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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Elimination of arthritis pain and inflammation for over 2 years with a single 90 min, topical 14% gallium nitrate treatment: Case reports and review of actions of gallium III
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Two-plane symmetry in the structural organization of man
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Abnormal proinsulin congeners as autoantigens that initiate the pathogenesis of Type 1 diabetes
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Statins lower the risk of developing Alzheimer's disease by limiting lipid raft endocytosis and decreasing the neuronal spread of Herpes simplex virus type 1
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Paroxysmal cough injury, vascular rupture and'shaken baby syndrome'
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Why don't humans get scrapie from eating sheep? A possible explanation based on secondary structure predictions
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Can worms defend our hearts? Chronic helminthic infections may attenuate the development of cardiovascular diseases
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Mechanisms involved in the neural construction of a body-centered reference axis for extrapersonal directed movements. A hypothesis
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Circulation DNA: Biological implications for cancer metastasis and immunology
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Plasticity imbalance in mental disorders the neuroscience of psychiatry: Implications for diagnosis and research
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Role of zinc and zinc transporters in the molecular pathogenesis of diabetes mellitus
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Etiology of Crohn's disease: Do certain food additives cause intestinal inflammation by molecular mimicry of mycobacterial lipids?
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Self-management of psychiatric symptoms using over-the-counter (OTC) psychopharmacology: The S-DTM therapeutic model - Self-diagnosis, self-treatment, self-monitoring
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Effects of 17β-estradiol on chemically induced long-term depression
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Is macrophage migration inhibitory factor (MIF) the “control point” of vascular hypo-responsiveness in septic shock?
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Impaired neuronal glucose uptake in pathogenesis of schizophrenia - Can GLUT 1 and GLUT 3 deficits explain imaging, post-mortem and pharmacological findings?
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The multiple feedback loop hypothesis of chronic diseases
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De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome
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Lower expression of cyclooxygenase-2: is it associated with the development of borderline ovarian tumors?
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The epsilon theory: a novel synthesis of the underlying molecular and electrophysiological mechanisms of primary generalized epilepsy and the possible mechanism of action of valproate
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A critical review of the function of neuromelanin and an attempt to provide a unified theory
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Insights from a novel tumor model: Indications for a quantitative link between tumor growth and invasion
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Oestrogen-receptors (ER) are likely to be promiscuous: Wider role for oestrogens and mimics
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Fascioscapulohumeral muscular dystrophy: A progressive degenerative disease that responds to diltiazem
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Etiology of antisocial personality disorder: Benefits for society from an evolutionary standpoint
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Peppermint oil in irritable bowel syndrome
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The effect of verapamil on the pharmacokinetics of paclitaxel in rats
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Percutaneous absorption of cyclizine and its alkyl analogues
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Application of graph theory: prediction of glycogen synthase kinase-3 β inhibitory activity of thiadiazolidinones as potential drugs for the treatment of Alzheimer's disease
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Production of enteric capsules by means of hot-melt extrusion
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A new sunscreen of the cinnamate class: Synthesis and enzymatic hydrolysis evaluation of glyceryl esters of p-methoxycinnamic acid
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Pharmacodynamic behaviour of the selective cyclooxygenase-2 inhibitor lumiracoxib in the lipopolysaccharide-stimulated rat air pouch model
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A simple predictive model for the tensile strength of binary tablets
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Investigation of the enhancing mechanism of sodium N-[8-(2-hydroxybenzoyl)amino]caprylate effect on the intestinal permeability of polar molecules utilizing a voltage clamp method
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Tissue penetration of cefpodoxime into the skeletal muscle and lung in rats
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A water-soluble prodrug of cyclosporine A for ocular application: A stability study
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An experimental investigation of the stability of ethylcellulose latex
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Dry and moist heat sterilisation cannot inactivate pyrogenicity of Gram positive microorganisms
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Forgiveness: A neurological model
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Effect of Cassia auriculata Linn. Root extract on cisplatin and gentamicin-induced renal injury
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A randomized double blind placebo-controlled clinical trial of Hochuekkito, a traditional herbal medicine, in the treatment of elderly patients with weakness N of one and responder restricted design
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Cardiovascular effects of the aqueous extract of Gynostemma pentaphyllum Makino
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The effects of carbenoxolone, a semisynthetic derivative of glycyrrhizinic acid, on peripheral and central ischemia-reperfusion injuries in the skeletal muscle and hippocampus of rats
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The efficacy of Liv-52 on liver cirrhotic patients: A randomized, double-blind, placebo-controlled first approach
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Effect of Aloe vera preparations on the human bioavailability of vitamins C and E
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The anticarcinogenic effect of propolis in human lymphocytes culture
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4-Alkylated homoibotenic acid (HIBO) analogues: Versatile pharmacological agents with diverse selectivity profiles towards metabotropic and ionotropic glutamate receptor subtypes
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The H3 receptor protean agonist proxyfan enhances the expression of fear memory in the rat
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The effect of competitive antagonist chain length on NMDA receptor subunit selectivity
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Histamine excites noradrenergic neurons in locus coeruleus in rats
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The effect of magnesium stearate particle size on tablet properties and tableting characteristics of granules prepared with standard formulation
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Towards mitochondria-specific delivery of apoptosis-inducing agents: DQAsomal incorporated paclitaxel
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Antioxidative activity and cytotoxicity of four different flavonoids for dermal applications
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Formulation and in vitro bioactivity of mitoxantrone-loaded biodegradable microspheres on rat glioma (RG2) cells
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Selective and enhanced transgene expression in hepatocellular carcinoma cells by asialofetuin-labelled liposomes and AFP promoter
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The need for pædiatric formulation: oral administration of nifedipine in children, a proof of concept
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Mucosal delivery of diphtheria toxoid using polymer-coated-bioadhesive liposomes as vaccine carriers
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Surface modification of adenovirus by zwitterionic (DMPC:Chol) liposomes can up- or down-regulate adenoviral gene transfer efficiency in vitro
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Formulation and characterisation of zein microspheres as delivery vehicles
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Design and in vitro evaluation of an extended-release matrix tablet for once-daily oral administration of oxybutynin
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Drug delivery from mucoadhesive disks based on a photo-cross-linkable polyaspartamide derivative
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Effect of lubrication on the compaction properties of pharmaceutical excipients as measured by die wall pressure
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Chemical gels of scleroglucan obtained by cross-linking with 1,ω-dicarboxylic acids: synthesis and characterization
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New α,γ-peptide tubulets
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Preparation, characterization, cytotoxicity and biodistribution of docetaxel-loaded polymeric micelle formulations
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Syntheses of novel heterocycles as anticancer agents
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Structure–affinity relationship studies on arylpiperazine derivatives related to quipazine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor
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Position-specific incorporation of a highly photodurable and blue-laser excitable fluorescent amino acid into proteins for fluorescence sensing
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Synthesis and antioxidant, anti-inflammatory and gastroprotector activities of anethole and related compounds
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Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase
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Synthesis and characterization of novel 6-fluoro-4-piperidinyl-1,2-benzisoxazole amides and 6-fluoro-chroman-2-carboxamides: antimicrobial studies
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Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives
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1′S-1′-Acetoxychavicol acetate as a new type inhibitor of interferon-β production in lipopolysaccharide-activated mouse peritoneal macrophages
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Topological models for prediction of anti-HIV activity of acylthiocarbamates
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Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents
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Dysfunction of the anterior hippocampus: The cause of fundamental schizophrenic symptoms?
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Exposure to nicotine is probably a major cause of inflammatory diseases among non-smokers
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Clinical multiple sclerosis occurs at one end of a spectrum of CNS pathology: A modified threshold liability model leads to new ways of thinking about the cause of clinical multiple sclerosis
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The concept of post-traumatic mood disorder
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Pro-kinetic medications as aids in imaging the small bowel by video-capsule
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Gene, gut and schizophrenia: the meeting point for the gene-environment interaction in developing schizophrenia
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Major depressive disorder: probiotics may be an adjuvant therapy
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REM sleep and the development of context memory
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Add Alzheimer's disease to the list of autoimmune diseases
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Pre-eclampsia and partial uterine denervation
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Male reproductive physiology as a sexually selected handicap? Erectile dysfunction is correlated with general health and health prognosis and may have evolved as a marker of poor phenotypic quality
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The dynamic range of biologic functions and variation of many environmental cues may be declining in the modern age: implications for diseases and therapeutics
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Will corticosteroids and other anti-inflammatory agents be effective for diarrhea-predominant irritable bowel syndrome?
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Graphical contents list
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The scavenger cell hypothesis of apoptosis: Apoptosis redefined as a process by which a cell in living tissue is destroyed by phagocytosis
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Forecasting versus projection models in epidemiology: The case of the SARS epidemics
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Does god play dice with schizophrenia? A probabilistic model for the understanding of causation in mental illness
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A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk
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Pathogenesis and etiology of essential hypertension: role of dietary carbohydrate
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Pharmacological manipulation of ataxia-telangiectasia kinase activity as a treatment for Parkinson's disease
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Novel hypothesis for the cause of panic disorder via the neuroepithelial bodies in the lung
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Selective reduction of estrogen receptor (ER) positive breast cancer occurrence by estrogen receptor modulators supports etiological distinction between ER positive and ER negative breast cancers
Fulltext Access 6 Pages 2005
Uncertainties in the current understanding of gas exchange in spontaneous pneumothorax: effective lung ventilation may persist in a smaller-sized pneumothorax
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Melatonin seems to be a mediator that transfers the environmental stimuli to oocytes for inheritance of adaptive changes through epigenetic inheritance system
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TGF-β1 could be a missing link in the interplay between ER and HER-2 in breast cancer
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