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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

A correlation study of bisphosphine ligand bite angles with enantioselectivity in Pd-catalyzed asymmetric transformations
Fulltext Access 4 Pages 2005
Substituent effects on the kinetics for the chemiluminescence reaction of 6-arylimidazo[1,2-a]pyrazin-3(7H)-ones (Cypridina luciferin analogues): support for the single electron transfer (SET)-oxygenation mechanism with triplet molecular oxygen
Fulltext Access 4 Pages 2005
Regioselective alkylation of 3,4-dihydro-2H-pyran by xanthate-mediated free radical nonchain process
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The first total synthesis of acutifolone A, a pinguisane-type sesquiterpenoid isolated from the Japanese liverwort Porella acutifolia subsp. tosana
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A highly stereoselective reductive amination of 3-ketosteroid with amines: an improved synthesis of 3α-aminosteroid
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Instructions to contributors
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Effect of iminic nitrogen substituents on [4+2] versus [3+2] cycloaddition pathways in reactions of nitrosoalkenes with simple acyclic imines: an experimental and theoretical investigation
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Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics
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Formation of 3,4-dimethyl-2-pyrones from allene carboxylates and 2-silyloxydienes via 3-carboethoxyethylidene cyclobutanols
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BiCl3-mediated opening of epoxides, a facile route to chlorohydrins or amino alcohols: one reagent, two paths
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Reaction of O6-methylguanosine with nitrite in the presence of carboxylic acid: synthesis of the purin-2-yl carboxylate
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Ceria/vinylpyridine polymer nanocomposite: an ecofriendly catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones
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A facile synthesis of fused spiroketal skeleton: 2,2′-spirobi(4-aryl-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydrochroman)
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A novel chlorinated norsesquiterpenoid and two related new metabolites from the soft coral Paralemnalia thyrsoides
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Stereoselective synthesis of ent-communiols A-C
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Oligothiophene phosphoramidites for oligonucleotide labelling
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Li+⋯π interaction in coronene-azacrown ether system
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Practical synthesis of (2S,3R)-3-hydroxy-3-methylproline, a constituent of papuamides, using a diastereoselective tandem Michael-aldol reaction
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Palladium-mediated transannular cyclizations of medium-ring olefinic enolsilanes
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Synthesis of P-chirogenic diarylphosphinoacetic acids and their proline derivatives for palladium-catalysed allylic alkylation reactions
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Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine and its analogues
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Importance of steric factors in face-selective cycloadditions: 1,6-annulated cyclohexa-1,3-dienes
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An amide orthoesterification route to N-(1′-alkylthioglucopyranosyl)indoles
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Fast and selective oxidation of thioglycosides to glycosyl sulfoxides using KF/m-CPBA
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Silica gel-promoted synthesis of 3,4,5-triaryltetrahydro-1,4-thiazine derivatives from β,β′-dichloro sulfides and aromatic amines
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A highly enantioselective catalyst for asymmetric hydroformylation of [2.2.1]-bicyclic olefins
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Regioselective thiocyanation of aromatic and heteroaromatic compounds using ammonium thiocyanate and oxone
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Oxazoline as a useful tool in organic synthesis: preparation of 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid skeleton
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Copper catalyzed asymmetric conjugate addition-bromination of α,β-unsaturated ketones: a highly efficient one-pot reaction for the synthesis of chiral α-bromo-β-alkylketones
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The furan approach to carbocyclic systems. Synthesis of cyclohexane derivatives from butenolides through an intramolecular Michael addition
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Synthetic studies of pestalotiopsin A: asymmetric synthesis of the 2-oxabicyclo[3.2.0]heptane substructure
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An efficient synthesis of N-protected threo (2R,3S)-3-amino-1,2-epoxy phenylbutane
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Preparation of enantiomerically pure (E)-β-sulfinylenones from β-ketoesters
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TiF4-mediated biomimetic alkylation-cyclization cascade reaction of 2-trimethylsilylmethyl-1,5-dienes with aldehydes
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Instructions to contributors
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Auxiliary strategies for the preparation of β-amino alcohols with reductive cross-coupling and a synthesis of (−)-cytoxazone
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Synthesis and oxidation of 'non-annulated' vitamin E-like compounds
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A green protocol for chemoselective O-acylation in the presence of zinc oxide as a heterogeneous, reusable and eco-friendly catalyst
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Synthesis of D-D4FC, a biologically active nucleoside via an unprecedented palladium mediated Ferrier rearrangement-type glycosidation with an aromatization prone xylo-furanoid glycal
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Catalytic enantioselective aryl transfer: asymmetric addition of boronic acids to aldehydes using pyrrolidinylmethanols as ligands
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Selective displacement of aryl fluorides with hydroquinone: synthesis of 4-phenoxyphenols
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Synthesis of a constrained tricyclic scaffold based on trans-4-hydroxy-l-proline
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Synthesis of the floresolide B hydroquinone lactone core using ring-closing metathesis
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Microwave-promoted synthesis of chiral pyridinium salts
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Aza-Michael reactions catalyzed by samarium diiodide
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Diisobutylaluminium hydride (DIBAL-H) is promoting a selective clockwise debenzylation of perbenzylated 6A,6D-dideoxy-α-cyclodextrin
Fulltext Access 4 Pages 2005
Environment friendly organic synthesis using bismuth compounds. An efficient method for carbonyl-ene reactions catalyzed by bismuth triflate
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Semipermanent p-nitrobenzyloxycarbonyl (pNZ) protection of Orn and Lys side chains: prevention of undesired α-Fmoc removal and application to the synthesis of cyclic peptides
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Direct hydroxylation of substituted benzenes to phenols with air and CO using molybdovanadophosphates as a key catalyst
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Recyclable ligand-free mesoporous heterogeneous Pd catalysts for Heck coupling
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Photochemical radical cyclization of γ,δ-unsaturated ketone oximes to 3,4-dihydro-2H-pyrroles
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Allylic oxidation: easy synthesis of alkenones from activated alkenes with TEMPO
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Iodine-catalyzed highly efficient Michael reaction of indoles under solvent-free condition
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A new, chiral aminoanthracene for the Diels-Alder/retro-Diels-Alder sequence in lactam and butenolide synthesis
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Pictet-Spengler heterocyclizations via microwave-assisted degradation of DMSO
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Computational evaluation of asymmetric Diels-Alder reactions of vinylboranes with chiral dienes
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Total synthesis of (±)-heliannuol C and E via aromatic Claisen rearrangement
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An exception to the normal Mitsunobu reaction with phenols; the formation of hydrazones from salicylaldehydes
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A study of polymer-supported bases for the solution phase synthesis of glycosyl trichloroacetimidates
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Self-assembly and characterization of a giant metallocycle
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The formal total synthesis of dragmacidin B, trans-dragmacidin C, and cis- and trans-dihydrohamacanthins A
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Novel highly potent, structurally simple γ-trifluoromethyl γ-sulfone hydroxamate inhibitor of stromelysin-1 (MMP-3)
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An efficient regioselective synthesis of endocrocin and structural related natural anthraquinones starting from emodin
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Beneficial effect of water as second solvent in ionic liquid biphasic catalytic hydrogenations
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Novel carboranylporphyrins for application in boron neutron capture therapy (BNCT) of tumors
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Instructions to contributors
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Strong phenyl–perfluorophenyl π–π stacking and C–H⋯F–C hydrogen bonding interactions in the crystals of the corresponding aromatic aldimines
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Metal-catalyzed cyclopropanation on the 8-oxabicyclo[3.2.1]oct-6-ene template
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Niobium(V) oxide: a new and efficient catalyst for the transesterification of β-keto esters
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Oxidative cyclization of aldazines with bis(trifluoroacetoxy)iodobenzene
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Hf[N(SO2C8F17)2]4-catalyzed Friedel-Crafts acylation in a fluorous biphase system
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First example of the activation of polymethylhydrosiloxane with molecular iodine: a facile synthesis of 3,6-dihydropyran derivatives
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An efficient and chemoselective method for protection of thiols catalyzed by aluminumdodecatungstophosphate (AlPW12O40), as a highly water tolerant Lewis acid catalyst
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5-Benzyl-1H-tetrazols from the reaction of 1-aryl-5-methyl-1H-tetrazoles with 1,2-dehydrobenzene
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A novel synthesis, including asymmetric synthesis, of α-quaternary α-amino acid methyl esters from ketones via sulfinyloxiranes
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Tandem one-pot intra- and inter-molecular McMurry coupling for the synthesis of bisindolostilbenophanes
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Asymmetric dihydroxylation of disubstituted allenes
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Selective deacetylation using iodine-methanol reagent in fully acetylated nucleosides
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Instructions to contributors
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Omriolide A and B; two new rearranged spongian diterpenes from the marine sponge Dictyodendrilla aff. retiara
Fulltext Access 4 Pages 2005
A new simple route to deoxyamino sugars from non-sugar material: synthesis of d-tolyposamine and 4-epi-d-tolyposamine and formal synthesis of d-vicenisamine
Fulltext Access 4 Pages 2005
Synthesis of fluorous trialkyl phosphines with the complete exclusion of PH3
Fulltext Access 4 Pages 2005
Mildbraedin, a novel kaempferol tetraglycoside from the tropical forest legume Mildbraediodendron excelsum
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Enantioselective three-component synthesis of 4-arylated dehydroprolines: [3+2] annulation of allenylstannane and α-imino ester
Fulltext Access 4 Pages 2005
A soluble 5-carbazolium-8-hydroxyquinoline Al(III) complex as a dipolar luminescent material
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Convenient preparation of highly active phase-transfer catalyst for catalytic asymmetric synthesis of α-alkyl- and α,α-dialkyl-α-amino acids: application to the short asymmetric synthesis of BIRT-377
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Synthesis and transformations of sulfur-substituted indolizidines and quinolizidines
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Synthetic approach to enyne and enediyne analogues of anticancer agents
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Ruthenium mediated SNAr reactions in synthetic approaches to ristocetin A aglycon: preparation of an ABCD ring intermediate
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Practical enantioselective synthesis of lamivudine (3TC™) via a dynamic kinetic resolution
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Palladium-copper catalysed heteroannulation of acetylenic compounds: an expeditious synthesis of isoindoline fused with triazoles
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Novel steroid mimics directed towards the estradiol skeleton
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Application of the thioimidate cyclopropane rearrangement to heterocyclic synthesis. Preparation of diaryl pyrrolines
Fulltext Access 4 Pages 2005
Photocatalytic oxidation of primary and secondary benzylic alcohols to carbonyl compounds catalyzed by H3PW12O40/SiO2 under an O2 atmosphere
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New synthetic methodology for 3-aminotropones
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Catalyst-free multicomponent Strecker reaction in acetonitrile
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Regio- and stereoselective 12-O-demethylation of schizandrin into gomisin T, an important intermediate to gomisin A, by Mortierella sp. (TM-I1104)
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Direct regio- and stereoselective synthesis of squalene 2,3;22,23-dioxide using dioxiranes
Fulltext Access 4 Pages 2005
Instructions to contributors
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Transition metal-free and substrate-selective oxidation of alcohols using water as an only solvent in the presence of β-cyclodextrin
Fulltext Access 4 Pages 2005
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