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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Synthesis of 2-mesityl-3-methylpyrrole via the Trofimov reaction for a new BODIPY with hindered internal rotation
Fulltext Access 6 Pages 2005
A computational study on the mechanism for the GaCl3-catalyzed [4+1] cycloaddition of α,β-unsaturated ketone and 2,6-dimethylphenyl isocyanide
Fulltext Access 6 Pages 2005
Preparation of isoxazol(in)yl substituted selenides and their further deselenenylation reaction to synthesize 3,5-disubstituted isoxazoles
Fulltext Access 6 Pages 2005
Structural and electronic features important to nπ*-ππ* inversion sensors: synthesis, luminescence, and electrochemical properties of sulfur and chlorine-containing macrocycles. Part 3
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1,2-Disubstituted cyclohexane nucleosides: comparative study for the synthesis of cis and trans adenosine analogues
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Studies on alkylation of bicyclo[2.2.2]octenones and 3,3-sigmatropic shift: synthesis of advanced cis-decalins
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Synthesis, electrochemical and photochromic behaviour of a series of (1,4-dithiafulven-6-yl)substituted 3H-naphtho[2,1-b]pyran derivatives
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Effect of electron-withdrawing substituents on the electrophilicity of carbonyl carbons
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Synthesis, characterization and optical response of polyene-cored stilbenoid dendrimers
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Dimethylzinc-initiated radical reaction of cyclic ethers with arylamines, alkoxyamines, and dialkylhydrazines
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A new protocol to synthesize 1,4-dihydropyridines by using 3,4,5-trifluorobenzeneboronic acid as a catalyst in ionic liquid: synthesis of novel 4-(3-carboxyl-1H-pyrazol-4-yl)-1,4-dihydropyridines
Fulltext Access 6 Pages 2005
Desymmetrization by direct cross-metathesis producing hitherto unreachable P-stereogenic phosphine oxides
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Total synthesis of four naturally occurring 2-azaanthraquinone antibiotics, 6-deoxy-8-methylbostrycoidin, 6-deoxybostrycoidin, 7-O-demethyl-6-deoxybostrycoidin and scorpinone
Fulltext Access 6 Pages 2005
Synthesis of activated 3-substituted indoles: an optimised one-pot procedure
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Synthesis, stereochemical and conformational properties of trans-2,3-dihydro-2-methyl-3-(1,2,4-triazolyl)-4H-1-benzopyran-4-one oxime ethers
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Highly strained tricyclic molecules: tricyclo[p.q.0.01,f]alkanes and phosphatricyclo[m.1.0.01,3]alkanes
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Graphical contents list
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Convenient synthetic route of versatile 21-monothiatetraphenylporphyrins of the A4 and AB3 type
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Total syntheses of the sesquiterpenoids (+)-trans-dracunculifoliol and (+)-4-hydroxyoppositan-7-one
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Graphical contents list
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Synthesis of novel pyrido[2,3-e][1,3]oxazines
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Cross-linked poly(4-vinylpyridine/styrene) copolymers as a support for immobilization of ytterbium triflate
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Ultrasound-assisted convenient synthesis of hypolipidemic active natural methoxylated (E)-arylalkenes and arylalkanones
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New insight into the oxidative chemistry of noradrenaline: competitive o-quinone cyclisation and chain fission routes leading to an unusual 4-[bis-(1H-5,6-dihydroxyindol-2-yl)methyl]-1,2-dihydroxybenzene derivative
Fulltext Access 6 Pages 2005
Regioselective synthesis of 1-allyl- and 1-arylmethyl uracil and thymine derivatives
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Stereoselective synthesis of (E)-β-arylvinyl bromides by microwave-induced reaction of anti-3-aryl-2,3-dibromopropanoic acids using an AgOAc-AcOH system
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Synthesis of the possible carcinogenic dihydrodiol and diol epoxide of phthalazine
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Enantioselective synthesis of m-carboranylalanine, a boron-rich analogue of phenylalanine
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Ziziphine N, O, P and Q, new antiplasmodial cyclopeptide alkaloids from Ziziphus oenoplia var. brunoniana
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Synthesis of upper rim calix[4]arene divalent glycoclusters via amide bond conjugation
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Studies on Wittig rearrangement of furfuryl ethers in steroidal side chain synthesis
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Pd-catalyzed intramolecular cyclization of pyrrolo-2-carboxamides: regiodivergent routes to pyrrolo-pyrazines and pyrrolo-pyridines
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Highly stereoselective and stereospecific syntheses of a variety of quercitols from d-(−)-quinic acid
Fulltext Access 6 Pages 2005
3,8,11,16-Tetrakis(aminomethyl)-1,2,9,10-tetrathia-cyclohexadecane tetra-trifluoroacetic acid: synthetic precursor to a novel thio-substituted diamine
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Sassafrins A-D, new antimicrobial azaphilones from the fungus Creosphaeria sassafras
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Chemical and enzymatic synthesis of glycocluster having seven sialyl lewis X arrays using β-cyclodextrin as a key scaffold material
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Diastereoselective addition of organolithiums to 1,3-oxazolidines complexed with aluminum tris(2,6-diphenylphenoxide) (ATPH)
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Product selectivity in the electroreduction of thioesters
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Characterization of PEDOT film functionalized with a series of automated synthesis ferrocenyl-containing oligonucleotides
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Regioselective synthesis of optically active (pyrazolyl)pyridines with adjacent quaternary carbon stereocenter: chiral N,N-donating ligands
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Comparison of AB2 and AB4 monomers in ferrocene-cored benzyl ether dendrimers
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Concise synthetic strategy toward cyclic α,α-disubstituted α-amino acids bearing a δ-nitrogen atom: chiral 1-substituted 4-aminopiperidine-4-carboxylic acids
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Optimized polymer-enzyme electrostatic interactions significantly improve penicillin G amidase efficiency in charged PEGA polymers
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Bis[3-(triethoxysilyl)propyl]tetrasulfide: the first liquid sulfur-transferring agent useful for conversion of nucleoside phosphites to the phosphorothioates
Fulltext Access 6 Pages 2005
The synthesis of calix[4]crown based dendrimer
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Relationship between the electrophilicity of substituting agents and substrate selectivity in Friedel-Crafts reactions
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Homogeneous catalytic aminocarbonylation of iodoalkenes and iodobenzene with amino acid esters under conventional conditions and in ionic liquids
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Ship-in-a-bottle synthesis of triphenylamine inside faujasite supercages and generation of the triphenylamminium radical ion
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Agariblazeispirol C from the cultured mycelia of the fungus, Agaricus blazei, and the chemical conversion of blazeispirol A
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Influence of catalytic system composition on formation of adamantane containing ketones
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Graphical contents list
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Graphical contents list
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Remote stereocontrol by sulfinyl groups: asymmetric alkylation of chiral 2-p-tolylsulfinyl benzyl carbanions
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NMR J-based analysis of nitrogen-containing moieties and application to dysithiazolamide, a new polychlorinated dipeptide from Dysidea sp.
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3-Nitro-2-naphthalenemethanol: a photocleavable protecting group for carboxylic acids
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Thiacalix[4]arene derivatives with proximally bridged lower rim
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Iridium-catalyzed enantioselective Pauson-Khand-type reaction of 1,6-enynes
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Synthesis of azaphenanthridines via anionic ring closure
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[60]Fullerene adducts with 9-substituted anthracenes: mechanochemical preparation and retro Diels-Alder reaction
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A furan ring expansion approach to the synthesis of novel pyridazino-psoralen derivatives
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Deprotonation of thiophenes using lithium magnesates
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Effective synthesis of some indole nitriles from the related carbaldoximes
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Synthesis of two calix[4]arene diamide derivatives for extraction of chromium(VI)
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Synthesis and absolute configuration of annuionone A
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Diversity-generation from an allenoate-enone coupling: syntheses of azepines and pyrimidones from common precursors
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Synthesis of C13-C22 of amphidinolide T2 via nickel-catalyzed reductive coupling of an alkyne and a terminal epoxide
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Enantioselective addition of amines to alkenoyl-N-oxazolidinones
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Gold catalysis: five new bonds by a domino hydroarylation/cycloisomerization
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Consecutive Rh(I)-catalyzed Alder-ene/Diels-Alder/Diels-Alder reaction sequence affording rapid entry to polycyclic compounds
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Multiple component Fischer indole reactions
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Rhodium(I) catalyzed four-component reaction of Fischer alkenyl carbene complexes and 1,1-diphenylallene
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Three-component indole synthesis using ortho-dihaloarenes
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Graphical contents list
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Colorimetric calcium-response of β-lactosylated μ-oxo-bis-[5,15-meso-diphenylporphyrinatoiron(III)]
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Stereoselective Z-iodoalkoxylation of 1,2-allenyl sulfides or selenides
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A catalyst- and solvent-free selective approach to biologically important quinazolines and benzo[g]quinazoline
Fulltext Access 6 Pages 2005
Synthesis of highly hindered polyanionic chelating ligands
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Ferric chloride/tetraethyl orthosilicate as an efficient system for synthesis of dihydropyrimidinones by Biginelli reaction
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Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions
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Mn(III)-based C-C bond formation: regioselective α′-allylation of various α,β-unsaturated, α and β-alkoxy α,β-unsaturated ketones
Fulltext Access 6 Pages 2005
Structural revision of clusianone and 7-epi-clusianone and anti-HIV activity of polyisoprenylated benzophenones
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Selective recognition of sodium cyanide and potassium cyanide by diaza-crown ether-capped Zn-porphyrin receptors in polar solvents
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Reductive lithiation of 1,3-dimethyl-2-arylimidazolidines
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An efficient microwave-assisted solvent-free synthesis of pyrido-fused ring systems applying the tert-amino effect
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Olefin cyclopropanation catalyzed by new diiminophosphorane and triiminophosphorane complexes of copper and palladium
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Isolation, structure elucidation and bioactivity of schischkiniin, a unique indole alkaloid from the seeds of Centaurea schischkinii
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IBX/n-Bu4NBr/CH2Cl2-H2O: a new mild system for selective oxidation of secondary alcohols
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Chemistry of 3-arylindenones: behavior in superacids and photodimerization
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Synthesis of mono- and polyhydroxylated cyclobutane nucleoside analogs
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Palladium-catalyzed regioselective Heck arylation of electron-rich olefins in a molecular solvent-ionic liquid cocktail
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A palladium catalyzed efficient synthesis of γ-methylene-α,β-unsaturated γ-lactones via cyclization of 3,4-alkadienoic acids
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On the efficiency of two-coordinate palladium(0) N-heterocyclic carbene complexes in amination and Suzuki-Miyaura reactions of aryl chlorides
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Reduction of indolo[2,3-b]quinoxalines
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The solvent effect on the reaction constants of tert-butyl radical addition to 2-substituted allyl chlorides
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Bi(III) halides as efficient catalysts for the O-acylative cleavage of tetrahydrofurans: an expeditious entry to tetralins
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A new efficient and practical synthesis of 2-deoxy-l-ribose
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Graphical contents list
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Ring-closing metathesis approach to symmetrical and unsymmetrical cycloakeno[c]fused 2,2′-bipyridine-based cyclophanes
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NMR structure determination of (11E)-trinervita-1(14),2,11-triene, a new diterpene from sexual glands of termites
Fulltext Access 6 Pages 2005
First successful synthesis, isolation and characterization of open-chain 1,2-diazidoethenes
Fulltext Access 6 Pages 2005
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