGF; vascular endothelial grow
FASN Inhibition and Taxane Treatment Combine to Enhance Anti-tumor Efficacy in Diverse Xenograft Tumor Models through Disruption of Tubulin Palmitoylation and Microtubule Organization and FASN Inhibition-Mediated Effects on Oncogenic Signaling and Gene Ex
Keywords: NSCLC; Non-small-cell lung cancer; TGI; Tumor growth inhibition; MEM; Minimal essential media; DMEM; Dulbecco's modified Eagle medium; FBS; Fetal bovine serum; CS-FBS; Charcoal-filtered FBS-fetal bovine serum; IMDM; Iscove's modified Eagle medium; LC-MS
Synthesis, anti-proliferative activity, SAR study, and preliminary in vivo toxicity study of substituted N,Nâ²-bis(arylmethyl)benzimidazolium salts against a panel of non-small cell lung cancer cell lines
Keywords: NCI; National Cancer Institute; IC50; inhibitory concentration 50%; NSCLC; non-small cell lung cancer; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SAR; structure-activity relationship; GI50; growth inhibition 50%; TGI; total growth
Synthesis, in vitro antitumor activity, dihydrofolate reductase inhibition, DNA intercalation and structure-activity relationship studies of 1,3,5-triazine analogues
Keywords: DHFR; dihydrofolate reductase; ct-DNA; calf thymus DNA; NADPH; nicotinamide adenine dinucleotide phosphate; TGI; total growth inhibition; LC50; 50% lethal concentration; GI50; 50% growth inhibition; IC50; 50% inhibitory concentration; Ka; binding constant
Imaging mass spectrometry detects dynamic changes of phosphatidylcholine in rat hippocampal CA1 after transient global ischemia
Keywords: AA; arachidonic acid; DHA; docosahexaenoic acid; ED1; ectodermal dysplasia 1; GFAP; glial fibrillary acidic protein; IMS; imaging mass spectrometry; MALDI; matrix-assisted laser desorption/ionization; NeuN; neuronal nuclei; PC; phosphatidylcholine; RT; ro
Different cell death responses induced by eupomatenoid-5 in MCF-7 and 786-0 tumor cell lines
Keywords: 786-0; human kidney cancer cell line; 7-AAD; 7-aminoactinomycin D; ATP; adenosine triphosphate; DCE; dichloromethanic crude extract; DCF; 2,7-dichlorofluorescein; DCFH; 2,7-dichlorodihydrofluorescein; DCFH-DA; dichlorofluorescin diacetate; DMSO; dimethyl
From arrow poison to herbal medicine - The ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae)
Keywords: Ig; immunoglobulin; OVA; ovalbumin; PG; prostaglandin; PHF; polyherbal formulation; TGI; total growth inhibition; MIC; minimum inhibitory concentration; IZD; inhibition zone diameter; MLE; methanolic leaf extract; HLE; hydroalcoholic leaf extract; HRE; hy
No evidence for transgenerational genomic instability in the F1 or F2 descendants of Mutaâ¢Mouse males exposed to N-ethyl-N-nitrosourea
Keywords: ENU; N-ethyl-N-nitrosourea; ESTR; expanded simple tandem repeat; MN; micronuclei; TGI; transgenerational genomic instability; Mouse; Germline; Mutation; Micronuclei;
Gene expression analysis in biomarker research and early drug development using function tested reverse transcription quantitative real-time PCR assays
Keywords: ALAS1; Aminolevulinate, delta- synthase-1; Cq; quantification cycle; FFPET; formalin-fixed paraffin-embedded tissue; HER2; human epidermal growth factor receptor 2; HPRT1; hypoxanthine phosphoribosyltransferase-1; PHC; personalized health care; qPCR; quan
A laccase-catalysed one-pot synthesis of aminonaphthoquinones and their anticancer activity
Keywords: Biocatalysis; Laccase; Oxidative enzymes; 1,4-Naphthohydroquinones; Aminonaphthoquinones; C–N bond formation; Primary amines; Monoamination; Anticancer agents; Cytostatic effects; Cytotoxic effects; GI50; TGI; LC50