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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

An octa-cationic core-shell dendrimer as a molecular template for the assembly of anionic fullerene derivatives
Fulltext Access 4 Pages 2005
Chiral terpene auxiliaries. Part 1: Highly enantioselective reduction of ketones with borane catalyzed by an oxazaborolidine derived from (−)-β-pinene
Fulltext Access 4 Pages 2005
Iodine-mediated Z-selective oxidation of ketones to α,β-unsaturated esters: synthesis and mechanistic studies
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Convergent synthesis of the IJKLM-ring part of ciguatoxin CTX3C
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Instructions to contributors
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A base-catalyzed, direct synthesis of 3,5-disubstituted 1,2,4-triazoles from nitriles and hydrazides
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A new method for stereoselective oxidation of chiral 2-pyrrolidino-1-ethanol derivatives to oxazolopyrrolidines using trimethylamine-N-oxide in the presence of iron carbonyls
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Dynamic kinetic resolution of secondary alcohols with a readily available ruthenium-based racemization catalyst
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Phenacyl esters as a new photocleavable linker in liquid-phase chemistry
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Photodecarboxylative cyclizations of ω-phthalimido-ortho-phenoxy carboxylates
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Enantioselective total synthesis of polyoxygenated cyclohexanoids: (+)-streptol, ent-RKTS-33 and putative ‘(+)-parasitenone’. Identity of parasitenone with (+)-epoxydon
Fulltext Access 4 Pages 2005
Stereoselective synthesis of tri- and tetrasubstituted oxepanes via n-Bu3SnH mediated 7-endo-trig vinyl radical cyclisation
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Synthesis of α1-(Cbz-aminoalkyl)-α2-(hydroxyalkyl)phosphinic esters
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A facile direct conversion of aldehydes to esters and amides using acetone cyanohydrin
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Convenient route to dialkyl diselenides from alkyl tosylates. Synthesis of di(cis-myrtanyl) diselenide
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An efficient stereoselective synthesis of (3S,4R)-4-(hydroxymethyl)pyrrolidin-3-ol from (S)-diethylmalate
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TEMPO-catalyzed oxidation of benzylic alcohols to aldehydes with the H2O2/HBr/ionic liquid [bmim]PF6 system
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A new efficient enantioselective synthesis of malonylphenylalanyl and malonylmethylphenylalanyl derivatives suitable for solid phase peptide synthesis
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First example of base-promoted tandem alkylation-bromination of 2-bromothiophene via halogen dance process: a remarkable temperature effect
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Efficient and highly diastereoselective preparation of a myrtenal derived bis-sulfoxide and its preliminary evaluation as chiral acyl donor
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Sustainable domino Michael reaction catalyzed by a Brønsted base on silica gel: synthesis of bicyclo[2.2.2]octane-2,5-dione derivatives
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Highly efficient KF/Al2O3-catalyzed versatile hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles to α,β-ethylenic compounds
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Instructions to contributors
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Novel generation of selenoaldehydes through stannic chloride-induced unsymmetrical C-Se bond cleavage of bis(N,N-dimethylcarbamoylseleno)methanes
Fulltext Access 4 Pages 2005
Regioselective synthesis of 1-arylindazoles via N-arylation of 3-trimethylsilylindazoles
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Cyclization of 1-phenyl-2-propen-1-ones into 1-indanones using H-zeolite and other solid acids. The role of mono- and dicationic intermediates
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Catalytic oxidation of catechins to p-benzoquinones with hydrogen peroxide/methyltrioxorhenium
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Synthesis of tetrasubstituted Zn(II)-phthalocyanines carrying four carboranyl-units as potential BNCT and PDT agents
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An amphiphilic C60 derivative with a tris(2,2′-bipyridine)ruthenium(II) polar head group: synthesis and incorporation in Langmuir films
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Regioselective cleavage of the bis-benzylidene acetal of d-mannitol under oxidative and reductive conditions: a new approach to C2-symmetric chiral ligands
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Synthesis of the enantiomer of nelarabine
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Instructions to contributors
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Synthesis of phosphorylcholines possessing 5,6- or 14,15-epoxyisoprostane A2 at sn-2 position
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General synthetic approach to bicyclo[9.3.0]tetradecenone: a versatile intermediate to clavulactone and clavirolides
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A novel all-organic chemical and electrochemical fluorescent switch
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New tridentate cyclometalated platinum(II) and palladium(II) complexes of N,2-diphenyl-8-quinolinamine: syntheses, crystal structures, and photophysical properties
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Intermediacy of cyclobutylidene in photochemical methylenecyclopropane rearrangement
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Enantioselective synthesis and absolute configurations of aculeatins A and B
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A novel synthesis of bicyclo[3.3.0]oct-1-en-3-ones from cyclobutanones through [chloro(p-tolylsulfinyl)methylidene]cyclobutanes with ring expansion
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Model dipeptides incorporating the trans cyclohexane analogues of phenylalanine: further evidence of the relationship between side-chain orientation and β-turn type
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Original synthesis of oxiranes via TDAE methodology: reaction of 2,2-dibromomethylquinoxaline with aromatic aldehydes
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Expedient synthesis of substituted imidazoles from nitriles
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Net directed 180° aryl-aryl bond rotation in a prototypical achiral biaryl lactone synthetic molecular motor
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TiCl3/PhN2+-mediated radical addition of ethers to aldimines generated in situ under aqueous conditions
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The first example of the generation of azomethine ylides from a fluorocarbene: 1,3-cyclization and 1,3-dipolar cycloaddition
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Synthesis of ene-allenes via palladium-catalyzed hydride-transfer reaction of propargylic amines under mild conditions
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Synthesis of a linear benzo[3]phenylene-[60]fullerene dyad
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Scope and limitations of the catalytic asymmetric rearrangement of epoxides to allylic alcohols using chiral lithium amide bases/lithiated imidazoles
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Synthesis of phosphatase-resistant analogues of phytic acid (InsP6)
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Nitric acid in the presence of P2O5 supported on silica gel-a useful reagent for nitration of aromatic compounds under solvent-free conditions
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Synthesis and spectroscopic characterization of enantiopure protected trans-4-amino-1-oxyl-2,2,6,6-tetramethyl piperidine-3-carboxylic acid (trans β-TOAC)
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Direct mono-phosphorylation of 1,3-diols. A synthesis of FTY720-phosphate
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Synthesis of selenoxides by oxidation of selenides with superoxide radical anions and 2-nitrobenzenesulfonyl chloride
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Fluoride-catalyzed three-component coupling reaction of a silylphosphine, activated alkenes and aldehydes
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Anodic oxidation of chiral sulfinylamines: a new route to highly diastereoselective α-alkylation of piperidine
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Advantages of the Ns group in the reactions of N1-SO2R inosines with benzylamine and with 15NH3
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Synthesis of hydrophenanthrenes through a 'green' Fischer carbene-alkyne coupling process
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Instructions to contributors
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The effect of phenolates in the (salen)Mn-catalyzed epoxidation reactions
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α-Methoxyphenyl acetic acid (MPA) for the configurational assignment of aromatic-heteroaromatic carbinols by 1H NMR spectroscopy
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NaIO4-mediated C-H activation of alkylbenzenes and alkanes with LiBr
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4-Phenyl-1,2,4-triazole-3,5-dione as a novel and reusable reagent for the aromatization of 1,4-dihydropyridines under mild conditions
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Synthesis of novel piperazine based building blocks: 3,7,9-triazabicyclo[3.3.1]nonane, 3,6,8-triazabicyclo[3.2.2]nonane, 3-oxa-7,9-diazabicyclo[3.3.1]nonane and 3-oxa-6,8-diazabicyclo[3.2.2]nonane
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Nickel-mediated carboxylative cyclization of enynes
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Anthracene-9-methanol-a novel fluorescent phototrigger for biomolecular caging
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Synthesis of dysiherbaine analogue
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Asymmetric synthesis of 1-substituted-1-(pyridin-2-yl)methylamines by diastereoselective reduction of enantiopure N-p-toluenesulfinyl ketimines
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Synthesis of pyrrolo[2,3-d]pyrimidine-2,4-diones by sunlight photolysis of N-(5-vinyluracil-6-yl)sulfilimines
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Sequential peptide chemical ligation by the thioester method and extended chemical ligation
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Direct solid-phase synthesis of quinoxaline-containing peptides
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Stereoselective synthesis of syn-β-amino esters using the TiCl4/R3N reagent system
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A new convenient synthesis of functionalized 2,3-dihydro-4-pyridones
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One-pot synthesis of α-alkylated nitriles with carbonyl compounds through consecutive aldol reaction/hydrogenation using a hydrotalcite-supported palladium nanoparticle as a multifunctional heterogeneous catalyst
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Nitric acid in the presence of supported P2O5 on silica gel: an efficient and novel reagent for oxidation of sulfides to the corresponding sulfoxides
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A simple route to novel functionalized tetrathiafulvalene vinylogues
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A mild esterification process in phosphonium salt ionic liquid
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An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves
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First synthesis of P-aryl-phosphinosugars, organophosphorus analogues of C-arylglycosides
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On the interaction of silyl triflates with enamines: iminium ion formation versus silylation
Fulltext Access 4 Pages 2005
The synthesis of 'tyrosyl' peptidomimetics by acid-catalyzed N(1)-C(4) ring opening of 4-(4′-hydroxyphenyl)-azetidine-2-ones
Fulltext Access 4 Pages 2005
Synthesis of 5-deoxy-5-phospho-d-ribonohydroxamic acid: a new competitive and selective inhibitor of type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis
Fulltext Access 4 Pages 2005
[Ru(DMSO)4]Cl2 catalyzes the α-alkylation of ketones by alcohols
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Tandem Michael addition and intramolecular aldol cyclization of 1,2-dideoxy-1-nitroheptitols derived from sugars
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Regioselective anti-addition of phenols to propargylic oxiranes by palladium(0) catalyst
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Annulated butanolides by ring closing metathesis of diallyltetronic acid derivatives
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Studies into the generation and Diels-Alder reactions of 7,8-quinolyne with furan dienes
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A highly regioselective bisselenation of allenes with diphenyl diselenide catalyzed by tetrakis(triphenylphosphine)palladium(0)
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Highly efficient asymmetric transfer hydrogenation of ketones catalyzed by chiral 'roofed' cis-diamine-Ru(II) complex
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Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls
Fulltext Access 4 Pages 2005
Addition reaction of zinc acetylides to thioiminium salts leading to 3-amino-1-sulfenyl-1,4-enynes
Fulltext Access 4 Pages 2005
Synthesis of 12-deoxyroyleanone, cryptoquinone, 11,14-dihydroxy-8,11,13-abietatrien-7-one, and related derivatives from dehydroabietic acid
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Synthesis of d-gluco-, l-ido-, d-galacto-, and l-altro-configured glycaro-1,5-lactams from tartaric acid
Fulltext Access 4 Pages 2005
Instructions to contributors
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A new synthetic approach to enantiomerically enriched dihydrobenzofurans: use of a hydrolytic kinetic resolution and an intramolecular epoxide ring opening protocol using 1-benzyloxy-2-oxiranylmethylbenzenes
Fulltext Access 4 Pages 2005
Cu-nanoparticles: a chemoselective catalyst for the aza-Michael reactions of N-alkyl- and N-arylpiperazines with acrylonitrile
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Catalytic transfer hydrogenation of ketones catalyzed by orthometalated ruthenium(III) 2-(arylazo)phenolate complexes containing triphenylarsine
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Synthesis of small cyclic peptides constrained with 3-(3-aminomethylphenyl)propionic acid linkers using free radical-mediated macrocyclization
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Glycosyl azides of sugar 2-sulfonic acids
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ortho-Phosphoryl stabilized hypervalent iodosyl- and iodyl-benzene reagents
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Hydrogenation of substituted aromatic aldehydes: nucleophilic trapping of the reaction intermediate, application to the efficient synthesis of methylene linked flavanol dimers
Fulltext Access 4 Pages 2005
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