Pelseneeriol-1 and -2: new furanosesquiterpene alcohols from porostome nudibranch Doriopsilla pelseneeri Fulltext Access 6 Pages 2005
Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase Fulltext Access 6 Pages 2005
Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties Fulltext Access 6 Pages 2005
Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase) Fulltext Access 6 Pages 2005
Combinatorial approaches towards the discovery of new tryptase inhibitors Fulltext Access 6 Pages 2005
Inhibitors of HCV NS5B polymerase: synthesis and structure-activity relationships of N-1-heteroalkyl-4-hydroxyquinolon-3-yl-benzothiadiazines Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II Fulltext Access 6 Pages 2005
An efficient synthesis of 7-hydroxy-2,6-dimethylchromeno[3,4-d]oxazol-4-one-a protected fragment of novenamine Fulltext Access 6 Pages 2005
Nucleophilic addition to dimethylvinylphosphine sulfide as a convenient route to polydentate ligands containing the 2-dimethylphosphinoethyl unit Fulltext Access 6 Pages 2005
Stereoselective total synthesis of (S)-Virol C and (S)-1-dehydroxyvirol A Fulltext Access 6 Pages 2005
Anthracene derivatives bearing two urea groups as fluorescent receptors for anions Fulltext Access 6 Pages 2005
Synthesis and in vitro study of novel Mannich bases as antibacterial agents Fulltext Access 6 Pages 2005
Chemo-, regio- and stereoselective Diels-Alder reactions of EWG bearing thiophene-1,1-dioxides Fulltext Access 6 Pages 2005
Silicaphosphine (Silphos): a filterable reagent for the conversion of alcohols and thiols to alkyl bromides and iodides Fulltext Access 6 Pages 2005
Applications of surfactant-modified clays to synthetic organic chemistry Fulltext Access 6 Pages 2005
The microbiological transformation of steroidal saponins by Curvularia lunata Fulltext Access 6 Pages 2005
Photoreduction of imines. An environmentally friendly approach to obtain amines Fulltext Access 6 Pages 2005
Amine side arm effect on the ion selectivity of 12-crown-O3N derivatives with an amine arm in aqueous and acetonitrile solutions Fulltext Access 6 Pages 2005
Aza Diels-Alder reactions utilizing 4-iodo-2-trimethylsilyloxy-butadiene Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates Fulltext Access 6 Pages 2005
Synthesis of a library of benzoindolizines using poly(ethylene glycol) as soluble support Fulltext Access 6 Pages 2005
A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX Fulltext Access 6 Pages 2005
Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives Fulltext Access 6 Pages 2005
Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists Fulltext Access 6 Pages 2005
Design of selective phenylglycine amide tissue factor/factor VIIa inhibitors Fulltext Access 6 Pages 2005
1,4-Benzodiazepine-2,5-diones as small molecule antagonists of the HDM2-p53 interaction: discovery and SAR Fulltext Access 6 Pages 2005
Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B Fulltext Access 6 Pages 2005
A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists Fulltext Access 6 Pages 2005
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 2: SAR studies on the pyridine ring 3-substituent Fulltext Access 6 Pages 2005
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with bis-sulfamates Fulltext Access 6 Pages 2005
New conformationally locked bicyclic N,O-nucleoside analogues of antiviral drugs Fulltext Access 6 Pages 2005
Identification of putative metabolites of docosahexaenoic acid as potent PPARγ agonists and antidiabetic agents Fulltext Access 6 Pages 2005
3,4-Disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity Fulltext Access 6 Pages 2005
Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction Fulltext Access 6 Pages 2005
Design and synthesis of novel 9-substituted-7-aryl-3,4,5,6-tetrahydro-2H-pyrido[4,3-b]- and [2,3-b]-1,5-oxazocin-6-ones as NK1 antagonists Fulltext Access 6 Pages 2005
Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists Fulltext Access 6 Pages 2005
Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase Fulltext Access 6 Pages 2005
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity Fulltext Access 6 Pages 2005
Novel and orally bioavailable inducible nitric oxide synthase inhibitors: synthesis and evaluation of optically active 4,5-dialkyl-2-iminoselenazolidine derivatives Fulltext Access 6 Pages 2005
N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP Fulltext Access 6 Pages 2005
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle Fulltext Access 6 Pages 2005
Ring opening of 2-(bromomethyl)-1-sulfonylaziridines towards 1,3-heteroatom substituted 2-aminopropane derivatives Fulltext Access 6 Pages 2005
Hetero Diels-Alder reactions (HDAR) of α,αâ²-dioxothiones on solid support Fulltext Access 6 Pages 2005
Mannich-type reaction of (1-methoxy-2-methylpropenyloxy)trimethylsilane with arylaldehydes and aromatic amines catalyzed by perfluorinated rare earth metal salts in fluorous phase Fulltext Access 6 Pages 2005
Synthesis of naturally occurring bioactive butyrolactones: maculalactones A-C and nostoclide I Fulltext Access 6 Pages 2005
Ring-closure reactions through intramolecular substitution of thiophenoxide by oxygen and nitrogen nucleophiles: simple stereospecific synthesis of 4,5-dihydroisoxazoles and 4,5-dihydropyrazoles Fulltext Access 6 Pages 2005
Simple and efficient preparation of sterically protected 1,4-diphosphafulvenes Fulltext Access 6 Pages 2005
Nitrosation of hydrochlorothiazide and the modes of binding of the N-nitroso derivative with two macrocycles possessing an 18-membered crown ether cavity Fulltext Access 6 Pages 2005
Halogen-lithium exchange between substituted dihalobenzenes and butyllithium: application to the regioselective synthesis of functionalized bromobenzaldehydes Fulltext Access 6 Pages 2005
Stereoselective synthesis of (2R,3S,4S)-3-hydroxy-4-methyl-2-tetradecyl-4-butanolide starting from 2,5-anhydro-d-mannitol Fulltext Access 6 Pages 2005
Selective palladium-catalyzed amination of β-chloroacroleins by substituted anilines Fulltext Access 6 Pages 2005
A novel 3,4-dihydroisoquinoline annulation: expedient access to isoquinoline heterocycles Fulltext Access 6 Pages 2005
Synthesis and interfacial properties of amphiphilic β-cyclodextrins and their substitution at the O-6 position with a mono bio-recognisable galactosyl antenna Fulltext Access 6 Pages 2005
Facile synthesis of α,β-acetylenic ketones and 2,5-disubstituted furans: consecutive activation of triple and double bond with ZnBr2 toward the synthesis of furan ring Fulltext Access 6 Pages 2005
Reductive metalation of 1,2-diaryl-substituted ethenes: synthetic applications Fulltext Access 6 Pages 2005
An approach to the synthesis of chemically modified bisazocalix[4]arenes and their extraction properties Fulltext Access 6 Pages 2005
Synthesis of furo[2,3-c]-2,7-naphthyridine derivatives via domino heterocyclization reaction Fulltext Access 6 Pages 2005
A mild and efficient aza-Diels-Alder reaction of N-benzhydryl imines with trans-1-methoxy-2-methyl-3-trimethylsiloxybuta-1,3-diene catalyzed by Yb(OTf)3 Fulltext Access 6 Pages 2005
Comparison of 'classic' 99mTc-DTPA, 99mTc(CO)3-DTPA and 99mTc(CO)2(NO)-DTPA Fulltext Access 6 Pages 2005
Highly efficient one-pot synthesis of 1-substituted-1,2,3,4-tetrahydropyrazino[1,2-a]indoles Fulltext Access 6 Pages 2005
Palladium catalyzed Suzuki cross-coupling reactions using N,O-bidentate ligands Fulltext Access 6 Pages 2005
DTBB-catalysed lithiation of 1,2-bis(phenylsulfanyl)ethene: does 1-lithio-2-phenylsulfanylethene really exist? Fulltext Access 6 Pages 2005
Direct synthesis of new arylanthranilic acids via a Suzuki cross-coupling reaction from iodoisatins Fulltext Access 6 Pages 2005
Preparation of polystyrene-supported soluble palladacycle catalyst for Heck and Suzuki reactions Fulltext Access 6 Pages 2005
Proton affinities and relative basicities of two 1,4,7-triazacyclononanes, Me3TACN and TP-TACN. Quantum-chemical ab initio calculations, solution measurements, and the structure of [TP-TACN·2H]2+ in the solid state Fulltext Access 6 Pages 2005
The effect of coordination on the reaction of N-tosyl imines with diethylzinc Fulltext Access 6 Pages 2005
Diastereoselectivity-switchable and regiospecific hetero Diels-Alder reaction of N-sulfinylper(poly)fluoroalkanesulfinamides with dienes Fulltext Access 6 Pages 2005
Understanding the enantioselectivity of a heterogeneous catalyst: the influence of ligand loading and of silica passivation Fulltext Access 6 Pages 2005
A convenient and efficient synthesis of (S)-lysine and (S)-arginine homologues via olefin cross-metathesis Fulltext Access 6 Pages 2005
A borderline case between meso and stable C1: an axially chiral, yet configurationally semi-stable biphenyl with two oppositely configured [10]paracyclophane portions Fulltext Access 6 Pages 2005
Biocatalytic and chemical investigations in the synthesis of sucrose analogues Fulltext Access 6 Pages 2005
Synthesis and characterisation of N-1,10-phenanthrolin-5-ylalkylamides and their photosensitising heteroleptic Ru(II) complexes Fulltext Access 6 Pages 2005
Deallyloxy- and debenzyloxycarbonylation of protected alcohols, amines and thiols via a naphthalene-catalysed lithiation reaction Fulltext Access 6 Pages 2005
Synthesis of thiazino[6,5-b]indole derivatives, analogues of the phytoalexin cyclobrassinin. A new method for preparation of 3-aminomethylindole Fulltext Access 6 Pages 2005
New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum Fulltext Access 6 Pages 2005
Synthesis of 4-halophosphaisocoumarins via halocyclization of 2-(1-alkynyl)phenylphosphonates Fulltext Access 6 Pages 2005
Versatile acenaphtho[1,2-b]pyrrol-carbonitriles as a new family of heterocycles: diverse SNArH reactions, cytotoxicity and spectral behavior Fulltext Access 6 Pages 2005
Reduction of alkyl and vinyl sulfonates using the CuCl2·2H2O-Li-DTBB(cat.) system Fulltext Access 6 Pages 2005
Bis- and tetracalix[4]arenes in the partial cone conformation: synthesis, structure and RCM reactions Fulltext Access 6 Pages 2005
Shielding effect of thioether C-S bond from proton chemical shifts of 4-thia-5α- and 4-thia-5β-androstane-17-ones Fulltext Access 6 Pages 2005
Unusual asymmetric oxidation of sulfide; the diastereoselective oxidation of prochiral sulfide-chiral acid salt with hydrogen peroxide without metal Fulltext Access 6 Pages 2005