Keywords: گروه اتصال دهنده روی; HDAC6 selective inhibitor; Computer-aided drug design; Anti-sepsis; HDAC; histone deacetylase; LPS; lipopolysaccharide; HDACi; histone deacetylase inhibitors; IL; interleukin; IFNγ; interferon γ; TNF-α; tumor necrosis factor-α; ZBD; zinc-binding group
مقالات ISI گروه اتصال دهنده روی (ترجمه نشده)
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Synthesis, biological evaluation and computational studies of novel iminothiazolidinone benzenesulfonamides as potent carbonic anhydrase II and IX inhibitors
Keywords: گروه اتصال دهنده روی; Carbonic anhydrase; Zinc-binding group; Nanomolar inhibition; Anti-glaucoma; Anti-tumour;
Synthesis and biological evaluation of novel pyrazoline-based aromatic sulfamates with potent carbonic anhydrase isoforms II, IV and IX inhibitory efficacy
Keywords: گروه اتصال دهنده روی; Carbonic anhydrase; ZInc-binding group; Aromatic sulfamates; Celecoxib; Sulfamoylation; Sub-nanomolar inhibition;
Discovery of thiazolin-4-one-based aromatic sulfamates as a new class of carbonic anhydrase isoforms I, II, IV, and IX inhibitors
Keywords: گروه اتصال دهنده روی; Carbonic anhydrase; Zinc-binding group; Aromatic sulfamates; Phenols; Sulfamoylation; Nanomolar inhibition;
Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform
Keywords: گروه اتصال دهنده روی; Carbonic anhydrase; Zinc-binding group; hCA IX; Dual-tails; Selectivity; Anti-tumor;
Synthesis and biological evaluation of Santacruzamate-A based analogues
Keywords: گروه اتصال دهنده روی; AcCN; acetonitrile; BnOH; benzyl alcohol; DMF; N,N-dimethylformamide; DMSO; dimethylsulphoxide; EtOAc; ethyl acetate; EtOH; ethanol; GABA; γ-aminobutyric acid; GADPH; glyceraldehyde 3-phosphate dehydrogenase; HBTU; O-(benzotriazol-1-yl)-N,N,Nâ²,Nâ²-tet
Design, synthesis, and biological activity of novel, potent, and highly selective fused pyrimidine-2-carboxamide-4-one-based matrix metalloproteinase (MMP)-13 zinc-binding inhibitors
Keywords: گروه اتصال دهنده روی; Matrix metalloproteinase; MMP-13; Fused pyrimidine-2-carboxamide; Zinc-binding group; Structure-based drug design; Osteoarthritis;
Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions
Keywords: گروه اتصال دهنده روی; Plasmodium falciparum; Malaria; Aminopeptidase inhibitors; Hydroxamic acid; Zinc-binding group; MAP; metalloaminopeptidase; ZBG; zinc binding group; Pf; Plasmodium falciparum; Dd2 SpiroR; NITD609-RDd2 clone#2; CDI; carbonyldiimidazole; FCC; flash column c
Synthesis of potential metal-binding group compounds to examine the zinc dependency of the GPI de-N-acetylase metalloenzyme in Trypanosoma brucei
Keywords: گروه اتصال دهنده روی; Glycosylphosphatidylinositol (GPI) biosynthesis; Zinc metalloenzyme inhibitor; Zinc-binding group; Branched monosaccharides; Phosphatidylinositol de-N-acetylase;
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors
Keywords: گروه اتصال دهنده روی; BSA; benzenesulfonamide; HPM; hydroxypyrimidinone; CA; carbonic anhydrase; MMP; matrix metalloproteinase; ZBG; zinc-binding group; HA; hydroxamic acid; Hydroxypyrimidinones; Carbonic anhydrase inhibitors; Sulfonamides; MMP inhibitors;
To bind zinc or not to bind zinc: An examination of innovative approaches to improved metalloproteinase inhibition
Keywords: گروه اتصال دهنده روی; Zinc-binding group; Mechanism-based inhibitor; MMP
Carbonic anhydrase inhibitors. Inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with anions
Keywords: گروه اتصال دهنده روی; Carbonic anhydrase; Candida glabrata; Candida albicans; Anion; Zinc-binding group; Bicarbonate; Antifungals
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs)
Keywords: گروه اتصال دهنده روی; Matrix metalloproteinase inhibitor; Arylsulfone; MMP-2; MMP-9; Zinc-binding group
Synthesis of a 200-member library of squaric acid N-hydroxylamide amides
Keywords: گروه اتصال دهنده روی; Squaric acid; Squaric acid N-hydroxylamide amide; Zinc-binding group; Metalloprotease; ADAMTS-5
Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A
Keywords: گروه اتصال دهنده روی; Carboxypeptidase A; Inhibition; Nitro; Zinc-binding group; X-ray crystallography; Transition-state analog inhibitor
Specific targeting of metzincin family members with small-molecule inhibitors: Progress toward a multifarious challenge
Keywords: گروه اتصال دهنده روی; Matrix metalloproteinases; MMP; Metzincins; ADAM; ADAMTS; PCP; Procollagen C-proteinase; Selective; Inhibitor; Specific; Zn-metalloproteinases; TACE; Hydroxamate; Phosphinic; Zinc-binding group
Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity
Keywords: گروه اتصال دهنده روی; Matrix metalloproteinase; Selective MMP-9 inhibition; Sulfonylhydrazide; Zinc-binding group; Ilomastat; Molecular modeling
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I
Keywords: گروه اتصال دهنده روی; Carbonic anhydrase; Foscarnet; Isozymes; X-ray crystallography; Zinc-binding group; Enzyme inhibitor; Enzyme activator