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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Synthesis and guest-binding study of polytopic multi(cyclophane) hosts
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Application of benzyl protecting groups in the synthesis of prenylated aromatic compounds
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A domino ring-closing metathesis as a key-step in the synthesis of chiral lactones from d-mannitol
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Significant solvent effects and unusual additions of p-chloranil in the photoinduced electron-transfer reaction of 2,2-dianisyl-4-isopropylidene-3,3-dimethylcyclobutanone
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Samarium triiodide-catalyzed conjugate addition of indoles with electron-deficient olefins
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Arylation of nitromethane: masked nucleophilic formylation of fluoroquinolones
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Avoiding the classical resolution during the synthesis of MeO-BIPHEP and 3,3′-disubstituted derivatives
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Highly selective glycine phase-transfer catalysis using fluoroanthracenylmethyl cinchonidine catalysts
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A new synthesis of 4-oxygenated β-carboline derivatives by Fischer indolization
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Copper catalyzed oxidation of sulfides to sulfoxides with aqueous hydrogen peroxide
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A facile method for synthesis of (R)-(−)- and (S)-(+)-homocitric acid lactones and related α-hydroxy dicarboxylic acids from d- or l-malic acid
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3-Bromo-propenyl acetate in organic synthesis: an expeditious route to 3-alkyl-4-acetoxy-5-iodomethyl isoxazolidines
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Instructions to contributors
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A practical synthesis of 3-indolyl α,β-unsaturated carbonyl compounds
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Fluorous 2-chloropyridinium salt (Mukaiyama condensation reagent) for amide formation reactions
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A simple approach to azirines containing an aldehyde functionality and their stabilization as palladium(II) complexes
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Chelation-controlled reduction: an enantioselective synthesis of (−)-tarchonanthuslactone
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Solid base-catalyzed synthesis of 5-substituted 4,5-dihydroisoxazoles
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Ionic liquids/H2O systems for the reaction of epoxides with NaN3: a new protocol for the synthesis of 2-azidoalcohols
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Efficient synthesis of β-C-glucosides via radical cyclization with a silicon tether based on the conformational restriction strategy
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Stereospecific isomerization of 2-(1-bromoalkyl)-1-sulfonylaziridines using magnesium bromide
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Studies towards the total synthesis of Sch 56036; isoquinolinone synthesis and the synthesis of phenanthrenes
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Efficient, protection-free Suzuki-Miyaura synthesis of ortho-biphenyltetrazoles
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One-pot carbanionic access to methylenebis(phosphonate) analogues of natural P1,P2-glycosyl-disubstituted pyrophosphates
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Synthesis of α-trifluoromethyl-α-amino-β-sulfone hydroxamates: novel nanomolar inhibitors of matrix metalloproteinases
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A neutral, water-soluble olefin metathesis catalyst based on an N-heterocyclic carbene ligand
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Nitrosation of β′-hydroxylamino-α,β-unsaturated oximes: synthesis of 1,7-dioxa-2,6-diaza-spiro[4,4]nona-2,8-diene ring system
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Microwave-assisted cross-coupling of 3-chloro-2-pyrazolines and 3-chloro-1-phenyl-1,4,5,6-tetrahydropyridazine with aryl boronic acids
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A Stille biaryl-coupling approach to dityrosines. Formal total synthesis of Hazimycin
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Self-assembly of chiral mesoionic heterocycles into smectic phases: a new class of polar liquid crystal
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Unexpected cycloadducts from 1,3-dipolar cycloaddition of 3,4-dehydromorpholine N-oxide to N-cinnamoyl piperidines—first report of the novel formation of 2:1 cycloadducts
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Sodium paeoniflorin sulfonate, a process derived artefact from paeoniflorin
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A novel tandem process leading to functionalized glutarimides
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Synthesis and characterization of novel imidazolium-based ionic discotic liquid crystals with a triphenylene moiety
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Metalloporphyrin and heteropoly acid catalyzed oxidation of CNOH bonds in an ionic liquid: biomimetic models of nitric oxide synthase
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Palladium versus copper-catalyzed N-arylation towards an efficient access to polysubstituted dibenzophenanthrolines and carbazoles
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An environmentally benign procedure for the Cu-catalyzed cyanation of aryl bromides
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Bismuth-catalyzed allylic oxidation using t-butyl hydroperoxide
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Toward a novel series of furanopyrimidine nucleoside analogues
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Total synthesis of didmolamides A and B
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Phosphine-catalyzed regioselective heteroaromatization between activated alkynes and isocyanides leading to pyrroles
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Sulfone-mediated synthesis of polysubstituted pyridines
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A novel synthetic protocol for poly(fluorenylenevinylene)s: a cascade Suzuki-Heck reaction
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2-Iodoethanols from aldehydes, diiodomethane and isopropylmagnesium chloride
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Selectivity aspects of the ring opening reaction of 2-alkenyl aziridines by carbon nucleophiles
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Instructions to contributors
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Organogel media for on-bead screening in combinatorial catalysis
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Synthesis and hyperpolarizabilities of high temperature triarylamine-polyene chromophores
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Synthesis of macrocyclic 1,1′-biarenol derivatives by the tandem Claisen rearrangement and their binding properties
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A protocol to accomplish 'homo-Robinson' annulation: application to the guanacastepene problem
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Photophysical studies on multichromophoric cyclotriphosphazenes. Trinuclear excimer formation in hexakis(2-naphthyloxy)cyclotriphosphazene
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Chiral syntheses of 6′-β-fluoroaristeromycin, 6′-β-fluoro-5′-noraristeromycin and aristeromycin
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1,5-Electrocyclisation of azomethine ylides leading to pyrrolo[2,1-a]isoquinolines-concise construction of the lamellarin skeleton
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Improved synthesis of functionalized 5,6-dihydro-pyrimido[4,5-b][1,4]oxazepines
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Wacker oxidation of terminal olefins in a mixture of [bmim][BF4] and water
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Access to 4-substituted 3,4-dihydroquinolin-2(1H)-ones by an unusual radical cyclisation of a secondary amide
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Formation of upper rim acylated calix[4]arenes using a sacrificial zinc anode
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An efficient and facile one-pot synthesis of cyanohydrin esters from carbonyl compounds catalyzed by iron(III) chloride
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Instructions to contributors
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Dynamic kinetic resolution during iron carbonyl promoted [6+2] ene-type reactions
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Regioselective synthesis of triiodo-o-carboranes and tetraiodo-o-carborane
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Rotational isomerism of a resveratrol tetramer, shoreaketone, in Shorea uliginosa
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Solid-phase synthesis of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives
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Microwave-assisted solid-phase Dötz benzannulation reaction: a facile synthesis of 2,3-disubstituted-1,4-naphthoquinones
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A hybrid macrocycle containing benzene and pyridine subunits is a better anion receptor than both its homoaromatic congeners
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Photoalkylation of 2,3-dicyanonaphthalene by methoxy-substituted 1,2-diarylcyclopropanes
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Petasis reaction of activated quinoline and isoquinoline with various boronic acids
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A total synthesis of the epoxyquinone based antifungal natural product (±)-ambuic acid
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A simple and efficient method for α-bromination of carbonyl compounds using N-bromosuccinimide in the presence of silica-supported sodium hydrogen sulfate as a heterogeneous catalyst
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Design and synthesis of novel oxa-bridged isoxazolidines and 1,3-aminoalcohols
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Synthesis of PI-88 analogue using novel O-glycosidation of exo-methylenesugars
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Lewis acid catalysed rearrangements of unsaturated bicyclic [2.2.n] endoperoxides in the presence of vinyl silanes; access to novel Fenozan BO-7 analogues
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Efficient one-pot ring-opening/aldol reactions using (cyclopropyl)methylstannanes
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The photochemical isomerization of cross-linked 1,3,5-tristyrylbenzene dendrimer with hula-twist mechanism
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Solid support synthesis of 15-membered macrocycles containing a serotonin unit
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Instructions to contributors
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Interfacial behavior and film-forming properties of an amphiphilic hexasubstituted [60]fullerene
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A third generation chiral phosphorus-containing dendrimer as ligand in Pd-catalyzed asymmetric allylic alkylation
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Weak C–H⋯O hydrogen bonds between diacylamidopyridine and thymine derivatives in solution and its influence on the binding constants
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A Baylis-Hillman/ozonolysis route towards (±) 4,5-dihydroxy-2,3-pentanedione (DPD) and analogues
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Hydrogen-bond directed palladium-catalyzed allylic substitution of cyclic substrates
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Syntheses of vinylindoles via a Brønsted acid catalyzed highly regio- and stereoselective cis-hydroarylation of ynamides
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One-pot conversion of activated alcohols into terminal alkynes using manganese dioxide in combination with the Bestmann-Ohira reagent
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Stereoselective acid-catalyzed homoallylic rearrangement of cyclopropylsilylmethanols: an efficient route to Z-homoallyl derivatives
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Remarkable Chichibabin-type cyclotrimerisation of 3-nitrotyrosine, tyrosine and phenylalanine to 3,5-diphenylpyridine derivatives induced by hypochlorous acid
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Uncatalysed Knoevenagel condensation in aqueous medium at room temperature
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Efficient formation of novel and versatile building blocks from mucohalic acids: new substitute for tetronic acid and γ-alkylidenebutenolide
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Reaction of δ-silyl-γ,δ-epoxy-α,β-unsaturated acylsilanes with cyanide ion: possibility of the formation of silicate intermediate in anion-induced ring opening of epoxysilanes
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Photocyclodimers from Z-ligustilide. Experimental results and FMO analysis
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Selective benzylic lithiation of N-Boc-2-phenylpiperidine and pyrrolidine: expedient synthesis of a 2,2-disubstituted piperidine NK1 antagonist
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Rate enhancement of PFP sulfonate ester aminolysis by chloride salts in organic and aqueous media
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A rapid, solvent-free, ligandless and mild method for preparing aromatic ketones from acyl chlorides and arylboronic acids via a Suzuki-Miyaura type of coupling reaction
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Reusable nano-sized chiral bisoxazoline catalysts
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A facile synthesis of antitumoral indeno[1,2-c]pyrazole-4-one by mild oxidation with molecular oxygen
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Synthesis and properties of purine-type base-discriminating fluorescent (BDF) nucleosides: distinction of thymine by fluorescence-labeled deoxyadenosine derivatives
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Aminomethylation of organic halides promoted by zinc in protic medium
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Design, synthesis, and validation of rigid linkers for bioactive peptides
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A new and rapid access towards exo-methylene-δ-valerolactones from (cyclopropyl)methylstannanes
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Amination and amidation of aryl iodides catalyzed by copper(I)-phenanthroline complexes
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A convenient synthesis of (E)-α-alkylidene-γ-lactams and (E)-3-alkylideneoxindoles by rhodium-catalyzed intramolecular hydroamidation
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