A Molecular Dynamics Approach to the Structural Characterization of Amyloid Aggregation Fulltext Access 16 Pages 2006
Three Key Residues Underlie the Differential Affinity of the TGFβ Isoforms for the TGFβ Type II Receptor Fulltext Access 16 Pages 2006
Engineering of Large Numbers of Highly Specific Homing Endonucleases that Induce Recombination on Novel DNA Targets Fulltext Access 16 Pages 2006
DNA Binding Domains and Nuclear Localization Signal of LEDGF: Contribution of two Helix-Turn-Helix (HTH)-like Domains and a Stretch of 58 Amino Acids of the N-terminal to the Trans-activation Potential of LEDGF Fulltext Access 16 Pages 2006
Rigidity and Flexibility of Dipeptidyl Peptidase IV: Crystal Structures of and Docking Experiments with DPIV Fulltext Access 16 Pages 2006
A Single Mutation Induces Amyloid Aggregation in the α-Spectrin SH3 Domain: Analysis of the Early Stages of Fibril Formation Fulltext Access 16 Pages 2006
Extended Flexible Linker Structures in the Complement Chimaeric Conjugate CR2-Ig by Scattering, Analytical Ultracentrifugation and Constrained Modelling: Implications for Function and Therapy Fulltext Access 16 Pages 2006
Phage Display Reveals Multiple Contact Sites between FhuA, an Outer Membrane Receptor of Escherichia coli, and TonB † Fulltext Access 16 Pages 2006
Exploring Transcription Factor Binding Properties of Several Non-coding DNA Sequence Elements in the Human NF-IL6 Gene Fulltext Access 16 Pages 2006
Multi-step Assembly Pathway of the cbb3-type Cytochrome c Oxidase Complex Fulltext Access 16 Pages 2006
Crystal Structure of the Archaeal A1AO ATP Synthase Subunit B from Methanosarcina mazei Gö1: Implications of Nucleotide-binding Differences in the Major A1AO Subunits A and B Fulltext Access 16 Pages 2006
Comparative analysis of tropism between canarypox (ALVAC) and vaccinia viruses reveals a more restricted and preferential tropism of ALVAC for human cells of the monocytic lineage Fulltext Access 16 Pages 2006
Effects of Calcium Binding on the Side-chain Methyl Dynamics of Calbindin D9k: A 2H NMR Relaxation Study Fulltext Access 16 Pages 2006
Molecular Mechanisms of PKCα localization and Activation by Arachidonic Acid. The C2 Domain also Plays a Role Fulltext Access 16 Pages 2006
Uncoupling of RNA Binding and PKR Kinase Activation by Viral Inhibitor RNAs Fulltext Access 16 Pages 2006
Solution Conformation and Heparin-induced Dimerization of the Full-length Extracellular Domain of the Human Amyloid Precursor Protein Fulltext Access 16 Pages 2006
GroEL Walks the Fine Line: The Subtle Balance of Substrate and Co-chaperonin Binding by GroEL. A Combinatorial Investigation by Design, Selection and Screening Fulltext Access 16 Pages 2006
Computational Study of the Fibril Organization of Polyglutamine Repeats Reveals a Common Motif Identified in β-Helices Fulltext Access 16 Pages 2006
A Critical Coiled Coil Motif in the Small Terminase, gp16, from Bacteriophage T4: Insights into DNA Packaging Initiation and Assembly of Packaging Motor Fulltext Access 16 Pages 2006
Molecular Structure of fd (f1, M13) Filamentous Bacteriophage Refined with Respect to X-ray Fibre Diffraction and Solid-state NMR Data Supports Specific Models of Phage Assembly at the Bacterial Membrane Fulltext Access 16 Pages 2006
Transition-state Complex of the Purine-specific Nucleoside Hydrolase of T. vivax: Enzyme Conformational Changes and Implications for Catalysis Fulltext Access 16 Pages 2006
Characterization of Intra-molecular Distances and Site-specific Dynamics in Chemically Unfolded Barstar: Evidence for Denaturant-dependent Non-random Structure Fulltext Access 16 Pages 2006
Herpes simplex virus regulatory proteins VP16 and ICP0 counteract an innate intranuclear barrier to viral gene expression Fulltext Access 16 Pages 2006
Plant viral movement proteins: Agents for cell-to-cell trafficking of viral genomes Fulltext Access 16 Pages 2006
Neutralization and infectivity characteristics of envelope glycoproteins from human immunodeficiency virus type 1 infected donors whose sera exhibit broadly cross-reactive neutralizing activity Fulltext Access 16 Pages 2006
Caspase-3 and -7 mediate apoptosis of human Chang's conjunctival cells induced by enterovirus 70 Fulltext Access 16 Pages 2006
Roles for herpes simplex virus type 1 UL34 and US3 proteins in disrupting the nuclear lamina during herpes simplex virus type 1 egress Fulltext Access 16 Pages 2006
CCAAT/enhancer-binding proteins modulate human T cell leukemia virus type 1 long terminal repeat activation Fulltext Access 16 Pages 2006
Adenovirus types 11p and 35 attach to and infect primary lymphocytes and monocytes, but hexon expression in T-cells requires prior activation Fulltext Access 16 Pages 2006
Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: Role of SIV-specific CD8+ T cell responses Fulltext Access 16 Pages 2006
Specific interaction of CXCR4 with CD4 and CD8α: Functional analysis of the CD4/CXCR4 interaction in the context of HIV-1 envelope glycoprotein-mediated membrane fusion Fulltext Access 16 Pages 2006
Widely varying SIV prevalence rates in naturally infected primate species from Cameroon Fulltext Access 16 Pages 2006
Characterization of the cellular receptors for the South American hemorrhagic fever viruses Junin, Guanarito, and Machupo Fulltext Access 16 Pages 2006
Rapid turnover and polyubiquitylation of the retroviral restriction factor TRIM5 Fulltext Access 16 Pages 2006
Structural Basis for Nucleic Acid and Toxin Recognition of the Bacterial Antitoxin CcdA Fulltext Access 16 Pages 2006
Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate Fulltext Access 16 Pages 2006
DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued Fulltext Access 16 Pages 2006
An intact sequence-specific DNA-binding domain is required for human cytomegalovirus-mediated sequestration of p53 and may promote in vivo binding to the viral genome during infection Fulltext Access 16 Pages 2006
The catalytic properties of the recombinant reverse transcriptase of bovine immunodeficiency virus Fulltext Access 16 Pages 2006
Requirements for capsid-binding and an effector function in TRIMCyp-mediated restriction of HIV-1 Fulltext Access 16 Pages 2006
Use of a novel assay based on intact recombinant viruses expressing green (EGFP) or red (DsRed2) fluorescent proteins to examine the contribution of pol and env genes to overall HIV-1 replicative fitness Fulltext Access 16 Pages 2006
Guidelines for the control of glycopeptide-resistant enterococci in hospitals Fulltext Access 16 Pages 2006
Universal vaccination of children against influenza: Are there indirect benefits to the community?: A systematic review of the evidence Fulltext Access 16 Pages 2006
Determining indications for adult vaccination: Patient self-assessment, medical record, or both? Fulltext Access 16 Pages 2006
The Human IgE-encoding Transcriptome to Assess Antibody Repertoires and Repertoire Evolution Fulltext Access 16 Pages 2006
Transmission Electron Microscopy Reveals an Optimal HIV-1 Nucleocapsid Aggregation with Single-stranded Nucleic Acids and the Mature HIV-1 Nucleocapsid Protein Fulltext Access 16 Pages 2006
Unbound and Acylated Structures of the MecR1 Extracellular Antibiotic-sensor Domain Provide Insights into the Signal-transduction System that Triggers Methicillin Resistance Fulltext Access 16 Pages 2006
Location of High and Low Affinity Fatty Acid Binding Sites on Human Serum Albumin Revealed by NMR Drug-competition Analysis Fulltext Access 16 Pages 2006
Small Proteins Fold Through Transition States With Native-like Topologies Fulltext Access 16 Pages 2006
The Asymmetric IscA Homodimer with an Exposed [2Fe-2S] Cluster Suggests the Structural Basis of the Fe-S Cluster Biosynthetic Scaffold Fulltext Access 16 Pages 2006
The Myosin Filament Superlattice in the Flight Muscles of Flies: A-band Lattice Optimisation for Stretch-activation? Fulltext Access 16 Pages 2006
Visualizing the Assembly of Human Rad51 Filaments on Double-stranded DNA Fulltext Access 16 Pages 2006
Flexibility and Adaptability in Binding of E. coli Cytidine Repressor to Different Operators Suggests a Role in Differential Gene Regulation Fulltext Access 16 Pages 2006
Structural Basis of the Nickel Response in Helicobacter pylori: Crystal Structures of HpNikR in Apo and Nickel-bound States Fulltext Access 16 Pages 2006
Methyl Substituents at the 11 or 12 Position of Retinal Profoundly and Differentially Affect Photochemistry and Signalling Activity of Rhodopsin Fulltext Access 16 Pages 2006
A Counterintuitive Mg2+-dependent and Modification-assisted Functional Folding of Mitochondrial tRNAs Fulltext Access 16 Pages 2006
Crystal Structures of the AppA BLUF Domain Photoreceptor Provide Insights into Blue Light-mediated Signal Transduction Fulltext Access 16 Pages 2006
Structure, Function and Dynamics in the mur Family of Bacterial Cell Wall Ligases Fulltext Access 16 Pages 2006
The 15 SCR Flexible Extracellular Domains of Human Complement Receptor Type 2 can Mediate Multiple Ligand and Antigen Interactions Fulltext Access 16 Pages 2006
Elucidation of Human Choline Kinase Crystal Structures in Complex with the Products ADP or Phosphocholine Fulltext Access 16 Pages 2006
DM2 CCTG•CAGG Repeats are Crossover Hotspots that are More Prone to Expansions than the DM1 CTG•CAG Repeats in Escherichia coli Fulltext Access 16 Pages 2006
Histidine Triad-like Motif of the Rotavirus NSP2 Octamer Mediates both RTPase and NTPase Activities Fulltext Access 16 Pages 2006
Structural Recognition between a Four-way DNA Junction and a Resolving Enzyme Fulltext Access 16 Pages 2006
Identification of the PXW Sequence as a Structural Gatekeeper of the Headpiece C-terminal Subdomain Fold Fulltext Access 16 Pages 2006
Tetramerization of the LexA Repressor in Solution: Implications for Gene Regulation of the E. coli SOS System at Acidic pH Fulltext Access 16 Pages 2006
In Silico Approaches Reveal the Potential for DNA Sequence-dependent Histone Octamer Affinity to Influence Chromatin Structure in Vivo Fulltext Access 17 Pages 2006
The Folding Energy Landscape of the Dimerization Domain of Escherichia coli Trp Repressor: A Joint Experimental and Theoretical Investigation Fulltext Access 17 Pages 2006
Polymorphism and Ultrastructural Organization of Prion Protein Amyloid Fibrils: An Insight from High Resolution Atomic Force Microscopy Fulltext Access 17 Pages 2006
Correlations between Scaffold/Matrix Attachment Region (S/MAR) Binding Activity and DNA Duplex Destabilization Energy Fulltext Access 17 Pages 2006
Electron Tomography of Swollen Rigor Fibers of Insect Flight Muscle Reveals a Short and Variably Angled S2 Domain Fulltext Access 17 Pages 2006
Crystallographic Structure of Human β-Hexosaminidase A: Interpretation of Tay-Sachs Mutations and Loss of GM2 Ganglioside Hydrolysis Fulltext Access 17 Pages 2006
Binding Site Structure of One LRP–RAP Complex:Implications for a Common Ligand–Receptor Binding Motif Fulltext Access 17 Pages 2006
β-Propeller Crystal Structure of Psathyrella velutina Lectin: An Integrin-like Fungal Protein Interacting with Monosaccharides and Calcium Fulltext Access 17 Pages 2006
Molecular Details of cAMP Generation in Mammalian Cells: A Tale of Two Systems Fulltext Access 17 Pages 2006
Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA Fulltext Access 17 Pages 2006
1.6 Å Crystal Structure of the Secreted Chorismate Mutase from Mycobacterium tuberculosis: Novel Fold Topology Revealed Fulltext Access 17 Pages 2006
Solution NMR Structure of the Junction between Tropomyosin Molecules: Implications for Actin Binding and Regulation Fulltext Access 17 Pages 2006
Towards a Comprehensive Analysis of the Protein Phosphatase 1 Interactome in Drosophila Fulltext Access 17 Pages 2006
Crystal Structures of Mouse 17α-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17α-reductive Activity of this Enzyme Fulltext Access 17 Pages 2006
Structures of in Vitro Evolved Binding Sites on Neocarzinostatin Scaffold Reveal Unanticipated Evolutionary Pathways Fulltext Access 17 Pages 2006
Molecular Dissection of the Inhibitor Binding Pocket of Mitotic Kinesin Eg5 Reveals Mutants that Confer Resistance to Antimitotic Agents Fulltext Access 17 Pages 2006
Origins of Sequence Selectivity in Homologous Genetic Recombination: Insights from Rapid Kinetic Probing of RecA-mediated DNA Strand Exchange Fulltext Access 17 Pages 2006
Φ-Analysis at the Experimental Limits: Mechanism of β-Hairpin Formation Fulltext Access 17 Pages 2006
From transcriptome to immunome: Identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library Fulltext Access 17 Pages 2006
Proteomic analysis of Neisseria lactamica and N eisseria meningitidis outer membrane vesicle vaccine antigens Fulltext Access 17 Pages 2006
A new intranasal influenza vaccine based on a novel polycationic lipid—ceramide carbamoyl-spermine (CCS): I. Immunogenicity and efficacy studies in mice Fulltext Access 17 Pages 2006
Structural Determinants of Natriuretic Peptide Receptor Specificity and Degeneracy Fulltext Access 17 Pages 2006
Probing Nature’s Knots: The Folding Pathway of a Knotted Homodimeric Protein Fulltext Access 17 Pages 2006
Functional Interplay between the Jaw Domain of Bacterial RNA Polymerase and Allele-specific Residues in the Product RNA-binding Pocket Fulltext Access 17 Pages 2006
Sequence Dependence of BNIP3 Transmembrane Domain Dimerization Implicates Side-chain Hydrogen Bonding and a Tandem GxxxG Motif in Specific Helix–Helix Interactions Fulltext Access 17 Pages 2006
A Framework for Describing Topological Frustration in Models of Protein Folding Fulltext Access 17 Pages 2006
New Peptide Inhibitors of Type IB Topoisomerases: Similarities and Differences Vis-a-vis Inhibitors of Tyrosine Recombinases Fulltext Access 17 Pages 2006