Antitumor agents. Part 236: Synthesis of water-soluble colchicine derivatives Fulltext Access 4 Pages 2005
Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic Fulltext Access 4 Pages 2005
The synthesis of substituted bipiperidine amide compounds as CCR3 antagonists Fulltext Access 4 Pages 2005
Interaction of dopamine and acetylcholine with an amphiphilic resorcinarene receptor in aqueous micelle system Fulltext Access 4 Pages 2005
Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol Fulltext Access 4 Pages 2005
Biaryls and heterobiaryls as α-glucosidase and protein tyrosine phosphatase inhibitors Fulltext Access 4 Pages 2005
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors Fulltext Access 4 Pages 2005
The discovery and synthesis of novel adenosine receptor (A2A) antagonists Fulltext Access 4 Pages 2005
Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics Fulltext Access 4 Pages 2005
Synthesis and radiopharmacological evaluation of 2â²-(4-fluorophenyl)-21-[18F]fluoro-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole as potential glucocorticoid receptor ligand for positron emission tomography (PET) Fulltext Access 4 Pages 2005
Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors Fulltext Access 4 Pages 2005
Novel 1β-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt Fulltext Access 4 Pages 2005
A new class of androgen receptor antagonists bearing carborane in place of a steroidal skeleton Fulltext Access 4 Pages 2005
Himeic acid A: a new ubiquitin-activating enzyme inhibitor isolated from a marine-derived fungus, Aspergillus sp. Fulltext Access 4 Pages 2005
Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA Fulltext Access 4 Pages 2005
Efficient cleavage of RNA, enhanced cellular uptake, and controlled intracellular localization of conjugate DNAzymes Fulltext Access 4 Pages 2005
Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase Fulltext Access 4 Pages 2005
Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2 Fulltext Access 4 Pages 2005
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties Fulltext Access 4 Pages 2005
Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core Fulltext Access 4 Pages 2005
Design and synthesis of a peptide-PEG transporter tool for carrying adenovirus vector into cells Fulltext Access 4 Pages 2005
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives Fulltext Access 4 Pages 2005
The discovery of a selective, high affinity A2B adenosine receptor antagonist for the potential treatment of asthma Fulltext Access 4 Pages 2005
Studies on the structure-activity relationship of 2â²,6â²-dimethyl-l-tyrosine (Dmt) derivatives: bioactivity profile of H-Dmt-NH-CH3 Fulltext Access 4 Pages 2005
Generation of a new class of hNK2 receptor ligands using the 'fragment approach' Fulltext Access 4 Pages 2005
Synthesis of modified proanthocyanidins: easy and general introduction of a hydroxy group at C-6 of catechin; efficient synthesis of elephantorrhizol Fulltext Access 4 Pages 2005
Synthesis of modified proanthocyanidins: introduction of acyl substituents at C-8 of catechin. Selective synthesis of a C-4 â O â C-3 ether-linked procyanidin-like dimer Fulltext Access 4 Pages 2005
Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists Fulltext Access 4 Pages 2005
Synthesis and acetylcholinesterase inhibition of derivatives of huperzine B Fulltext Access 4 Pages 2005
Enantiomerical excess determination, purification and biological evaluation of (3S) and (3R) α,β-butenolide analogues of isobenzofuranone Fulltext Access 4 Pages 2005
Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase Fulltext Access 4 Pages 2005
Synthesis and evaluation of diverse analogs of amygdalin as potential peptidomimetics of peptide T Fulltext Access 4 Pages 2005
2-Substituted-4-aryl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,5]oxazocin-5-one as a structurally new NK1 antagonist Fulltext Access 4 Pages 2005
Crystal structures of human HSP90α-complexed with dihydroxyphenylpyrazoles Fulltext Access 4 Pages 2005
Electronic structure calculations on the thiazole-containing antibiotic thiostrepton: molecular mechanics, semi-empirical and ab initio analyses Fulltext Access 4 Pages 2005
Discovery and SAR of new benzazepines as potent and selective 5-HT2C receptor agonists for the treatment of obesity Fulltext Access 4 Pages 2005
Structure-activity relationships and sub-type selectivity in an oxabicyclic estrogen receptor α/β agonist scaffold Fulltext Access 4 Pages 2005
4-(2-Aminoethoxy)-N-(phenylsulfonyl)indoles as novel 5-HT6 receptor ligands Fulltext Access 4 Pages 2005
Novel fluoroquinolones: design, synthesis, and in vivo activity in mice against Mycobacterium tuberculosis H37Rv Fulltext Access 4 Pages 2005
3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis Fulltext Access 4 Pages 2005
Identification of small molecule inhibitors of the hepatitis C virus RNA-dependent RNA polymerase from a pyrrolidine combinatorial mixture Fulltext Access 4 Pages 2005
Antitubercular agents. Part 1: Synthesis of phthalimido- and naphthalimido-linked phenazines as new prototype antitubercular agents Fulltext Access 4 Pages 2005
Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors Fulltext Access 4 Pages 2005
Synthesis and pharmacological investigation of novel 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a new class of H1-antihistaminic agents Fulltext Access 4 Pages 2005
Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2 Fulltext Access 4 Pages 2005
Structure-activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists Fulltext Access 4 Pages 2005
Asymmetric synthesis of novel tetrahydroquinoline derivatives with a sugar building block and their bioactivities Fulltext Access 4 Pages 2005
Enhancement in antimicrobial activity of 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine Fulltext Access 4 Pages 2005
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14 Fulltext Access 4 Pages 2005
Novel cyclized Pifithrin-α p53 inactivators: synthesis and biological studies Fulltext Access 4 Pages 2005
Structure-activity relationships of the oxindole growth hormone secretagogues Fulltext Access 4 Pages 2005
Novel 2-aminothiazonaphthalimides as visible light activatable photonucleases: effects of intercalation, heterocyclic-fused area and side chains Fulltext Access 4 Pages 2005
N-Acyl arylsulfonamides as novel, reversible inhibitors of human steroid sulfatase Fulltext Access 4 Pages 2005
Discovery and structure-activity relationships of 2-benzylpyrrolidine-substituted aryloxypropanols as calcium-sensing receptor antagonists Fulltext Access 4 Pages 2005
Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors Fulltext Access 4 Pages 2005
7α,11β-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties Fulltext Access 4 Pages 2005
Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists Fulltext Access 4 Pages 2005
Amide derivatives of 9,11-seco-estra-1,3,5(10)-trien-11-oic acid as modified orally active estrogen agonists with moderate antagonistic activity Fulltext Access 4 Pages 2005
Characterization of l-glutamine:2-deoxy-scyllo-inosose aminotransferase (tbmB) from Streptomyces tenebrarius Fulltext Access 4 Pages 2005
Design, synthesis and evaluation of 5-substituted amino-2,4-diamino-8-chloropyrimido-[4,5-b]quinolines as novel antimalarials Fulltext Access 4 Pages 2005
2,3-Ethylene- and 2,3-trimethylene-bridged analogues of the group III metabotropic glutamate receptor ligand 2-amino-4-phosphonobutanoic acid Fulltext Access 4 Pages 2005
Syntheses of 2,4,6-trisubstituted pyrimidine derivatives as a new class of antifilarial topoisomerase II inhibitors Fulltext Access 4 Pages 2005
Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas Fulltext Access 4 Pages 2005
A new strategy to combat Alzheimer's disease. Combining radical-scavenging potential with metal-protein-attenuating ability in one molecule Fulltext Access 4 Pages 2005
From a total synthesis of cepabactin and its 3:1 ferric complex to the isolation of a 1:1:1 mixed complex between iron (III), cepabactin and pyochelin Fulltext Access 4 Pages 2005
Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification Fulltext Access 4 Pages 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates Fulltext Access 4 Pages 2005
Dipyridyl amides: potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists Fulltext Access 4 Pages 2005
Nonpeptide αvβ3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics Fulltext Access 4 Pages 2005
3-(2,5-Dihydro-1H-pyrrol-2-ylmethoxy)pyridines: synthesis and analgesic activity Fulltext Access 4 Pages 2005
3-Arylidene-1-(4-nitrophenylmethylene)-3,4-dihydro-1H-naphthalen-2-ones and related compounds displaying selective toxicity and reversal of multidrug resistance in neoplastic cells Fulltext Access 4 Pages 2005
Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation Fulltext Access 4 Pages 2005
The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide Fulltext Access 4 Pages 2005
Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin Fulltext Access 4 Pages 2005
Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol Fulltext Access 4 Pages 2005
Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents: parallel synthesis for lead optimization of amide region Fulltext Access 4 Pages 2005
Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2) Fulltext Access 4 Pages 2005
Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide Fulltext Access 4 Pages 2005
Synthesis of isonicotinic acid Nâ²-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents Fulltext Access 4 Pages 2005