The Ig Doublet Z1Z2: A Model System for the Hybrid Analysis of Conformational Dynamics in Ig Tandems from Titin Fulltext Access 11 Pages 2006
Capsid Conformational Sampling in HK97 Maturation Visualized by X-Ray Crystallography and Cryo-EM Fulltext Access 11 Pages 2006
Crystal Structure of Human Iron Regulatory Protein 1 as Cytosolic Aconitase Fulltext Access 11 Pages 2006
Activation and Catalysis of the Di-Heme Cytochrome c Peroxidase from Paracoccus pantotrophus Fulltext Access 11 Pages 2006
Mapping the Structure and Function of the E1 and E2 Glycoproteins in Alphaviruses Fulltext Access 11 Pages 2006
A Second FMN Binding Site in Yeast NADPH-Cytochrome P450 Reductase Suggests a Mechanism of Electron Transfer by Diflavin Reductases Fulltext Access 11 Pages 2006
The Structure of the N-Terminal Domain of the Fragile X Mental Retardation Protein: A Platform for Protein-Protein Interaction Fulltext Access 11 Pages 2006
Structure and Specific RNA Binding of ADAR2 Double-Stranded RNA Binding Motifs Fulltext Access 11 Pages 2006
Molecular Basis for Phosphorylation-Dependent, PEST-Mediated Protein Turnover Fulltext Access 11 Pages 2006
Structural and Functional Aspects of the Sensor Histidine Kinase PrrB from Mycobacterium tuberculosis Fulltext Access 11 Pages 2006
Crystal Structure of Group A Streptococcus Mac-1: Insight into Dimer-Mediated Specificity for Recognition of Human IgG Fulltext Access 11 Pages 2006
The Crystal Structure of Aspergillus fumigatus Cyclophilin Reveals 3D Domain Swapping of a Central Element Fulltext Access 11 Pages 2006
Structure of the Catalytic and Ubiquitin-Associated Domains of the Protein Kinase MARK/Par-1 Fulltext Access 11 Pages 2006
Structure of Complement Component C2a: Implications for Convertase Formation and Substrate Binding Fulltext Access 11 Pages 2006
FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding Fulltext Access 11 Pages 2006
“Similarity Trap” in Protein-Protein Interactions Could Be Carcinogenic: Simulations of p53 Core Domain Complexed with 53BP1 and BRCA1 BRCT Domains Fulltext Access 11 Pages 2006
Electron Transfer Complex Formation between Oxygenase and Ferredoxin Components in Rieske Nonheme Iron Oxygenase System Fulltext Access 11 Pages 2006
Stability and Dynamics of Virus Capsids Described by Coarse-Grained Modeling Fulltext Access 11 Pages 2006
Structural Insights into the Specific Binding of Huntingtin Proline-Rich Region with the SH3 and WW Domains Fulltext Access 11 Pages 2006
P-TEFb-Mediated Phosphorylation of hSpt5 C-Terminal Repeats Is Critical for Processive Transcription Elongation Fulltext Access 11 Pages 2006
Conserved XPB Core Structure and Motifs for DNA Unwinding: Implications for Pathway Selection of Transcription or Excision Repair Fulltext Access 11 Pages 2006
Inhibition of Msh6 ATPase Activity by Mispaired DNA Induces a Msh2(ATP)-Msh6(ATP) State Capable of Hydrolysis-Independent Movement along DNA Fulltext Access 11 Pages 2006
Unfolding of mRNA Secondary Structure by the Bacterial Translation Initiation Complex Fulltext Access 11 Pages 2006
The Conserved Transmembrane Nucleoporin NDC1 Is Required for Nuclear Pore Complex Assembly in Vertebrate Cells Fulltext Access 11 Pages 2006
Epidermal growth factor affects the synthesis and degradation of type I collagen in cultured human dermal fibroblasts Fulltext Access 11 Pages 2006
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage Fulltext Access 11 Pages 2006
Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis Fulltext Access 11 Pages 2006
Characterization of fibroblast morphology on bioactive surfaces using vertical scanning interferometry Fulltext Access 11 Pages 2006
Mechanosensitive synoviocytes: A Ca2+–PKCα–MAP kinase pathway contributes to stretch-induced hyaluronan synthesis in vitro Fulltext Access 11 Pages 2006
Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression Fulltext Access 11 Pages 2006
Lumbricus Erythrocruorin at 3.5 Å Resolution: Architecture of a Megadalton Respiratory Complex Fulltext Access 11 Pages 2006
Crystal Structure of Rab11 in Complex with Rab11 Family Interacting Protein 2 Fulltext Access 11 Pages 2006
Prokaryotic Type II and Type III Pantothenate Kinases: The Same Monomer Fold Creates Dimers with Distinct Catalytic Properties Fulltext Access 11 Pages 2006
A Steric Antagonism of Actin Polymerization by a Salmonella Virulence Protein Fulltext Access 11 Pages 2006
Structural Insight into Interactions between Dihydrolipoamide Dehydrogenase (E3) and E3 Binding Protein of Human Pyruvate Dehydrogenase Complex Fulltext Access 11 Pages 2006
Principles of Protein-DNA Recognition Revealed in the Structural Analysis of Ndt80-MSE DNA Complexes Fulltext Access 11 Pages 2006
Structural Determinants for High-Affinity Binding in a Nedd4 WW3∗ Domain-Comm PY Motif Complex Fulltext Access 11 Pages 2006
Structure of a Leu3-DNA Complex: Recognition of Everted CGG Half-Sites by a Zn2Cys6 Binuclear Cluster Protein Fulltext Access 11 Pages 2006
The Crystal Structure of Carnitine Palmitoyltransferase 2 and Implications for Diabetes Treatment Fulltext Access 11 Pages 2006
The Endosome-Associated Protein Hrs Is Hexameric and Controls Cargo Sorting as a “Master Molecule” Fulltext Access 11 Pages 2006
Bridging Conformational Dynamics and Function Using Single-Molecule Spectroscopy Fulltext Access 11 Pages 2006
Two Structurally Atypical HEAT Domains in the C-Terminal Portion of Human eIF4G Support Binding to eIF4A and Mnk1 Fulltext Access 11 Pages 2006
Structures and Polymorphic Interactions of Two Heptad-Repeat Regions of the SARS Virus S2 Protein Fulltext Access 11 Pages 2006
YfhJ, a Molecular Adaptor in Iron-Sulfur Cluster Formation or a Frataxin-like Protein? Fulltext Access 11 Pages 2006
RNA Kink-Turns as Molecular Elbows: Hydration, Cation Binding, and Large-Scale Dynamics Fulltext Access 11 Pages 2006
Cell Apoptosis: Requirement of H2AX in DNA Ladder Formation, but Not for the Activation of Caspase-3 Fulltext Access 12 Pages 2006
Distinct Structural and Functional Properties of the ATPase Sites in an Asymmetric ABC Transporter Fulltext Access 12 Pages 2006
ATP Binding and ATP Hydrolysis Play Distinct Roles in the Function of 26S Proteasome Fulltext Access 12 Pages 2006
Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer Fulltext Access 12 Pages 2006
A Transient Heterochromatic State in Xist Preempts X Inactivation Choice without RNA Stabilization Fulltext Access 12 Pages 2006
Swi6/HP1 Recruits a JmjC Domain Protein to Facilitate Transcription of Heterochromatic Repeats Fulltext Access 12 Pages 2006
Dephosphorylation and Genome-Wide Association of Maf1 with Pol III-Transcribed Genes during Repression Fulltext Access 12 Pages 2006
Translation Arrest Requires Two-Way Communication between a Nascent Polypeptide and the Ribosome Fulltext Access 12 Pages 2006
Coherence and Timing of Cell Cycle Start Examined at Single-Cell Resolution Fulltext Access 12 Pages 2006
Ubiquitylation of Cyclin E Requires the Sequential Function of SCF Complexes Containing Distinct hCdc4 Isoforms Fulltext Access 12 Pages 2006
Divergence from a Dedicated Cellular Suicide Mechanism: Exploring the Evolution of Cell Death Fulltext Access 12 Pages 2006
Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy Fulltext Access 12 Pages 2006
Structure of the τ60/Δτ91 Subcomplex of Yeast Transcription Factor IIIC: Insights into Preinitiation Complex Assembly Fulltext Access 12 Pages 2006
Yng1 PHD Finger Binding to H3 Trimethylated at K4 Promotes NuA3 HAT Activity at K14 of H3 and Transcription at a Subset of Targeted ORFs Fulltext Access 12 Pages 2006
Determinants for Dephosphorylation of the RNA Polymerase II C-Terminal Domain by Scp1 Fulltext Access 12 Pages 2006
Genome-Wide Distribution of Yeast RNA Polymerase II and Its Control by Sen1 Helicase Fulltext Access 12 Pages 2006
The X-Ray Structure of a BAK Homodimer Reveals an Inhibitory Zinc Binding Site Fulltext Access 12 Pages 2006
Crystal Structure of the PP2A Phosphatase Activator: Implications for Its PP2A-Specific PPIase Activity Fulltext Access 12 Pages 2006
Polypyrimidine Tract Binding Protein Regulates IRES-Mediated Gene Expression during Apoptosis Fulltext Access 12 Pages 2006
The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability Fulltext Access 12 Pages 2006
Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds through a Concerted β Strand Displacement Mechanism Fulltext Access 12 Pages 2006
Is Dimerization Required for the Catalytic Activity of Bacterial Biotin Carboxylase? Fulltext Access 12 Pages 2006
IRBIT Suppresses IP3 Receptor Activity by Competing with IP3 for the Common Binding Site on the IP3 Receptor Fulltext Access 12 Pages 2006
The E3 SUMO Ligase PIASy Is a Regulator of Cellular Senescence and Apoptosis Fulltext Access 12 Pages 2006
Combinatorial Analysis of Transcription Factor Partners Reveals Recruitment of c-MYC to Estrogen Receptor-α Responsive Promoters Fulltext Access 12 Pages 2006
Condensin I Interacts with the PARP-1-XRCC1 Complex and Functions in DNA Single-Strand Break Repair Fulltext Access 12 Pages 2006
A Homotrimer–Heterotrimer Switch in Sir2 Structure Differentiates rDNA and Telomeric Silencing Fulltext Access 12 Pages 2006
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase Fulltext Access 12 Pages 2006
Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1 Fulltext Access 12 Pages 2006
Differential Regulation of EGF Receptor Internalization and Degradation by Multiubiquitination within the Kinase Domain Fulltext Access 12 Pages 2006
Destruction of Claspin by SCFβTrCP Restrains Chk1 Activation and Facilitates Recovery from Genotoxic Stress Fulltext Access 12 Pages 2006
Proteomic Profiling of ClpXP Substrates after DNA Damage Reveals Extensive Instability within SOS Regulon Fulltext Access 12 Pages 2006
A Spliceosomal Intron Binding Protein, IBP160, Links Position-Dependent Assembly of Intron-Encoded Box C/D snoRNP to Pre-mRNA Splicing Fulltext Access 12 Pages 2006
Type IV Pilus Structure by Cryo-Electron Microscopy and Crystallography: Implications for Pilus Assembly and Functions Fulltext Access 12 Pages 2006
Substrate and Functional Diversity of Lysine Acetylation Revealed by a Proteomics Survey Fulltext Access 12 Pages 2006
Cockayne Syndrome A and B Proteins Differentially Regulate Recruitment of Chromatin Remodeling and Repair Factors to Stalled RNA Polymerase II In Vivo Fulltext Access 12 Pages 2006
SeqA Blocking of DnaA-oriC Interactions Ensures Staged Assembly of the E. coli Pre-RC Fulltext Access 12 Pages 2006
Architecture of the 99 bp DNA-Six-Protein Regulatory Complex of the λ att Site Fulltext Access 12 Pages 2006
Evaluation of a Diffusion-Driven Mechanism for Substrate Ubiquitination by the SCF-Cdc34 Ubiquitin Ligase Complex Fulltext Access 12 Pages 2006
Mapping the Phosphoinositide-Binding Site on Chick Cofilin Explains How PIP2 Regulates the Cofilin-Actin Interaction Fulltext Access 12 Pages 2006
SV40 VP2 and VP3 Insertion into ER Membranes Is Controlled by the Capsid Protein VP1: Implications for DNA Translocation out of the ER Fulltext Access 12 Pages 2006
Mechanistic Insights into Sulfur Relay by Multiple Sulfur Mediators Involved in Thiouridine Biosynthesis at tRNA Wobble Positions Fulltext Access 12 Pages 2006