دانلود مقالات ISI درباره پارتیشن بافت + ترجمه فارسی

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Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Keywords: پارتیشن بافت; pulmonary; tissue partition; pharmacokinetics; pulmonary drug delivery; distribution; Cu,cell; intracellular unbound drug concentration; Cu,lungISF; unbound drug concentration in the lung interstitial fluid; fu,lung; fraction of unbound drug in diluted lu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

پیش بینی شیوه های غیرفعال و فعال: ضرایب پراکندگی پلاسما: متغیر بین فردی و بین گونه ای

Predicting Passive and Active Tissue:Plasma Partition Coefficients: Interindividual and Interspecies Variability

Keywords: پارتیشن بافت; tissue partition; physicochemical properties; population pharmacokinetic/pharmacodynaMic Models; drug transport; active transport; QSPR; Monte Carlo; in silico Modeling; computational ADME; computational biology;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations

Keywords: پارتیشن بافت; active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites

Keywords: پارتیشن بافت; ABC transporters; transporters; skin; P-glycoprotein; tissue partition; ABCB1; ATP binding cassette subfamily B member 1; ABCG2; ATP binding cassette subfamily G member 2; BCRP; breast cancer resistance protein; CRC; colorectal cancer; CYP3A4; cytochrome

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2017 سفارش ترجمه

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Keywords: پارتیشن بافت; pharmacokinetics; pulmonary drug delivery; tissue partition; distribution; pulmonary; IT; intratracheal; PBPK; physiologically based pharmacokinetic; PK; pharmacokinetic; t1/2; half-life; V0; volume of the airspaces in the lung slices; Vu,lung; unbound dr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Propagation of Error in Ocular Pharmacokinetic Parameters Estimate of Azithromycin in Rabbits

Keywords: پارتیشن بافت; analytical chemistry; bioequivalence; LC-MS; tissue partition; pharmacokinetics; bioanalysis;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Partitioning and diffusion of parathion in human dermis

Keywords: پارتیشن بافت; Albumin; Dermis; Diffusion; Drug transport; Permeability; Protein binding; Membrane transport; Tissue partition; Mathematical model

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Skin Microdialysis-Based Estimation of Systemic Bioavailability Fraction

Keywords: پارتیشن بافت; bioavailability; dose-proportionality; microdialysis; pharmacokinetics; oral absorption; tissue partition;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Physiologically Based Pharmacokinetic Tissue Compartment Model Selection in Drug Development and Risk Assessment

Keywords: پارتیشن بافت; pharmacokinetics; physiological model; well stirred model; tissue partition; in silico modeling; physicochemical; singular perturbation; asymptotic matching; flow-limited; compartmental modeling;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Tissue lipids and drug distribution: Dog versus rat

Keywords: پارتیشن بافت; dog; tissue constituents; in silico modeling; pharmacokinetics; phospholipids; tissue partition; physiological model; physicochemical properties; partition coefficients; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

In Vitro Measurement of Drug Efficiency Index to Aid Early Lead Optimization

Keywords: پارتیشن بافت; ADME; biomimetics; HPLC (high-performance/pressure liquid chromatography); log P; protein binding; phospholipids; tissue partition; drug-like properties;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

An Extended Database of Keratin Binding

Keywords: پارتیشن بافت; adsorption; skin; QSAR; nail; partial least squares; percutaneous; tissue partition; physicochemical properties; protein binding;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Examination of the Ability of the Nasal Administration Route to Confer a Brain Exposure Advantage for Three Chemical Inhibitors of P-Glycoprotein

Keywords: پارتیشن بافت; blood-brain barrier; CNS; nasal drug delivery; targeted drug delivery; tissue partition; P-glycoprotein; rifampin; quinidine; GF120918;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Improved Method for Determining Partition and Diffusion Coefficients in Human Dermis

Keywords: پارتیشن بافت; albumin; diffusion; drug transport; in vitro models; passive diffusion/transport; permeability; protein binding; membrane transport; skin; tissue partition;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2010 سفارش ترجمه

A Physiologically Based Pharmacokinetic (PBPK) Model for Predicting the Efficacy of Drug Overdose Treatment With Liposomes in Man

Keywords: پارتیشن بافت; liposomes; pharmacokinetic/pharmacodynamic models; physiological model; tissue partition; pharmacokinetics; drug transport; dynamic simulation; toxicokinetics; simulations;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2010 سفارش ترجمه

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors

Keywords: پارتیشن بافت; Stearoyl CoA desaturase (SCD); HEPG2 assay; Microsomal assay; Tissue partition; Tissue distribution; Saturation index

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2009 سفارش ترجمه

Cassette Dosing Pharmacokinetic Studies for Evaluation of Ophthalmic Drugs for Posterior Ocular Diseases

Keywords: پارتیشن بافت; preclinical pharmacokinetics; tissue partition; distribution; site-specific absorption; site-specific delivery; eye; ocular pharmacokinetics; retina; vitreous humor; choroid;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

Prediction of Drug Tissue to Plasma Concentration Ratios Using a Measured Volume of Distribution in Combination With Lipophilicity

Keywords: پارتیشن بافت; physiochemical properties; tissue partition; computational ADME; pharmacokinetics; physiological model; distribution; preclinical pharmacokinetics; log P; clinical pharmacokinetics; ADME;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Molecular Design for Enhancement of Ocular Penetration

Keywords: پارتیشن بافت; tissue partition; drug design; permeability; solubility; structure-property relationship (SPR); epithelial delivery/permeability;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2008 سفارش ترجمه

Pharmacokinetic studies of green tea catechins in maternal plasma and fetuses in rats

Keywords: پارتیشن بافت; catechins; pregnancy; pharmacokinetics; tissue partition; distribution; placenta;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Keywords: پارتیشن بافت; in silico modelling; pharmacokinetics; phospholipids; tissue partition; physiological model; physicochemical properties; partition coefficients; QSAR; PBPK modelling;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2006 سفارش ترجمه

Pharmacokinetics and Tissue Distribution of Etoposide Delivered in Parenteral Emulsion

Keywords: پارتیشن بافت; emulsion; nanospheres; pharmacokinetics; tissue partition;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2005 سفارش ترجمه

Tissue Distribution of Basic Drugs: Accounting for Enantiomeric, Compound and Regional Differences Amongst β-Blocking Drugs in Rat

Keywords: پارتیشن بافت; phospholipids; tissue partition; chirality; pharmacokinetics; physiological model; physicochemical properties; PBPK modelling; beta-blockers; partition coefficients;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

Keywords: پارتیشن بافت; in silico modeling; pharmacokinetics; phospholipids; tissue partition; physiological model; physicochemical properties; beta-blockers; partition coefficients; QSAR; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2005 سفارش ترجمه