Enhanced Specificity and Efficiency of the CRISPR/Cas9 System with Optimized sgRNA Parameters in Drosophila Fulltext Access 12 Pages 2014
A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1 Fulltext Access 12 Pages 2014
VEGFR2-Mediated Vascular Dilation as a Mechanism of VEGF-Induced Anemia and Bone Marrow Cell Mobilization Fulltext Access 12 Pages 2014
TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression Fulltext Access 12 Pages 2014
E3 Ligase Subunit Fbxo15 and PINK1 Kinase Regulate Cardiolipin Synthase 1 Stability and Mitochondrial Function in Pneumonia Fulltext Access 12 Pages 2014
Dppa5 Improves Hematopoietic Stem Cell Activity by Reducing Endoplasmic Reticulum Stress Fulltext Access 12 Pages 2014
GILZ Promotes Production of Peripherally Induced Treg Cells and Mediates the Crosstalk between Glucocorticoids and TGF-β Signaling Fulltext Access 12 Pages 2014
Dual Toxic-Peptide-Coding Staphylococcus aureus RNA under Antisense Regulation Targets Host Cells and Bacterial Rivals Unequally Fulltext Access 12 Pages 2014
AKAP-Anchored PKA Maintains Neuronal L-type Calcium Channel Activity and NFAT Transcriptional Signaling Fulltext Access 12 Pages 2014
A Role for Dendritic mGluR5-Mediated Local Translation of Arc/Arg3.1 in MEF2-Dependent Synapse Elimination Fulltext Access 12 Pages 2014
Folliculin Controls Lung Alveolar Enlargement and Epithelial Cell Survival through E-Cadherin, LKB1, and AMPK Fulltext Access 12 Pages 2014
Mitotic Position and Morphology of Committed Precursor Cells in the Zebrafish Retina Adapt to Architectural Changes upon Tissue Maturation Fulltext Access 12 Pages 2014
TRIM27/MRTF-B-Dependent Integrin β1 Expression Defines Leading Cells in Cancer Cell Collectives Fulltext Access 12 Pages 2014
Disease-causing mutations associated with four bestrophinopathies exhibit disparate effects on the localization, but not the oligomerization, of Bestrophin-1 Fulltext Access 12 Pages 2014
myosin 7aaâ/â mutant zebrafish show mild photoreceptor degeneration and reduced electroretinographic responses Fulltext Access 12 Pages 2014
Capacity of aflibercept to counteract VEGF-stimulated abnormal behavior of retinal microvascular endothelial cells Fulltext Access 12 Pages 2014
The CD3 Conformational Change in the γδ T Cell Receptor Is Not Triggered by Antigens but Can Be Enforced to Enhance Tumor Killing Fulltext Access 12 Pages 2014
APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor Fulltext Access 12 Pages 2014
Induced pluripotent stem cells as custom therapeutics for retinal repair: Progress and rationale Fulltext Access 12 Pages 2014
A detailed three-step protocol for live imaging of intracellular traffic in polarized primary porcine RPE monolayers Fulltext Access 12 Pages 2014
Retinal vasculature of adult zebrafish: In vivo imaging using confocal scanning laser ophthalmoscopy Fulltext Access 12 Pages 2014
Path to the Clinic: Assessment of iPSC-Based Cell Therapies In Vivo in a Nonhuman Primate Model Fulltext Access 12 Pages 2014
Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation Fulltext Access 13 Pages 2014
ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis Fulltext Access 13 Pages 2014
IMP3 RNP Safe Houses Prevent miRNA-Directed HMGA2 mRNA Decay in Cancer and Development Fulltext Access 13 Pages 2014
Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants Fulltext Access 13 Pages 2014
Dendrite Development Regulated by the Schizophrenia-Associated Gene FEZ1 Involves the Ubiquitin Proteasome System Fulltext Access 13 Pages 2014
Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions Fulltext Access 13 Pages 2014
The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest Fulltext Access 13 Pages 2014
Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation Fulltext Access 13 Pages 2014
MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon's capsule fibroblasts upon hydroxycamptothecin exposure Fulltext Access 13 Pages 2014
Exendin-4 alleviates retinal vascular leakage by protecting the blood-retinal barrier and reducing retinal vascular permeability in diabetic Goto-Kakizaki rats Fulltext Access 13 Pages 2014
Diabetes induces changes in KIF1A, KIF5B and dynein distribution in the rat retina: Implications for axonal transport Fulltext Access 13 Pages 2014
Perinatally acquired HIV infection in adolescents from sub-Saharan Africa: a review of emerging challenges Fulltext Access 13 Pages 2014
The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study Fulltext Access 13 Pages 2014
Extended spectrum β-lactamase producers among nosocomial Enterobacteriaceae in Latin America Fulltext Access 13 Pages 2014
The Strength of an Ig Switch Region Is Determined by Its Ability to Drive R Loop Formation and Its Number of WGCW Sites Fulltext Access 13 Pages 2014
Silencing of the DNA Mismatch Repair Gene MLH1 Induced by Hypoxic Stress in a Pathway Dependent on the Histone Demethylase LSD1 Fulltext Access 13 Pages 2014
Invadopodia Are Required for Cancer Cell Extravasation and Are a Therapeutic Target for Metastasis Fulltext Access 13 Pages 2014
The RBBP6/ZBTB38/MCM10 Axis Regulates DNA Replication and Common Fragile Site Stability Fulltext Access 13 Pages 2014
Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene Fulltext Access 13 Pages 2014
Fibroblast Growth Factor Maintains Chondrogenic Potential of Limb Bud Mesenchymal Cells by Modulating DNMT3A Recruitment Fulltext Access 13 Pages 2014
Hypoxia Induces VEGF-C Expression in Metastatic Tumor Cells via a HIF-1α-Independent Translation-Mediated Mechanism Fulltext Access 13 Pages 2014
High-Throughput Flow Cytometry Screening Reveals a Role for Junctional Adhesion Molecule A as a Cancer Stem Cell Maintenance Factor Fulltext Access 13 Pages 2014
Microcephaly-Associated Protein WDR62 Regulates Neurogenesis through JNK1 in the Developing Neocortex Fulltext Access 13 Pages 2014
NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells Fulltext Access 13 Pages 2014
SRC-2 Is an Essential Coactivator for Orchestrating Metabolism and Circadian Rhythm Fulltext Access 13 Pages 2014
Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5 Fulltext Access 13 Pages 2014
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation Fulltext Access 13 Pages 2014
Temporospatial Coordination of Meiotic DNA Replication and Recombination via DDK Recruitment to Replisomes Fulltext Access 13 Pages 2014
Mycobacterium Tuberculosis Proteome Microarray for Global Studies of Protein Function and Immunogenicity Fulltext Access 13 Pages 2014
Channelrhodopsin-Assisted Patching: In Vivo Recording of Genetically and Morphologically Identified Neurons throughout the Brain Fulltext Access 13 Pages 2014
PCAF Improves Glucose Homeostasis by Suppressing the Gluconeogenic Activity of PGC-1α Fulltext Access 13 Pages 2014
RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells Fulltext Access 13 Pages 2014
Integrins Regulate Apical Constriction via Microtubule Stabilization in the Drosophila Eye Disc Epithelium Fulltext Access 13 Pages 2014
Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila Fulltext Access 13 Pages 2014
CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration Fulltext Access 13 Pages 2014
Interplay of Cell Shape and Division Orientation Promotes Robust Morphogenesis of Developing Epithelia Fulltext Access 13 Pages 2014
Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance Fulltext Access 13 Pages 2014
Supergenomic Network Compression and the Discovery of EXP1 as a Glutathione Transferase Inhibited by Artesunate Fulltext Access 13 Pages 2014
ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion Fulltext Access 13 Pages 2014
Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo Fulltext Access 13 Pages 2014
Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment Fulltext Access 13 Pages 2014
KRas Localizes to the Plasma Membrane by Spatial Cycles of Solubilization, Trapping and Vesicular Transport Fulltext Access 13 Pages 2014
Asymmetric Friction of Nonmotor MAPs Can Lead to Their Directional Motion in Active Microtubule Networks Fulltext Access 13 Pages 2014
Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling Fulltext Access 13 Pages 2014
A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia Fulltext Access 13 Pages 2014
Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer Fulltext Access 13 Pages 2014
High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies Fulltext Access 13 Pages 2014
A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains Fulltext Access 13 Pages 2014
Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα Fulltext Access 13 Pages 2014
Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression Fulltext Access 13 Pages 2014
Single-Cell RNA Sequencing Reveals T Helper Cells Synthesizing Steroids De Novo to Contribute to Immune Homeostasis Fulltext Access 13 Pages 2014
Inhibition of Endothelial p53 Improves Metabolic Abnormalities Related to Dietary Obesity Fulltext Access 13 Pages 2014
Optogenetic Mapping of Cerebellar Inhibitory Circuitry Reveals Spatially Biased Coordination of Interneurons via Electrical Synapses Fulltext Access 13 Pages 2014
BRCA2 Coordinates the Activities of Cell-Cycle Kinases to Promote Genome Stability Fulltext Access 13 Pages 2014
Mapping the Interaction Sites between AMPA Receptors and TARPs Reveals a Role for the Receptor N-Terminal Domain in Channel Gating Fulltext Access 13 Pages 2014
The Tumor Suppressor Smad4/DPC4 Is Regulated by Phosphorylations that Integrate FGF, Wnt, and TGF-β Signaling Fulltext Access 13 Pages 2014
Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion Fulltext Access 13 Pages 2014
Growth of the Developing Cerebral Cortex Is Controlled by MicroRNA-7 through the p53 Pathway Fulltext Access 13 Pages 2014
An MHC II-Dependent Activation Loop between Adipose Tissue Macrophages and CD4+ T Cells Controls Obesity-Induced Inflammation Fulltext Access 13 Pages 2014
Expression Quantitative Trait Loci and Receptor Pharmacology Implicate Arg1 and the GABA-A Receptor as Therapeutic Targets in Neuroblastoma Fulltext Access 13 Pages 2014
Structural Insights into How Yrb2p Accelerates the Assembly of the Xpo1p Nuclear Export Complex Fulltext Access 13 Pages 2014
De Novo Formation of Insulin-Producing “Neo-β Cell Islets” from Intestinal Crypts Fulltext Access 13 Pages 2014
Discovering Protein-Protein Interactions within the Programmed Cell Death Network Using a Protein-Fragment Complementation Screen Fulltext Access 13 Pages 2014
Whole-Genome Analysis of Muscle Founder Cells Implicates the Chromatin Regulator Sin3A in Muscle Identity Fulltext Access 13 Pages 2014
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression Fulltext Access 13 Pages 2014
Serotonergic versus Nonserotonergic Dorsal Raphe Projection Neurons: Differential Participation in Reward Circuitry Fulltext Access 13 Pages 2014