Keywords: Trx، thioredoxin; APN, adiponectin; HCC, hepatocellular carcinoma; JNK, C-Jun N-terminal kinase; Trx, thioredoxin; NAC, N-acetylcysteine; AMPK, 5′-adenosine monophosphate-activated protein kinase; ROS, reactive oxygen species; ASK1, apoptosis signal-regulating kinase 1; PC
مقالات ISI Trx، thioredoxin (ترجمه نشده)
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Keywords: Trx، thioredoxin; ROS, reactive oxygen species; RCS, reactive chlorine species; Trx, thioredoxin; Grx, glutaredoxin; Gor, glutathione oxidoreductase; GSH, glutathione; HOCl, hypochlorous acid; DUOX, dual oxidase; TA, tail-anchored; RO/CS, reactive oxygen and chlorine speci
Keywords: Trx، thioredoxin; ASD, autism spectrum disorders; ROS, reactive oxygen species; TRX, thioredoxin; BMI, body mass index; CARS, Childhood Autism Rating Scale; CV, coefficients of variation; WBC, white blood cell count; Hs-CRP, high sensitivity C-reactive protein; HCY, homocy
Adenine nucleotide-dependent and redox-independent control of mitochondrial malate dehydrogenase activity in Arabidopsis thaliana
Keywords: Trx، thioredoxin; AMS, 4-acetamido-4′-maleimidylstilbene-2,2′-disulfonate; mMDH, mitochondrial malate dehydrogenase; TCA cycle, tricarboxylic acid cycle; Trx, thioredoxin; OAA, oxaloacetic acidAdenine nucleotide balance; Arabidopsis thaliana; Mitochondrial malate dehydroge
Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells
Keywords: Trx، thioredoxin; T2DM, type 2 diabetes mellitus; ROS, reactive oxygen species; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Trx, thioredoxin; TrxR, thioredoxin reductase; ASK1, apoptosis signal-regulating kinase 1; JNK, c-Jun NH2-terminal kinaseSodiu
Purification and characterization of Taenia crassiceps cysticerci thioredoxin: insight into thioredoxin-glutathione-reductase (TGR) substrate recognition
Keywords: Trx، thioredoxin; Eg, Echinococcus granulosus; Fh, Fasciola hepatica; GSH, reduced glutathione; HsTrx, human thioredoxin; Pf, Plasmodium falciparum; Sm, Schistosoma mansoni; Tc, Taenia crassiceps; Ts, Taenia solium; TE, 50 mM Tris plus 1 mM EDTA buffer; Trx, thioredoxin; T
Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-κB pathway
Keywords: Trx، thioredoxin; AP-1, activator protein 1; ASK1, apoptosis signal-regulating kinase 1; CT antigen, cancer-testis antigen; NF-κB, nuclear factor-κB; Txl-2, thioredoxin-like protein 2; Trx, thioredoxin; VCR, vincristineColon cancer; Proliferation; Apoptosis; Thioredoxin-li
Identification of distinctive interdomain interactions among ZP-N, ZP-C and other domains of zona pellucida glycoproteins underlying association of chicken egg-coat matrix
Keywords: Trx، thioredoxin; ZP, zona pellucida; IHP, internal hydrophobic patch; EHP, external hydrophobic patch; TGFR, transforming growth factor-β receptor; Trx, thioredoxin; His6, hexahistidine; EGF, epidermal growth factor; DTT, dithiothreitol; CBB, Coomassie Brilliant Blue; RT,
Substitution of Thr55 by Gly and Lys48 by Asp in OsTrx20 using site-directed mutagenesis
Keywords: Trx، thioredoxin; Rice; Site-directed mutagenesis; Thioredoxin; OsTrx20IPTG, isopropyl β-d-thiogalactopyranoside; Trx, Thioredoxin; Os, Oryza sativa
Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format
Keywords: Trx، thioredoxin; DENV, dengue virus serotype; HCV, hepatitis C virus; NS3, non-structural protein 3; FL, full length; H, helicase domain; Trx, thioredoxin; RFU, relative fluorescence unitDengue virus; NS3; RNA helicase; ATP hydrolysis; Suramin; Counter screen
Brain mitochondria from DJ-1 knockout mice show increased respiration-dependent hydrogen peroxide consumption
Keywords: Trx، thioredoxin; DJ-1; Thioredoxin; Thioredoxin reductase; Oxidative stress; Mitochondria; Parkinson’s diseasePD, Parkinson’s disease; DA, dopaminergic; Trx, thioredoxin; TrxR, thioredoxin reductase; Trx1, cytosolic trx; Trx2, mitochondrial trx; TrxR1, cytosolic TrxR; Trx
Adenanthin targets proteins involved in the regulation of disulphide bonds
Keywords: Trx، thioredoxin; DMSO, dimethyl sulfoxide; EAE, experimental autoimmune encephalitis; FBS, fetal bovine serum; MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; PDI, protein disulphide isomerase; Prdx, peroxiredoxin; Trx, thioredoxin; TrxR, thioredoxin re
Suppression of the pro-inflammatory NLRP3/interleukin-1β pathway in macrophages by the thioredoxin reductase inhibitor auranofin
Keywords: Trx، thioredoxin; IL-1, interleukin-1; LPS, lipopolysaccharide; NLRP3, Nod-like receptor protein 3; TLR, toll-like receptor; Trx, thioredoxin; TrxR, thioredoxin reductaseMacrophage; Thioredoxin reductase; Interleukin-1β; NLRP3; Toll-like receptor; Inflammation
METHODS FOR RECOMBINANT EXPRESSION AND FUNCTIONAL CHARACTERIZATION OF HUMAN CANNABINOID RECEPTOR CB2
Keywords: Trx، thioredoxin; Cannabinoid receptor CB2; recombinant expression; purification; functional reconstitution; G protein activationGPCR, G protein-coupled receptors; MBP, maltose-binding protein; Trx, thioredoxin; CHS, cholesteryl hemisuccinate; DDM, n-dodecyl β-D-maltoside;
Peptide Binding by Catalytic Domains of the Protein Disulfide Isomerase-Related Protein ERp46
Keywords: Trx، thioredoxin; EDTA, ethylenediaminetetraacetic acid; ER, endoplasmic reticulum; GST, glutathione S-transferase; PDB, Protein Data Bank; PDI, protein disulfide isomerase; Trx, thioredoxin; WT, wild typechaperone; substrate binding; peptide microarray; X-ray crystal stru
Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target
Keywords: Trx، thioredoxin; PfTrxR, Plasmodium falciparum thioredoxin reductase; HsTrxR, homo sapiens thioredoxin reductase; Trx, thioredoxin; GSH, reduced glutathione; NADPH, nicotinamide adenine dinucleotide phosphate; FAD, flavin adenine dinucleotide; DTNB, 5,5′-dithio-bis (2-nit
The first chordate big defensin: Identification, expression and bioactivity
Keywords: Trx، thioredoxin; Protochordate; Amphioxus; Branchiostoma; Big defensin; Antimicrobial activityBjBD, Branchiostoma japonicum big defensin; AMPs, antimicrobial peptides; qRT-PCR, quantitative real-time PCR; LPS, lipopolysaccharide; LTA, lipoteichoic acid; Trx, thioredoxin;
Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression
Keywords: Trx، thioredoxin; Srx, sulfiredoxin; Prx, peroxiredoxin; CP, peroxidatic cysteine; CR, resolving cysteine; Trx, thioredoxin; Grx, glutaredoxin; TLR4, Toll-like receptor 4; ARE, antioxidant response element; NF-κB, nuclear factor-κB; AP-1, activator protein-1; TPA, 12-O-tet
Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent
Keywords: Trx، thioredoxin; ethaselen, 1,2-[bis(1,2-benzisoselenazolone 3(2H)-ketone)] ethane; GR, glutathione reductase; GSH, glutathione; GSH-Px, glutathione peroxidase; GSSG, glutathione disulfide; ROS, reactive oxygen species; Sec, selenocysteine; Trx, thioredoxin; TrxR, thiored
Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes
Keywords: Trx، thioredoxin; ROS, reactive oxygen species; GSH, reduced glutathione; Grx, glutaredoxin; Glr, glutathione reductase; Trx, thioredoxin; Trr, thioredoxin reductase; GSSG, glutathione disulfide; rxYFP, redox-sensitive yellow fluorescent protein; IMS, mitochondrial interme
Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells
Keywords: Trx، thioredoxin; 2-DG, 2-deoxy-D-Glucose; 6-AN, 6-aminonicotinamide; ROS, reactive oxygen species; PPP, pentose phosphate pathway; Trx, thioredoxin; ASK1, Apoptosis signal-regulating kinase 1; JNK, c-Jun N-terminal kinase; MAPKKK, mitogen-activated protein kinase kinase k
Split intein facilitated tag affinity purification for recombinant proteins with controllable tag removal by inducible auto-cleavage
Keywords: Trx، thioredoxin; DnaBN, N-terminal domain of Ssp DnaB intein; DnaBC, C-terminal domain of Ssp DnaB intein; CBD, chitin binding domain; Trx, thioredoxin; MBP, maltose binding protein; ETI, Erythrina trypsin inhibitor; BNP, brain natriuretic peptideProtein splicing; Protein
Redox regulation of UDP-glucose pyrophosphorylase from Entamoeba histolytica
Keywords: Trx، thioredoxin; UDP-glucose pyrophosphorylase; Entamoeba histolytica; Redox; Carbohydrate metabolism; ThiolDTT, dithiothreitol; GPI, glycosylphosphatidylinositol; RNS, nitrogen reactive species; ROS, oxygen reactive species; SNP, sodium nitroprusside; TRX, thioredoxin; T
Catalytic activity of selenomethionine in removing amino acid, peptide, and protein hydroperoxides
Keywords: Trx، thioredoxin; BSA, bovine serum albumin; FOX, Fe(II)–xylenol orange complex; GPx, glutathione peroxidase; GSSG, glutathione disulfide; GSH, l-glutathione; Sec, selenocysteine; SeMet, seleno-l-methionine; SeMetO, seleno-l-methionine selenoxide; Trx, thioredoxin; TrxR, t
Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila
Keywords: Trx، thioredoxin; TRX, Thioredoxin; ROS, reactive oxygen species; Sod, superoxide dismutase; cat, catalase; GS, glutathione synthetase; RT-PCR, real-time polymerase chain reaction; UAS, upstream activating sequenceThioredoxin; Paraquat; Hydrogen peroxide; Protein carbonyl
Cell migration-promoting and apoptosis-inhibiting activities of Bm-TFF2 require distinct structure basis
Keywords: Trx، thioredoxin; Bm-TFF2; Expression; Cell migration; Anti-apoptosis; Wound healingTFF, trefoil factor; SP, spasmolytic polypeptide; ITF, intestinal trefoil factor; TRX, thioredoxin; ERK, extracellular signal-regulated kinase; pERK1/2, phospho-ERK1/2; PARP, poly ADP–ribos
Increased levels of thioredoxin in patients with abdominal aortic aneurysms (AAAs). A potential link of oxidative stress with AAA evolution
Keywords: Trx، thioredoxin; TRX, thioredoxin; AAA, abdominal aortic aneurysm; RBCs, red blood cells; PMNs, polymorphonuclear neutrophils; MPO, myeloperoxidase; MIF, macrophage inhibitory factorBiomarkers; Abdominal aortic aneurysm; Oxidative stress
p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells
Keywords: Trx، thioredoxin; TXNIP, thioredoxin interacting protein; TRX, Thioredoxin; HG, high glucose; MMC, mouse mesangial cell; DN, diabetic nephropathy; MAPK, mitogen-activated protein kinase; ROS, reactive oxygen speciesHigh glucose; Thioredoxin interacting protein; p38 mitogen
trans-Resveratrol downregulates Txnip overexpression occurring during liver ischemia-reperfusion
Keywords: Trx، thioredoxin; VDUP-1; Hepatoprotection; Thioredoxin; Oxidative stress; PolyphenolI/R, ischemia-reperfusion; T-res, trans-resveratrol; Txnip, thioredoxin-interacting protein; Trx, thioredoxin; TrxR, thioredoxin reductase
Mechanisms and genes involved in enhancement of HIV infectivity by tobacco smoke
Keywords: Trx، thioredoxin; FRAP, ferric reducing ability of plasma; t-BOOH, tert-butyl-hydroperoxide; Trx, thioredoxin; TSE, tobacco smoke extractTobacco; Smoke; HIV-1; Infectivity
Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat
Keywords: Trx، thioredoxin; GSH, glutathione; GSHr, glutathione reductase; TRX, thioredoxin; TRXr, thioredoxin reductase; SOD, superoxide dismutaseNeuronal protection; Redox system; Nerve injury; Hypoglossal; Rat
The roles of the thioredoxin system and peroxiredoxins in 1-methyl-4-phenyl-pyridinium ion-induced cytotoxicity in rat pheochromocytoma cells
Keywords: Trx، thioredoxin; DA, dopamine; DHE, dihydroethidine; MPP+, 1-methyl-4-phenyl-pyridinium ion; PC12, pheochromocytoma; Trx, thioredoxin; TrxR, thioredoxin reductase; Prx, peroxiredoxin11-Methyl-4-phenyl-pyridinium ion; Peroxiredoxin; Thioredoxin; Thioredoxin reductase
Evidence of non-functional redundancy between two pea h-type thioredoxins by specificity and stability studies
Keywords: Trx، thioredoxin; Protein stability; Protein structure; Protein target; Proteomics; ThioredoxinCD, circular dichroism; GdmCl, guanidinium hydrochloride; PsTRXh1, Pisum sativum thioredoxin h1; PsTRXh2, Pisum sativum thioredoxin h2; Tm, thermal midpoint; TRX, thioredoxin; UV
Redox regulation of the tumor suppressor PTEN by glutathione
Keywords: Trx، thioredoxin; PTEN, phosphatase and tensin homolog deleted on chromosome 10; H2O2, hydrogen peroxide; GSH, glutathione; Trx, thioredoxin; Gsh1, γ-glutamylcysteine synthetase; Gsh2, GSH synthetase; NEM, N-ethylmaleimide; PAGE, polyacrylamide gel electrophoresis; HPLC, h
Engineered mutated glutaredoxins mimicking peculiar plant class III glutaredoxins bind iron–sulfur centers and possess reductase activity
Keywords: Trx، thioredoxin; Active site; Glutaredoxin; Iron–sulfur cluster; PlantGrx, glutaredoxin; GSH, reduced glutathione; ISC, iron–sulfur cluster; Trx, thioredoxin
Mitochondrial 1-Cys-peroxiredoxin/thioredoxin system protects manganese-containing superoxide dismutase (Mn-SOD) against inactivation by peroxynitrite in Saccharomyces cerevisiae
Keywords: Trx، thioredoxin; ONOO−, peroxynitrite; Prx, peroxiredoxin; Trx, thioredoxin; Trr, thioredoxin reductase; TPx, thioredoxin peroxidase; Mn-SOD, manganese-containing superoxide dismutase; DHR, dihydroxyrhodamine; SIN-1, 3-morpholinosydnonimine; DTPA, diethylene triamine pent
Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor α liver injury
Keywords: Trx، thioredoxin; TNFα, tumor necrosis factor α; CYP2E1, cytochrome P4502E1; PY, pyrazole; ROS, reactive oxygen species; ASK-1, apoptosis signal-regulating kinase-1; Trx, thioredoxin; MAPK, mitogen-activated protein kinase; MAP3K, MAP kinase kinase kinase; MKK, MAP kinase
Rational Design and Biophysical Characterization of Thioredoxin-Based Aptamers: Insights into Peptide Grafting
Keywords: Trx، thioredoxin; Trx, thioredoxin; eIF4E, elongation initiation factor 4E; MDM2, mouse double minute 2; ITC, isothermal titration calorimetry; TrxA, Escherichia coli thioredoxin; CDK, cyclin-dependent kinase; eIF4G, elongation initiation factor G; eIF4GI, elongation initi
The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe–S proteins
Keywords: Trx، thioredoxin; EPR, electron paramagnetic resonance; HBSS, Hanks’ balanced salt solution; HO•, hydroxyl radical; INT, iodonitrotetrazolium; O2•−, superoxide; SDH, succinate dehydrogenase; Trx, thioredoxin; ZFS, zero field splittingChromate; Chromium(VI); Mitochondria; I
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention
Keywords: Trx، thioredoxin; GR, glutathione reductase; GSH, glutathione; Sec, selenocysteine; Trx, thioredoxin; TrxR, thioredoxin reductase; CA, trans-cinnamaldehyde; CAC, cinnamic acid; SSP1, 2-methoxycinnamaldehyde; BCA, 2-benzoyloxycinnamaldehyde; HCA, 2-hydroxycinnamaldehyde; SS
Redox Regulation of Plasmodium falciparum Ornithine δ-Aminotransferase
Keywords: Trx، thioredoxin; OAT, ornithine δ-aminotransferase; Trx, thioredoxin; Pf, Plasmodium falciparum; Grx, glutaredoxin; Plrx, plasmoredoxin; SPR, surface plasmon resonance; PLP, pyridoxal-5′-phosphate; α-KG, α-ketoglutarate; P5C, pyrroline-5-carboxylate; hOAT, human OAT; wt,
Mechanism of inhibition of ribonucleotide reductase with motexafin gadolinium (MGd)
Keywords: Trx، thioredoxin; RNR, ribonucleotide reductase; Trx, thioredoxin; TrxR, thioredoxin reductase; Grx, glutaredoxin; GR, glutathione reductase; MGd, motexafin gadolinium; FCS, fluorescence correlation spectroscopyMotexafin gadolinium; Ribonucleotide reductase
Preferential overexpression of glutaredoxin3 in human colon and lung carcinoma
Keywords: Trx، thioredoxin; Glrx, glutaredoxin; PICOT, PKC-interacting cousin of thioredoxin; Prx, peroxiredoxin; Trx, thioredoxin; CEA, carcinoembryonic antigen; NSE, neuron-specific enolase; DTT, dithiothreitol; SDS, sodium dodecyl sulfate; PAGE, polyacrylamide gel electrophoresis
Metabolism of selenium compounds catalyzed by the mammalian selenoprotein thioredoxin reductase
Keywords: Trx، thioredoxin; TrxR, thioredoxin reductase; Trx, thioredoxin; Sec(U), selenocysteine; GPx, glutathione peroxidase; GSH, glutathione; DTNB, 5,5′-dithiobis(2-nitrobenzoic acid); DTT, dithiothreitol; NADPH, nicotinamide adenine dinucleotide phosphate hydrogen; SBP2, SECIS
Structure and stability of a thioredoxin reductase from Sulfolobus solfataricus: A thermostable protein with two functions
Keywords: Trx، thioredoxin; Trx, thioredoxin; TrxR, thioredoxin reductase; SsTrxRB3, S. solfataricus TrxRB3; EcTrxR, E. coli TrxR; AtTrxR, A. thaliana TrxR; HpTrxR, H. pylori TrxR; MtTrxR, M. tuberculosis TrxR; FAD, flavin adenine dinucleotide; NADP, nicotinamide adenine dinucleotid
Thioredoxin-related protein 14, a new member of the thioredoxin family with disulfide reductase activity: Implication in the redox regulation of TNF-α signaling
Keywords: Trx، thioredoxin; TRP14, Trx-related protein 14; Trx, thioredoxin; NF-κB, nuclear factor-κB; TNF-α, tumor necrosis factor-α; MAPK, mitogen-activated protein kinase; Grx, glutaredoxin; Nrx, nucleoredoxin; PDI, protein disulfide isomerase; RNR, ribonucleotide reductase; Prx,
Methionine Sulfoxide Reductase B Displays a High Level of Flexibility
Keywords: Trx، thioredoxin; Msr, methionine sulfoxide reductase; Met-O, methionine sulfoxide; Trx, thioredoxin; PDB, Protein Data Bank; SeMet, selenomethionine; PEG, polyethylene glycol; MRNT, Ministère de la Recherche et des Nouvelles Technologiesmethionine sulfoxide reductase B; X
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
Keywords: Trx، thioredoxin; Trx, thioredoxin; TrxR, thioredoxin reductase; DTNB, 5,5′-dithiobis[2-nitrobenzoic acid]; Sec, selenocysteine; DNCB, 1-chloro-2,4-dinitrobenzene; cDDP, cisplatin; Oxa, oxaliplatin; SecTRAP, selenium-compromised thioredoxin reductase-derived apoptotic prot
Comparative modeling of thioredoxin glutathione reductase from Schistosoma mansoni: A multifunctional target for antischistosomal therapy
Keywords: Trx، thioredoxin; WHO, World Health Organization; Grx, Glutaredoxin; Trx, Thioredoxin; GR, Glutathione Reductase; GSH, Glutathione; GPx, Glutathione Peroxidase; GSSG, Glutathione disulfide; TR, Thioredoxin Reductase; TPx, Thioredoxin Peroxidase; SeC, Selenocysteine motif;
In silico identification of the protein disulfide isomerase family from a protozoan parasite
Keywords: Trx، thioredoxin; PDI, protein disulfide isomerase; Trx, thioredoxin; SNP, single nucleotide polymorphism; ER, endoplasmic reticulumProtozoa; Parasite; Entamoeba histolytica; Protein disulfide isomerase family