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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

1,2,3,4,5,6-Hexahydrophosphinine 1-oxides with an exocyclic P-function at position 3: diastereoselective synthesis, stereostructure and conformation
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Synthesis of an extended hexagonal molecule as a highly symmetrical ligand
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Synthesis of lysine derivatives containing aza-crown ethers and a chromophore unit
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A regioselective synthesis of 2,4-dialkyl resorcinols
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Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to α,β-unsaturated carbonyl compounds
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Sonogashira cross-coupling reactions with heteroaryl halides in the presence of a tetraphosphine-palladium catalyst
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Synthesis of hedychenone, yunnancoronarins and aframodial derivatives
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Synthesis of sidechain adapted β-turn mimics for modifying the C-terminus of substance P
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Nα-Dmc protected amino acid aglycones: versatile hydrogenolysis stable acceptors for O-glycosylation
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Synthesis of 2-amino-3-hydroxy-4-substituted pyridines via regioselective metalation of 3-(1-ethylpropyl)-[1,3]oxazolo[4,5-b]pyridin-2(3H)-one and application to corticotropin releasing factor1 receptor ligands
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The first synthesis of β-phenylchalcogeno-α,β-unsaturated esters via hydrochalcogenation of acetylenes using microwave and solvent-free conditions
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The synthesis of diaminopimelic acid containing peptidoglycan fragments using metathesis cross coupling
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An efficient synthesis of sterically hindered arylboronic acids
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A short asymmetric total synthesis of chloramphenicol using a selectively protected 1,2-diol
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Isotope effects and the mechanism of palladium-catalyzed allylic alkylation
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Oxidative cyclization of a seco-cladiellane diterpenoid
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Regioselective synthesis of 6-benzylthiazolo[3,2-b]1,2,4-triazoles during Sonogashira coupling
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Vesicle formation from a synthetic adenosine based lipid
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Instructions to contributors
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An efficient synthesis of novel heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine using Ugi condensation
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Synthesis, properties, and electrogenerated chemiluminescence (ECL) of a novel carbazole-based chromophore
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New deuterium isotope effects on 13C and 19F chemical shifts across intramolecular hydrogen bonds of non-resonance assisted systems
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Isotope effects and the mechanism of fragmentation of epoxy imino-1,3,4-oxadiazolines
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Novel method for catalyst immobilization using an ionic polymer: a case study using recyclable ytterbium triflate
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Aerobic oxidation of primary alcohols in the presence of activated secondary alcohols
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Total synthesis of pawhuskin C: a directed ortho metalation approach
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Hydrazine hydrate induced reductive cleavage of α,β-epoxy ketones: an efficient procedure for the preparation of β-hydroxy ketones
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Facile chemoselective rhodium carbenoid N-H insertion reactions: synthesis of 3-arylamino- or 3-heteroarylpiperidin-2-ones
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Instructions to contributors
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Synthetic applications of the amine-base treatment in the ozonolysis of substituted-allyl silyl ethers or -allyl esters via a novel ene-diol type rearrangement
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Dramatically enhanced N→O acyl migration during the trifluoroacetic acid-based deprotection step in solid phase peptide synthesis
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A convenient method for the preparation of primary amines using tritylamine
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Selective alkylation and Suzuki coupling as an efficient strategy for introducing functional anchors to the ethylene-bis(indenyl) ligand
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Solid supported synthesis of structurally diverse dihydropyrido[2,3-d]pyrimidines using microwave irradiation
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An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005)
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Design and characterisation of novel hexadentate 3-hydroxypyridin-4-one ligands
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Acetate aldol reactions of chiral oxocarbenium ions
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A convenient synthesis of 2-nitroindoles
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Stereoselective synthesis of substituted dienes by the double ortho ester Claisen rearrangement
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Directed H-bonding inhibition in molecular recognition: an NMR case study of the H-bonding of a dicarboxylic acid with a new mixed diamide receptor having one adjacent pyridine-N-oxide
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Amino acid binding in water by a new guanidiniocarbonyl pyrrole dication: the effect of the experimental conditions on complex stability and stoichiometry
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Podospermic acid, 1,3,5-tri-O-(7,8-dihydrocaffeoyl)quinic acid from Podospermum laciniatum (Asteraceae)
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Straightforward synthesis of enantiopure 2-aminomethyl and 2-hydroxymethyl pyrrolidines with complete stereocontrol
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Mevashuntin, a novel metabolite produced by inhibition of the mevalonate pathway in Streptomyces prunicolor
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Reaction of electron deficient NN bonds with acyloxyketenes and mesoionic 1,3-dioxolium-4-olates: fast equilibrium between acyloxyketenes and mesoionic 1,3-dioxolium-4-olates
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Formal total synthesis of (±)-martinellic acid
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Microwave-assisted one-pot synthesis of 2,3-disubstituted 3H-quinazolin-4-ones
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Synthesis of indenothiophenone derivatives by cycloaromatization of non-conjugated thienyl tetraynes
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Instructions to contributors
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Bromide selective fluorescent anion receptor with glycoluril molecular scaffold
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A chemoselective deprotection of trimethylsilyl acetylenes catalyzed by silver salts
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Instructions to contributors
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Novel biotransformation of pentacyclic triterpenoid acids by Nocardia sp. NRRL 5646
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A short synthesis of morachalcone A
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Samarium/N-bromosuccinimide-induced reductive dimerization of carbonyl compounds
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Indium-mediated Barbier-type allylation of aldehydes as a convenient method for the highly enantioselective synthesis of homoallylic alcohols
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ZrCl4 mediated cross-cyclization between epoxides and homoallylic alcohols: synthesis of 4-chlorotetrahydropyran derivatives
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Synthesis and liquid crystalline properties of a disc-shaped molecule with azobenzene at the periphery
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A ring-closing metathesis route to 7-membered aza-heteroannulated sugars
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A short and versatile route to chiral spiroketal skeletons
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A simple procedure for the synthesis of γ-hydroxy-α,β-(E)-alkenoic esters: formal synthesis of (+)-macrosphelides A and B
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Reaction of N-fluoropyridinium fluoride with isonitriles: a convenient route to picolinamides
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Highly reactive and enantioselective kinetic resolution of terminal epoxides with H2O and HCl catalyzed by new chiral (salen)Co complex linked with Al
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Efficient synthesis of substituted biaryl anilines and biaryl phenols via a Suzuki cross-coupling reaction
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Unprecedented carbocyclization of 1,6-allenynes on addition of organoboronic acids under Pd-catalysis
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Asymmetric synthesis of 3-methylthio alcohols by intramolecular Michael addition reactions
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Kinetic resolution of sec-alcohols by a new class of pyridine catalysts having a conformation switch system
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A cysteine-appended deoxyuridine for the postsynthetic DNA modification using native chemical ligation
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An efficient catalytic asymmetric addition of trimethylsilyl cyanide to aldehydes at room temperature
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Benzannulation of heterocyclic ring systems through coupling of Fischer carbene complexes and heterocycle-bridged enynes
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Heteroatom transfer to alkenes by N-protected-oxaziridines: new reaction pathways and products
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Cerium(III) chloride-promoted chemoselective esterification of phenolic alcohols
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Instructions to contributors
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New chiral ferrocenyl amidophosphine ligand for remarkable improvement of enantioselectivities in copper-catalyzed addition of diethylzinc to N-sulfonylimines
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One-step synthesis and photochromic properties of a stable triangle terthiophene
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Unexpected 1,2 syn diastereoselectivity in the three-component 'aza Sakurai-Hosomi' reaction
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Transformation of thioacetals to cyclopropanes
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Synthesis of regiospecifically substituted quinolines from anilines
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A practical entry to C18-constrained-E-ring analogues of methyllycaconitine (MLA): a concise new stereoselective approach to 8-oxa-decahydroisoquinolines accompanied by a simple microwaves-assisted synthesis of the succinimidobenzoate appendage of MLA
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A facile access to chalcogen and dichalcogen bearing dialkylamines and diols
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Ternary complex formation inducing large expansions of chemomechanical polymers by metal chelators, aminoacids and peptides as effectors
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Nucleophilic addition to 3,4-cis-diacetyl-1,2,3,4-tetramethyl-1-cyclobutene: remarkably fast intramolecular hemiketalization
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A model of porphyrin ring current effect
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Instructions to contributors
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Enantioselective Morita-Baylis-Hillman (MBH) reaction promoted by a heterobimetallic complex with a Lewis base
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Carbolithiation of vinyl pyridines as a route to 7-azaindoles
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Metallic samarium and iodine promoted facile and efficient syntheses of trisubstituted alkenes from the acetates of Baylis-Hillman adducts
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Grignard reagent-promoted selective ring expansion and alkylation of formyl borneol and isoborneol: a new route to highly substituted cyclopentanes
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Formation of the unexpected 3-alkylated flavonoids in the alkylation of B-ring substituted 5,7-dihydroxy flavones
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Synthetic studies toward tricyclic cembranoids: a modular approach for the construction of the tricyclic framework of eunicin
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Location effect of an OH group on the chemiluminescence efficiency of 4-hydroperoxy-2-(o-, m-, or p-hydroxyphenyl)-4,5-diphenyl-4H-isoimidazoles
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Nucleophilic vinylic substitutions of (Z)-(2-aroyloxyvinyl)phenyl-λ3-iodanes with tetrabutylammonium halides: vinylic SN2 reactions and ligand coupling on iodine(III)
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Synthesis of 6,7-disubstituted-5H-pyrrolo[2,3-b]pyrazines via palladium-catalyzed heteroannulation
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Transformation of methyl N-methyl-N-(6-substituted-5-nitro-4-pyrimidinyl)aminoacetates into 4-methylamino-5-nitrosopyrimidines and 9-methylpurin-8-ones
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Evidence for a nucleophilic anti-attack on the cleaved C(2)-oxygen bond in Cl2AlH-catalyzed ring-opening of 2-substituted 1,3-dioxolanes
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Enantioselective syntheses of 3,4,5-trisubstituted γ-lactones: formal synthesis of (−)-blastmycinolactol
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Statistical experimental design-driven discovery of room-temperature conditions for palladium-catalyzed cyanation of aryl bromides
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Fluorous synthesis of biaryl-substituted proline analogs by 1,3-dipolar cycloaddition and Suzuki coupling reactions
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Catalytic asymmetric aza Diels-Alder reactions of hydrazones using a chiral zirconium catalyst
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Radical deoxygenation of alcohols and intermolecular carbon-carbon bond formation with surfactant-type radical chain carriers in water
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