Hydroxymethylation at Gene Regulatory Regions Directs Stem/Early Progenitor Cell Commitment during Erythropoiesis Fulltext Access 14 Pages 2014
Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation Fulltext Access 14 Pages 2014
Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition Fulltext Access 14 Pages 2014
Pharmacogenetic Inhibition of eIF4E-Dependent Mmp9 mRNA Translation Reverses Fragile X Syndrome-like Phenotypes Fulltext Access 14 Pages 2014
SPG7 Variant Escapes Phosphorylation-Regulated Processing by AFG3L2, Elevates Mitochondrial ROS, and Is Associated with Multiple Clinical Phenotypes Fulltext Access 14 Pages 2014
Lhx1 Controls Terminal Differentiation and Circadian Function of the Suprachiasmatic Nucleus Fulltext Access 14 Pages 2014
Human-Chromatin-Related Protein Interactions Identify a Demethylase Complex Required for Chromosome Segregation Fulltext Access 14 Pages 2014
The Essential Function of the MRN Complex in the Resolution of Endogenous Replication Intermediates Fulltext Access 14 Pages 2014
Suppression of TET1-Dependent DNA Demethylation Is Essential for KRAS-Mediated Transformation Fulltext Access 14 Pages 2014
Phosphorylation and DNA Binding of HJURP Determine Its Centromeric Recruitment and Function in CenH3CENP-A Loading Fulltext Access 14 Pages 2014
Hipk2 and PP1c Cooperate to Maintain Dvl Protein Levels Required for Wnt Signal Transduction Fulltext Access 14 Pages 2014
Cell-Autonomous Repression of Shh by Transcription Factor Pax6 Regulates Diencephalic Patterning by Controlling the Central Diencephalic Organizer Fulltext Access 14 Pages 2014
GPS2/KDM4A Pioneering Activity Regulates Promoter-Specific Recruitment of PPARγ Fulltext Access 14 Pages 2014
The RNA-Binding Protein DDX1 Promotes Primary MicroRNA Maturation and Inhibits Ovarian Tumor Progression Fulltext Access 14 Pages 2014
Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth Fulltext Access 14 Pages 2014
Sox4 Links Tumor Suppression to Accelerated Aging in Mice by Modulating Stem Cell Activation Fulltext Access 14 Pages 2014
A Comprehensive and High-Resolution Genome-wide Response of p53 to Stress Fulltext Access 14 Pages 2014
MicroRNA-Mediated Regulation of Dp53 in the Drosophila Fat Body Contributes to Metabolic Adaptation to Nutrient Deprivation Fulltext Access 14 Pages 2014
The Extreme Anterior Domain Is an Essential Craniofacial Organizer Acting through Kinin-Kallikrein Signaling Fulltext Access 14 Pages 2014
Crosstalk between the Rb Pathway and AKT Signaling Forms a Quiescence-Senescence Switch Fulltext Access 14 Pages 2014
Global Transcriptional Profiling Reveals Distinct Functions of Thymic Stromal Subsets and Age-Related Changes during Thymic Involution Fulltext Access 14 Pages 2014
Control of Embryonic Stem Cell Identity by BRD4-Dependent Transcriptional Elongation of Super-Enhancer-Associated Pluripotency Genes Fulltext Access 14 Pages 2014
A Histone Methylation Network Regulates Transgenerational Epigenetic Memory in C. elegans Fulltext Access 14 Pages 2014
JNK Suppresses Tumor Formation via a Gene-Expression Program Mediated by ATF2 Fulltext Access 14 Pages 2014
Rewiring of an Epithelial Differentiation Factor, miR-203, to Inhibit Human Squamous Cell Carcinoma Metastasis Fulltext Access 14 Pages 2014
NF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells Fulltext Access 14 Pages 2014
Cdk1 Coordinates Timely Activation of MKlp2 Kinesin with Relocation of the Chromosome Passenger Complex for Cytokinesis Fulltext Access 14 Pages 2014
Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function Fulltext Access 14 Pages 2014
Circulating AIM Prevents Hepatocellular Carcinoma through Complement Activation Fulltext Access 14 Pages 2014
Selective Protection of an ARF1-GTP Signaling Axis by a Bacterial Scaffold Induces Bidirectional Trafficking Arrest Fulltext Access 14 Pages 2014
Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function Fulltext Access 14 Pages 2014
Fungal extrolites as a new source for therapeutic compounds and as building blocks for applications in synthetic biology Fulltext Access 14 Pages 2014
Cooperativity, Specificity, and Evolutionary Stability of Polycomb Targeting in Drosophila Fulltext Access 15 Pages 2014
Polarized Expression of p75NTR Specifies Axons during Development and Adult Neurogenesis Fulltext Access 15 Pages 2014
Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors Fulltext Access 15 Pages 2014
Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L. Fulltext Access 15 Pages 2014
Determining lower limits of detection of digital PCR assays for cancer-related gene mutations Fulltext Access 15 Pages 2014
Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells Fulltext Access 15 Pages 2014
Cholesterol Regulates Syntaxin 6 Trafficking at trans-Golgi Network Endosomal Boundaries Fulltext Access 15 Pages 2014
Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin Fulltext Access 15 Pages 2014
High Runx1 Levels Promote a Reversible, More-Differentiated Cell State in Hair-Follicle Stem Cells during Quiescence Fulltext Access 15 Pages 2014
Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis Fulltext Access 15 Pages 2014
FXR1P Limits Long-Term Memory, Long-Lasting Synaptic Potentiation, and De Novo GluA2 Translation Fulltext Access 15 Pages 2014
Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation Fulltext Access 15 Pages 2014
A TGF-β receptor 1 inhibitor for prevention of proliferative vitreoretinopathy Fulltext Access 15 Pages 2014
DNA Hydroxymethylation Profiling Reveals that WT1 Mutations Result in Loss of TET2 Function in Acute Myeloid Leukemia Fulltext Access 15 Pages 2014
Genome-wide RNAi Screen Reveals a Role for Multipass Membrane Proteins in Endosome-to-Golgi Retrieval Fulltext Access 15 Pages 2014
Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress Fulltext Access 15 Pages 2014
The Oncogenic STP Axis Promotes Triple-Negative Breast Cancer via Degradation of the REST Tumor Suppressor Fulltext Access 15 Pages 2014
Glucose Regulates Mitochondrial Motility via Milton Modification by O-GlcNAc Transferase Fulltext Access 15 Pages 2014
Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States Fulltext Access 15 Pages 2014
Type II Cadherins Guide Assembly of a Direction-Selective Retinal Circuit Fulltext Access 15 Pages 2014
Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus Fulltext Access 15 Pages 2014
Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells Fulltext Access 15 Pages 2014
Function of a Foxp3 cis-Element in Protecting Regulatory T Cell Identity Fulltext Access 15 Pages 2014
Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function Fulltext Access 15 Pages 2014
Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function Fulltext Access 15 Pages 2014
Enhanced TLR-MYD88 Signaling Stimulates Autoinflammation in SH3BP2 Cherubism Mice and Defines the Etiology of Cherubism Fulltext Access 15 Pages 2014
κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation Fulltext Access 15 Pages 2014
PGC1β Activates an Antiangiogenic Program to Repress Neoangiogenesis in Muscle Ischemia Fulltext Access 15 Pages 2014
Npas4 Regulates Mdm2 and thus Dcx in Experience-Dependent Dendritic Spine Development of Newborn Olfactory Bulb Interneurons Fulltext Access 15 Pages 2014
Structural Basis of hAT Transposon End Recognition by Hermes, an Octameric DNA Transposase from Musca domestica Fulltext Access 15 Pages 2014
Endogenous RNAs Modulate MicroRNA Sorting to Exosomes and Transfer to Acceptor Cells Fulltext Access 15 Pages 2014
Ribosome Profiling Reveals Pervasive Translation Outside of Annotated Protein-Coding Genes Fulltext Access 15 Pages 2014
Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria Fulltext Access 15 Pages 2014
E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation Fulltext Access 15 Pages 2014
Sequencing of Captive Target Transcripts Identifies the Network of Regulated Genes and Functions of Primate-Specific miR-522 Fulltext Access 15 Pages 2014
Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease Fulltext Access 15 Pages 2014
ATP-Dependent Lon Protease Controls Tumor Bioenergetics by Reprogramming Mitochondrial Activity Fulltext Access 15 Pages 2014
APC Is an RNA-Binding Protein, and Its Interactome Provides a Link to Neural Development and Microtubule Assembly Fulltext Access 15 Pages 2014
Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment Fulltext Access 15 Pages 2014
A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways Fulltext Access 15 Pages 2014
mTORC1 Controls PNS Myelination along the mTORC1-RXRγ-SREBP-Lipid Biosynthesis Axis in Schwann Cells Fulltext Access 15 Pages 2014
Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man Fulltext Access 16 Pages 2014
lncRNA Directs Cooperative Epigenetic Regulation Downstream of Chemokine Signals Fulltext Access 16 Pages 2014
A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping Fulltext Access 16 Pages 2014
Enhancer Activation Requires trans-Recruitment of a Mega Transcription Factor Complex Fulltext Access 16 Pages 2014
Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function Fulltext Access 16 Pages 2014
Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects Fulltext Access 16 Pages 2014
Host Cell Factor-1 Recruitment to E2F-Bound and Cell-Cycle-Control Genes Is Mediated by THAP11 and ZNF143 Fulltext Access 16 Pages 2014
A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease Fulltext Access 16 Pages 2014
Behavioral Abnormalities and Circuit Defects in the Basal Ganglia of a Mouse Model of 16p11.2 Deletion Syndrome Fulltext Access 16 Pages 2014
MicroRNA Targeting of CoREST Controls Polarization of Migrating Cortical Neurons Fulltext Access 16 Pages 2014
Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein Fulltext Access 16 Pages 2014
HIV-1 Adaptation to Antigen Processing Results in Population-Level Immune Evasion and Affects Subtype Diversification Fulltext Access 16 Pages 2014