Rob Ashley of AmpliMed discusses the discovery and development of Imexon Fulltext Access 4 Pages 2005
Sourcing a chemical succession for cyclosporin from parasites and human pathogens Fulltext Access 4 Pages 2005
When counting sheep does not help: the growing incidence of sleep disorders Fulltext Access 4 Pages 2005
British Columbia's biotechnology industry: blending research, business and lifestyle Fulltext Access 4 Pages 2005
Steve Carney talks to Vincent Lee on the pharma industry, the FDA and public education with respect to drugs and their development Fulltext Access 4 Pages 2005
Broad spectrum immune monitoring in immune-mediated inflammatory disorders Fulltext Access 4 Pages 2005
Avoiding overfitting in multilayer perceptrons with feeling-of-knowing using self-organizing maps Fulltext Access 4 Pages 2005
Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression Fulltext Access 4 Pages 2005
Drug treatment of premature ejaculation: Pharmacodynamic and pharmacokinetic paradigms Fulltext Access 4 Pages 2005
Stearoyl-CoA desaturase: A therapeutic target of insulin resistance and diabetes Fulltext Access 4 Pages 2005
11β-Hydroxysteroid dehydrogenase type 1 as a therapeutic target in the metabolic syndrome Fulltext Access 4 Pages 2005
Locked nucleic acid (LNA): High affinity targeting of RNA for diagnostics and therapeutics Fulltext Access 4 Pages 2005
Therapeutic targets in rheumatoid arthritis: More to come but which one(s) to select? Fulltext Access 4 Pages 2005
Relationship between subclinical inflammation, obesity, diabetes and related disorders Fulltext Access 4 Pages 2005
Sir Michael Rawlins on being NICE - and fair - about drug development and availability Fulltext Access 4 Pages 2005
Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action Fulltext Access 4 Pages 2005
Peter Corr outlines Pfizer's approach to innovation, maximizing capabilities and delivering essential medicine Fulltext Access 4 Pages 2005
Chris Ashton talks about his career and the recent merger of Argenta Discovery and Etiologics Fulltext Access 4 Pages 2005
The furan approach to oxacycles. Part 5: Synthesis of a chiral butenolide, building block towards biologically interesting natural products Fulltext Access 4 Pages 2005
Biosynthetic studies on the antibiotics PF1140: a novel pathway for a 2-pyridone framework Fulltext Access 4 Pages 2005
Simultaneous accumulation of both skeletal and appendage-based diversities on tandem Ugi/Diels-Alder products Fulltext Access 4 Pages 2005
Novel and efficient regioselective enzymatic approach to 3â²-, 5â²- and 3â²,5â²-di-O-crotonyl 2â²-deoxynucleoside derivatives Fulltext Access 4 Pages 2005
Single step synthesis of 2,3-dialkyl-6-nitro-quinazolin-4(3H)-imines and 3,5-dialkyl-9-nitro-imidazo[1,2-c]quinazolin-2(3H)-ones Fulltext Access 4 Pages 2005
Regio- and stereoselective annelation of phenanthridines with α,β-acetylenic γ-hydroxyacid nitriles Fulltext Access 4 Pages 2005
Generation of ortho-quinone methides upon thermal extrusion of sulfur dioxide from benzosultones Fulltext Access 4 Pages 2005
Tryptamine-based human β3-adrenergic receptor agonists. Part 3: Improved oral bioavailability via modification of the sulfonamide moiety Fulltext Access 4 Pages 2005
Uric acid may inhibit glucose-induced insulin secretion via binding to an essential arginine residue in rat pancreatic β-cells Fulltext Access 4 Pages 2005
Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide Fulltext Access 4 Pages 2005
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold Fulltext Access 4 Pages 2005
Five-member thio-heterocyclic fused naphthalimides with aminoalkyl side chains: intercalation and photocleavage to DNA Fulltext Access 4 Pages 2005
Synthesis of half-mustard combi-molecules with fluorescence properties: correlation with EGFR status Fulltext Access 4 Pages 2005
Reversal of anticancer drug resistance by COTC based on intracellular glutathione and glyoxalase I Fulltext Access 4 Pages 2005
Structure-activity relations of azafluorenone and azaanthraquinone as antimicrobial compounds Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors Fulltext Access 4 Pages 2005
Detection and control of aspartimide formation in the synthesis of cyclic peptides Fulltext Access 4 Pages 2005
Reversible microencapsulation of pybox-Ru chiral catalysts: scope and limitations Fulltext Access 4 Pages 2005
Antimitotic activity and reversal of breast cancer resistance protein-mediated drug resistance by stilbenoids from Bletilla striata Fulltext Access 4 Pages 2005
Synthesis and pharmacological evaluation of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-dione derivatives as potent euglycemic and hypolipidemic agents Fulltext Access 4 Pages 2005
Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities Fulltext Access 4 Pages 2005
Synthesis of argentatin A derivatives as growth inhibitors of human cancer cell lines in vitro Fulltext Access 4 Pages 2005
Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate Fulltext Access 4 Pages 2005
Studies towards the next generation of antidepressants. Part 4: Derivatives of 4-(5-fluoro-1H-indol-3-yl)cyclohexylamine with affinity for the serotonin transporter and the 5-HT1A receptor Fulltext Access 4 Pages 2005
Chemoenzymatic synthesis of CD52 glycoproteins carrying native N-glycans Fulltext Access 4 Pages 2005
Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives Fulltext Access 4 Pages 2005