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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Osteolytic bone diseases: physiological analogues of bone resorption effectors as alternative therapeutic tools
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The gastrointestinal tract and the regulation of appetite
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Pemphigus: Pathogenic mechanisms and potential therapeutic targets
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Oncogenic alterations of metabolism and the Warburg effect
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Host-tumor interactions influencing cancer progression
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Functions of the retinoblastoma protein that contribute to tumor suppression
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Telomerase as a therapeutic target in cancer
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Harnessing the power of fireflies and mice for assessing cancer mechanisms
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Mutated kinases as targets for cancer drugs
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Ligand efficiency indices as guideposts for drug discovery
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Transgenic chickens as bioreactors for protein-based drugs
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Regeneration and replacement in the vertebrate inner ear
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High-throughput drug discovery: What can we expect from HTS?
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Subclinical inflammation and obesity, diabetes and related disorders
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Protein biochips: A new and versatile platform technology for molecular medicine
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Fragment-based lead discovery: leads by design
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Computational prediction of genotoxicity: room for improvement
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Monitoring of trophic chains
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Fourier's law of heat transfer and its implication to cell motility
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In silico screening of drug databases for TSE inhibitors
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Markov chains: Computing limit existence and approximations with DNA
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An age-structured model with delay mortality
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The surface-based approach for DNA computation is unreliable for SAT
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The linear alometric relationship between total metabolic energy per life span and body mass of poikilothermic animals
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Mechanisms of multiple sclerosis
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Models for human cervical cancer
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Exploiting new approaches for natural product drug discovery in the biotechnology industry
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Single molecule technologies
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Recent advances in microarrays
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Next generation sequencing technologies
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Ontologies in drug discovery
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Modeling pathogen and host: in vitro, in vivo and in silico models of latent Mycobacterium tuberculosis infection
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Models of contact dermatitis and atopic eczema
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Models for alcohol dependence: A clinical perspective
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Models of neural tube defects
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Cell line models of leukemia
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Genetically engineered mouse models for lung cancer
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Models of gastric cancer
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Role of the protein tau in Alzheimer's disease
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Models of breast cancer
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Models of cardiovascular disease in stem cell research
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Unraveling neuronal circuitry regulating energy homeostasis: Plasticity in feeding circuits
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Metabolic perturbations in the pathogenesis of hypertrophic cardiomyopathy
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Do PPARs play a role in cardiac hypertrophy and heart failure?
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Gender differences in cardiovascular disease: The effects of estrogen
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Transcriptional mechanisms of congenital heart disease
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Molecular mechanisms in atrial fibrillation
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Chemokines in rheumatoid arthritis
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Has rheumatoid arthritis become a milder disease?
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Hormonal mediation of energy homeostasis in obesity, diabetes and related disorders
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Ionic liquid soluble photosensitizers
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The three component reaction involving isocyanides, dimethyl acetylenedicarboxylate and quinoneimides: a facile synthesis of spirofused γ-iminolactams
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Synthesis of galactose-linked uridine derivatives with simple linkers as potential galactosyltransferase inhibitors
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Regioselectivity in the reactions of polyfunctionalised pyrroles with nucleophiles
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Synthesis of new acyl, furoyl, and benzoylthiocarbamates as polydentate systems. Structural study of isopropyl N-(2-furoyl)thiocarbamate
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Synthesis of new nucleoside analogues comprising a methylenecyclobutane unit
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Synthesis of novel cyclodextrin derivatives by aromatic spacer insertion and their inclusion ability
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Generation of quinone methide from aminomethyl(hydroxy)arenes precursors in aqueous solution
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Synthesis of 3,4,5-trisubstituted indoles via iterative directed lithiation of 1-(triisopropylsilyl)gramines
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Electrolytic partial fluorination of organic compounds. Part 78: Regioselective anodic fluorination of 2-oxazolidinones
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The reactivity of 1,1-diamino-2,2-dinitroethene (FOX-7)
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Stereoselective formation of dicondensed spiropyran product obtained from the reaction of excess Fischer base with salicylaldehydes: first full characterization by X-ray crystal structure analysis of a DC·acetone crystal
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Biphasic enantioselective partitioning studies using small-molecule chiral selectors
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Bis(4,5-dimethoxy-2-nitrophenyl)ethylene glycol: a new and efficient photolabile protecting group for aldehydes and ketones
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Stereoselective synthesis of novel benzoins catalysed by benzaldehyde lyase in a gel-stabilised two-phase system
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Solid-state and solution photocycloadditions of 4-acyloxy-2-pyrones with maleimide
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Catalytic effects of hydrogen-bond acceptor solvent on nucleophilic aromatic substitution reactions in non-polar aprotic solvent: reactions of phenyl 2,4,6-trinitrophenyl ether with amines in benzene-acetonitrile mixtures
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Stereoselectivity ratios in a simple Diels-Alder reaction in aqueous salt solutions of alcohols
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New access to racemic β3-amino acids
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3′-Selective modification of a 4′,5′-didehydro-5′-deoxy-2′,3′-epoxyuridine using nucleophiles
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Transformations of hispanolone. Novel Michael adducts with in planta activity against rice blast
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Participation of host 'spacer' atoms in carboxylic acid binding: implications for amino acid recognition
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Side arm participation in lariat ether carboxylate-alkali metal cation complexes in solution
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Synthesis of l,l-puromycin
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Transformations of lignans. Part 10: Acid-catalysed rearrangements of arboreol and wodeshiol and conversion of gmelanone oxime into a dihydropyranone derivative
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Synthesis and structural studies of peptides containing a glucose-derived furanoid sugar amino acid
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Practical proteomic biomarker discovery: taking a step back to leap forward
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Cognitive landscape and information: new perspectives to investigate the ecological complexity
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Event-related potentials in an auditory oddball situation in the rat
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A measure of local variation of inter-spike intervals
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Stochastic resonance in the LIF models with input or threshold noise
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Structural elucidation of new ferulic acid-containing phenolic dimers and trimers isolated from maize bran
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Michael addition approach for the synthesis of novel spiro compounds and 2-substituted malonic acid derivatives from Meldrum's acid
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Highly efficient C-H insertion reactions of hydrogen peroxide catalyzed by homogeneous and heterogeneous methyltrioxorhenium systems in ionic liquids
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4-Amino-1,8-naphthalimide-based anion receptors: employing the naphthalimide N-H moiety in the cooperative binding of dihydrogenphosphate
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A new 3-methylidenepentane-1,5-dianion synthon: synthesis of perhydropyrano[2,3-b]pyrans and 1,7-dioxaspiro[4.5]decanes
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Synthetic studies on thiostrepton family of peptide antibiotics: synthesis of the dihydroquinoline portion of thiostrepton, the siomycins, and the thiopeptins
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An easy access to unsymmetric trisubstituted methane derivatives (TRSMs)
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Isolation of naturally occurring dactylomelane metabolites as Laurencia constituents
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Bismuth(III) chloride-catalyzed direct deoxygenative allylation of substituted benzylic alcohols with allyltrimethylsilane
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Cyclen based lanthanide ion ribonuclease mimics: the effect of pyridine cofactors upon phosphodiester HPNP hydrolysis
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Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling
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Immunologically driven antibodies chemical engineering: design and synthesis of a hapten aimed at nerve agent hydrolysis
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A protecting group-free approach to C-glycosides using the Ramberg-Bäcklund reaction
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Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions
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Graphical contents list
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Preparation of complex bridged bicyclic ring systems from 3,3-diacetoxy-2-phenylsulfonylpropene and β-keto esters
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The furan approach to oxacycles. Part 3: Stereoselective synthesis of 2,3-disubstituted tetrahydropyrans
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A convenient new synthesis of fused 1,2,4-triazoles: the oxidation of heterocyclic hydrazones using copper dichloride
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2-Cyanopyridazin-3(2H)-ones: effective and chemoselective electrophilic cyanating agents
Fulltext Access 6 Pages 2005
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