Insecticidal activity of proteinous venom from tentacle of jellyfish Rhopilema esculentum Kishinouye Fulltext Access 4 Pages 2005
1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors Fulltext Access 4 Pages 2005
Active site directed inhibitors of replication-specific bacterial DNA polymerases Fulltext Access 4 Pages 2005
Estrogen receptor ligands. Part 11: Synthesis and activity of isochromans and isothiochromans Fulltext Access 4 Pages 2005
Pyrenyldiazomethane, a versatile reagent for nucleotide phosphate alkylation Fulltext Access 4 Pages 2005
Synthesis and antifungal activity of noble 5-arylamino- and 6-arylthio-4,7-dioxobenzoselenazoles Fulltext Access 4 Pages 2005
Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase Fulltext Access 4 Pages 2005
Cleavage at 5-methylcytosine in DNA by photosensitized oxidation with 2-methyl-1,4-naphthoquinone tethered oligodeoxynucleotides Fulltext Access 4 Pages 2005
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold Fulltext Access 4 Pages 2005
Biarylcarboxybenzamide derivatives as potent vanilloid receptor (VR1) antagonistic ligands Fulltext Access 4 Pages 2005
Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents Fulltext Access 4 Pages 2005
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol Fulltext Access 4 Pages 2005
Design and synthesis of macrocycles active against vancomycin-resistant enterococci (VRE): the interplay between d-Ala-d-Lac binding and hydrophobic effect Fulltext Access 4 Pages 2005
Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid Fulltext Access 4 Pages 2005
Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents Fulltext Access 4 Pages 2005
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides Fulltext Access 4 Pages 2005
The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines Fulltext Access 4 Pages 2005
Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin Fulltext Access 4 Pages 2005
Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide Fulltext Access 4 Pages 2005
Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods Fulltext Access 4 Pages 2005
Utilizing the intramolecular Fukuyama–Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists Fulltext Access 4 Pages 2005
Synthesis of cyclic peptidosulfonamides as scaffolds for MC4 pharmacophoric groups Fulltext Access 4 Pages 2005
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme Fulltext Access 4 Pages 2005
Synthesis and SAR of novel 4,5-diarylimidazolines as potent P2X7 receptor antagonists Fulltext Access 4 Pages 2005
Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis Fulltext Access 4 Pages 2005
Saucerneol B derivatives as human acyl-CoA: cholesterol acyltransferase inhibitors Fulltext Access 4 Pages 2005
(S,E)-N-[1-(3-Heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity Fulltext Access 4 Pages 2005
Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus Fulltext Access 4 Pages 2005
Schizophyllan-folate conjugate as a new non-cytotoxic and cancer-targeted antisense carrier Fulltext Access 4 Pages 2005
Structure-antioxidant activity relationships of flavonoids isolated from the resinous exudate of Heliotropium sinuatum Fulltext Access 4 Pages 2005
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity Fulltext Access 4 Pages 2005
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers Fulltext Access 4 Pages 2005
A new ligand binding to G-G mismatch having improved thermal and alkaline stability Fulltext Access 4 Pages 2005
Discovery of a novel, potent and selective human β3-adrenergic receptor agonist Fulltext Access 4 Pages 2005
Crystallographic determination of stereochemistry of biologically active 2â³,3â³-dibromo-7-epi-10-deacetylcephalomannine Fulltext Access 4 Pages 2005
Triaryl bis-sulfones as a new class of cannabinoid CB2 receptor inhibitors: identification of a lead and initial SAR studies Fulltext Access 4 Pages 2005
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors Fulltext Access 4 Pages 2005
Quinazolinethiones and quinazolinediones, novel inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships Fulltext Access 4 Pages 2005
Novel 3-aminochromans as potential pharmacological tools for the serotonin 5-HT7 receptor Fulltext Access 4 Pages 2005
A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor Fulltext Access 4 Pages 2005
Synthesis of (1,4)-naphthoquinono-[3,2-c]-1H-pyrazoles and their (1,4)-naphthohydroquinone derivatives as antifungal, antibacterial, and anticancer agents Fulltext Access 4 Pages 2005
Metabolism investigation leading to novel drug design: Orally active prostacyclin mimetics. Part 4 Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel bisphosphonates with dual activities on bone in vitro Fulltext Access 4 Pages 2005
6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand Fulltext Access 4 Pages 2005
Synthesis and antitumor activity of the hexacyclic camptothecin derivatives Fulltext Access 4 Pages 2005
Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists Fulltext Access 4 Pages 2005
Action of a novel pyrrolo[1,2-c][1.3]benzodiazepine on the viability of Jurkat and neuronal/glial cells Fulltext Access 4 Pages 2005
Pharmacophore-based design, synthesis, biological evaluation, and 3D-QSAR studies of aryl-piperazines as α1-adrenoceptor antagonists Fulltext Access 4 Pages 2005
Discovery of non-steroidal mifepristone mimetics: Pyrazoline-based PR antagonists Fulltext Access 4 Pages 2005
Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia Fulltext Access 4 Pages 2005
Discovery and synthesis of a novel and selective drug-like P2X1 antagonist Fulltext Access 4 Pages 2005
Investigation of human serum albumin (HSA) binding specificity of certain photosensitizers related to pyropheophorbide-a and bacteriopurpurinimide by circular dichroism spectroscopy and its correlation with in vivo photosensitizing efficacy Fulltext Access 4 Pages 2005
New series of potent δ-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif Fulltext Access 4 Pages 2005
Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases Fulltext Access 4 Pages 2005
A thiolate ligand on a cytochrome P-450 mimic permits the use of simple environmentally benign oxidants for biomimetic steroid hydroxylation in water Fulltext Access 4 Pages 2005
New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors Fulltext Access 4 Pages 2005
Efficient synthesis of C-terminal modified peptide ketones for chemical ligations Fulltext Access 4 Pages 2005
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416 Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors Fulltext Access 4 Pages 2005
SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: A novel class of cytotoxic agents for prostate cancer Fulltext Access 4 Pages 2005
O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity Fulltext Access 4 Pages 2005
Novel peptide derivatives of bleomycin A5: Synthesis, antitumor activity and interaction with DNA Fulltext Access 4 Pages 2005
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists Fulltext Access 4 Pages 2005
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism Fulltext Access 4 Pages 2005
Synthesis, in vivo and in vitro biological activity of novel azaline B analogs Fulltext Access 4 Pages 2005
Azinomycin inspired bisepoxides: influence of linker structure on in vitro cytotoxicity and DNA interstrand cross-linking Fulltext Access 4 Pages 2005
Anti-malarial activity of Baylis–Hillman adducts from substituted 2-chloronicotinaldehydes Fulltext Access 4 Pages 2005
Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13 Fulltext Access 4 Pages 2005
A micromethod for the stereochemical analysis of fatty acid desaturase-mediated sulfoxidation reactions Fulltext Access 4 Pages 2005
The evaluation of 2,8-disubstituted benzoxazinone derivatives as anti-inflammatory and anti-platelet aggregation agents Fulltext Access 4 Pages 2005
Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants Fulltext Access 4 Pages 2005
Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase Fulltext Access 4 Pages 2005
Chiral discrimination in binding of enantiomers of 2-(aminoalkoxy)-substituted 4-(2-thienyl)pyrimidines and 4,6-bis(2-thienyl)pyrimidines with duplex DNA Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of 5-methoxy- and 5-hydroxy-6-fluoro-1,8-naphthyridone-3-carboxylic acid derivatives Fulltext Access 4 Pages 2005
Redox-responsive and calcium-dependent switching of glycosyldisulfide interactions with Concanavalin A Fulltext Access 4 Pages 2005