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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

An efficient synthesis of 5-silyl-2,3-dihydrofurans via acid-catalyzed ring-enlargement of cyclopropyl silyl ketones and their functionalization
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Diastereoselective formation of cyclochiral amino acids-substituted resorcin[4]arenes
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Convenient construction of a variety of glycosidic linkages using a universal glucosyl donor
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Synthetic studies toward merrilactone A: a short synthesis of AB ring motif
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Chiral diphosphine ligands based on camphor: synthesis and applications in asymmetric hydrogenations
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New cleavable isocyanides for the combinatorial synthesis of α-amino acid analogue tetrazoles
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Microwave-accelerated cross-metathesis reactions of N-allyl amino acid substrates
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Intramolecular 1,3-dipolar nitrone cycloaddition route to bicyclic fused enediyne
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Facile synthesis of 7-amino anilinoquinazolines via direct amination of the quinazoline core
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A chemoselective ligation for the synthesis of amino acid derivatives of virginiamycin M1
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Enantiospecific total synthesis of phytoalexins, (+)-solanascone, (+)-dehydrosolanascone, and (+)-anhydro-β-rotunol
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Recyclable polymer-supported Pd catalysts for aryl amination reactions
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Synthesis of protected pseudopeptides from dicarboxylic amino acids by Mitsunobu condensation
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Alkene synthesis: elimination of arenesulfinic acid from alkyl aryl sulfones using potassium trimethylsilanolate as base
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First example of asymmetric transfer hydrogenation in water induced by a chiral amino alcohol hydrochloride
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The total synthesis of eupomatilones 2 and 5
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Diels-Alder reactions of pyrrolo[3,4-b]porphyrins
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Synthesis and properties of 1,6-methano[10]annuleno[3,4-c]thiophene and its 1,3-dicyano derivative
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Photo-induced aromatic assembly of benzocycloalka[1,2-b] furan and spiro[furan-2(3H),1′-benzocycloalkane] derivatives
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An efficient synthesis of LY544344·HCl: a prodrug of mGluR2 agonist LY354740
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Copper-catalyzed cross-coupling of sulfonamides with aryl iodides and bromides facilitated by amino acid ligands
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Instructions to contributors
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Hydrogen bonding-mediated self-assembly of square and triangular metallocyclophanes
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Sulfide ion transfer from a vicinal dithiolate. A new route for the synthesis of mesocyclic trithiaethers
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Towards the total synthesis of tangutorine by intramolecular Diels-Alder reaction
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Synthesis of pyrrolidine analogues of solamin
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N-[Chloro(dimethylamino)methylene]-N-methylmethanaminium chloride (TMUCl Cl), the reagent of choice for the solid-phase synthesis of anilides
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Concise synthesis of multiply substituted stereodefined cis,cis-2,4-diene-1,6-dials, cis,cis-2,4-diene-1,6-diols and further applications
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Carboranylcorroles
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Traceless solid-phase synthesis of 1,4-disubstituted-6-nitro-3,4-dihydro-1H-quinoline-2-ones
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β-Bromodifluoromethyl β-enaminoketones: versatile synthetic intermediates for synthesis of CF2-containing compounds
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Template-assisted control of porphyrin aggregation by ladder-type supramolecular assemblies
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Urea and thiourea based efficient colorimetric sensors for oxyanions
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Stereoselective synthesis of spiroannulated cyclopentenones by the Pauson-Khand reaction on carbohydrate derived enynes
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A novel mesoionic ring system: unusual cyclization of thio- and amino-acid derivatives of 6-azauracil
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First enantiospecific synthesis of marine nor-sesquiterpene (+)-austrodoral from (−)-sclareol
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Efficient and mild benzoin condensation reaction catalyzed by simple 1-N-alkyl-3-methylimidazolium salts
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Pd-catalyzed couplings of (α-fluoro)vinyl tris(trimethylsilyl)germanes
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Copper catalyzed tandem asymmetric conjugate addition-cyclization reaction in the presence of chiral phosphoramidite ligands
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The first asymmetric synthesis of (2S,3S,4R)-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine
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A cyclative cleavage approach to solid-phase synthesis of annulated pyrimidinones using Baylis-Hillman derivatives
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Synthetic studies toward the zoanthamine alkaloids: synthesis of the fully functionalized BC ring motif
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Synthesis and photophysical properties of phenothiazine-labeled conjugated dendrimers
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Carexanes: prenyl stilbenoid derivatives from Carex distachya
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Fragmentation of carbohydrate anomeric alkoxyl radicals. Synthesis of highly functionalized chiral vinyl sulfones
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Instructions to contributors
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Calix[4]arenesulfonylamidines. Synthesis, structure and influence on Mg2+, ATP-dependent calcium pumps
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Synthèse en une étape de N-méthoxyindolinones, de N-méthoxymaléimides et d'anhydrides maléiques à partir d'acides hydroxamiques α-halogénés
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An efficient method for the synthesis of hydrocyclopenta[1,2-b]furan with various side chains at 3a-position
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Solid-phase synthesis of quinoxaline, thiazine, and oxazine analogs through a benzyne intermediate
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Calendar
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Synthesis of highly substituted ureas and thioureas through 1,3-diaza-Claisen rearrangements
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An expedient, regioselective synthesis of 2-alkylamino- and 2-alkylthiothiazolo[5,4-e]indoles
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Highly regioselective Diels-Alder reactions of 9-substituted anthracenes and 2-acetamidoacrylate: synthesis of conformationally constrained α-amino acids
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A novel and efficient route to diarylmethanes catalyzed by nickel(II) ion on nanoporous carbon
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Montmorillonite K-10 as a mild acid for the Nicholas reaction
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Synthesis of trifunctional somatostatin based derivatives for improved cellular and subcellular uptake
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Polyisoprenylated benzophenone derivatives from Clusia obdeltifolia
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Synthesis of sterically hindered tris(4-imidazolyl)carbinol ligands and their copper(I) complexes related to metalloenzymes
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Synthesis and biological evaluation of unnatural canthine alkaloids
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Reaction of a 5α-bromo-6β,19-epoxysteroid with BF3·Et2O/Ac2O
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Catalytic asymmetric Simmons-Smith cyclopropanation of unfunctionalized olefins
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Instructions to contributors
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Evidence for the importance of conformational equilibria in Rh-diphosphine complexes for the enantioselection in Rh-catalyzed asymmetric hydrogenation
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Two-step syntheses of 2,4,6-triisopropylbenzenesulfonyl aziridines
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Synthesis of C-disaccharide analogues of the α-d-arabinofuranosyl-(1→5)-α-d-arabinofuranosyl motif of mycobacterial cell walls via alkynyl intermediates
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Stereoselective 1,5-rearrangement of vinylketene-N,O-acetals: novel vinylogous Ferrier reaction
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Bis-paracyclophane N-heterocyclic carbene-ruthenium catalyzed asymmetric ketone hydrosilylation
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An efficient catalyst system for diaryl ether synthesis from aryl chlorides
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Medium dependant production of corymbiferone a novel product from Penicillium hordei cultured on plant tissue agar
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Synthesis of 2,5-diethynyl substituted oxepins from trans-1,4-diethynylcyclohexa-2,5-diene-1,4-diols
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Enantioselective reactions of tert-butyl glycinate-benzophenone Schiff base catalyzed by chiral phase-transfer catalyst in aqueous media without any organic solvent
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Pegylation of 1,4,8,11-tetraazacyclotetradecane (cyclam) and its Cu(II) complexation
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Efficient aqueous-phase Suzuki coupling of activated aryl chlorides with arylboronic acids using d-glucosamine-based dicyclohexylarylphosphine
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Synthesis of graphislactones A-D through a palladium-mediated biaryl coupling reaction of phenyl benzoate derivatives
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Preparation of RCM substrates for azepinoindole synthesis: reductive amination versus tetrahydro-γ-carboline formation
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A new method for the synthesis of 1,4,5-oxadiazocines and its application in the structure modification of natural products
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One-pot synthesis of α-acyloxyaminoamides via nitrones as imine surrogates in the Ugi MCR
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A novel and efficient synthesis of 2,5-substituted 1,2,4-triazol-3-ones
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Deprotonation of furans using lithium magnesates
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Molybdenum-mediated cyclocarbonylation of 1-ethynyl-2-allenylbenzenes to 1H-cyclopenta[a]inden-2-ones
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A new type of boronic acid fluorescent reporter compound for sugar recognition
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Silphos [PCl3−n(SiO2)n]: a heterogeneous phosphine reagent for formylation and acetylation of alcohols and amines with ethyl formate and acetate
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Solid-phase synthesis of biarylalanines via Suzuki cross-coupling and intramolecular N-acyliminium Pictet-Spengler reactions
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An efficient asymmetric synthesis of grenadamide
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Enantioselective total synthesis of the polyketide natural product (−)-EI-1941-2: a novel interleukin-1β converting enzyme (ICE) inhibitor
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A convenient access to thermodynamically nonstabilised spiroketal isomers: the first synthesis of (Z)-7-methyl-1,6-dioxaspiro[4.5]decane
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A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone
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Barium ion sensing by a 2,2′-binaphthalene derivative bearing two monoaza-15-crown-5 ethers
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Synthesis of N-substituted 2,4-thiazolidinediones from oxazolidinethiones
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Instructions to contributors
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A rapid and efficient method for migration-free acylation of lysophospholipids: synthesis of phosphatidylcholines with sn-2-chain-terminal reporter groups
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Palladium-catalyzed cross-coupling reaction of alkynylzincs with benzylic electrophiles
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Pillared salicylaldehyde derivatives as building blocks for the design of cofacial salen-type ligands
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Tosylation/mesylation of 4-hydroxy-3-nitro-2-pyridinones as an activation step in the construction of dihydropyrido[3,4-b] benzo[f][1,4]thiazepin-1-one based anti-HIV agents
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Regioselective N- and C2-electrophilic substitution of 3-substituted indoles
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Regioselective synthesis of [1,2,3]-triazoles catalyzed by Cu(I) generated in situ from Cu(0) nanosize activated powder and amine hydrochloride salts
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Asymmetric reduction of ortho-multisubstituted benzophenones catalyzed by diamine-Zn-diol complexes
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Metalloporphyrin Cr(TPP)Cl-catalyzed Claisen rearrangement of simple aliphatic allyl vinyl ethers and its unique stereoselectivity
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Facile generation method for conjugated allenyl esters based on retro-Dieckmann-type ring-opening reactions
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