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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

New pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds
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Influence of chelating silyl scavengers on the diastereoselectivity of chromium catalyzed pinacol cross couplings
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Nucleophilic substitution of chlorobis(4-methoxyphenyl)methane: reactivity of carbenium ions in ILs-trifluoroethanol mixtures
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New aromatic annulation reaction via a C14 enaminone synthon: synthesis of 'terpenoid-like chalcones'
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Palladium-catalyzed construction of amino acid derivatives possessing vicinal chiral quaternary and tertiary carbon centers at the α and β positions
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A catalyst system for the formation of amides by reaction of carboxylic acids with blocked isocyanates
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Regioselective synthesis of quinolone-annulated sulfur heterocycles by aryl radical cyclization
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New approach to the synthesis of oligodeoxyribonucleotides modified with phosphorothioates of predetermined sense of P-chirality
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New synthetic strategy for o-NBS protected amino acids and their use in synthesis of mono-benzylated peptides
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Enantioselective synthesis of epi-(+)-Sch 642305: observation of an interesting diastereoselection during RCM
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Synthesis of neodysiherbaine
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A fluorescent cavitand for the recognition of GTP
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Instructions to contributors
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A highly efficient synthesis of antiobestic ligand GW501516 for the peroxisome proliferator-activated receptor δ through in situ protection of the phenol group by reaction with a Grignard reagent
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Samarium-induced convenient reductive dimerization of aromatic ketones in aqueous methanol: a mechanistic approach
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A simple and regioselective α-bromination of alkyl aromatic compounds by two-phase electrolysis
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Ultrasound-assisted rapid and efficient synthesis of propargylamines
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Design and synthesis of a potent biotinylated Smac mimetic
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Synthesis of oligomers including eight P-chiral centers and the construction of the 12-phosphacrown-4 skeleton
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A new boronic acid fluorescent reporter that changes emission intensities at three wavelengths upon sugar binding
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First example of a palladium catalyzed coupling reaction between cationic porphyrins and alkynyls in aqueous medium
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Aromatic ring favorable and efficient H-D exchange reaction catalyzed by Pt/C
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A chiral auxiliary derived from levoglucosenone in asymmetric Diels-Alder transformations
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Differentiation between the ethoxycarbonyl groups in diethyl malate via their titanium-catalyzed reductive cyclopropanation with ethylmagnesium bromide and subsequent site-selective three-carbon ring cleavage
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Instructions to contributors
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Unusual oxidative free-radical additions of 1,3-dicarbonyl compounds to benzonorbornadiene and oxabenzonorbornadiene
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Molecular iodine: a powerful catalyst for the easy and efficient synthesis of quinoxalines
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A practical synthesis of (−)-kazusamycin A (revised)
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Practical synthesis of an orally active renin inhibitor aliskiren
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Electrophilic substitutions and HOMOs in azines and purines
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A new synthetic approach for 4(S)-hydroxycyclopent-2-enone: a precursor to prostanoid synthesis
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Enantioselective synthesis and stereochemical revision of communiols A-C
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A proton sponge-based fluorescent switch
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Halogen effects in Robinson-Gabriel type reaction of cyclopropanecarboxylic acid N′-substituted-hydrazides with PPh3/CX4
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One-pot synthesis of aza-Morita-Baylis-Hillman adducts from α-oxo ketene-S,S-acetals, arylaldehydes and nitriles
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Synthesis of highly substituted pyrrolidines via palladium catalysed formal [2+3] cycloaddition of 5-vinyloxazolidin-2-ones to activated alkenes
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Stereoselective syntheses of (+)-proto, (−)-gala quercitols and carba-l-rhamnose from d-(−)-quinic acid
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The azulene moiety as a chromogenic building block for anion receptors
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A facile photoinduced iodoperfluoroalkylation of dienes, diynes, and enynes with perfluoroalkyl iodides via selective radical cyclization
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A facile S-transalkylation of 2,2′-bipyridine alkyl sulfides-a new tool for the synthesis of annulated biheterocycles
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Claisen self-condensation/decarboxylation as the key steps in the synthesis of C2-symmetrical 1,7-dioxaspiro[5.5]undecanes
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Orthogonally protected carbohydrate-based scaffolds
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Aglycon switch approach toward unnatural glycosides from natural glycoside with glycosyltransferase VinC
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Instructions to contributors
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Novel efficient synthesis of 3,4-dihydro-6-substituted-3-phenylpyrimidin-2(1H)-ones
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Synthesis of adenosine-based fluorosides containing a novel heterocyclic ring system
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Polymer-supported synthesis of mono-substituted porphyrins
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Drastic change in the rate of photochemical rearrangement of 1,6-(N-phenyl)aza-[60]fulleroids by switching the excited states through simple methyl substitution on the phenyl group
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Palladium-catalyzed coupling reaction of propargylic oxiranes with arylboronic acids in aqueous media
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Structures and C-H⋯π interactions in DMF inclusion complexes of homoazacalix[4]arenes
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A convergent route to β-hydroxy δ-lactones through Prins cyclisation as the key step: synthesis of (+)-prelactones B, C and V
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One pot direct synthesis of amides or oxazolines from carboxylic acids using Deoxo-Fluor reagent
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Asymmetric synthesis of dihydroquinazolinones via directed ortho metalation and addition to tert-butanesulfinyl imines
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Facile addition of alkynes to aza-aromatic systems: a new protocol for the preparation of 2-alkynyl-1,2-dihydroquinolines
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Novel protocol for the generation of β-branched Baylis-Hillman adducts from ethyl sorbate and aryl aldehydes
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Cu(I)-catalyzed intramolecular cyclization of ene-carbamates: synthesis of indoles and pyrrolo[2,3-c]pyridines
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A general asymmetric route for the synthesis of the alexine and australine family of pyrrolizidine alkaloids. The first asymmetric synthesis of 1,2-diepi-alexine and 1,2,7-triepi-australine
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Synthesis and electrochemical characterization of donor-acceptor phenylazomethine dendrimers
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A new strategy for the synthesis of aryl- and heteroaryl-substituted exocyclic olefins from allyl alcohols using PBr3
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Calix[8]arene anions: solid state structure of an inclusion compound with a tetrabutylammonium cation
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Instructions to contributors
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A novel calix[4]arene fluorescent receptor for selective recognition of acetate anion
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Synthesis of Mannich type products via a three-component coupling reaction
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A concise and practical catalytic asymmetric synthesis of (−)-CP-99,994 and (−)-L-733,061
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Biosynthesis of plaunotol in Croton stellatopilosus proceeds via the deoxyxylulose phosphate pathway
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Preparation of N-protected allylic amines and α-methylene-β-amino acids from vinylalumination/Baylis-Hillman products via tandem SN2′ substitution-Overman rearrangement
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Solvent effects in a carbenoid N-H insertion route to triarylamines via 2-diazo-1,3-cyclohexanedione
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A high yielding template-directed synthesis of the first fluorenone-containing [2]catenane
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A modified procedure for the Dakin-West reaction: an efficient and convenient method for a one-pot synthesis of β-acetamido ketones using silica sulfuric acid as catalyst
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A room temperature alternative of the Claisen rearrangement route to ortho allylated phenols: unique reactivity pattern of allylindium reagents
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Synthesis of trimethyl (2S,3R)- and (2R,3R)-[2-2H1]-homocitrates and the corresponding dimethyl ester lactones-towards elucidating the stereochemistry of the reaction catalysed by homocitrate synthase and by the Nif-V protein
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Microwave-induced clay-catalyzed ring opening of N-tosylaziridines: a green approach to achiral and chiral diamines
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Toward a total synthesis of the novel neurotrophic sesquiterpene merrilactone A: a RCM and [2+2]-photocycloaddition based approach to framework construction
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Efficient cleavage of carboxylic tert-butyl and 1-adamantyl esters, and N-Boc-amines using H2SO4 in CH2Cl2
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Direct glycosylation: synthesis of α-indoline ribonucleosides
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An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using molecular iodine as the catalyst
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Avoiding pyran ring opening during palladium acetate catalyzed C-glycosidation of peracetylated glycals
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Enyne and dienyne metathesis reactions in β-carbolines
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Asymmetric synthesis of the tricyclic core of cyathin diterpenoids via intramolecular Heck reaction
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Regioselective ipso formylation of p-tert-butylcalix[4]arene
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Amide-nitrophenyl based colorimetric receptors for selective sensing of fluoride ions
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Stereoselective transformation of easily available (2Z,4E)-2,4-alkadien-1-ols into (E)-3-alkene-1,2,5-triol derivatives
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Chromone-3-carboxaldehydes in Diels-Alder reactions with indole-o-quinodimethane. Synthesis of tetrahydrochromeno[2,3-b]carbazoles
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Stereoselective synthesis of the octahydroisobenzofuran skeleton of the eunicellins
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Highly active phosphine-free carbene ruthenium catalyst for cross-metathesis of acrylonitrile with functionalized olefins
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Synthesis of 1,3-diarylbenzo[c]selenophenes
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A novel entry into 1-methyl- and 1-aryl-octahydropyrrolo[3,4-b]pyrroles and their N-1-C-2 fused derivatives: stereoselective synthesis via an intramolecular azomethine ylide cycloaddition reaction
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A new reaction of diazomethane with norbornyl α-diketones
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Pyrene-azacrown ether hybrid: cation-π interaction
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A tandem C-H insertion-acetal cleavage sequence: stereocontrolled synthesis of substituted tetrahydrofurans
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Synthesis of 3-sulfanylpropanols containing three consecutive stereocenters via tandem Michael-aldol reaction of enoylthioamides with acetals as key reaction
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Synchronous helicity control in zinc bilinone trimer
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Self-assembled discotic liquid crystals formed by hydrogen bonding of alkoxystilbazoles
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Efficient synthesis of arylsulfamides by reaction of amines with arylsulfamoyl imidazolium triflate
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Application of AM SURE™ resin to solid-phase peptide synthesis
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Pd-catalyzed desulfonylative homocoupling of arenesulfonyl chlorides in the presence of hexamethyldisilane forming biaryls
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Domino addition/annulation of δ-alkynylaldehydes and oxygen nucleophiles: a new entry to [1,4]oxazino[4,3-a]indoles
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Instructions to contributors
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First isolation and characterization of 1,2-oxaphosphetanes with three phenyl groups at the phosphorus atom in typical Wittig reaction using cyclopropylidenetriphenylphosphorane
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Enantioselective nucleophilic addition to N-(2-pyridylsulfonyl)imines by use of dynamically induced chirality
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