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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Total synthesis of BE-23254, a chlorinated angucycline antibiotic
Fulltext Access 4 Pages 2005
Convenient synthesis of 5-methylene-4-substituted-2(5H)-furanones
Fulltext Access 4 Pages 2005
Synthesis of medium-sized cyclic γ-haloketones by radical mediated ring-opening reaction of Lewis acid catalyzed (2+2)-cycloaddition products
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A highly efficient enantioselective synthesis of 2-methyl chromans via four sequential palladium-catalyzed reactions
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Zinc-mediated intramolecular acyl and imino transfer reactions of aryl iodides
Fulltext Access 4 Pages 2005
A mild and efficient method for the synthesis of vinylogous carbamates from alkyl azides
Fulltext Access 4 Pages 2005
Crystallization-induced asymmetric transformation (CIAT) with simultaneous epimerization at two stereocenters. A short synthesis of conformationally constrained homophenylalanines
Fulltext Access 4 Pages 2005
Asymmetric 1,4-addition of β-keto esters to cyclic enones catalyzed by Ru amido complexes
Fulltext Access 4 Pages 2005
An efficient Pd(II)-based catalyst system for carboxylation of aromatic C-H bond by addition of a phosphenium salt
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New generation of nucleophilic glycine equivalents
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Synthesis of 8-(S)-methoxy-11-desmethyl laulimalide: a novel laulimalide analogue
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Utilization of microwave heating in the McMurry reaction for facile coupling of aldehydes and ketones to give alkenes
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Novel porphyrin-quinone architectures via 1,3-dipolar cycloaddition reactions
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Synthesis of polyester dendrimers and dendrons starting from Michael reaction of acrylates with 3-hydroxyacetophenone
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Isolation and synthesis of a novel β-carboline guanidine derivative tiruchanduramine from the Indian ascidian Synoicum macroglossum
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From unsaturated dodecahedranes to C40 cages?
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Microwave promoted oxazole synthesis: cyclocondensation cascade of oximes and acyl chlorides
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Domino conversions of allyl tetronates and 4-allyloxycoumarins to all-trans 1,3,4,5-tetrasubstituted γ-butyrolactams
Fulltext Access 4 Pages 2005
1,2,3-Triazole as a safer and practical substitute for cyanide in the Bruylants reaction for the synthesis of tertiary amines containing tertiary alkyl or aryl groups
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Total synthesis of stevastelin B3
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Highly regio- and stereocontrolled brominations of gem-difluorinated vinyloxiranes
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Instructions to contributors
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A novel aromatic alkylation of anilines with cyclic and acyclic ketones under hydrothermal conditions
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The enantioselective halo aldol reaction utilizing cyclopropyl ketone-derived enolates
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Regioselective synthesis of 1,2- and 1,3-diols from ω-hydroxy allyl acetates and carbonates via Pd complexes using boric acid and trialkyl borates
Fulltext Access 4 Pages 2005
Regioselective intramolecular N1-C3 cyclizations on pyrrole-proline to ABC tricycles of dibromophakellin and ugibohlin
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Instructions to contributors
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A novel propargyltitanation of acetylenes. Heteroatom substituent-dependent manifold in intermolecular coupling of allene and acetylene
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Synthesis of new axially dissymmetric ligand with large perfluoroalkyl groups
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Synthesis of novel amino squaric acids via addition of dianion enolates derived from N-Boc amino acid esters
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Ring-closing double reductive amination route to aza-heteroannulated sugars
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Supramolecular hydrogels and organogels based on novel l-valine and l-isoleucine amphiphiles
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Microwave-assisted, regioselective, Petasis olefination of unsymmetrical oxalates. Formation of pyruvate-based enol ethers and enamines
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Photochemical and radical initiator-induced reaction of allylic indium compounds
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A stannylene strategy for regioselective acylation and phosphorylation of 1,2-cyclohexylidene-myo-inositol. Its convenient resolution and phosphatidylinositol synthesis
Fulltext Access 4 Pages 2005
A practical synthesis of LFA-1 inhibitors utilizing CuCl-promoted intramolecular cyclization of thiohydantoins
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Self-complementary bis-porphyrins
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Silica gel supported InBr3 and InCl3: new catalysts for the facile and rapid oxidation of 2′-hydroxychalcones and flavanones to their corresponding flavones under solvent free conditions
Fulltext Access 4 Pages 2005
Synthetic studies of the HIV-1 protease inhibitive didemnaketals: precise and stereocontrolled synthesis of the key mother spiroketal
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A new cavitand ionophore bearing two rigid crown ether groups
Fulltext Access 4 Pages 2005
Direct synthesis of novel 2-imino-1,3-selenazolidine derivatives from O-methanesulfonyl β-amino alcohol hydrochlorides
Fulltext Access 4 Pages 2005
A practical synthetic method for vinyl chlorides and vinyl bromides from ketones via the corresponding vinyl phosphate intermediates
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Pd-catalyzed cross-coupling reaction of (Z)- and (E)-bromoenyne: unusual stereochemical outcome
Fulltext Access 4 Pages 2005
A novel one-pot two-component synthesis of tricyclic pyrano[2,3-b]quinoxalines
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Efficient peptide coupling method of conjugated carboxylic acids with methyl ester amino acids hydrochloride. Application to the synthesis of Fa-Met, an important enzymatic substrate
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Alternative protocol for oxidation in water: an effective epoxidation system promoted by the combination of Oxone® and an amphiphilic ketone
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The first N,N′-ditosyl-substituted cyclic boron cation, stabilized by neighboring-group participation by two sulfonyl groups, and the alternative, stabilized by polar solvents
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Instructions to contributors
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Time-resolved pH jump study of photochemical cleavage and release of carboxylic acids from α-keto amides
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Ruthenium-catalyzed generation of hydrogen from iso-propanol
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The reaction of nitrones with pyrroles and furan: an easy access to heteroaromatic hydroxylamines and bis(heteroaryl)alkanes
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Solid-phase synthesis of pyrido[2,3-d]pyrimidin-7-ones
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Chemoselective hydrolysis of terminal isopropylidene acetals in acetonitrile using molecular iodine as a mild and efficient catalyst
Fulltext Access 4 Pages 2005
Synthesis and properties of novel guanidine bases. N,N′,N″-Tris(3-dimethylaminopropyl)-guanidine
Fulltext Access 4 Pages 2005
Synthesis of 1-aryl-tetralins and 4-aryl-benzopyrans by sulfoxide-mediated benzylic carbocation cyclizations
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Glycosyl azide-a novel substrate for enzymatic transglycosylations
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2-Nitrofurans as dienophiles in Diels-Alder reactions
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Enantioselective synthesis of both enantiomers of tert-butylphenylphosphine oxide from (S)-prolinol
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A new route to 3,4-disubstituted piperidines: formal synthesis of (−)-paroxetine and (+)-femoxetine
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Studies on the formation of porphyrinogens from monopyrroles in presence of the enzymes PBG deaminase and/or Uro'gen III synthase
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Synthesis of novel organoselenium as catalyst for Baeyer-Villiger oxidation with 30% H2O2
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Synthesis of symmetrical 1,3-butadiynes by homocoupling reactions of alkynylboronates mediated by a copper salt
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New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cancer cell, SBC-3
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The synthesis and characterization of phenylacetylene tripodal compounds containing boroxine cores
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Asymmetric Michael addition using N-cinnamoyl- and N-crotonyl-trans-hexahydrobenzoxazolidin-2-ones
Fulltext Access 4 Pages 2005
Total synthesis of (±)-cyclooroidin
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Instructions to contributors
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Synthesis of fused triazolo-imidazole derivatives by sequential van Leusen/alkyne-azide cycloaddition reactions
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Synthesis of fused imidazo azepine derivatives by sequential van Leusen/enyne metathesis reactions
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Synthesis of arylglycines via the Dötz benzannulation reaction
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Solid-phase synthesis of 2,3-diphenylpropionic acid library as VLA-4 antagonists
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Edulisones A and B, two epimeric benzo[b]oxepine derivatives from the bark of Aglaia edulis
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Cross-coupling reactions catalyzed by P, O chelate palladium complexes at room temperature
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Concise syntheses of the 1,7-dihydropyrano[2,3-g]indole ring system of the stephacidins, aspergamides and norgeamides
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A multi-photo responsive photochromic dithienylethene containing coumarin derivative
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Conformational control of flexible molecular tweezers by intramolecular CH/π interaction
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Geminal bond participation in Alder ene reaction
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Novel reactions of 6,7-dimethoxy-3,4-dihydroisoquinoline and 3,4-dihydro-β-carboline with dipolarophiles
Fulltext Access 4 Pages 2005
A higher yielding synthesis of the clinical prodrug ZD2767P using di-protected 4-[N,N-bis(2-hydroxyethyl)amino]phenyl chloroformate
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A one-pot process for the enantioselective preparation of saturated secondary alcohols from propargyl ketones under hydrogen transfer conditions
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Regio- and diastereoselective synthesis of bifunctionalized limonenes
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Preparation of vinylphenols from 2- and 4-hydroxybenzaldehydes
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Facile synthesis of novel monodisperse linear 3,9-linked oligocarbazoles
Fulltext Access 4 Pages 2005
Efficient method for the direct preparation of amides from carboxylic acids using tosyl chloride under solvent-free conditions
Fulltext Access 4 Pages 2005
1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions
Fulltext Access 4 Pages 2005
Selectivity in the electrochemical deprotection of cinnamyl groups from oxygen and nitrogen functionalities: carbonates versus carbamates
Fulltext Access 4 Pages 2005
A zwitterionic cyclopentadienyl annulated imidazolium salt
Fulltext Access 4 Pages 2005
Reductive sulfur extrusion reaction of 2,1,3-benzothiadiazole compounds: a new methodology using NaBH4/CoCl2·6H2O(cat) as the reducing system
Fulltext Access 4 Pages 2005
New facile and mild synthesis of 2-substituted oxazolopyridines
Fulltext Access 4 Pages 2005
Synthesis of tripeptide hydrolysate from papuamide A: determination of absolute stereostructure of β-methoxytyrosine
Fulltext Access 4 Pages 2005
Synthesis of (+)-laurencin via ring expansion of a C-glycoside derivative
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Acceleration of solid state Diels-Alder reactions by incorporating the reactants into crystalline charge transfer complexes
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Sulfide oxygenation by tert-butyl hydroperoxide with mononuclear (Me3TACN)Mn catalysts
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Instructions to contributors
Fulltext Access 4 Pages 2005
5-Nitro[2.2]paracyclophanepyran-6-one-building block for the synthesis of [2.2]paracyclophanes containing condensed benzofuran subunits
Fulltext Access 4 Pages 2005
Proline-catalyzed aldol reactions of acyl cyanides with acetone: an efficient and convenient synthesis of 1,3-diketones
Fulltext Access 4 Pages 2005
Zr-Mediated hydroboration: stereoselective synthesis of vinyl boronic esters
Fulltext Access 4 Pages 2005
Luminescence behaviour of calix[4]arenes bearing an increasing number of appended-pyrenes
Fulltext Access 4 Pages 2005
Synthesis of polyacetylenic acids isolated from Nanodea muscosa
Fulltext Access 4 Pages 2005
Preparation and identification of bis(formylmethano)[60]fullerene isomers: the first systematic study on bifunctionalized [60]fullerenes with dissymmetric addends
Fulltext Access 4 Pages 2005
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