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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Oxaphosphetane versus betaine formation in epoxide ring opening by PPh3: a mechanistic probe by ab initio and DFT modeling
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Microwave-accelerated Fischer glycosylation
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Ionic liquid/water as a recyclable medium for Tsuji-Trost reaction assisted by microwave
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Stereoselective synthesis of cis- and trans-2,3-disubstituted eight-membered medium-ring ethers based on Ireland-Claisen rearrangement of 3-alkoxy-2-propenyl glycolate esters and ring-closing olefin metathesis
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The synthesis of unique structures of tetra-crown ethers through Michael addition
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Practical optical resolution of dl-muscone using tartaric acid derivatives as a chiral auxiliary
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A sorbitol-selective fluorescence sensor
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Instructions to contributors
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Calendar
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Ionic discotic liquid crystals: synthesis and characterization of pyridinium bromides containing a triphenylene core
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Rapid, highly efficient and stereoselective deoxygenation of epoxides by ZrCl4/NaI
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An efficient route to regioselective opening of N-tosylaziridines with zinc(II) halides
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N-Silylation of amines and amino acid esters under neutral conditions employing TMS-Cl in the presence of zinc dust
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Allylation and cyanation of aza-aromatics activated by chloroformate and a catalytic amount of iodine
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Aromaticity of anthranil and its isomers, 1,2-benzisoxazole and benzoxazole
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Synthesis of N-phthalimido β-aminoethanesulfonyl chlorides: the use of thionyl chloride for a simple and efficient synthesis of new peptidosulfonamide building blocks
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A diastereoselective approach for an asymmetric synthesis in pinnaic acid series
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An affinity-based probe for the proteomic profiling of aspartic proteases
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A novel synthesis of N-protected carbazoles involving electrocyclization of in situ generated enamines
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Sequential N-acylamide methylenation-enamide ring-closing metathesis: a synthetic entry to 1,4-dihydroquinolines
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Rhodium perfluorobutyramide (Rh2(pfm)4): a synthetically useful catalyst for olefin aziridinations
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First organophosphorus radical-mediated cyclisations to afford medium-sized rings: eight-membered lactones and seven- and eight-membered lactams
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New methodology for 2-alkylation of 3-furoic acids: application to the synthesis of tethered UC-781/d4T bifunctional HIV reverse-transcriptase inhibitors
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Sterically congested 'roofed' 2-thiazolines as new chiral ligands for copper(II)-catalyzed asymmetric Diels-Alder reactions
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Preparation of optically active α-hydroxy oxime ether by diastereoselective imino 1,2-Wittig rearrangement of hydroximates and its application to synthesis of (+)-cytoxazone
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Glycosidation via conjugate addition of anomeric alkoxides to nitroalkenes and nitrosoalkenes
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The use of deep cavity tetraformyl calix[4]arenes in the synthesis of static and dynamic macrocyclic libraries
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Asymmetric hydrogenation of imines catalyzed by iridium complexes with phosphine-phosphite ligands: importance of backbone flexibility
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Cyclizations of 2-alkylthiazolines and 2-alkyloxazolines with α,α-disubstituted diacid chlorides or N-(chlorocarbonyl) isocyanate
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5,6-Dihydropyrrolo[2,1-b]isoquinolines as scaffolds for synthesis of lamellarin analogues
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Isotope effects and the mechanism of deoxygenation of epoxides with dichlorocarbene
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Mucohalic acid in Lewis acid catalyzed Mukaiyama aldol reaction: a concise method for highly functionalized γ-substituted γ-butenolides
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Diastereoselective Petasis Mannich reactions accelerated by hexafluoroisopropanol: a pyrrolidine-derived arylglycine synthesis
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Total synthesis of (−)-centrolobine: β-C-glycoside formation via a tandem Grignard addition and stereoselective hemi-ketal reduction
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Instructions to contributors
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Exploiting π-shielding interactions: a highly selective chiral auxiliary derived from a biogenic building block
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Green approach for the conversion of olefins into vic-halohydrins using N-halosuccinimides in ionic liquids
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Remarkably facile Heck and Suzuki reactions in water using a simple cationic surfactant and ligand-free palladium catalysts
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Synthesis of bhimamycin B based on oxidative rearrangement of 4-acetylnaphtho[1,2-b]furan-5-ol to naphtho[2,3-c]furan-4,9-dione
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A highly stereoselective preparation of CF3-substituted 1-aryl-1,2-diphenylethenes: application to the synthesis of panomifene
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An expedient one-pot entry to catecholestrogens and other catechol compounds via IBX-mediated phenolic oxygenation
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Gymnocin-B with the largest contiguous polyether rings from the red tide dinoflagellate, Karenia (formerly Gymnodinium) mikimotoi
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A novel oxidative degradation pathway of indomethacin under the stressing by hydrogen peroxide
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A novel intramolecular Diels-Alder cyclization involving indoloazepines
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Synthesis of a tetra-deuterium-labeled derivative of potent and selective anticancer agent AA005
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High throughput screening of O-glycosylation conditions
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Unexpected formation of new chiral 3-amino-5-alkyl-2,5-dihydro-1H-pyrrolin-2-ones from N-Boc-α-amino esters
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1,4-Dihydropicolinic acid derivatives: novel NADH analogues with an altered connectivity pattern
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Baeyer-Villiger oxidation of ketones with hydrogen peroxide catalyzed by Sn-palygorskite
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Chiral 5-(diphenylphosphanyl)-1,2,3,4-tetrahydroacridines: new N,P-ligands for asymmetric catalysis
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Iridium-catalyzed double incorporation reaction of N-benzylmaleimide to styrene via ortho-C-H bond activation, initiated by precoordination of the double bond of styrene to iridium
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An improved cyclization protocol for the synthesis of diazabicyclo[4.3.0]alkanes
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Isothiouronium-modified gold nanoparticles capable of colorimetric sensing of oxoanions in aqueous MeOH solution
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Selective oxidations of sulfides to sulfoxides using immobilised cerium alkyl phosphonate
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Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides
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Medium-dependent lithiated side products in the reductive lithiation of allylic phenyl thioethers. Diethyl ether versus tetrahydrofuran
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Regioselective Michael-induced cyclisation of γ- and δ-hydroxy vinyl sulfides and vinyl dithiocarbamates
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Synthesis of a S-linked heparan sulfate trisaccharide as the substrate mimic of heparanase
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Stereoselective synthesis of nucleoside monophosphate HepDirect™ prodrugs
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A simple and efficient method to prepare thioesters in aqueous solutions
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Reductive allylation of 1H-pyridine-2-(thio)ones by means of the novel lithium allyldibutylmagnesate reagent
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Stereoselective synthesis of the various isomers of 3,4-dideoxy furanoid sugar amino acids with methyl substitution at the C6 position
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Michael reaction of 1,3-dicarbonyls with enones catalyzed by a hydroxyapatite-bound La complex
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Stereocontrolled synthesis of 3-amino-2-hydroxyalkyl diphenylphosphine oxides mediated by chiral azetidinium salts and epoxyamines
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Instructions to contributors
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4-(Phenylsulfonyl)-4-lithiocyclopentene as a nucleophilic 2-pentene-1,5-dial synthetic equivalent. An aziridine-based synthetic approach to (−)-alstonerine
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2-Oxo-1,2-ethylenedioxy group as a linker for solution-, liquid-, and solid-phase syntheses to discover drug-like small molecules
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Synthesis of new chiral ionic liquids from natural acids and their applications in enantioselective Michael addition
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Synthesis, resolution and racemisation studies of new tridentate ligands for asymmetric catalysis
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Iridium-catalyzed oxidative esterification reaction of aliphatic aldehydes and olefinic alcohols with precoordination of the double bond of alcohols to iridium
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Synthesis of benzimidazole based JNK inhibitors
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Synthesis and thermal modulation of the fluorescence of a pyrene-arylmaleimide dyad and its Diels-Alder adduct
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Catalytic aerobic photooxidation of primary benzylic amines using hindered acridinium salts
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Expedient synthesis of 1,2,3-triazole-fused tetracyclic compounds by intramolecular Huisgen ('click') reactions on carbohydrate-derived azido-alkynes
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Ring fragmentation processes resulting from acid catalysed diazo ketone cyclisations
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Synthesis of a N-glycan nonasaccharide of the bisecting type with additional core-fucose
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Ionic liquid mediated efficient reduction of nitroarenes using stannous chloride under sonication
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2-α-Hydroxybenzhydryl- and 2,7-di(α-hydroxybenzhydryl)-1,8-bis(dimethylamino)naphthalenes: the first examples of stabilization of in/out proton sponge conformers by intramolecular hydrogen bonding. The most flattened amino group ever participating in IH
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General method for the synthesis of 2′-O-carboranyl-nucleosides
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Enantioselective addition of aldehydes to amines via combined catalytic biomimetic oxidation and organocatalytic C-C bond formation
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Acceleration of the Passerini reaction in the presence of nucleophilic additives
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Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones
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Instructions to contributors
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The fragmentation of exo-5-norbornenyl-2-oxychlorocarbene: stereochemistry and mechanism
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Potassium trifluoro(organo)borates in rhodium-catalyzed 1,4-additions to α,β-unsaturated esters
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A new macrocycle that forms pseudorotaxane-like complexes with dibenzylammonium ions
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Synthesis of C(1)-C(11) oxygen-bridged pregnanes
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Activation of superoxide by boron trifluoride: chemoselective and efficient oxidation of sulfides to sulfoxides via tetrafluorodiboronperoxide
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Niobium(V) chloride catalyzed microwave assisted synthesis of 2,3-unsaturated O-glycosides by the Ferrier reaction
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First chemical synthesis of triglucosylated tetradecasaccharide (Glc3Man9GlcNAc2), a common precursor of asparagine-linked oligosaccharides
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Synthesis and photophysical properties of a fluorescent TREN-type ligand incorporating the coumarin chromophore and its zinc complex
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Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2′ reactions
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A sequence of electrophile induced cyclisation and concomitant N-deprotection of alkenylsulfinimines and alkenylsulfinamides as a direct route to cyclic or spirocyclic imines, pyrrolidines and piperidines
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A study on the metalation of alkoxydibromobenzenes
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The exclusive formation of cyclopentenones from molybdenum hexacarbonyl-catalyzed Pauson-Khand reactions of 5-allenyl-1-ynes
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Synthesis of cationic water-soluble esters of chlorin e6
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Synthesis, structure, and electrochemical properties of biferrocenes annulated with 1,2-dithiin and 1,2-dithiin 1,1-dioxides
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Instructions to contributors
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A C-C bond formation reaction at the α-carbon atom of α-oxo ketene dithioacetals via the Baylis-Hillman type reaction
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Three novel diepoxy tetrahydrochromones from agarwood artificially produced by intentional wounding
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