Evidence that Loading of Cohesin Onto Chromosomes Involves Opening of Its SMC Hinge Fulltext Access 15 Pages 2006
Macrophage/Cancer Cell Interactions Mediate Hormone Resistance by a Nuclear Receptor Derepression Pathway Fulltext Access 15 Pages 2006
The Response of Human Epithelial Cells to TNF Involves an Inducible Autocrine Cascade Fulltext Access 15 Pages 2006
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans Fulltext Access 15 Pages 2006
Miniature Neurotransmission Stabilizes Synaptic Function via Tonic Suppression of Local Dendritic Protein Synthesis Fulltext Access 15 Pages 2006
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling Fulltext Access 15 Pages 2006
Histone H2B Monoubiquitination Functions Cooperatively with FACT to Regulate Elongation by RNA Polymerase II Fulltext Access 15 Pages 2006
RNAi Components Are Required for Nuclear Clustering of Polycomb Group Response Elements Fulltext Access 15 Pages 2006
Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast Fulltext Access 15 Pages 2006
Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach Fulltext Access 15 Pages 2006
The Processivity of Multiubiquitination by the APC Determines the Order of Substrate Degradation Fulltext Access 15 Pages 2006
Reconstitution, Activities, and Structure of the Eukaryotic RNA Exosome Fulltext Access 15 Pages 2006
Large-Scale Sequencing Reveals 21U-RNAs and Additional MicroRNAs and Endogenous siRNAs in C. elegans Fulltext Access 15 Pages 2006
Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification Fulltext Access 15 Pages 2006
Role for the PP2A/B56δ Phosphatase in Regulating 14-3-3 Release from Cdc25 to Control Mitosis Fulltext Access 15 Pages 2006
A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes Fulltext Access 15 Pages 2006
GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland Fulltext Access 15 Pages 2006
Substrate-Specific Translocational Attenuation during ER Stress Defines a Pre-Emptive Quality Control Pathway Fulltext Access 15 Pages 2006
The Conserved KMN Network Constitutes the Core Microtubule-Binding Site of the Kinetochore Fulltext Access 15 Pages 2006
The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation Fulltext Access 15 Pages 2006
Assessment of the genotoxic potential of the antipsychotic sigma receptor ligand E-5842 Fulltext Access 15 Pages 2006
Kinetics of ATP-stimulated Nuclease Activity of the Escherichia coli RecBCD Enzyme Fulltext Access 15 Pages 2006
The Structure of Apo-wild-type Cellular Retinoic Acid Binding Protein II at 1.4 Å and its Relationship to Ligand Binding and Nuclear Translocation Fulltext Access 15 Pages 2006
Structure, Dynamics and Heparin Binding of the C-terminal Domain of Insulin-like Growth Factor-binding Protein-2 (IGFBP-2) Fulltext Access 15 Pages 2006
Hepatocyte Nuclear Factor 4 Alpha Ligand Binding and F Domains Mediate Interaction and Transcriptional Synergy with the Pancreatic Islet LIM HD Transcription Factor Isl1 Fulltext Access 15 Pages 2006
Residue-level NMR View of the Urea-driven Equilibrium Folding Transition of SUMO-1 (1-97): Native Preferences Do Not Increase Monotonously Fulltext Access 15 Pages 2006
Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin Fulltext Access 15 Pages 2006
Co-evolutionary Analysis of Domains in Interacting Proteins Reveals Insights into Domain–Domain Interactions Mediating Protein–Protein Interactions Fulltext Access 15 Pages 2006
Biochemical Analysis of a DNA Replication Origin in the Archaeon Aeropyrum pernix Fulltext Access 15 Pages 2006
Quantitative Evaluation of Each Catalytic Subsite of Cathepsin B for Inhibitory Activity Based on Inhibitory Activity–Binding Mode Relationship of Epoxysuccinyl Inhibitors by X-ray Crystal Structure Analyses of Complexes Fulltext Access 15 Pages 2006
Structural Basis for Rab11-mediated Recruitment of FIP3 to Recycling Endosomes Fulltext Access 15 Pages 2006
Synthesis of a set of sulfated and/or phosphorylated oligosaccharide derivatives from the carbohydrate–protein linkage region of proteoglycans Fulltext Access 15 Pages 2006
Measurements of metaphase and interphase chromosome aberrations transmitted through early cell replication rounds in human lymphocytes exposed to low-LET protons and high-LET 12C ions Fulltext Access 15 Pages 2006
Distributions of five common point mutants in the human tracheal-bronchial epithelium Fulltext Access 15 Pages 2006
Expanded simple tandem repeat (ESTR) mutation induction in the male germline: Lessons learned from lab mice Fulltext Access 15 Pages 2006
Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species Fulltext Access 15 Pages 2006
Role of the mismatch repair system and p53 in the clastogenicity and cytotoxicity induced by bleomycin Fulltext Access 15 Pages 2006
Translating Innate Immunity into Immunological Memory: Implications for Vaccine Development Fulltext Access 15 Pages 2006
Synaptic Protein Synthesis Associated with Memory Is Regulated by the RISC Pathway in Drosophila Fulltext Access 15 Pages 2006
VEGF-Induced Adult Neovascularization: Recruitment, Retention, and Role of Accessory Cells Fulltext Access 15 Pages 2006
Structure–activity relationships in platelet-activating factor. Part 14: Synthesis and biological evaluation of piperazine derivatives with dual anti-PAF and anti-HIV-1 activity Fulltext Access 15 Pages 2006
Profiling of structurally labile oxylipins in plants by in situ derivatization with pentafluorobenzyl hydroxylamine Fulltext Access 15 Pages 2006
Best literature values for the pK of carbonic and phosphoric acid under physiological conditions Fulltext Access 15 Pages 2006
Experimental and modelling study of different process modes for retroviral production in a fixed bed reactor Fulltext Access 15 Pages 2006
Characterization of heterologous hemoglobin and flavohemoglobin promoter regulation in Escherichia coli Fulltext Access 15 Pages 2006
Properties of neutral cellobiose dehydrogenase from the ascomycete Chaetomium sp. INBI 2-26(–) and comparison with basidiomycetous cellobiose dehydrogenases Fulltext Access 15 Pages 2006
Over-expression of hTERT in CHO K1 results in decreased apoptosis and reduced serum dependency Fulltext Access 15 Pages 2006
Stoichiometric and kinetic characterisation of Nitrosomonas sp. in mixed culture by decoupling the growth and energy generation processes Fulltext Access 15 Pages 2006
Generation of hybrid transgenic silkworms that express Bombyx mori prolyl-hydroxylase α-subunits and human collagens in posterior silk glands: Production of cocoons that contained collagens with hydroxylated proline residues Fulltext Access 15 Pages 2006
Simultaneous separation of acid and basic bioactive peptides by electrodialysis with ultrafiltration membrane Fulltext Access 15 Pages 2006
The effect of polysaccharide-degrading wine yeast transformants on the efficiency of wine processing and wine flavour Fulltext Access 15 Pages 2006
Dynamics of in vivo power output and efficiency of Nasonia asynchronous flight muscle Fulltext Access 15 Pages 2006
Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors Fulltext Access 15 Pages 2006
Improvement of the fungal enzyme pyranose 2-oxidase using protein engineering Fulltext Access 15 Pages 2006
Improved transgene expression fine-tuning in mammalian cells using a novel transcription–translation network Fulltext Access 15 Pages 2006
A novel flow based hollow-fiber blood–brain barrier in vitro model with immortalised cell line PBMEC/C1–2 Fulltext Access 15 Pages 2006
Identification of circular codes in bacterial genomes and their use in a factorization method for retrieving the reading frames of genes Fulltext Access 15 Pages 2006
Twenty years research in cholinesterase biosensors: From basic research to practical applications Fulltext Access 15 Pages 2006
Matrix inclusion within synthetic hydrogel guidance channels improves specific supraspinal and local axonal regeneration after complete spinal cord transection Fulltext Access 15 Pages 2006
A comparison of micro CT with other techniques used in the characterization of scaffolds Fulltext Access 15 Pages 2006
Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells Fulltext Access 15 Pages 2006
A new type of ketolide bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether: Synthesis and structure–activity relationships (2) Fulltext Access 15 Pages 2006
Synthesis of sucrose analogues and the mechanism of action of Bacillus subtilis fructosyltransferase (levansucrase) Fulltext Access 15 Pages 2006
The binding of DNA intercalating and non-intercalating compounds to A-form and protonated form of poly(rC)·poly(rG): Spectroscopic and viscometric study Fulltext Access 15 Pages 2006
Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential Fulltext Access 15 Pages 2006
C19-Steroids as androgen receptor modulators: Design, discovery, and structure-activity relationship of new steroidal androgen receptor antagonists Fulltext Access 15 Pages 2006
CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues Fulltext Access 15 Pages 2006
Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone Fulltext Access 15 Pages 2006
Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes Fulltext Access 15 Pages 2006
Flavonoids and cinnamic acid esters as inhibitors of fungal 17β-hydroxysteroid dehydrogenase: A synthesis, QSAR and modelling study Fulltext Access 15 Pages 2006
Novel 1,3-dicarbonyl compounds having 2(3H)-benzazolonic heterocycles as PPARγ agonists Fulltext Access 15 Pages 2006
Design of potent inhibitors for Schistosoma japonica glutathione S-transferase Fulltext Access 15 Pages 2006
Structural basis for androgen receptor agonists and antagonists: Interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR Fulltext Access 15 Pages 2006
Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes Fulltext Access 15 Pages 2006
Synthesis of functionalized biphenyl-C-nucleosides and their incorporation into oligodeoxynucleotides Fulltext Access 15 Pages 2006
Modeling of activity of cyclic urea HIV-1 protease inhibitors using regularized-artificial neural networks Fulltext Access 15 Pages 2006
Bicyclic[4.1.0]heptanes as phenyl replacements for melanin concentrating hormone receptor antagonists Fulltext Access 15 Pages 2006
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 Fulltext Access 15 Pages 2006