Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes Fulltext Access 8 Pages 2015
Ang-(1-7) promotes the migration and invasion of human renal cell carcinoma cells via Mas-mediated AKT signaling pathway Fulltext Access 8 Pages 2015
CD200R1 agonist attenuates LPS-induced inflammatory response in human renal proximal tubular epithelial cells by regulating TLR4-MyD88-TAK1-mediated NF-κB and MAPK pathway Fulltext Access 8 Pages 2015
Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells Fulltext Access 8 Pages 2015
Expression of seipin in adipose tissue rescues lipodystrophy, hepatic steatosis and insulin resistance in seipin null mice Fulltext Access 8 Pages 2015
Sevoflurane pretreatment attenuates TNF-α-induced human endothelial cell dysfunction through activating eNOS/NO pathway Fulltext Access 8 Pages 2015
p53 signalling mediates acupuncture-induced neuroprotection in Parkinson's disease Fulltext Access 8 Pages 2015
miR-340 inhibits glioblastoma cell proliferation by suppressing CDK6, cyclin-D1 and cyclin-D2 Fulltext Access 8 Pages 2015
Metabolism and cytotoxic effects of phosphatidylcholine hydroperoxide in human hepatoma HepG2 cells Fulltext Access 8 Pages 2015
Coordinated regulation by two VPS9 domain-containing guanine nucleotide exchange factors in small GTPase Rab5 signaling pathways in fission yeast Fulltext Access 8 Pages 2015
Ulinastatin suppresses lipopolysaccharide induced neuro-inflammation through the downregulation of nuclear factor-κB in SD rat hippocampal astrocyte Fulltext Access 8 Pages 2015
Dysregulation of long non-coding RNAs in mouse models of localization-related epilepsy Fulltext Access 8 Pages 2015
A phosphomimetic mutant TDP-43 (S409/410E) induces Drosha instability and cytotoxicity in Neuro 2A cells Fulltext Access 8 Pages 2015
MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma Fulltext Access 8 Pages 2015
Inhibition of miR-146b expression increases radioiodine-sensitivity in poorly differential thyroid carcinoma via positively regulating NIS expression Fulltext Access 8 Pages 2015
Bradykinin increased the permeability of BTB via NOS/NO/ZONAB-mediating down-regulation of claudin-5 and occludin Fulltext Access 8 Pages 2015
Differential regulation of HIF-1α and HIF-2α in neuroblastoma: Estrogen-related receptor alpha (ERRα) regulates HIF2A transcription and correlates to poor outcome Fulltext Access 8 Pages 2015
OCT4 mediates FSH-induced epithelial-mesenchymal transition and invasion through the ERK1/2 signaling pathway in epithelial ovarian cancer Fulltext Access 8 Pages 2015
Transforming growth factor-α induces human ovarian cancer cell invasion by down-regulating E-cadherin in a Snail-independent manner Fulltext Access 8 Pages 2015
Idebenone protects against oxidized low density lipoprotein induced mitochondrial dysfunction in vascular endothelial cells via GSK3β/β-catenin signalling pathways Fulltext Access 8 Pages 2015
Fatty acid transport protein-2 inhibitor Grassofermata/CB5 protects cells against lipid accumulation and toxicity Fulltext Access 8 Pages 2015
Characterization of monoclonal antibodies against porcine pulmonary alveolar macrophages of gnotobiotic miniature swine Fulltext Access 8 Pages 2015
Coupled binding-bending-folding: The complex conformational dynamics of protein-DNA binding studied by atomistic molecular dynamics simulations Fulltext Access 8 Pages 2015
Rhodamine B-conjugated encrypted vipericidin nonapeptide is a potent toxin to zebrafish and associated with in vitro cytotoxicity Fulltext Access 8 Pages 2015
Action mechanism of 6, 6â²-dihydroxythiobinupharidine from Nuphar japonicum, which showed anti-MRSA and anti-VRE activities Fulltext Access 8 Pages 2015
Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR Fulltext Access 8 Pages 2015
Photocytotoxicity of a cyanine dye with two chromophores toward melanoma and normal cells Fulltext Access 8 Pages 2015
Evolution of the active site of human glutathione transferase A2-2 for enhanced activity with dietary isothiocyanates Fulltext Access 8 Pages 2015
Molecular recognition in naphthoquinone derivatives - G-quadruplex complexes by NMR Fulltext Access 8 Pages 2015
Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells Fulltext Access 8 Pages 2015
Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice Fulltext Access 8 Pages 2015
Chemical and thermal influence of the [4Fe-4S]2Â + cluster of A/G-specific adenine glycosylase from Corynebacterium pseudotuberculosis Fulltext Access 8 Pages 2015
Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity Fulltext Access 8 Pages 2015
Effect of the urease-derived peptide Jaburetox on the central nervous system of Triatoma infestans (Insecta: Heteroptera) Fulltext Access 8 Pages 2015
Esculetin attenuates receptor activator of nuclear factor kappa-B ligand-mediated osteoclast differentiation through c-Fos/nuclear factor of activated T-cells c1 signaling pathway Fulltext Access 8 Pages 2015
Sustained hypertension despite endothelial-specific eNOS rescue in eNOS-deficient mice Fulltext Access 8 Pages 2015
K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling Fulltext Access 8 Pages 2015
PRR11 regulates late-S to G2/M phase progression and induces premature chromatin condensation (PCC) Fulltext Access 8 Pages 2015
Differential effects of estrogen-dependent transactivation vs. transrepression by the estrogen receptor on invasiveness of HER2 overexpressing breast cancer cells Fulltext Access 8 Pages 2015
miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway Fulltext Access 8 Pages 2015
Inhibition of H3K9 methyltransferase G9a induces autophagy and apoptosis in oral squamous cell carcinoma Fulltext Access 8 Pages 2015
Mitochondrial Ca2+ uniporter is critical for store-operated Ca2+ entry-dependent breast cancer cell migration Fulltext Access 8 Pages 2015
Ghrelin ameliorates intestinal barrier dysfunction in experimental colitis by inhibiting the activation of nuclear factor-kappa B Fulltext Access 8 Pages 2015
Nanoscale analysis of unstained biological specimens in water without radiation damage using high-resolution frequency transmission electric-field system based on FE-SEM Fulltext Access 8 Pages 2015
Prospective validation of DACH2 as a novel biomarker for prediction of metastasis and prognosis in muscle-invasive urothelial carcinoma of the bladder Fulltext Access 8 Pages 2015
A novel mutation MT-COIII m.9267G>C and MT-COI m.5913G>A mutation in mitochondrial genes in a Tunisian family with maternally inherited diabetes and deafness (MIDD) associated with sever nephropathy Fulltext Access 8 Pages 2015
MicroRNAs downregulated in neuropathic pain regulate MeCP2 and BDNF related to pain sensitivity Fulltext Access 8 Pages 2015
Interferon-gamma inhibits the neuronal differentiation of neural progenitor cells by inhibiting the expression of Neurogenin2 via the JAK/STAT1 pathway Fulltext Access 8 Pages 2015
Yhhu4488, a novel GPR40 agonist, promotes GLP-1 secretion and exerts anti-diabetic effect in rodent models Fulltext Access 8 Pages 2015
Oral administration of PDX1 confers protection against insulitis in the non-obese diabetic (NOD) mice Fulltext Access 8 Pages 2015
Genomic analyses and expression evaluation of thaumatin-like gene family in the cacao fungal pathogen Moniliophthora perniciosa Fulltext Access 8 Pages 2015
High glucose and interleukin 1β-induced apoptosis in human umbilical vein endothelial cells involves in down-regulation of monocarboxylate transporter 4 Fulltext Access 8 Pages 2015
Glutathione metabolism links FOXRED1 to NADH:ubiquinone oxidoreductase (complex I) deficiency: A hypothesis Fulltext Access 8 Pages 2015
Melatonin attenuates the mitochondrial translocation of mitochondrial fission proteins and Bax, cytosolic calcium overload and cell death in methamphetamine-induced toxicity in neuroblastoma SH-SY5Y cells Fulltext Access 8 Pages 2015
Broad phenotypic variability in patients with complex I deficiency due to mutations in NDUFS1 and NDUFV1 Fulltext Access 8 Pages 2015
Mitochondrial tRNASer(UCN) variants in 2651 Han Chinese subjects with hearing loss Fulltext Access 8 Pages 2015
Fingerprinting of metabolic states by NAD(P)H fluorescence lifetime spectroscopy in living cells: A review Fulltext Access 8 Pages 2015
Murine erythroid 5-aminolevulinate synthase: Adenosyl-binding site Lys221 modulates substrate binding and catalysis Fulltext Access 8 Pages 2015
PRDM14 maintains pluripotency of embryonic stem cells through TET-mediated active DNA demethylation Fulltext Access 8 Pages 2015
Inhibition of ASCT2 is essential in all-trans retinoic acid-induced reduction of adipogenesis in 3T3-L1 cells Fulltext Access 8 Pages 2015
Small molecules inhibiting the nuclear localization of YAP/TAZ for chemotherapeutics and chemosensitizers against breast cancers Fulltext Access 8 Pages 2015
p38α controls self-renewal and fate decision of neurosphere-forming cells in adult hippocampus Fulltext Access 8 Pages 2015
Interaction of the dual targeting peptide of Thr-tRNA synthetase with the chloroplastic receptor Toc34 in Arabidopsis thaliana Fulltext Access 8 Pages 2015
The cytotoxicity of BAMLET complexes is due to oleic acid and independent of the α-lactalbumin component Fulltext Access 8 Pages 2015
Analysis of a temperature-sensitive mutation in Uba1: Effects of the click reaction on subsequent immunolabeling of proteins involved in DNA replication Fulltext Access 8 Pages 2015
Oligomer-dependent and -independent chaperone activity of sHsps in different stressed conditions Fulltext Access 8 Pages 2015
Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells Fulltext Access 8 Pages 2015
NADH oxidase and alkyl hydroperoxide reductase subunit C (peroxiredoxin) from Amphibacillus xylanus form an oligomeric assembly Fulltext Access 8 Pages 2015
Friend or foe: Endoplasmic reticulum protein 29 (ERp29) in epithelial cancer Fulltext Access 8 Pages 2015
Diffuse binding of Zn2+ to the denatured ensemble of Cu/Zn superoxide dismutase 1 Fulltext Access 8 Pages 2015
Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2 Fulltext Access 8 Pages 2015
PDCD5 protects against cardiac remodeling by regulating autophagy and apoptosis Fulltext Access 8 Pages 2015
Girdin/GIV regulates transendothelial permeability by controlling VE-cadherin trafficking through the small GTPase, R-Ras Fulltext Access 8 Pages 2015
Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression Fulltext Access 8 Pages 2015
Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy Fulltext Access 8 Pages 2015
Genome-wide mRNA-seq profiling reveals predominant down-regulation of lipid metabolic processes in adipose tissues of Small Tail Han than Dorset sheep Fulltext Access 8 Pages 2015
TRIM26 functions as a novel tumor suppressor of hepatocellular carcinoma and its downregulation contributes to worse prognosis Fulltext Access 8 Pages 2015
Delivery of human NKG2D-IL-15 fusion gene by chitosan nanoparticles to enhance antitumor immunity Fulltext Access 8 Pages 2015
Pivotal role of Sirt6 in the crosstalk among ageing, metabolic syndrome and osteoarthritis Fulltext Access 8 Pages 2015
MiR-32 promotes gastric carcinoma tumorigenesis by targeting Kruppel-like factor 4 Fulltext Access 8 Pages 2015
3â² and 5â² microRNA-end post-biogenesis modifications in plant transcriptomes: Evidences from small RNA next generation sequencing data analysis Fulltext Access 8 Pages 2015
Transcriptional factors p300 and MRTF-A synergistically enhance the expression of migration-related genes in MCF-7 breast cancer cells Fulltext Access 8 Pages 2015
Biomechanical and Structural Features of CS2 Fimbriae of Enterotoxigenic Escherichia coli Fulltext Access 8 Pages 2015
Puerarin prevents cardiac hypertrophy induced by pressure overload through activation of autophagy Fulltext Access 8 Pages 2015
Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts Fulltext Access 8 Pages 2015
Crystal structure of Legionella pneumophila type IV secretion system effector LegAS4 Fulltext Access 8 Pages 2015
PRDX1 is involved in palmitate induced insulin resistance via regulating the activity of p38MAPK in HepG2 cells Fulltext Access 8 Pages 2015
Identification of miR-2400 gene as a novel regulator in skeletal muscle satellite cells proliferation by targeting MYOG gene Fulltext Access 8 Pages 2015
SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt Fulltext Access 8 Pages 2015
Equilibrium dissociation and unfolding of human papillomavirus E2 transactivation domain Fulltext Access 8 Pages 2015
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells Fulltext Access 8 Pages 2015
SIRT1 regulates autophagy and diploidization in parthenogenetic haploid embryonic stem cells Fulltext Access 8 Pages 2015
Over-expression of TRIM37 promotes cell migration and metastasis in hepatocellular carcinoma by activating Wnt/β-catenin signaling Fulltext Access 8 Pages 2015
Transcriptomic changes during maize roots development responsive to Cadmium (Cd) pollution using comparative RNAseq-based approach Fulltext Access 8 Pages 2015