Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action Fulltext Access 6 Pages 2015
Structural basis for the substrate selectivity of a HAD phosphatase from Thermococcus onnurineus NA1 Fulltext Access 6 Pages 2015
Tumor-infiltrating lymphocyte activity is enhanced in tumors with low IL-10 production in HBV-induced hepatocellular carcinoma Fulltext Access 6 Pages 2015
Enhanced expression of the β4-N-acetylgalactosaminyltransferase 4 gene impairs tumor growth of human breast cancer cells Fulltext Access 6 Pages 2015
Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA Fulltext Access 6 Pages 2015
NFAT5 promotes proliferation and migration of lung adenocarcinoma cells in part through regulating AQP5 expression Fulltext Access 6 Pages 2015
Tsukushi expression is dependent on Notch signaling and oscillated in the presomitic mesoderm during chick somitogenesis Fulltext Access 6 Pages 2015
Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway Fulltext Access 6 Pages 2015
The E-box-like sterol regulatory element mediates the insulin-stimulated expression of hepatic clusterin Fulltext Access 6 Pages 2015
Neuronal differentiation of human iPS cells induced by baicalin via regulation of bHLH gene expression Fulltext Access 6 Pages 2015
Dehydrodiconiferyl alcohol suppresses monocyte adhesion to endothelial cells by attenuation of JNK signaling pathway Fulltext Access 6 Pages 2015
Myelin basic protein is a glial microtubule-associated protein - Characterization of binding domains, kinetics of polymerization, and regulation by phosphorylation and a lipidic environment Fulltext Access 6 Pages 2015
AMPK dependent protective effects of metformin on tumor necrosis factor-induced apoptotic liver injury Fulltext Access 6 Pages 2015
Metformin reduces the endotoxin-induced down-regulation of apolipoprotein E gene expression in macrophages Fulltext Access 6 Pages 2015
MicroRNA-135b suppresses extravillous trophoblast-derived HTR-8/SVneo cell invasion by directly down regulating CXCL12 under low oxygen conditions Fulltext Access 6 Pages 2015
Red-shifted red/green-type cyanobacteriochrome AM1_1870g3 from the chlorophyll d-bearing cyanobacterium Acaryochloris marina Fulltext Access 6 Pages 2015
Micropillar displacements by cell traction forces are mechanically correlated with nuclear dynamics Fulltext Access 6 Pages 2015
PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction Fulltext Access 6 Pages 2015
Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia Fulltext Access 6 Pages 2015
Activation of AMPA receptor promotes TNF-α release via the ROS-cSrc-NFκB signaling cascade in RAW264.7 macrophages Fulltext Access 6 Pages 2015
High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats Fulltext Access 6 Pages 2015
Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways Fulltext Access 6 Pages 2015
Myostatin regulates miR-431 expression via the Ras-Mek-Erk signaling pathway Fulltext Access 6 Pages 2015
miR-29a promotes scavenger receptor A expression by targeting QKI (quaking) during monocyte-macrophage differentiation Fulltext Access 6 Pages 2015
Regulation of retinoid mediated cholesterol efflux involves liver X receptor activation in mouse macrophages Fulltext Access 6 Pages 2015
The intravenous injection of oxidized LDL- or Apolipoprotein B100 - Coupled splenocytes promotes Th1 polarization in wildtype and Apolipoprotein E - Deficient mice Fulltext Access 6 Pages 2015
ABT-737 sensitizes curcumin-induced anti-melanoma cell activity through facilitating mPTP death pathway Fulltext Access 6 Pages 2015
N-glycosylation modulates filopodia-like protrusions induced by sez-6 through regulating the distribution of this protein on the cell surface Fulltext Access 6 Pages 2015
Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor Fulltext Access 6 Pages 2015
Piperlongumine selectively suppresses ABC-DLBCL through inhibition of NF-κB p65 subunit nuclear import Fulltext Access 6 Pages 2015
An integrated RNA-Seq and network study reveals a complex regulation process of rice embryo during seed germination Fulltext Access 6 Pages 2015
Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1 Fulltext Access 6 Pages 2015
Lafora disease proteins laforin and malin negatively regulate the HIPK2-p53 cell death pathway Fulltext Access 6 Pages 2015
Anti-arthritis effect of a novel quinazoline derivative through inhibiting production of TNF-α mediated by TNF-α converting enzyme in murine collagen-induced arthritis model Fulltext Access 6 Pages 2015
Disruption of β-catenin binding to parathyroid hormone (PTH) receptor inhibits PTH-stimulated ERK1/2 activation Fulltext Access 6 Pages 2015
Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channel Fulltext Access 6 Pages 2015
NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair Fulltext Access 6 Pages 2015
Phospholipase Cβ1b directly binds the SH3 domain of Shank3 for targeting and activation in cardiomyocytes Fulltext Access 6 Pages 2015
Differences in antiproliferative effect of STAT3 inhibition in HCC cells with versus without HBV expression Fulltext Access 6 Pages 2015
Subglutinol A, an immunosuppressive α-pyrone diterpenoid from Fusarium subglutinans, acts as an estrogen receptor antagonist Fulltext Access 6 Pages 2015
NCYM promotes calpain-mediated Myc-nick production in human MYCN-amplified neuroblastoma cells Fulltext Access 6 Pages 2015
Antisense oligonucleotide-mediated exon skipping of CHRNA1 pre-mRNA as potential therapy for Congenital Myasthenic Syndromes Fulltext Access 6 Pages 2015
The small GTPase Rab33A participates in regulation of amylase release from parotid acinar cells Fulltext Access 6 Pages 2015
Off-response in ASH neurons evoked by CuSO4 requires the TRP channel OSM-9 in Caenorhabditis elegans Fulltext Access 6 Pages 2015
Suppression of liver receptor homolog-1 by microRNA-451 represses the proliferation of osteosarcoma cells Fulltext Access 6 Pages 2015
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia Fulltext Access 6 Pages 2015
Eukaryotic initiation factor 4AI interacts with NS4A of Dengue virus and plays an antiviral role Fulltext Access 6 Pages 2015
Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p Fulltext Access 6 Pages 2015
Omeprazole induces NAD(P)H quinone oxidoreductase 1 via aryl hydrocarbon receptor-independent mechanisms: Role of the transcription factor nuclear factor erythroid 2-related factor 2 Fulltext Access 6 Pages 2015
Trichostatin A and Tamoxifen inhibit breast cancer cell growth by miR-204 and ERα reducing AKT/mTOR pathway Fulltext Access 6 Pages 2015
Long non-coding RNA ANRIL is up-regulated in bladder cancer and regulates bladder cancer cell proliferation and apoptosis through the intrinsic pathway Fulltext Access 6 Pages 2015
Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5 Fulltext Access 6 Pages 2015
Spatial dynamics of action potentials estimated by dendritic Ca2+ signals in insect projection neurons Fulltext Access 6 Pages 2015
Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects Fulltext Access 6 Pages 2015
Hepassocin is required for hepatic outgrowth during zebrafish hepatogenesis Fulltext Access 6 Pages 2015
Identification and characterization of the linear region of ATG3 that interacts with ATG7 in higher eukaryotes Fulltext Access 6 Pages 2015
Efficient and dynamic nuclear localization of green fluorescent protein via RNA binding Fulltext Access 6 Pages 2015
Ablation of Dicer leads to widespread perturbation of signaling pathways Fulltext Access 6 Pages 2015
Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy Fulltext Access 6 Pages 2015
Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK Fulltext Access 6 Pages 2015
Drosophila peptidyl-prolyl isomerase Pin1 modulates circadian rhythms via regulating levels of PERIOD Fulltext Access 6 Pages 2015
Chemoresistance of CD133+ colon cancer may be related with increased survivin expression Fulltext Access 6 Pages 2015
Ectopic expression of anti-HIV-1 shRNAs protects CD8+ T cells modified with CD4ζ CAR from HIV-1 infection and alleviates impairment of cell proliferation Fulltext Access 6 Pages 2015
Autophagy sustains the survival of human pancreatic cancer PANC-1 cells under extreme nutrient deprivation conditions Fulltext Access 6 Pages 2015
TGF-β induced miR-132 enhances the activation of TGF-β signaling through inhibiting SMAD7 expression in glioma cells Fulltext Access 6 Pages 2015
Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer Fulltext Access 6 Pages 2015
Pharmacology of hSlo3 channels and their contribution in the capacitation-associated hyperpolarization of human sperm Fulltext Access 6 Pages 2015
Autophagy regulated by prolyl isomerase Pin1 and phospho-Ser-GSK3αβ involved in protection of oral squamous cell carcinoma against cadmium toxicity Fulltext Access 6 Pages 2015
Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes Fulltext Access 6 Pages 2015
PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1 Fulltext Access 6 Pages 2015
1-o-acetylbritannilactone (ABL) inhibits angiogenesis and lung cancer cell growth through regulating VEGF-Src-FAK signaling Fulltext Access 6 Pages 2015
The relationship between glycan structures and expression levels of an endoplasmic reticulum-resident glycoprotein, UDP-glucose: Glycoprotein glucosyltransferase 1 Fulltext Access 6 Pages 2015
Anti-HCV effect of Lentinula edodes mycelia solid culture extracts and low-molecular-weight lignin Fulltext Access 6 Pages 2015
Osteocalcin protects pancreatic beta cell function and survival under high glucose conditions Fulltext Access 6 Pages 2015
A carboxy terminal domain of the L protein of rinderpest virus possesses RNA triphosphatase activity - The first enzyme in the viral mRNA capping pathway Fulltext Access 6 Pages 2015
Functional relationship between CABIT, SAM and 14-3-3 binding domains of GAREM1 that play a role in its subcellular localization Fulltext Access 6 Pages 2015
Unique MicroRNA signatures associated with early coronary atherosclerotic plaques Fulltext Access 6 Pages 2015
XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides Fulltext Access 6 Pages 2015
miR-502 inhibits cell proliferation and tumor growth in hepatocellular carcinoma through suppressing phosphoinositide 3-kinase catalytic subunit gamma Fulltext Access 6 Pages 2015
Stromal cell-derived factor-1 alpha alleviates hypoxic-ischemic brain damage in mice Fulltext Access 6 Pages 2015
A wheat salinity-induced WRKY transcription factor TaWRKY93 confers multiple abiotic stress tolerance in Arabidopsis thaliana Fulltext Access 6 Pages 2015
De novo characterization of Panax japonicus C. A. Mey transcriptome and genes related to triterpenoid saponin biosynthesis Fulltext Access 6 Pages 2015
Tumor-suppressive effects of natural-type interferon-β through CXCL10 in melanoma Fulltext Access 6 Pages 2015
Phosphorylation of Mycobacterium tuberculosis protein tyrosine kinase A PtkA by Ser/Thr protein kinases Fulltext Access 6 Pages 2015
Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress Fulltext Access 6 Pages 2015
Caenorhabditis elegans ATAD-3 modulates mitochondrial iron and heme homeostasis Fulltext Access 6 Pages 2015
Ubiquitous versus restricted expression of the two mouse dendritic cell C-type lectin receptors, DCIR1 and DCAR2, among myeloid cells Fulltext Access 6 Pages 2015
Hepatic scavenger receptor BI is associated with type 2 diabetes but unrelated to human and murine non-alcoholic fatty liver disease Fulltext Access 6 Pages 2015
Selective enhancement of wnt4 expression by cyclic AMP-associated cooperation between rat central astrocytes and microglia Fulltext Access 6 Pages 2015
p53-dependent and p53-independent anticancer activity of a new indole derivative in human osteosarcoma cells Fulltext Access 6 Pages 2015
Direct fluorescence in situ hybridization on human metaphase chromosomes using quantum dot-platinum labeled DNA probes Fulltext Access 6 Pages 2015
Ubiquitination-dependent degradation of p73 by the mitochondrial E3 ubiquitin ligase Hades Fulltext Access 6 Pages 2015