Keywords: Cancer; Resistance; Drug metabolizing enzymes; UGTs; GSTs; DPDs; TPMTs;
مقالات ISI (ترجمه نشده)
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Keywords: Therapeutic drug monitoring; Antipsychotic; Antidepressant; Psychopharmacology; Psychiatry; Psychopharmacotherapy; Pharmacokinetics; HPLC; Mass spectrometry; LC-MS/MS; ABCB1; ATP-binding cassette sub-family B member 1; AGNP; Arbeitsgemeinschaft für Neuro
Keywords: ABCB; ATP-binding cassette sub-family B; Apo; apolipoprotein; ASBT; apical sodium dependent bile acid transporter; BDL; bile duct ligation; BSEP; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; C/EBP; CCAAT-enhancer-binding protein; C
Keywords: Diethylnitrosamine; Alkenal/one oxidoreductase; Carcinogen detoxification enzymes; 4-Hidroxynonenal; Tumor marker; HCC; hepatocellular carcinoma; DEN; diethylnitrosamine; S&F; Solt and Farber model; LTB4; leukotriene B4; PGE2; prostaglandin E2; 15d-PGJ2;
Keywords: Rhubarb; Anthraquinones; Glucuronidation; UGTs; Regioselectivity
Keywords: AD; Alzheimer's disease; Aβ; β amyloid peptide; ERT; estrogen replacement therapy; ESR; estrogen receptor; E1; estrone; E2; estradiol; E3; estriol; CYP; cytochrome P450; CYP11A1; cytochrome P450 cholesterol side chain cleavage enzyme; HSD-3β; 3β-hydro
Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Keywords: CYP450; CYP2C9 variants; Synthetic cannabinoids; Enzyme kinetics; Toxicity; Î9-THC; (â)-Î9-Tetrahydrocannabinol; P450; cytochrome P450; CYP; specific P450; UGTs; uridine diphosphate (UDP)-glucuronosyltransferases; LC-MS/MS; Liquid chromatography-tande
Integrated metabolomic and transcriptomic analyses revealed the distribution of saponins in Panax notoginseng
Keywords: AACT; acetoacetyl-CoA acyltransferase; DS; dammarenediol-II synthase; DXPS; 1-deoxy-d-xylulose 5-phosphate synthase; DXPR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPS; farnesyl pyrophosphate synthase; FPP; farnesyl diphosphate; GDPS; gerenyl diph
Downregulation of aldose reductase is responsible for developmental abnormalities of the silkworm purple quail-like mutant (q-lp)
Keywords: q-lp; purple quail-like; AR; aldose reductase; BmAR; Bombyx mori aldose reductase; 2-DE; two-dimensional gel electrophoresis; qRT-PCR; quantitative reverse transcription PCR; NADPH; nicotinamide adenine dinucleotide phosphate; SDS-PAGE; sodium dodecyl sul
Resveratrol represses estrogen-induced mammary carcinogenesis through NRF2-UGT1A8-estrogen metabolic axis activation
Keywords: 2-MeOE1/E2; 4-MeOE1/E2, methoxyestrogens; 2-OHE1/E2; 4-OHE1/E2, hydroxyestrogens; 53BP1; tumor protein p53 binding protein 1; DMBA; 7,12-dimethylbenz(a)anthracene; DSBs; DNA double-strand breaks; E1; estrone; E2; estradiol; E2-3G; E2-3-glucuronide; E2-17G
UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro
Keywords: Morusin; Glucuronidation; First-pass metabolism; Pharmacokinetics; UGTs; CYPs;
Inhibition of UDP-glucuronosyltransferase (UGT)-mediated glycyrrhetinic acid 3-O-glucuronidation by polyphenols and triterpenoids
Keywords: UDP-Glucuronosyltransferase; UGT; Licorice; Glycyrrhetinic acid; Glycyrrhizin; Glucuronidation; Glucuronide; Natural medicine; Adverse reaction; Pseudohyperaldosteronism; DMSO; dimethyl sulfoxide; GA; Glycyrrhetinic acid; HPLC; high-performance liquid chr
Genome-wide identification of glycosyltransferases converting phloretin to phloridzin in Malus species
Keywords: DHC; dihydrochalcone; GTs; glycosyltransferases; HPLC; high performance liquid chromatography; PSPG; plant secondary product glycosyltransferase; qRT-PCR; quantitative real-time PCR; RT-PCR; reverse-transcription PCR; UDP; uridine diphosphate; UGTs; UDP-d
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors
Keywords: UDPGA; 5â²-diphosphoglucuronic acid; CRMs; chemically reactive metabolites; CYP; cytochrome P450; HLM; human liver microsomes; PHH; primary human hepatocytes; UGTs; UDP-glucuronosyltransferases; β-estradiol (PubChem CID:5757); Chenodeoxycholic acid (Pub
Identification and characterization of human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of ursolic acid
Keywords: Ursolic acid; UDP-glucuronosyltransferases; Metabolism pathway; Metabolism characterization; UA; ursolic acid; HLMs; human liver microsomes; HIMs; human intestinal microsomes; UGTs; UDP-glucuronosyltransferases; DDI; drug-drug interactions; RILD; Resear
Genome-wide analysis of Family-1 UDP-glycosyltransferases in soybean confirms their abundance and varied expression during seed development
Keywords: UGTs; UDP-glycosyltransferases; PSPG; plant secondary product glycosyl-transferase; RPKM; reads per kilobase of gene model per million mapped reads; CAZy; carbohydrate-active enzymes; MEME; multiple em for motif elicitation; UDP; uridine-diphosphate; PSWM
MicroRNAs as key mediators of hepatic detoxification
Keywords: CYP; cytochrome p450; UGTs; UDP glycosyltransferases; GSTs; glutathione-S-transferases; SULTs; sulfotransferases; OATs; organic anion transporters; MRPs; multidrug-resistance proteins; DGCR8; DiGeorge Syndrome Critical Region Gene 8; RISC; RNA-induced sil
Regio- and Isoform-Specific Glucuronidation of Psoralidin: Evaluation of 3-O-Glucuronidation as a Functional Marker for UGT1A9
Keywords: glucuronidation; UGTs; psoralidin; functional marker; reaction phenotyping;
Synthesis of amphiphilic resveratrol lipoconjugates and evaluation of their anticancer activity towards neuroblastoma SH-SY5Y cell line
Keywords: Resveratrol; Amphiphilic resveratrol lipoconjugates; Neuroblastoma SH-SY5Y cells; Human fibroblasts; Antitumour activity; CHD; coronary heart disease; SULTs; sulfotransferases; UGTs; uridine diphosphate glucuronosyltransferases; DBU; 1,8-diazabicyclo[5.4.
Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line
Keywords: PXR; pregnane X receptor; hPXR; human pregnane X receptor; PBDE; polybrominated diphenyl ethers; BDE-47; 2,2â²,4,4â²-tetra-bromodiphenyl ether; CYP3A4; cytochrome P450 3A4; TRs; thyroid receptors; TREs; thyroid hormone response elements; UGTs; uridine d
Regioselective glucuronidation of the isoflavone calycosin by human liver microsomes and recombinant human UDP-glucuronosyltransferases
Keywords: HLMs; human liver microsomes; UGTs; UDP-glucuronosyltransferases; SGR; Structure-glucuronidation relationship; HPLC; high performance liquid chromatography; NADPH; nicotinamide adenine dinucleotide phosphate reduced; CYP450s; cytochrome P450s; PAPS; 3â
Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes
Keywords: UGTs; uridine diphosphate glucuronosyltransferase; UDPGA; uridine diphosphate-glucuronic acid; APAP; acetaminophen, paracetamol; ALT; alanine aminotransferase; AST; aspartate aminotransferase; GSH; glutathione; LDH; lactate dehydrogenase; MDA; malondialde
Absorption and metabolism of milk thistle flavanolignans in humans
Keywords: HCV; hepatitis C virus; ESI; electrospray interface; MRM; multiple reaction monitoring; UDP; uridine diphosphate; UGTs; UDP-glucuronosyltransferases; SULTs; sulphotransferases; EHR; entero-hepatic recirculation; amu; atomic mass unit; Flavanolignans; Urin
Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes
Keywords: UDP-glucuronosyltransferase; Astrocytes; Oxidative stress; NADPH:cytochrome P450 reductase; NAD(P)H:quinone oxidoreductase 1; 1-NP; 1-naphthol; ARE; antioxidant response element; DMSO; dimethyl sulfoxyde; FeHQ; FeCl3/8-hydroxyquinoline; FITC; fluorescein
Pharmacokinetic Interplay of Phase II Metabolism and Transport: A Theoretical Study
Keywords: phase II metabolism; interplay; efflux transporters; Caco-2 cells; PBPK; UGTs; glucuronidation; CYP enzymes;
Use of Physiologically Based Pharmacokinetic Models to Evaluate the Impact of Intestinal Glucuronide Hydrolysis on the Pharmacokinetics of Aglycone
Keywords: Intestinal metabolism; hepatic metabolism; UGTs; glucuronidation; intestinal bacteria; ABC transporters; pharmacokinetics;
Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors
Keywords: ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A
First-Pass Metabolism via UDP-Glucuronosyltransferase: a Barrier to Oral Bioavailability of Phenolics
Keywords: phenolics; polyphenols; glucuronidation; bioavailability; UGTs; flavonoids; regioselectivity; first-pass metabolism
Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats
Keywords: BBR; pharmacokinetics; metabolic clearance; microsomes; enzyme kinetics; CYPs; UGTs;
Molecular cloning and characterization of one member of 3β-hydroxy sterol glucosyltransferase gene family in Withania somnifera
Keywords: Withania somnifera; Sterol glucosyltransferase; UGTs; Substrate specificity; Secondary metabolism; Salicylic acid; Heat shock
Phenylalanine90 and phenylalanine93 are crucial amino acids within the estrogen binding site of the human UDP-glucuronosyltransferase 1A10
Keywords: UGTs; UGT1A10; Estrogens; Binding site; Site-directed mutagenesis
Nrf2-Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species
Keywords: ARE; Antioxidant-responsive element; BHA; Butylated hydroxyanisole; BTB; Broad complex-tramtrack-bric-a-brac; bZip; Basic leucine zipper; CBP; CREB binding protein; C/EBPβ; CCAAT/enhancer binding protein β; CNC; Cap' n' collar; Cox2; Cyclooxygenase
Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
Keywords: Akt; protein kinase B; ERKs; extracellular signal-regulated kinases; ITCs; isothiocyanates; JNK; c-Jun N-terminal kinase; MAPKs; mitogen-activated protein kinases; MRP2; multidrug resistance-associated protein 2; NF-κB; nuclear factor-kappa B; NQO1; NADP