Keywords: TLR4، گیرنده شماره 4; TLRs, toll-like receptors; TLR4, toll-like receptor 4; ICH, intracerebral hemorrhage; VEGF, vascular endothelial growth factor; BDNF, brain-derived neurotrophic factor; BrdU, 5-bromo-2-deoxyuridine; MMP-9, matrix metalloproteinase-9Intracerebral hemorrhag
مقالات ISI TLR4، گیرنده شماره 4 (ترجمه نشده)
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Keywords: TLR4، گیرنده شماره 4; ALT, alanine transaminase; i.p., intraperitoneal; LPA, lysophosphatidic acid; LPS, lipopolysaccharide; MPO, myeloperoxidase; TLR4, toll-like receptor 4; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling
Keywords: TLR4، گیرنده شماره 4; TLR4, Toll-like receptor 4; PDB, Protein Data Bank; cyno, cynomolgus monkey; LPS, lipopolysaccharide; CDR, complementarity-determining region; BLI, Bio-Layer Interferometry; SPR, surface plasmon resonance; PBS, phosphate-buffered saline; BSA, bovine serum
Keywords: TLR4، گیرنده شماره 4; JG-03-14 pyrrole compound; RAW264.7 macrophages; Inflammation; NF-κB; TNF-α; Nitric oxideNF-κB, Nuclear factor kappa B; LPS, Lipopolysaccharide; TLR4, Toll-like receptor 4; IKK, Inhibitor of nuclear factor kappa B kinase; IκB-α, Inhibitor of nuclear facto
Foxo1-mediated inflammatory response after cerebral hemorrhage in rats
Keywords: TLR4، گیرنده شماره 4; Foxo1, the forkhead box O1; ICH, intracerebral hemorrhage; siRNA, small interfering RNA; TLR4, toll-like receptor 4; NF-κB, nuclear factor-k-gene binding; TNF-α, tumor necrosis factor; IL-1β, interleukin-1β; IL-18, interleukin-18; MPO, myeloperoxidase; PA
Flavonoids from Radix Tetrastigmae inhibit TLR4/MD-2 mediated JNK and NF-κB pathway with anti-inflammatory properties
Keywords: TLR4، گیرنده شماره 4; RTFs, flavonoids isolated from Radix Tetrastigmae; TLR4, Toll-like receptor 4; MD-2, myeloid differentiation factor-2; NF-κB, nuclear transcription factor-kappa B; MAPKs, mitogen-activated protein kinases; JNK, c-Jun N-terminal kinase; LPS, lipopolysaccha
Gegen Qinlian decoction alleviates experimental colitis via suppressing TLR4/NF-κB signaling and enhancing antioxidant effect
Keywords: TLR4، گیرنده شماره 4; Gegen Qinlian decoction; UC; TLR4; NF-κB; Antioxidant effectGQ, Gegen Qinlian decoction; UC, acute ulcerative colitis; DSS, dextran sulfate sodium; TLR4, toll-like receptor 4; TNF-α, tumor necrosis factor-α; IL, interleukin; MPO, myeloperoxidase; MDA, mal
E3 ubiquitin ligases as novel targets for inflammatory diseases
Keywords: TLR4، گیرنده شماره 4; HECT, homologous to the E6AP carboxyl terminus; RING, really interesting new gene; UPS, ubiquitin proteasome system; TNFα, tumour necrosis factor-α; MCP-1, monocyte chemotactic protein-1; CCR2, CC chemokine receptor type 2; TLR4, toll-like receptor 4;; GM
Metabolic endotoxemia with obesity: Is it real and is it relevant?
Keywords: TLR4، گیرنده شماره 4; Obesity; Metabolic endotoxemia; Substrate metabolism; Inflammation; Endotoxin detectionLPS, lipopolysaccharide; TLR4, Toll-Like Receptor 4; T2D, Type II Diabetes; GLP2, Glucagon Like Peptide 2; eCB, endocannabinoid; ROS, reactive oxygen species; CD, clust
Lipopolysaccharide supports maintaining the stemness of CD133+ hepatoma cells through activation of the NF-κB/HIF-1α pathway
Keywords: TLR4، گیرنده شماره 4; HCC, hepatocellular carcinoma; CSCs, cancer stem cells; TICs, tumor initiating cells; LPS, lipopolysaccharide; EMT, epithelial–mesenchymal transition; FBS, fetal bovine serum; 5-Fu, 5-fluorouracil; TLR4, toll-like receptor 4; PAMPs, pathogen-associated mo
Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice
Keywords: TLR4، گیرنده شماره 4; TNBS, 2,4,6-trinitrobenzene sulfonic acid; Treg, regulatory T cell; IL-8, interleukin-8; TLR4, Toll-like receptor 4; TNF-α, tumor necrosis factor alpha; IL-6, interleukin-6; IL-10, interleukin-10; SOD, Superoxide dismutase; GSH-px, glutathione peroxidase;
TMEM126A, a CD137 ligand binding protein, couples with the TLR4 signal transduction pathway in macrophages
Keywords: TLR4، گیرنده شماره 4; TMEM126A, transmembrane protein 126A; TLR4, Toll-like receptor 4; LPS, lipopolysacchride; APC, antigen presenting cell; MHC, major histocompatibility complex; TNF-α, tumor necrosis factor alpha; IFN, interferon; MAPK, mitogen-activated protein kinase; JNK
The dopamine D3 receptor regulates the effects of methamphetamine on LPS-induced cytokine production in murine mast cells
Keywords: TLR4، گیرنده شماره 4; METH, methamphetamine; HIV, human immunodeficiency virus; D3R, dopamine D3 receptor; DA, dopamine; LPS, lipopolysaccharide; TNF-a, tumour necrosis factor; TLR4, Toll-like receptor 4; NSn, ormal saline; BMMC, bone marrow-derived mast cells; WT, wild-type;
Apigenin protects blood–brain barrier and ameliorates early brain injury by inhibiting TLR4-mediated inflammatory pathway in subarachnoid hemorrhage rats
Keywords: TLR4، گیرنده شماره 4; EBI, early brain injury; SAH, subarachnoid hemorrhage; BBB, blood–brain barrier; ZO-1, zonula occludens-1; TLR4, toll-like receptor 4; HMGB-1, high mobility group box-1; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; iNOS, inducible nitric oxide syn
Anti-TNF-α monoclonal antibody reverses psoriasis through dual inhibition of inflammation and angiogenesis
Keywords: TLR4، گیرنده شماره 4; TNF-α, tumor necrosis factor alpha; SPR, surface plasmon resonance; TLR4, toll-like receptor 4; LPS, lipopolysaccharide; IFN, interferon; NF-κB, nuclear factor-κB; mAb, monoclonal antibody; ELISA, enzyme-linked immuno sorbent assay; IHC, immunohistochemis
ES-62, a therapeutic anti-inflammatory agent evolved by the filarial nematode Acanthocheilonema viteae
Keywords: TLR4، گیرنده شماره 4; APC, antigen presenting cell; RA, rheumatoid arthritis; CIA, collagen-induced arthritis; DC, dendritic cell; IFN, interferon; IL, interleukin; LPS, lipopolysaccharide; MC, mast cell; PC, phosphorylcholine; TLR4, Toll-like receptor 4; TNF, tumor necrosis f
Phospholipase D1 is required for lipopolysaccharide-induced tumor necrosis factor-α expression and production through S6K1/JNK/c-Jun pathway in Raw 264.7 cells
Keywords: TLR4، گیرنده شماره 4; Phospholipase D1; Lipopolysaccharide; TNF-α; TLR4; c-JunPLD, phospholipase D; LPS, lipopolysaccharide; TNF-α, tumor necrosis factor-α; TLR4, toll-like receptor 4; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinases; JNK, c-
Essential role of IL-10/STAT3 in chronic stress-induced immune suppression
Keywords: TLR4، گیرنده شماره 4; TLR4, toll-like receptor 4; WT, wild-type; KO, knockout; DC, dendritic cell; IHC, immunohistochemistry; Th1, T helper-1; Th2, T helper-2TLR4; STAT3; p38; Chronic stress; Apoptosis; Immune suppression
Wogonin inhibits LPS-induced tumor angiogenesis via suppressing PI3K/Akt/NF-κB signaling
Keywords: TLR4، گیرنده شماره 4; PI3K, phosphoinositide 3-kinase; Akt, v-Akt murine thymoma viral oncogene; NF-κB, nuclear factor-kappa B; IKK, IκB kinase; LPS, lipopolysaccharide; VEGF, vascular endothelial growth factor; TLR4, toll-like receptor 4; ERK, extracellular signal-regulated k
Incidence and risk factors of anti-HLA immunization after pregnancy
Keywords: TLR4، گیرنده شماره 4; Ab, antibody; Ag, antigen; BAFF, B cell Activating Factor; CDC, complement dependent cytotoxicity; CRP, C-reactive Protein; DTT, dithiothreitol; HLA, human leukocyte antigen; IL-6, interleukine 6; sHLA-G, soluble HLA-G; TLR4, toll-like receptor 4
Feline serum amyloid A protein as an endogenous Toll-like receptor 4 agonist
Keywords: TLR4، گیرنده شماره 4; SAA, serum amyloid A; NF-κB, nuclear factor-kappa B; TLR4, Toll-like receptor 4; APP, acute phase protein; LPS, lipopolysaccharide; PRR, pattern recognition receptor; FPRL1, formyl peptide receptor-like 1; SR-B1, scavenger receptor class B type 1; A-SAA,
Molecular characterisation of porcine miR-155 and its regulatory roles in the TLR3/TLR4 pathways
Keywords: TLR4، گیرنده شماره 4; miRNA, microRNA; TLRs, Toll-like receptors; TLR3, Toll-like receptor 3; TLR4, Toll-like receptor 4; LPS, lipopolysaccharide; poly (I:C), polyinosinic polycytidylic acid; dsRNA, double-stranded RNA; PAMP, pathogen-associated molecular patterns; NFκB, nucle
Dietary omega-3 polyunsaturated fatty acids attenuate hepatic ischemia/reperfusion injury in rats by modulating toll-like receptor recruitment into lipid rafts
Keywords: TLR4، گیرنده شماره 4; Hepatic ischemia/reperfusion injury; Toll-like receptor 4; Omega-3 polyunsaturated fatty acidsω-3 PUFAs, omega-3 polyunsaturated fatty acids; I/R, ischemia and reperfusion; TLR4, toll-like receptor 4; HMGB1, high mobility group box 1
Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-кB signaling pathway in isoproterenol-induced myocardial hypertrophy
Keywords: TLR4، گیرنده شماره 4; As IV, astragaloside IV; Iso, isoproterenol; TLR4, toll-like receptor 4; NF-кB, nuclear factor-кB; Pro, propranolol; IκBα, inhibitor-κBα; TNF-α, tumor necrosis factor α; IL-6, interleukin-6; NCM, neonatal cardiomyocytes; HMI, heart mass index; LVMI, left
Lipid A 3′-O-deacylation by Salmonella outer membrane enzyme LpxR modulates the ability of lipid A to stimulate Toll-like receptor 4
Keywords: TLR4، گیرنده شماره 4; LPS, lipopolysaccharide; TLR4, Toll-like receptor 4; S. Typhimurium, Salmonella enterica serovar Typhimurium; TLC, thin layer chromatography; HPTLC, high performance thin layer chromatography; U-lipid A, unmodified lipid A; P-lipid A, palmitoylated lipid
Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in cancer: A meta-analysis
Keywords: TLR4، گیرنده شماره 4; TLR4, Toll-like receptor 4; TLRs, Toll-like receptors; ORs, odds ratios; CIs, confidence intervals; SNP, single nucleotide polymorphisms; LPS, Lipopolysaccharide; HWE, Hardy–Weinberg equilibrium; LPS, Lipopolysaccharide; HB, hospital based; PB, population
Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: A meta-analysis
Keywords: TLR4، گیرنده شماره 4; TLR4, Toll-like receptor 4; HWE, Hardy-Weinberg equilibrium; OR, odds ratio; CI, confidence interval; SNP, single nucleotide polymorphism; LPS, lipopolysaccharide; CD14, cluster of differentiation 14; IL-6, interleukin-6; TNF-a, tumor necrosis factor-a; I
Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4
Keywords: TLR4، گیرنده شماره 4; FRP, follistatin-related protein; FSTL1, follistatin-like 1; TLR4, toll-like receptor 4; TGF-β, transforming growth factor β; DIP2A, disco-interacting protein 2 homolog A from Drosophila; RA, rheumatoid arthritis; MMPs/Mmps, matrix metalloproteinases; CAI
Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4
Keywords: TLR4، گیرنده شماره 4; 4-HNE, 4-hydroxynonenal; BAL, bronchoalveolar lavage; EMSA, electrophoretic mobility shift assay; iNOS, inducible nitric oxide synthase; NF-κB, nuclear factor-kappa B; SP, surfactant protein; TLR4, toll-like receptor 4; TNFα, tumor necrosis factor-alphaOz
Short-term immunological effects of non-ethanolic short-chain alcohols
Keywords: TLR4، گیرنده شماره 4; NFAT, nuclear factor of activated T cells; AP-1, activator protein-1; NF-κB, nuclear factor-κB; ERK, extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinase; TLR4, Toll-like receptor 4; TCR, T-cell receptor; APC, antigen-presenting c
Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood–brain barrier via TLR4/IRF-3 signaling
Keywords: TLR4، گیرنده شماره 4; BBB, blood-brain barrier; IRF-3, interferon regulatory factor-3; LPS, lipopolysaccharide; PCB, polychlorinated biphenyl; TLR4, toll-like receptor 4; ZO, zonula occludensBlood–brain barrier; Inflammation; Interferon regulatory factor-3; Polychlorinated bip
Deficiency in TLR2 but not in TLR4 impairs dendritic cells derived IL-10 responses to schistosome antigens
Keywords: TLR4، گیرنده شماره 4; TLR2, Toll-like receptor 2; TLR4, Toll-like receptor 4; BMDCs, bone marrow-derived dendritic cells; SSA, soluble schistosomule antigen; SEA, soluble egg antigenTLR2; TLR4; Antigen; Schistosome; Innate immunity
Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression
Keywords: TLR4، گیرنده شماره 4; Srx, sulfiredoxin; Prx, peroxiredoxin; CP, peroxidatic cysteine; CR, resolving cysteine; Trx, thioredoxin; Grx, glutaredoxin; TLR4, Toll-like receptor 4; ARE, antioxidant response element; NF-κB, nuclear factor-κB; AP-1, activator protein-1; TPA, 12-O-tet
Chitosan oligosaccharide as potential therapy of inflammatory bowel disease: Therapeutic efficacy and possible mechanisms of action
Keywords: TLR4، گیرنده شماره 4; COS, chitosan oligosaccharide; IEC, intestinal epithelial cell; TNF-α, tumor necrosis factor-α; IL-6, interleukin-6; NF-κB, nuclear factor kappa B; LPS, lipopolysaccharide; DAPI, 4′,6′-diamidino-2′-phenylindoledihydrochloride; TLR4, Toll-like receptor 4;
Mutations in the lipid A deacylase PagL which release the enzyme from its latency affect the ability of PagL to interact with lipopolysaccharide in Salmonella enterica serovar Typhimurium
Keywords: TLR4، گیرنده شماره 4; LPS, lipopolysaccharides; S. Typhimurium, Salmonella enterica serovar Typhimurium; TLR4, Toll-like receptor 4; PBS, phosphate-buffered salineOuter membrane; Endotoxin; Deacylation; Gram-negative bacteria; Membrane lipid
Toll-like receptor 4 participates in gastric mucosal protection through Cox-2 and PGE2
Keywords: TLR4، گیرنده شماره 4; TLR4, Toll-like receptor 4; Cox-1, cyclooxygenase-1; Cox-2, cyclooxygenase-2; PGE2, prostaglandin E2; ELISA, enzyme-linked immunosorbent assay; LPS, lipopolysaccharide; IF, immunofluorescent; PAMPs, pathogen-associated molecular patterns; DAMPs, damage-as
Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex
Keywords: TLR4، گیرنده شماره 4; TLR4, Toll-Like receptor 4; MD-2, myeloid differentiation factor 2; COS, chitosan oligosaccharides; LPS, lipopolysaccharide; PMB, polymyxin B; MAPKs, mitogen-activated protein kinases; NF-κB, nuclear factor-κBLPS; IL-1β; Chitosan oligosaccharides; MAPKs;
LPS-induced iNOS expression in Bv-2 cells is suppressed by an oxidative mechanism acting on the JNK pathway—A potential role for neuroprotection
Keywords: TLR4، گیرنده شماره 4; LPS, lipopolysaccharide; NAC, N-acetyl-L-cysteine; NOS, nitric oxide synthase; RNS, reactive nitrogen species; ROS, reactive oxygen species; TLR4, Toll-like receptor 4; NO, nitric oxide; NO2−, nitrite; ∙ O2−, superoxide anion; ONOO−, peroxynitriteMicrogli
SOS regulatory elements are essential for UPEC pathogenesis
Keywords: TLR4، گیرنده شماره 4; SOS response; Host-pathogen interactions; Urinary tract infections; Oxidative stressUPEC, uropathogenic Escherichia coli; UTI, urinary tract infection; IBC, intracellular bacterial community; TLR4, toll-like receptor 4
Leptospirosis-associated disturbances of blood vessels, lungs and hemostasis
Keywords: TLR4، گیرنده شماره 4; β2GPI, β2 glycoprotein I; DIC, disseminated intravascular coagulation; IL, interleukin; LPS, lipopolysaccharide; SPHS, severe pulmonary hemorrhage syndrome; TLR4, Toll-like receptor 4; TNF-α, tumor necrosis factor α; TTP, thrombotic thrombocytopenic purpu
Endotoxin tolerance: Selective alterations in gene expression and protection against lymphocyte death
Keywords: TLR4، گیرنده شماره 4; Apoptosis; Cytokines; Inflammation; Necrosis; Sepsis; Shock; T-cellsLPS, lipopolysaccharide; TH1 TH2, T helper 1 or 2; TLR4, Toll-like receptor 4; CLP, cecal ligature and puncture; PARP, poly(ADP-ribose) polymerase; IL, interleucine; TNF, tumor-necrosis f
Lipopolysaccharide: Biosynthetic pathway and structure modification
Keywords: TLR4، گیرنده شماره 4; Gram-negative bacteria; Outer membrane; Lipopolysaccharide; Endotoxin; Lipid A; LPS biosynthesisLPS, lipopolysaccharide; TLR4, toll-like receptor 4; Kdo, 3-deoxy-D-manno-octulosonic acid; Hep, l-glycero-d-manno-heptose; CAMPs, cationic antimicrobial pepti
Induction of COX-2/PGE2/IL-6 is crucial for cigarette smoke extract-induced airway inflammation: Role of TLR4-dependent NADPH oxidase activation
Keywords: TLR4، گیرنده شماره 4; COPD, chronic obstructive pulmonary disease; CSE, cigarette smoke extract; COX-2, cyclooxygenase-2; PGE2, prostaglandin E2; TLR4, Toll-like receptor 4; HTSMC, human tracheal smooth muscle cell; ROS, reactive oxygen speciesCigarette smoke; Oxidative stress
TLR4-dependent and -independent regulation of hepatic cytochrome P450 in mice with chemically induced inflammatory bowel disease
Keywords: TLR4، گیرنده شماره 4; P450, cytochrome P450; TLR4, toll-like receptor 4; DSS, dextran sulfate sodium; TNBS, trinitrobenzenesulfonic acid; IL, interleukin; TNFα, tumor necrosis factor alpha; LPS, lipopolysaccharide; PMN, polymorphonuclear lymphocytes; PPARα, peroxisome prolifer
Chronic restraint stress promotes immune suppression through Toll-like receptor 4-mediated phosphoinositide 3-kinase signaling
Keywords: TLR4، گیرنده شماره 4; TLR4, Toll-like receptor 4; PI3K, phosphoinositide 3-kinase; GSK-3β, glycogen synthase kinase-3βStress; Lymphocytes; TLR4; PI3K; GSK-3β; Immune response
LPS induces inflammatory responses in human aortic vascular smooth muscle cells via Toll-like receptor 4 expression and nitric oxide production
Keywords: TLR4، گیرنده شماره 4; LPS, lipopolysaccharide; TLR4, Toll-like receptor 4; VSMCs, vascular smooth muscle cells; HASMCs, human aortic smooth muscle cells; PBS, phosphate-buffered saline; ELISA, enzyme-linked immunosorbent assay; iNSO, inducible nitric oxide synthase; NOS, NO sy
Leukocyte adhesion in the liver: Distinct adhesion paradigm from other organs
Keywords: TLR4، گیرنده شماره 4; Con A, Concanavalin A; HA, Hyaluronan; LAD-1, leukocyte adhesion deficiency type 1; NKT cell, natural killer T cell; RHAMM, Receptor for hyaluronan mediated motility; TLR4, Toll-like receptor 4; Treg, T regulatory cell; VAP-1, Vascular adhesion protein-1L
Augmentation of 11β-hydroxysteroid dehydrogenase type 1 in LPS-activated J774.1 macrophages – Role of 11β-HSD1 in pro-inflammatory properties in macrophages
Keywords: TLR4، گیرنده شماره 4; 11β-HSD1, 11β-hydroxysteroid dehydrogenase type 1; 11β-HSD2, 11β-hydroxysteroid dehydrogenase type 2; LPS, lipopolysaccharide; TLR4, toll-like receptor 4; IL-1β, interleukin 1β; IL1R1, interleukin 1 receptor type 1; TNF-α, tumor necrosis factor α; TNFR1,
Preadipocyte response and impairment of differentiation in an inflammatory environment
Keywords: TLR4، گیرنده شماره 4; TLR4, toll-like receptor 4; CCL2, chemokine (C–C motif) ligand 2 = MCP-1; CCL5, chemokine (C–C motif) ligand 5 = RANTES; CCL11, chemokine (C–C motif) ligand 11 = eotaxin; IL6, interleukin 6; NOS2, nitric oxide synthase 2A = iNOS; PTGS2, prostaglandin-endo
Neospora caninum: High susceptibility to the parasite in C57BL/10ScCr mice
Keywords: TLR4، گیرنده شماره 4; Neospora caninum acute infection; Apicomplexa; C57BL/10 ScCr (ScCr) mice; C57BL/10 ScSn (ScSn) mice; NcT, Neospora caninum tachyzoites; IFN-γ, interferon-γ; IL-4, interleukin-4; IL-12, interleukin-12; TLR4, Toll-like receptor 4; IL-12R, IL-12 receptor; Th