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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Amperometric biosensors based on carbon paste electrodes modified with nanostructured mixed-valence manganese oxides and glucose oxidase
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Elemental distribution in fluorinated amorphous carbon thin films
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Mass spectral behavior of some homoleptic and mixed aryldichalcogenide bis(diphenylphosphino)ferrocenenickel(II), palladium(II), and platinum(II), and bis(diisopropylphosphino)ferrocenepalladium(II) complexes
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Electron capture dissociation of polypeptides in a three-dimensional quadrupole ion trap: Implementation and first results
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Multiple charging of poly(propylene glycol) by binary mixtures of cations in electrospray
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Direct tissue analysis of phospholipids in rat brain using MALDI-TOFMS and MALDI-ion mobility-TOFMS
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In situ formation of C-glycosides during electrospray ionization tandem mass spectrometry of a series of synthetic amphiphilic cholesteryl polyethoxy neoglycolipids containing N-acetyl-D-glucosamine
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Solvent-free MALDI-MS for the analysis of biological samples via a mini-ball mill approach
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Absolute configuration assignment of ortho, meta, or para isomers by mass spectrometry
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Formation of nanoparticles of a hydrophilic drug using supercritical carbon dioxide and microencapsulation for sustained release
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Atomic force microscopy analysis of the Huntington protein nanofibril formation
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Clustering and diversity of fluctuations for proteins
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Time dependence of the frequency and amplitude of the local nanomechanical motion of yeast
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Detection and Quantification of 3,5,3′-Triiodothyronine and 3,3′,5′-Triiodothyronine by Electrospray Ionization Tandem Mass Spectrometry
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Formation of high-resistance supported lipid bilayer on the surface of a silicon substrate with microelectrodes
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Nanomedicine and protein misfolding diseases
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Modeling kinase-substrate specificity: implication of the distance between substrate nucleophilic oxygen and attacked phosphorus of ATP analog on binding affinity
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Structure analysis of the protein transduction domain of human Period1 and its mutant analogs
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Thermal stability of benzorods: Molecular-dynamics simulations
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Predictive models for hERG potassium channel blockers
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Identification of synthetic compounds active against VRE: the role of the lipidated aminoglucose and the structure of glycopeptide binding pocket
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A new class of high affinity thyromimetics containing a phenyl-naphthylene core
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Discovery of novel, potent, and orally active spiro-urea human glucagon receptor antagonists
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ERβ ligands. Part 4: Synthesis and structure–activity relationships of a series of 2-phenylquinoline derivatives
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First QSAR report on FSH receptor antagonistic activity: Quantitative investigations on physico-chemical and structural features among 6-amino-4-phenyltetrahydroquinoline derivatives
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13-Deoxytedanolide, a marine sponge-derived antitumor macrolide, binds to the 60S large ribosomal subunit
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β-Peptides as inhibitors of protein-protein interactions
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Cancer preventive agents. Part 1: Chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds
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Antioxidant activity of differently regioselective chitosan sulfates in vitro
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On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex
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Novel, flexible, and conformationally defined analogs of gepirone: synthesis and 5-HT1A, 5-HT2A, and D2 receptor activity
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Technetium-99m labelled integrated tropane-BAT as a potential dopamine transporter tracer
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A theoretical study on the structure-activity relationships of metabolites of folates as antioxidants and its implications for rational design of antioxidants
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QSAR studies-potent benzodiazepine γ-secretase inhibitors
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Cell adhesion inhibitory activity of (d)-corynoline, a hexahydrobenzo[c]phenanthridine-type alkaloid, and its structure-activity relationship, studied by X-ray crystal structure analysis and molecular docking study
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Topological models for the prediction of anti-HIV activity of dihydro (alkylthio) (naphthylmethyl) oxopyrimidines
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Synthesis and structure-activity relationships of 2-vinylchroman-4-ones as potent antibiotic agents
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Natural ozone scavenger prevents asthma in sensitized rats
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1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors
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Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids
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Synthesis and antiproliferative activity of [1,2,3,5]tetrazino[5,4-a]indoles, a new class of azolo-tetrazinones
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Amino substituted derivatives of 5′-amino-5′-deoxy-5′-noraristeromycin
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Structure identification and prophylactic antimalarial efficacy of 2-guanidinoimidazolidinedione derivatives
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Novel Fragmentation Pathway for CID of (bn − 1 + Cat)+ Ions from Model, Metal Cationized Peptides
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The Role of Esterification on Detection of Protonated and Deprotonated Peptide Ions in Matrix Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS)
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Efficiency of Nano-Electrospray Ionization
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MALDI-MS Imaging of Features Smaller than the Size of the Laser Beam
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Cyclization Reactions of Acylium and Thioacylium Ions with Isocyanates and Isothiocyanates: Gas Phase Synthesis of 3,4-Dihydro-2,4-Dioxo-2H-1,3,5-Oxadiazinium Ions
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Multiply-Charged Negative Clusters of Adenosine-5′-Monophosphate in the Gas Phase
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Accurate Mass Precursor Ion Data and Tandem Mass Spectrometry Identify a Class I Human Leukocyte Antigen A*0201-Presented Peptide Originating from Vaccinia Virus
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Graphical contents list
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Interaction of cromolyn sodium with human serum albumin: A fluorescence quenching study
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New efficient and totally stereoselective copper allylic benzoyloxylation of sterol derivatives
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Key intermediates in the synthesis of enantiopure antagonists at NMDA receptors: a structural study
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First synthesis of 3′-deoxy Lewisx pentasaccharide
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Graphical contents list
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Graphical contents list
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Microbial and homogenous asymmetric catalysis in the reduction of 1-[3,5-bis(trifluoromethyl)phenyl]ethanone
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(R)-(4-(Benzyloxycarbonylphenyl)-3-hydroxy-4,4-dimethyl-2-pyrrolidinone) acrylate derivative as a chiral dienophile for the synthesis of enantiopure 2-aminocyclohexane carboxylic acids
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Synthesis of new chiral crown ethers containing a (p-methoxyphenoxy)methyl moiety and their chiral recognition ability towards amino acid esters
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N-Functionalization of uracil derivatives: synthesis of chiral 2-(3-methyl-5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)alkanoic acids and their methyl esters
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Enzymatic resolution of 1,1-dimethoxybut-3-en-2-ol and 1,1-dimethoxypent-4-en-2-ol, α-hydroxyaldehyde precursors for aldol-type reactions
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Synthesis of enantiopure 5.7-spirodiamines: (S)-1,7-diaza[4.6]undecane and related compounds
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New cytotoxic-antineoplastic prenyl-1,2-naphthohydroquinone derivatives
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NMR enantiodiscrimination by cyclic tetraamidic chiral solvating agents
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Ferrocenyl bis-phosphine ligands bearing sulfinyl, sulfonyl or sulfenyl groups: applications in asymmetric hydrogenation and allylic alkylation reactions
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A novel case of 1,3-asymmetric induction in rhodium-catalyzed hydroformylation of an allylic double bond using perbenzylated C-glucosides as chiral directors
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The first enzymatic resolution of quaternary α′-acetoxy α,β-unsaturated cyclohexenones and cyclopentenones
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Application of newly available bio-reducing agents to the synthesis of chiral hydroxy-β-lactams: model for aldose reductase selectivity
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New enantiopure C2 symmetric bis(2-oxazolinyl)cage (Cage-Box) ligands from 4,5-dicyanopyridazine
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An enantiospecific total synthesis of (−)-patchouli alcohol
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Enantiomeric resolution of cyclobutanones and related derivatives by enzyme-catalyzed acylation and hydrolysis
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Synthesis and applications of chiral phosphite ligands derived from incompletely condensed silsesquioxane backbones
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Graphical contents list
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Δ(ΔS‡) and Δ(ΔS) for the Competing Bond Cleavage Reactions in (CH3CN)(ROH)H+ [R = CH3, C2H5, C3H7, (CH3)2CH]
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Microbial transformation of (−)-isolongifolol and butyrylcholinesterase inhibitory activity of transformed products
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Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs
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Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization
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Geometric diversity through permutation of backbone configuration in cyclic peptide libraries
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Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes
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Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives
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Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: Structure–activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor
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Novel cell-penetrating α-keto-amide calpain inhibitors as potential treatment for muscular dystrophy
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Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: New lead compounds for the development of anticancer agents
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Synthesis and structure–activity relationships of 1,2,4-triazoles as a novel class of potent tubulin polymerization inhibitors
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Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with l-histidine as a platform for the design of stronger activators
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Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints
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Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives
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Electrospray Ionization (ESI) Tandem Mass Spectrometric Analysis of meso-Tetrakis(Heptafluoropropyl)Porphyrin
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Studies on the cytochrome P450 catalyzed oxidation of 13C labeled 1-cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridine by 13C NMR
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Synthesis and biological study of a flavone acetic acid analogue containing an azido reporting group designed as a multifunctional binding site probe
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Synthesis and biological evaluation of α- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF
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Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides
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Novel synthetic isoquinolino[5,4-ab]phenazines: Inhibition toward topoisomerase I, antitumor and DNA photo-cleaving activities
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Graphical contents list
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Synthesis, growth inhibition, and cell cycle evaluations of novel flavonoid derivatives
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QSAR of the testosterone binding globulin affinity by means of correlation weighting of local invariants of the graph of atomic orbitals
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2-(Aryl)-3-furan-2-ylmethyl-thiazolidin-4-ones as selective HIV-RT Inhibitors
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Multifunctional action of antifungal polygodial against Saccharomyces cerevisiae: Involvement of pyrrole formation on cell surface in antifungal action
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Isolation, characterization and biological evaluation of datura lactones as potential immunomodulators
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