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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Ring-opening of lactones with enolate nucleophiles: a simple access to functionalised β-ketoesters, β,δ-diketoesters and β-ketosulfoxides
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Novel regiochemistry in the aqueous singlet oxygen ene reactions of carboxylic acid salts: a comparison of substrate structure
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Some reactions of persistent benzofuranone radicals related to the 'old' diazonamide structure
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Homo Diels-Alder chemistry in the synthesis of portulal: construction of the functionalized hydroazulene core
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Distorted benzene bearing two bulky substituents on adjacent positions: structure of 1,2-bis(1,2-dicarba-closo-dodecaboran-1-yl)benzene
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Derivatives of pentamidine designed to target the Leishmania lipophosphoglycan
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Synthesis of an N-glycan decasaccharide of the hybrid type
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Target-induced selection of ligands from a dynamic combinatorial library of mono- and bi-conjugated oligonucleotides
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Highly efficient Beckmann rearrangement and dehydration of oximes
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The synthesis of amides and dipeptides from unprotected amino acids by a simultaneous protection-activation strategy using boron trifluoride diethyl etherate
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Imidazolium salts as phase transfer catalysts for the dialkylation and cycloalkylation of active methylene compounds
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Tricoordinate diphenylboron cation prepared in solution
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Amberlyst-15®-promoted efficient 2-halogenation of 1,3-keto-esters and cyclic ketones using N-halosuccinimides
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Instructions to contributors
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Iron-catalyzed 1,6-addition of aryl Grignard reagents to 2,4-dienoates and -dienamides
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The first example of magnesium carbenoid 1,3-CH insertion reaction: a novel method for synthesis of cyclopropanes from 1-chloroalkyl phenyl sulfoxides in high yields
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On the mechanism of a double ring-closing metathesis reaction
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Chiral imides as potential chiroptical switches: synthesis and optical properties
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Cross-metathesis of 1,3-dienes with electron-deficient olefins
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Desmethylubiquinone Q2 from the Far-Eastern ascidian Aplidium glabrum: structure and synthesis
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Remarkable effects of titanium tetrachloride in diastereoselective aza Diels-Alder cycloaddition: synthesis of (S)-piperazic acid
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Instructions to contributors
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Hexa-peri-hexabenzocoronene/perylenedicarboxymonoimide and diimide dyads as models to study intramolecular energy transfer
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An efficient strategy for the preparation of one-bead-one-peptide libraries on a new biocompatible solid support
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Synthesis and in vitro photodynamic activity of novel galactose-containing phthalocyanines
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Search for dioxocarbenes in photochemical reactions of 5-diazo-4,6-dioxo-1,3-dioxanes, associated diazirines, and S-ylides
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Solid-phase synthesis of substituted 3-amino-3′-carboxy-tetrahydrocarbazoles
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Highly convergent synthesis of a rebeccamycin analog with benzothioeno(2,3-a)pyrrolo(3,4-c)carbazole as the aglycone
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Instructions to contributors
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Preparation of ginkgolide and F-seco-ginkgolide lactols: the unique reactivity of α-hydroxy lactones toward NaBH4
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Preparation of chiral 7,7′-disubstituted BINAPs for Rh-catalyzed 1,4-addition of arylboronic acids
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Asymmetric reduction of prochiral ketones using in situ generated oxazaborolidine derived from (1S,2S,3R,4R)-3-amino-7,7-dimethoxynorbornan-2-ol. An efficient synthesis of enantiopure (R)-tomoxetine
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A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids
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Cyclization of functionalized ketene-N,S-acetals to substituted pyrroles: applications in the synthesis of marine pyrrole alkaloids
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New γ-pyrone propionates from the Indian Ocean sacoglossan Placobranchus ocellatus
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Stereoselective alkylation of thiacalix[4]arenes
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α-Hydroxylation of carbonyls using iodine
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Triple self-condensation of fused cycloalkanonylparacyclophanes promoted by titanium tetrachloride and triethylamine
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Unexpected formation of porphyrinic enyne under Sonogashira conditions
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Facile solid phase synthesis of 1,2-disubstituted-6-nitro-1,4-dihydroquinazolines using a tetrafunctional scaffold
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2-Acylimino-3-alkyl-3H-thiazoline derivatives: one-pot, three-component condensation synthesis of novel β-turn mimics
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Parallel synthesis of tandem Ugi/Diels-Alder reaction products on a soluble polymer support directed toward split-pool realization of a small molecule library
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Synthesis of the hamigeran skeleton through an electro-oxidative coupling reaction
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One-pot dehydrogenation of carboxylic acid derivatives to α,β-unsaturated carbonyl compounds under mild conditions
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Highly efficient utilization of H2O2 for oxygenation of organic sulfides catalyzed by [γ-SiW10O34(H2O)2]4−
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Total synthesis of stevastelins B3 and C3: structure confirmation of stevastelin B3 and revision of stevastelin C3
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Rhodium-catalyzed alkylation of aromatic azines with alkenes via C-H bond activation
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Regioselective hydrosilylation of terminal acetylenes via acetylene-Co2(CO)4dppm complex: effects of the ligands in acetylenedicobalt complex
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Synthesis of benz[5,6]azepino[4,3-b]indoles by 1,7-electrocyclisation of azomethine ylides
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[60]Fullerene diol issued from pentaerythritol derivatives
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Synthesis of cyclobutanones and four-membered enol ethers by using a rearrangement reaction of enol triflates
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A solid phase linker strategy for the direct synthesis of EDANS-labelled peptide substrates
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Synthesis and absolute configuration of (1S,8S)-as-hydrindacene-1,8-diol as determined by the circular dichroism exciton chirality method
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Bioluminescence activity of Latia luciferin analogues: replacement of the 2,6,6-trimethylcyclohexene ring onto the methyl-substituted phenyl groups
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Stereoselective synthesis of substituted N-heterocycles via sequential cross metathesis-reductive cyclization
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Synthesis of organosilicon polymers by using the Lewis-acid-catalyzed trans-allylsilylation of alkynes
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A new synthesis of β-keto amides by reduction of Passerini adducts
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New pyrazole-tethered Schiffs bases as ligands for the Suzuki reaction
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Instructions to contributors
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Selective oxidation of benzylic or allylic hydroxyl group of sec-1,2-diols
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Barrelene-semibullvalene rearrangement induced by visible light: synthesis of dicorannulenosemibullvalene dimethyl dicarboxylate
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Chiral ferrocenyl diphosphines for asymmetric transfer hydrogenation of acetophenone
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A thermally-cleavable linker for solid-phase synthesis
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Hydrosilylation of alkynes catalyzed by ruthenium carbene complexes
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Molecular mechanics-assisted crystal engineering of solid state photoreactions: application to the Yang photocyclization of α-1-norbornylacetophenone derivatives
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Design and synthesis of novel ionic liquid/liquid crystals (IL2Cs) with axial chirality
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Domino functionalizations of the amino terminus of 6-aminopenicillanates with Ph3PCCO
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Access to 11β-ethynyl-androst-5-ene
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Microwave-assisted synthesis of 4,4′-diaminotriphenylmethanes
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Preparation of 2A,3A-alloepimino-2A,3A-dideoxy-β-cyclodextrin as a versatile scaffold candidate for the hetero-2A,3A-bifunctionalization
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Application of modular nucleophilic glycine equivalents for truly practical asymmetric synthesis of β-substituted pyroglutamic acids
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Oxidative coupling of 2-substituted 1,2-dihydro-1-naphthols using Jones reagent: a simple entry into 3,3′-disubstituted 1,1′-binaphthyl-4,4′-diols
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A novel clathrate host allowing structural adjustment during the inclusion of 1,2-diaminoethanes
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Synthesis and structural revision of calafianin, a member of the spiroisoxazole family isolated from the marine sponge, Aplysina gerardogreeni
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Diastereoselective synthesis of unsaturated 1,2-amino alcohols from α-hydroxy allyl ethers using chlorosulfonyl isocyanate
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Calendar
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Calixarene-based dendrimers. Second generation of a calix[4]-dendrimer with a 'tren' as core
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Cu-catalysed asymmetric 1,4-addition of Me3Al to nitroalkenes. Synthesis of (+)-ibuprofen
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4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β-hydroxysteroid dehydrogenase II. Part 1: Synthetic approach
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Rapid Mo(CO)6 catalysed one-pot deoxygenation of heterocyclic halo-benzyl alcohols with Lawesson's reagent
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Chemoselective reduction of ketones: trifluoromethylketones versus methylketones
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A simple one-pot procedure for the iminium salt formation: an efficient route to β-arylethylamines
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A facile tandem radical cyclization route to propellanes and its application to a total synthesis of modhephene
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An efficient catalytic enantioselective fluorination of β-ketophosphonates using chiral palladium complexes
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Regioselective preparation of 5-amino- and 6-amino-1,3-benzoxazole-4,7-diones from symmetrical diaminophenol and aminoresorcinol
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Studies on 6-[(dimethylamino)methylene]aminouracil: a facile one-pot synthesis of novel pyrimido[4,5-d]pyrimidine derivatives
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Self-inclusion properties of C60-linked calix[5]arene
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Instructions to contributors
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Sodium borohydride-iodine mediated reduction of γ-lactam carboxylic acids followed by DDQ mediated oxidative aromatisation: a facile entry to N-aryl-formylpyrroles
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Mercury chloride assisted cyclization toward benzimidazoles by focused microwave irradiation
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Selective complexation of metals with isoxazolidine-containing fluorophores
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Sulfur-containing and dimeric flavanols from Glycosmis montana
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A new Hg2+-selective fluorescent sensor based on a dansyl amide-armed calix[4]-aza-crown
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An efficient preparation of stereospecific β-hydroxy nitriles
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A novel and unusual method for C-N bond formation in 1-substituted-pyrrolidin-2-ones
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Synthesis of chiral γ-lactams via Rh(II) catalyzed intramolecular C-H insertion: α-substituents and conformational effects
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Synthesis of a highly soluble superstructured phenanthroline strapped porphyrin
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Synthesis and binding studies of novel bisthiacalix[4]arenes with diimime linkages
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Synthesis of water-soluble porphyrin and the corresponding highly planar benzoporphyrin without meso-substituents
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Regio/diastereo-controls of the Bingel-type biscyclopropanation of [60]fullerene by using bismalonates with a Tröger base analogue-derived tether
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